Biosynthesis of cyclosporins and other natural peptidyl prolyl cis/trans isomerase inhibitors
Peptidyl-prolyl-cis/trans-isomerases (PPIases) are ubiquitously expressed and have been implicated in a wide range of biological functions. Their inhibition is beneficial in immunosuppression, cancer treatment, treatment of autoimmune diseases, protozoan and viral infections. Three classes of PPIase...
Saved in:
| Published in | Biochimica et biophysica acta Vol. 1850; no. 10; pp. 2111 - 2120 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.10.2015
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0304-4165 0006-3002 1872-8006 |
| DOI | 10.1016/j.bbagen.2014.12.009 |
Cover
| Abstract | Peptidyl-prolyl-cis/trans-isomerases (PPIases) are ubiquitously expressed and have been implicated in a wide range of biological functions. Their inhibition is beneficial in immunosuppression, cancer treatment, treatment of autoimmune diseases, protozoan and viral infections.
Three classes of PPIases are known, each class having their own specific inhibitors. This review will cover the present knowledge on the biosynthesis of the natural PPIase inhibitors. These include for the cyclophilins: the cyclosporins, the analogues of peptolide SDZ 214-103 and the sanglifehrins; for the FKBPs: ascomycin, rapamycin and FK506 and for the parvulins the naphtoquinone juglone.
Over the last thirty years much progress has been made in understanding PPIase function and the biosynthesis of natural PPIase inhibitors. Non-immunosuppressive analogues were discovered and served as lead compounds for the development of novel antiviral drugs. There are, however, still unsolved questions which deserve further research into this exciting field.
As all the major natural inhibitors of the cyclophilins and FKBPs are synthesized by complex non-ribosomal peptide synthetases and/or polyketide synthases, total chemical synthesis is not a viable option. Thus, fully understanding the modular enzyme systems involved in their biosynthesis may help engineering enzymes capable of synthesizing novel PPIase inhibitors with improved functions for a wide range of conditions. This article is part of a Special Issue entitled Proline-directed Foldases: Cell signaling catalysts and drug targets.
•Cyclosporin A, a strong immunosuppressant, has also antiviral activity.•Cyclosporin A is synthesized by trans action of 3 enzymes.•Using cyclosporin synthetase, the non-immunosuppressive analogue NIM-811 was obtained.•The antiviral activity of NIM-811 triggered development of many new PPIase inhibitors.•Pathway engineering may yield better compounds to fight HIV and HCV. |
|---|---|
| AbstractList | Peptidyl-prolyl-cis/trans-isomerases (PPIases) are ubiquitously expressed and have been implicated in a wide range of biological functions. Their inhibition is beneficial in immunosuppression, cancer treatment, treatment of autoimmune diseases, protozoan and viral infections.Three classes of PPIases are known, each class having their own specific inhibitors. This review will cover the present knowledge on the biosynthesis of the natural PPIase inhibitors. These include for the cyclophilins: the cyclosporins, the analogues of peptolide SDZ 214-103 and the sanglifehrins; for the FKBPs: ascomycin, rapamycin and FK506 and for the parvulins the naphtoquinone juglone.Over the last thirty years much progress has been made in understanding PPIase function and the biosynthesis of natural PPIase inhibitors. Non-immunosuppressive analogues were discovered and served as lead compounds for the development of novel antiviral drugs. There are, however, still unsolved questions which deserve further research into this exciting field.As all the major natural inhibitors of the cyclophilins and FKBPs are synthesized by complex non-ribosomal peptide synthetases and/or polyketide synthases, total chemical synthesis is not a viable option. Thus, fully understanding the modular enzyme systems involved in their biosynthesis may help engineering enzymes capable of synthesizing novel PPIase inhibitors with improved functions for a wide range of conditions. This article is part of a Special Issue entitled Proline-directed Foldases: Cell signaling catalysts and drug targets. Peptidyl-prolyl-cis/trans-isomerases (PPIases) are ubiquitously expressed and have been implicated in a wide range of biological functions. Their inhibition is beneficial in immunosuppression, cancer treatment, treatment of autoimmune diseases, protozoan and viral infections.BACKGROUNDPeptidyl-prolyl-cis/trans-isomerases (PPIases) are ubiquitously expressed and have been implicated in a wide range of biological functions. Their inhibition is beneficial in immunosuppression, cancer treatment, treatment of autoimmune diseases, protozoan and viral infections.Three classes of PPIases are known, each class having their own specific inhibitors. This review will cover the present knowledge on the biosynthesis of the natural PPIase inhibitors. These include for the cyclophilins: the cyclosporins, the analogues of peptolide SDZ 214-103 and the sanglifehrins; for the FKBPs: ascomycin, rapamycin and FK506 and for the parvulins the naphtoquinone juglone.SCOPE OF REVIEWThree classes of PPIases are known, each class having their own specific inhibitors. This review will cover the present knowledge on the biosynthesis of the natural PPIase inhibitors. These include for the cyclophilins: the cyclosporins, the analogues of peptolide SDZ 214-103 and the sanglifehrins; for the FKBPs: ascomycin, rapamycin and FK506 and for the parvulins the naphtoquinone juglone.Over the last thirty years much progress has been made in understanding PPIase function and the biosynthesis of natural PPIase inhibitors. Non-immunosuppressive analogues were discovered and served as lead compounds for the development of novel antiviral drugs. There are, however, still unsolved questions which deserve further research into this exciting field.MAJOR CONCLUSIONSOver the last thirty years much progress has been made in understanding PPIase function and the biosynthesis of natural PPIase inhibitors. Non-immunosuppressive analogues were discovered and served as lead compounds for the development of novel antiviral drugs. There are, however, still unsolved questions which deserve further research into this exciting field.As all the major natural inhibitors of the cyclophilins and FKBPs are synthesized by complex non-ribosomal peptide synthetases and/or polyketide synthases, total chemical synthesis is not a viable option. Thus, fully understanding the modular enzyme systems involved in their biosynthesis may help engineering enzymes capable of synthesizing novel PPIase inhibitors with improved functions for a wide range of conditions. This article is part of a Special Issue entitled Proline-directed Foldases: Cell signaling catalysts and drug targets.GENERAL SIGNIFICANCEAs all the major natural inhibitors of the cyclophilins and FKBPs are synthesized by complex non-ribosomal peptide synthetases and/or polyketide synthases, total chemical synthesis is not a viable option. Thus, fully understanding the modular enzyme systems involved in their biosynthesis may help engineering enzymes capable of synthesizing novel PPIase inhibitors with improved functions for a wide range of conditions. This article is part of a Special Issue entitled Proline-directed Foldases: Cell signaling catalysts and drug targets. Peptidyl-prolyl-cis/trans-isomerases (PPIases) are ubiquitously expressed and have been implicated in a wide range of biological functions. Their inhibition is beneficial in immunosuppression, cancer treatment, treatment of autoimmune diseases, protozoan and viral infections. Three classes of PPIases are known, each class having their own specific inhibitors. This review will cover the present knowledge on the biosynthesis of the natural PPIase inhibitors. These include for the cyclophilins: the cyclosporins, the analogues of peptolide SDZ 214-103 and the sanglifehrins; for the FKBPs: ascomycin, rapamycin and FK506 and for the parvulins the naphtoquinone juglone. Over the last thirty years much progress has been made in understanding PPIase function and the biosynthesis of natural PPIase inhibitors. Non-immunosuppressive analogues were discovered and served as lead compounds for the development of novel antiviral drugs. There are, however, still unsolved questions which deserve further research into this exciting field. As all the major natural inhibitors of the cyclophilins and FKBPs are synthesized by complex non-ribosomal peptide synthetases and/or polyketide synthases, total chemical synthesis is not a viable option. Thus, fully understanding the modular enzyme systems involved in their biosynthesis may help engineering enzymes capable of synthesizing novel PPIase inhibitors with improved functions for a wide range of conditions. This article is part of a Special Issue entitled Proline-directed Foldases: Cell signaling catalysts and drug targets. •Cyclosporin A, a strong immunosuppressant, has also antiviral activity.•Cyclosporin A is synthesized by trans action of 3 enzymes.•Using cyclosporin synthetase, the non-immunosuppressive analogue NIM-811 was obtained.•The antiviral activity of NIM-811 triggered development of many new PPIase inhibitors.•Pathway engineering may yield better compounds to fight HIV and HCV. Peptidyl-prolyl-cis/trans-isomerases (PPIases) are ubiquitously expressed and have been implicated in a wide range of biological functions. Their inhibition is beneficial in immunosuppression, cancer treatment, treatment of autoimmune diseases, protozoan and viral infections. Three classes of PPIases are known, each class having their own specific inhibitors. This review will cover the present knowledge on the biosynthesis of the natural PPIase inhibitors. These include for the cyclophilins: the cyclosporins, the analogues of peptolide SDZ 214-103 and the sanglifehrins; for the FKBPs: ascomycin, rapamycin and FK506 and for the parvulins the naphtoquinone juglone. Over the last thirty years much progress has been made in understanding PPIase function and the biosynthesis of natural PPIase inhibitors. Non-immunosuppressive analogues were discovered and served as lead compounds for the development of novel antiviral drugs. There are, however, still unsolved questions which deserve further research into this exciting field. As all the major natural inhibitors of the cyclophilins and FKBPs are synthesized by complex non-ribosomal peptide synthetases and/or polyketide synthases, total chemical synthesis is not a viable option. Thus, fully understanding the modular enzyme systems involved in their biosynthesis may help engineering enzymes capable of synthesizing novel PPIase inhibitors with improved functions for a wide range of conditions. This article is part of a Special Issue entitled Proline-directed Foldases: Cell signaling catalysts and drug targets. |
| Author | Lawen, Alfons |
| Author_xml | – sequence: 1 givenname: Alfons surname: Lawen fullname: Lawen, Alfons email: Alfons.Lawen@monash.edu organization: Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25497210$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkU9v1DAQxS1URLeFb4BQjlyS2k5ixxyQaMU_qRIXOCLLccZ0Vll78XiR9tvjatsLB-rLWPLvPY3fu2BnMUVg7LXgneBCXW27eXa_IHaSi6ETsuPcPGMbMWnZTpyrM7bhPR_aQajxnF0QbXk9oxlfsHM5DkZLwTfs5zUmOsZyB4TUpND4o18T7VPGSI2LS5PqW26iK4fs1mYP-4LLsV5yWuvwSFclu8oipR1kR9BgvMMZS8r0kj0PbiV49TAv2Y9PH7_ffGlvv33-evPhtvW9GUurwWtnplEv0gTlAhhQfTCqd70WS3CzD2pWcgCnnBz0OIN0ziywhH4yAkJ_yd6efOtWvw9Axe6QPKyri5AOZGX9uRRKavMkKjSfTA1Oi4q-eUAP8w4Wu8-4c_loH9OrwLsT4HMiyhCsx-IKplgjwdUKbu-rslt7qsreV2WFtLWqKh7-ET_6PyF7f5JBzfMPQrbkEaKHBTP4YpeE_zf4CwKMsX4 |
| CitedBy_id | crossref_primary_10_3851_IMP3012 crossref_primary_10_1038_s41467_018_06712_1 crossref_primary_10_1088_1755_1315_565_1_012052 crossref_primary_10_1016_j_bbagen_2015_05_010 crossref_primary_10_1039_D1CB00154J crossref_primary_10_1021_acs_orglett_9b00395 crossref_primary_10_1134_S0022093019040021 crossref_primary_10_1002_oby_21208 crossref_primary_10_3390_cancers13123041 crossref_primary_10_1038_s41429_019_0203_y crossref_primary_10_3390_separations8120241 crossref_primary_10_1016_j_synbio_2020_07_004 crossref_primary_10_1080_17460441_2018_1445085 crossref_primary_10_1021_acssynbio_2c00472 crossref_primary_10_1177_1934578X231225538 |
| Cites_doi | 10.1016/j.chembiol.2011.01.017 10.1073/pnas.182156699 10.1111/j.1432-1033.1991.tb16167.x 10.1016/j.antiviral.2011.01.003 10.1021/ja0587603 10.1002/hep.22131 10.1002/hlca.19850680318 10.1074/jbc.M209719200 10.1002/bip.20240 10.1016/j.cld.2009.05.002 10.1002/hlca.19870700103 10.1371/journal.pgen.1003496 10.1007/s00705-013-1803-7 10.1016/S0021-9258(19)38600-4 10.1016/j.jhep.2012.02.024 10.1016/0300-9084(92)90092-S 10.1021/bi00237a023 10.1016/S0079-6468(08)70303-5 10.1016/S0168-8278(09)60624-3 10.1093/infdis/174.4.850 10.7164/antibiotics.42.1283 10.1007/s002030100324 10.1111/j.1574-6968.1995.tb07328.x 10.1016/S1387-2656(03)09002-1 10.1021/ja021327y 10.1074/jbc.M202191200 10.1177/095632029400500507 10.1128/AAC.38.8.1763 10.1021/bi973162p 10.1007/BF00313798 10.1016/S0079-6468(08)70276-5 10.1128/JVI.69.4.2451-2461.1995 10.1562/0031-8655(2003)077<0129:PLOTNM>2.0.CO;2 10.1016/j.bbrc.2006.03.059 10.1007/3-540-29717-0_15 10.1016/S0040-4039(01)88807-9 10.1016/j.pep.2005.07.012 10.1039/C0MB00234H 10.1358/dof.1995.020.06.300693 10.1038/ja.2010.126 10.1093/emboj/16.14.4174 10.1517/13543784.2012.658641 10.1039/C1MD00227A 10.1007/BF01212947 10.4049/jimmunol.171.2.542 10.1038/341758a0 10.1126/science.7604280 10.1002/(SICI)1097-0282(1996)40:5<585::AID-BIP16>3.0.CO;2-G 10.1016/j.virol.2009.10.043 10.1074/jbc.270.11.6163 10.1016/S0031-9422(00)86833-8 10.1111/j.1365-3083.2006.01702.x 10.1016/S0021-9258(19)74290-2 10.1016/j.bmcl.2003.09.042 10.1016/S0021-9258(18)98439-5 10.1126/science.1122928 10.1099/0022-1317-78-4-825 10.1039/b804602f 10.7164/antibiotics.52.466 10.1016/j.str.2007.05.008 10.1042/bj3000395 10.1023/A:1008990919682 10.1021/jm0109863 10.1021/jm500223x 10.7164/antibiotics.45.133 10.1016/S0014-5793(98)00795-9 10.1016/S0021-9258(20)80748-0 10.1038/337476a0 10.1073/pnas.92.17.7839 10.1016/S0168-8278(09)61047-3 10.1128/AAC.01627-10 10.1016/S0969-2126(00)00120-9 10.1073/pnas.1015773108 10.1515/znb-1968-0224 10.1111/j.1432-1033.1997.00526.x 10.1042/BST0380841 10.1128/JVI.78.23.12800-12808.2004 10.1002/hlca.19760590509 10.3390/v4112558 10.1038/nature07162 10.1016/0014-5793(92)80712-P 10.1006/expr.1996.0132 10.1016/j.abb.2012.11.011 10.1128/JVI.69.2.814-824.1995 10.1016/j.biotechadv.2011.03.004 10.7164/antibiotics.52.474 10.1074/jbc.273.35.22773 10.1128/AAC.00660-09 10.1016/S0021-9258(18)99934-5 10.1038/380544a0 10.1038/337473a0 10.1126/science.6238408 10.1016/S0021-9258(17)42019-9 10.1016/S0378-1119(00)00171-2 10.1021/cr960029e 10.1016/S0040-4039(00)01267-3 10.1016/j.cld.2012.09.008 10.1021/bi960224n 10.1002/hlca.19760590412 10.1002/hep.22835 10.1002/anie.200453764 |
| ContentType | Journal Article |
| Copyright | 2014 Elsevier B.V. Copyright © 2014 Elsevier B.V. All rights reserved. |
| Copyright_xml | – notice: 2014 Elsevier B.V. – notice: Copyright © 2014 Elsevier B.V. All rights reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7S9 L.6 |
| DOI | 10.1016/j.bbagen.2014.12.009 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | AGRICOLA MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry Biology Engineering |
| EISSN | 1872-8006 |
| EndPage | 2120 |
| ExternalDocumentID | 25497210 10_1016_j_bbagen_2014_12_009 S0304416514004097 |
| Genre | Journal Article Review |
| GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 23N 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABEFU ABFNM ABGSF ABMAC ABUDA ABXDB ABYKQ ACDAQ ACIUM ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEHWI AEKER AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CS3 DOVZS EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HLW HVGLF HZ~ IHE J1W KOM LX3 M41 MO0 N9A O-L O9- OAUVE OHT OZT P-8 P-9 PC. Q38 R2- ROL RPZ SBG SCC SDF SDG SDP SES SEW SPCBC SSU SSZ T5K UQL WH7 WUQ XJT XPP ~G- AAHBH AATTM AAXKI AAYWO AAYXX ABWVN ACLOT ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGQPQ AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP CITATION EFKBS ~HD -~X .55 .GJ AAYJJ ABJNI AFFNX AI. CGR CUY CVF ECM EIF F5P H~9 K-O MVM NPM RIG TWZ UHS VH1 X7M Y6R YYP ZE2 ZGI ~KM 7X8 7S9 L.6 |
| ID | FETCH-LOGICAL-c395t-7ec7a9857d29f6afe9e63f963a371dfabcf6b624ea6a2475be2aa9dedf3891ef3 |
| IEDL.DBID | .~1 |
| ISSN | 0304-4165 0006-3002 |
| IngestDate | Sun Sep 28 11:30:59 EDT 2025 Fri Sep 05 03:12:29 EDT 2025 Thu Apr 03 07:01:31 EDT 2025 Thu Apr 24 23:11:25 EDT 2025 Wed Oct 01 00:42:33 EDT 2025 Fri Feb 23 02:34:16 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Keywords | Cyclosporin synthetase Cyclosporin analogues Rapamycin and analoges Sanglifehrins Juglone SDZ 214-103 |
| Language | English |
| License | Copyright © 2014 Elsevier B.V. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c395t-7ec7a9857d29f6afe9e63f963a371dfabcf6b624ea6a2475be2aa9dedf3891ef3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| PMID | 25497210 |
| PQID | 1708903071 |
| PQPubID | 23479 |
| PageCount | 10 |
| ParticipantIDs | proquest_miscellaneous_2000216279 proquest_miscellaneous_1708903071 pubmed_primary_25497210 crossref_citationtrail_10_1016_j_bbagen_2014_12_009 crossref_primary_10_1016_j_bbagen_2014_12_009 elsevier_sciencedirect_doi_10_1016_j_bbagen_2014_12_009 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | October 2015 2015-10-00 2015-Oct 20151001 |
| PublicationDateYYYYMMDD | 2015-10-01 |
| PublicationDate_xml | – month: 10 year: 2015 text: October 2015 |
| PublicationDecade | 2010 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Biochimica et biophysica acta |
| PublicationTitleAlternate | Biochim Biophys Acta |
| PublicationYear | 2015 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Fischer, Wittmann-Liebold, Lang, Kiefhaber, Schmid (bb0095) 1989; 337 Schwabe, Steinheider, Lawen, Traber, Hildebrandt (bb0450) 1995; 121 Flisiak, Feinman, Jablkowski, Horban, Kryczka, Pawlowska, Heathcote, Mazzella, Vandelli, Nicolas-Métral, Grosgurin, Liz, Scalfaro, Porchet, Crabbé (bb0105) 2009; 49 Lawen, Traber, Geyl (bb0300) 1991; 266 Evers, Barrière, Bashiardes, Bousseau, Carry, Dereu, Filoche, Henin, Sablé, Vuilhorgne, Mignani (bb0080) 2003; 15 Handschumacher, Harding, Rice, Drugge, Speicher (bb0165) 1984; 226 Lawen, Traber, Geyl, Zocher, Kleinkauf (bb0295) 1989; 42 Sanglier, Quesniaux, Fehr, Hofmann, Mahnke, Memmert, Schuler, Zenke, Gschwind, Maurer, Schilling (bb0435) 1999; 52 Velkov, Singaretnam, Lawen (bb0565) 2006; 45 Lawen, Traber, Reuille, Ponelle (bb0315) 1994; 300 König, Schwecke, Molnár, Böhm, Lowden, Staunton, Leadlay (bb0270) 1997; 247 Bushley, Raja, Jaiswal, Cumbie, Nonogaki, Boyd, Owensby, Knaus, Elser, Miller, Di, McPhail, Spatafora (bb0030) 2013; 9 Schwecke, Aparicio, Molnár (bb0455) 1995; 92 cyclosporin for the treatment of hepatitis C infection and pharmaceutical composition comprising said [D-MeAla] Andexer, Kendrew, Nur-e-Alam, Lazos, Foster, Zimmermann, Warneck, Suthar, Coates, Koehn, Skotnicki, Carter, Gregory, Martin, Moss, Leadlay, Wilkinson (bb0005) 2011; 108 Härtel, Iblher, Puzik, Wortmeier, Ebel, Schultz, Müller-Steinhardt (bb0175) 2006; 63 Traber, Hoffman, Loosli, Ponelle, von Wartburg (bb0535) 1987; 70 Lawen, Dittmann, Schmidt, Riesner, Kleinkauf (bb0310) 1992; 74 Wolvetang, Larm, Moutsoulas, Lawen (bb0600) 1996; 7 Rosenwirth, Billich, Datema, Donatsch, Hammerschmid, Harrison, Hiestand, Jaksche, Mayer, Peichl (bb9005) 1994; 38 Halestrap (bb0160) 2010; 38 Dreyfuss, Chapela (bb0065) 1994 Sedrani, Kallen, Martin Cabrejas, Papageorgiou, Senia, Rohrbach, Wagner, Thai, Jutzi Eme, France, Oberer, Rihs, Zenke, Wagner (bb0460) 2003; 125 Lawitz, Godofsky, Rouzier, Marbury, Nguyen, Ke, Huang, Praestgaard, Serra, Evans (bb0325) 2011; 89 Loor, Tiberghien, Wenandy, Didier, Traber (bb0340) 2002; 45 Steinkasserer, Harrison, Billich, Hammerschmid, Werner, Wolff, Peichl, Palfi, Schnitzel, Mlynar, Rosenwirth (bb0495) 1995; 69 cyclosporin. Keating, Marshall, Walsh, Keating (bb0235) 2002; 9 . Lawen, Traber (bb0285) 1993; 268 Flisiak, Horban, Gallay, Bobardt, Selvarajah, Wiercinska-Drapalo, Siwak, Cielniak, Higersberger, Kierkus, Aeschlimann, Grosgurin, Nicolas-Métral, Dumont, Porchet, Crabbé, Scalfaro (bb0100) 2008; 47 Campbell (bb0035) 1969; 10 Stachelhaus, Schneider, Marahiel (bb0485) 1995; 269 Leistner, Zenk (bb0330) 1968; 23 Takahashi, Hayano, Suzuki (bb0520) 1989; 337 Müller, Leistner (bb0380) 1976; 15 Offenzeller, Santer, Totschnig, Su, Moser, Traber, Schneider-Scherzer (bb0395) 1996; 35 Lawen, Traber, Geyl (bb0305) 1991; 50 Frueh, Arthanari, Koglin, Vosburg, Bennett, Walsh, Wagner (bb0115) 2008; 454 Hopkins, Scorneaux, Huang, Murray, Wring, Smitley, Harris, Erdmann, Fischer, Ribeill (bb0200) 2010; 54 De-Eknamkul (bb0050) 1999 Weber, Baumgartner, Renner, Marahiel, Holak (bb0590) 2000; 8 Lin (bb0335) 2011 M.M. Dreyfuss, M.H. Schreier, H. Tscherter and R. Wenger (15.06.1988), Cyclosporin peptolides, their preparation by fermentation or chemical synthesis and their use as pharmaceuticals. Stachelhaus, Marahiel (bb0480) 1995; 125 di Salvo, Florio, Paiardini, Vivoli, D'Aguanno, Contestabile (bb0055) 2013; 529 1989, 111, 152146a. URL Mlynar, Bevec, Billich, Rosenwirth, Steinkasserer (bb0365) 1997; 78 Lu, Hanes, Hunter (bb0345) 1996; 380 Membreno, Espinales, Lawitz (bb0360) 2013; 17 Offenzeller, Su, Santer, Moser, Traber, Memmert, Schneider-Scherzer (bb0390) 1993; 268 Svarstad, Bugge, Dhillion (bb0510) 2000; 9 Gregory, Gaisser, Lill, Hong, Sheridan, Wilkinson, Petkovic, Weston, Carletti, Lee, Staunton, Leadlay (bb0145) 2004; 43 Billich, Hammerschmid, Peichl, Wenger, Zenke, Quesniaux, Rosenwirth (bb0015) 1995; 69 Hopkins, DiMassimo, Rusnak, Heuman, Lalezari, Sluder, Scorneaux, Mosier, Kowalczyk, Ribeill, Baugh, Gallay (bb0205) 2012; 57 Lawen (bb0280) 1996; 33 Velkov, Lawen (bb0545) 2003; 9 Olano (bb0400) 2011; 64 P. Scalfaro, J.-M. Dumont, G. Vuagniaux and R.-Y. Mauvernay (03. 10. 2005), Use of [D-MeAla] Borel (bb0020) 1985; 3 R.M. Wenger, M. Mutter, P. Garrouste, R. Lysex, O. Turpin, G. Vuagniaux, V. Nicolas, L.N. Zanolari and R. Crabbé (2010), Cycloundecadepsipeptide compounds and use of said compounds as a medicament. Rüegger, Kuhn, Lichti, Loosli, Huguenin, Quiuerez, von Wartburg (bb0425) 1976; 59 Hensens, White, Goegelman, Inamine, Patchett (bb0185) 1992; 45 Gaither, Borawski, Anderson, Balabanis, Devay, Joberty, Rau, Schirle, Bouwmeester, Mickanin, Zhao, Vickers, Lee, Deng, Baryza, Fujimoto, Lin, Compton, Wiedmann (bb0120) 2010; 397 S.J. Moss, B. Wilkinson and M.A. Gregory (2012b), Macrocyclic compounds and methods for their production. WO 2012/131377 A1. URL Steinschulte, Taner, Thomson, Bein, Hackstein (bb0500) 2003; 171 Traber, Kobel, Loosli, Senn, Rosenwirth, Lawen (bb0540) 1994; 5 Kallen, Mikol, Quesniaux, Walkinshaw, Schneider-Scherzer, Schörgendorfer, Weber, Fliri (bb0220) 1997; Vol.7 Moss, Bobardt, Leyssen, Coates, Chatterji, Dejian, Foster, Liu, Nur-e-Alam, Suthar, Yongsheng, Warneck, Zhang, Neyts, Gallay, Wilkinson, Gregory (bb0370) 2012; 3 Fischer, Bang, Mech (bb0090) 1984; 43 Velkov, Lawen (bb0550) 2003; 278 Sokolskaja, Sayah, Luban (bb0470) 2004; 78 Graziani (bb0140) 2009; 26 Hennig, Christner, Kipping, Schelbert, Rücknagel, Grabley, Küllertz, Fischer (bb0180) 1998; 37 WO 9425606 A2. URL Stachelhaus, Marahiel (bb0475) 1995; 270 Gregory, Bobardt, Obeid, Chatterji, Coates, Foster, Gallay, Leyssen, Moss, Neyts, Nur-e-Alam, Paeshuyse, Piraee, Suthar, Warneck, Zhang, Wilkinson (bb0150) 2011; 55 Koglin, Mofid, Löhr, Schäfer, Rogov, Blum, Mittag, Marahiel, Bernhard, Dötsch (bb0265) 2006; 312 S.Y. Ko, H. Kobel, B. Risenwirth, D. Seebach, R.P. Traber, R. Wenger and P. Bollinger (1991), Cyclosporine. H.P. Kocher, E. Schneider-Scherzer, K. Schoergendorfer and G. Weber (1994), Recombinant Alanine Racemase and GAPDH from Tolypocladium. Bennett, Singaretnam, Zhao, Lawen, Ng (bb0010) 1998; 431 EP 0 296 123 A2 (1989) Harding, Galat, Uehling, Schreiber (bb0170) 1989; 341 M. Hijikata, K. Shimotohno, Watashi, K., Use of modified cyclosporins for the treatment of HCV disorders. U. S. Patent Appl. US 7,968,518 B2, 2011. URL EP 0 484 281 B1. URL WO 2010/052559 A1. URL Edlich, Fischer (bb0075) 2006; 172 Kleinkauf, Dittmann, Lawen (bb0245) 1991; 50 Hoffmann, Schneider-Scherzer, Kleinkauf, Zocher (bb9000) 1994; 269 Hoppert, Gentzsch, Schörgendorfer (bb0210) 2001; 176 Velkov, Horne, Scanlon, Capuano, Yuriev, Lawen (bb0570) 2011; 18 Rosenwirth, Billich, Steinkasserer, Peichl, Donatsch, Lawen, Wenger, Traber (bb0415) 1995; 20 WO 2006/038088 A1. URL Senn, Weber, Kobel, Traber (bb0465) 1991; 199 Sweeney, Fu, Wiedmann (bb0515) 2014; 57 Survase, Kagliwal, Annapure, Singhal (bb0505) 2011; 29 Ke, Lawitz, Rozier, Marbury, Nguyen, Serra, Dole, Praestgaard, Huang, Evans (bb0225) 2009; 50 Flisiak, Jaroszewicz, Flisiak, Łapiński (bb0110) 2012; 21 Goto, Watashi, Murata, Hishiki, Hijikata, Shimotohno (bb0135) 2006; 343 Gatto, Boyne, Kelleher, Walsh (bb0130) 2006; 128 Borvak, Chou, Van Dyke, Rosenwirth, Vitetta, Ramilo (bb0025) 1996; 174 Conti, Stachelhaus, Marahiel, Brick (bb0045) 1997; 16 Velkov, Lawen (bb0555) 2003; 77 Fehr, Kallen, Oberer, Sanglier, Schilling (bb0085) 1999; 52 EtVal von Wartburg, Traber (bb0575) 1988; 25 Clarke, McStay, Halestrap (bb0040) 2002; 277 Weber, Schörgendorfer, Schneider-Scherzer, Leitner (bb0585) 1994; 26 Taylor, Mikol, Kallen, Burkhard, Walkinshaw (bb0525) 1996; 40 Lawen, Zocher (bb0290) 1990; 265 Petcher, Weber, Ruegger (bb0405) 1976; 59 Wu, Chung, Revill, Katz, Reeves (bb0605) 2000; 251 Nielsen, Hsu, Byrne, Kaplan (bb0385) 1991; 30 M.A. Gregory, S.J. Moss, Wilkinson, B., Novel compound and methods for its production. US Patent Appl. US 2012/025181, 2012. URL Marahiel, Stachelhaus, Mootz (bb0350) 1997; 97 Velkov, Lawen (bb0560) 2014 Lawitz, Rouzier, Nguyen, Huang, Ke, Praestgaard, Serra, Koziel, Evans (bb0320) 2009; 50 Hopkins, Gallay (bb0195) 2012; 4 Samel, Schönafinger, Knappe, Marahiel, Essen (bb0430) 2007; 15 Dittmann, Wenger, Kleinkauf, Lawen (bb0060) 1994; 269 Traber (bb0530) 1997 Stachelhaus, Mootz, Bergendahl, Marahiel (bb0490) 1998; 273 Wang, Etzkorn (bb0580) 2006; 84 Schmidt, Riesner, Lawen, Kleinkauf (bb0445) 1992; 307 Imran, Manzoor, Khattak, Khalid, Ahmed, Parvaiz, Tariq, Ashraf, Ashraf, Azam, Ashraf (bb0230) 2014; 159 Kessler, Loosli, Oschkinat (bb0240) 1985; 68 Kürnsteiner, Zinner, Kück (bb0275) 2002; Vol.7 Hubler, Rückle, Patiny, Muamba, Guichou, Mutter, Wenger (bb0215) 2000; 41 Gallay (bb0125) 2009; 13 Kocken, van der Wel, Rosenwirth, Thomas (bb0260) 1996; 84 Qu, Jiang, Xu, Shao, Tang, Wilkinson, Liu (bb0410) 2011; 7 May, Kessler, Marahiel, Stubbs (bb0355) 2002; 99 10.1016/j.bbagen.2014.12.009_bb0190 Fehr (10.1016/j.bbagen.2014.12.009_bb0085) 1999; 52 10.1016/j.bbagen.2014.12.009_bb0070 Fischer (10.1016/j.bbagen.2014.12.009_bb0095) 1989; 337 Handschumacher (10.1016/j.bbagen.2014.12.009_bb0165) 1984; 226 Steinschulte (10.1016/j.bbagen.2014.12.009_bb0500) 2003; 171 Velkov (10.1016/j.bbagen.2014.12.009_bb0555) 2003; 77 Kallen (10.1016/j.bbagen.2014.12.009_bb0220) 1997; Vol.7 Hoppert (10.1016/j.bbagen.2014.12.009_bb0210) 2001; 176 Hennig (10.1016/j.bbagen.2014.12.009_bb0180) 1998; 37 Gregory (10.1016/j.bbagen.2014.12.009_bb0145) 2004; 43 Rosenwirth (10.1016/j.bbagen.2014.12.009_bb9005) 1994; 38 Survase (10.1016/j.bbagen.2014.12.009_bb0505) 2011; 29 Imran (10.1016/j.bbagen.2014.12.009_bb0230) 2014; 159 Traber (10.1016/j.bbagen.2014.12.009_bb0530) 1997 Goto (10.1016/j.bbagen.2014.12.009_bb0135) 2006; 343 Ke (10.1016/j.bbagen.2014.12.009_bb0225) 2009; 50 Gregory (10.1016/j.bbagen.2014.12.009_bb0150) 2011; 55 Hoffmann (10.1016/j.bbagen.2014.12.009_bb9000) 1994; 269 Lawen (10.1016/j.bbagen.2014.12.009_bb0285) 1993; 268 Lawen (10.1016/j.bbagen.2014.12.009_bb0305) 1991; 50 Gallay (10.1016/j.bbagen.2014.12.009_bb0125) 2009; 13 Stachelhaus (10.1016/j.bbagen.2014.12.009_bb0490) 1998; 273 Offenzeller (10.1016/j.bbagen.2014.12.009_bb0390) 1993; 268 Wang (10.1016/j.bbagen.2014.12.009_bb0580) 2006; 84 Flisiak (10.1016/j.bbagen.2014.12.009_bb0110) 2012; 21 10.1016/j.bbagen.2014.12.009_bb0595 Schwabe (10.1016/j.bbagen.2014.12.009_bb0450) 1995; 121 Gatto (10.1016/j.bbagen.2014.12.009_bb0130) 2006; 128 Edlich (10.1016/j.bbagen.2014.12.009_bb0075) 2006; 172 Schwecke (10.1016/j.bbagen.2014.12.009_bb0455) 1995; 92 Frueh (10.1016/j.bbagen.2014.12.009_bb0115) 2008; 454 von Wartburg (10.1016/j.bbagen.2014.12.009_bb0575) 1988; 25 Koglin (10.1016/j.bbagen.2014.12.009_bb0265) 2006; 312 Velkov (10.1016/j.bbagen.2014.12.009_bb0560) 2014 De-Eknamkul (10.1016/j.bbagen.2014.12.009_bb0050) Evers (10.1016/j.bbagen.2014.12.009_bb0080) 2003; 15 Campbell (10.1016/j.bbagen.2014.12.009_bb0035) 1969; 10 Stachelhaus (10.1016/j.bbagen.2014.12.009_bb0480) 1995; 125 Conti (10.1016/j.bbagen.2014.12.009_bb0045) 1997; 16 Gaither (10.1016/j.bbagen.2014.12.009_bb0120) 2010; 397 Hopkins (10.1016/j.bbagen.2014.12.009_bb0195) 2012; 4 Lawen (10.1016/j.bbagen.2014.12.009_bb0290) 1990; 265 Sweeney (10.1016/j.bbagen.2014.12.009_bb0515) 2014; 57 Lawitz (10.1016/j.bbagen.2014.12.009_bb0325) 2011; 89 Svarstad (10.1016/j.bbagen.2014.12.009_bb0510) 2000; 9 Kocken (10.1016/j.bbagen.2014.12.009_bb0260) 1996; 84 Velkov (10.1016/j.bbagen.2014.12.009_bb0545) 2003; 9 Harding (10.1016/j.bbagen.2014.12.009_bb0170) 1989; 341 Membreno (10.1016/j.bbagen.2014.12.009_bb0360) 2013; 17 Dittmann (10.1016/j.bbagen.2014.12.009_bb0060) 1994; 269 Sanglier (10.1016/j.bbagen.2014.12.009_bb0435) 1999; 52 Hopkins (10.1016/j.bbagen.2014.12.009_bb0205) 2012; 57 Rüegger (10.1016/j.bbagen.2014.12.009_bb0425) 1976; 59 Bennett (10.1016/j.bbagen.2014.12.009_bb0010) 1998; 431 10.1016/j.bbagen.2014.12.009_bb0255 Senn (10.1016/j.bbagen.2014.12.009_bb0465) 1991; 199 10.1016/j.bbagen.2014.12.009_bb0375 Rosenwirth (10.1016/j.bbagen.2014.12.009_bb0415) 1995; 20 10.1016/j.bbagen.2014.12.009_bb0250 Stachelhaus (10.1016/j.bbagen.2014.12.009_bb0485) 1995; 269 Borvak (10.1016/j.bbagen.2014.12.009_bb0025) 1996; 174 Dreyfuss (10.1016/j.bbagen.2014.12.009_bb0065) 1994 Moss (10.1016/j.bbagen.2014.12.009_bb0370) 2012; 3 Samel (10.1016/j.bbagen.2014.12.009_bb0430) 2007; 15 Halestrap (10.1016/j.bbagen.2014.12.009_bb0160) 2010; 38 Leistner (10.1016/j.bbagen.2014.12.009_bb0330) 1968; 23 Olano (10.1016/j.bbagen.2014.12.009_bb0400) 2011; 64 König (10.1016/j.bbagen.2014.12.009_bb0270) 1997; 247 Lawen (10.1016/j.bbagen.2014.12.009_bb0300) 1991; 266 Lin (10.1016/j.bbagen.2014.12.009_bb0335) 2011 Hensens (10.1016/j.bbagen.2014.12.009_bb0185) 1992; 45 Qu (10.1016/j.bbagen.2014.12.009_bb0410) 2011; 7 Kleinkauf (10.1016/j.bbagen.2014.12.009_bb0245) 1991; 50 Clarke (10.1016/j.bbagen.2014.12.009_bb0040) 2002; 277 Hopkins (10.1016/j.bbagen.2014.12.009_bb0200) 2010; 54 Keating (10.1016/j.bbagen.2014.12.009_bb0235) 2002; 9 Hubler (10.1016/j.bbagen.2014.12.009_bb0215) 2000; 41 Lawen (10.1016/j.bbagen.2014.12.009_bb0315) 1994; 300 Taylor (10.1016/j.bbagen.2014.12.009_bb0525) 1996; 40 Härtel (10.1016/j.bbagen.2014.12.009_bb0175) 2006; 63 di Salvo (10.1016/j.bbagen.2014.12.009_bb0055) 2013; 529 Marahiel (10.1016/j.bbagen.2014.12.009_bb0350) 1997; 97 Kürnsteiner (10.1016/j.bbagen.2014.12.009_bb0275) 2002; Vol.7 Fischer (10.1016/j.bbagen.2014.12.009_bb0090) 1984; 43 Wolvetang (10.1016/j.bbagen.2014.12.009_bb0600) 1996; 7 Mlynar (10.1016/j.bbagen.2014.12.009_bb0365) 1997; 78 Offenzeller (10.1016/j.bbagen.2014.12.009_bb0395) 1996; 35 Bushley (10.1016/j.bbagen.2014.12.009_bb0030) 2013; 9 Andexer (10.1016/j.bbagen.2014.12.009_bb0005) 2011; 108 Sedrani (10.1016/j.bbagen.2014.12.009_bb0460) 2003; 125 10.1016/j.bbagen.2014.12.009_bb0155 Loor (10.1016/j.bbagen.2014.12.009_bb0340) 2002; 45 Schmidt (10.1016/j.bbagen.2014.12.009_bb0445) 1992; 307 Sokolskaja (10.1016/j.bbagen.2014.12.009_bb0470) 2004; 78 Müller (10.1016/j.bbagen.2014.12.009_bb0380) 1976; 15 Billich (10.1016/j.bbagen.2014.12.009_bb0015) 1995; 69 Weber (10.1016/j.bbagen.2014.12.009_bb0590) 2000; 8 Lawen (10.1016/j.bbagen.2014.12.009_bb0295) 1989; 42 Nielsen (10.1016/j.bbagen.2014.12.009_bb0385) 1991; 30 Flisiak (10.1016/j.bbagen.2014.12.009_bb0105) 2009; 49 Velkov (10.1016/j.bbagen.2014.12.009_bb0565) 2006; 45 Lu (10.1016/j.bbagen.2014.12.009_bb0345) 1996; 380 Kessler (10.1016/j.bbagen.2014.12.009_bb0240) 1985; 68 Lawen (10.1016/j.bbagen.2014.12.009_bb0280) 1996; 33 Traber (10.1016/j.bbagen.2014.12.009_bb0535) 1987; 70 Wu (10.1016/j.bbagen.2014.12.009_bb0605) 2000; 251 10.1016/j.bbagen.2014.12.009_bb0440 Graziani (10.1016/j.bbagen.2014.12.009_bb0140) 2009; 26 Velkov (10.1016/j.bbagen.2014.12.009_bb0570) 2011; 18 Borel (10.1016/j.bbagen.2014.12.009_bb0020) 1985; 3 Takahashi (10.1016/j.bbagen.2014.12.009_bb0520) 1989; 337 Lawen (10.1016/j.bbagen.2014.12.009_bb0310) 1992; 74 Weber (10.1016/j.bbagen.2014.12.009_bb0585) 1994; 26 Lawitz (10.1016/j.bbagen.2014.12.009_bb0320) 2009; 50 Stachelhaus (10.1016/j.bbagen.2014.12.009_bb0475) 1995; 270 Petcher (10.1016/j.bbagen.2014.12.009_bb0405) 1976; 59 Steinkasserer (10.1016/j.bbagen.2014.12.009_bb0495) 1995; 69 Flisiak (10.1016/j.bbagen.2014.12.009_bb0100) 2008; 47 Velkov (10.1016/j.bbagen.2014.12.009_bb0550) 2003; 278 May (10.1016/j.bbagen.2014.12.009_bb0355) 2002; 99 Traber (10.1016/j.bbagen.2014.12.009_bb0540) 1994; 5 |
| References_xml | – volume: 5 start-page: 331 year: 1994 end-page: 339 ident: bb0540 article-title: [MeIle publication-title: Antivir. Chem. Chemother. – volume: 7 start-page: 1315 year: 1996 end-page: 1325 ident: bb0600 article-title: Apoptosis induced by inhibitors of the plasma membrane NADH-oxidase involves Bcl-2 and calcineurin publication-title: Cell Growth Differ. – volume: 47 start-page: 817 year: 2008 end-page: 826 ident: bb0100 article-title: The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus publication-title: Hepatology – volume: 278 start-page: 1137 year: 2003 end-page: 1148 ident: bb0550 article-title: Mapping of publication-title: J. Biol. Chem. – start-page: 49 year: 1994 end-page: 80 ident: bb0065 article-title: Potential of fungi in the discovery of novel, low-molecular weight pharmaceuticals publication-title: The Discovery of Natural Products with Therapeutic Potential – volume: 159 start-page: 831 year: 2014 end-page: 846 ident: bb0230 article-title: Current and future therapies for hepatitis C virus infection: from viral proteins to host targets publication-title: Arch. Virol. – volume: Vol.7 start-page: 129 year: 2002 end-page: 156 ident: bb0275 article-title: Immunosuppressants publication-title: The Mycota. A comprehensive treatise on fungi as experimental systems for basic and applied research. Volume X, Industrial Applications – volume: 3 start-page: 944 year: 2012 end-page: 949 ident: bb0370 article-title: Sangamides, a new class of cyclophilin-inhibiting host-targeted antivirals for treatment of HCV infection publication-title: Med. Chem. Commun. – reference: WO 9425606 A2. URL: – volume: 108 start-page: 4776 year: 2011 end-page: 4781 ident: bb0005 article-title: Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 269 start-page: 2841 year: 1994 end-page: 2846 ident: bb0060 article-title: Mechanism of biosynthesis of cyclosporin A: evidence for synthesis via a single linear undecapeptide precursor publication-title: J. Biol. Chem. – volume: 277 start-page: 34793 year: 2002 end-page: 34799 ident: bb0040 article-title: Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilin-D at a different site from cyclosporin A publication-title: J. Biol. Chem. – volume: 337 start-page: 476 year: 1989 end-page: 478 ident: bb0095 article-title: Cyclophilin and peptidyl-prolyl publication-title: Nature – year: 1999 ident: bb0050 article-title: Chasing the key enzymes of secondary metabolite—biosynthesis from Thai medicinal plants – volume: 431 start-page: 386 year: 1998 end-page: 390 ident: bb0010 article-title: Peptidyl-prolyl- publication-title: FEBS Lett. – volume: 380 start-page: 544 year: 1996 end-page: 547 ident: bb0345 article-title: A human peptidyl-prolyl isomerase essential for regulation of mitosis publication-title: Nature – volume: 59 start-page: 1480 year: 1976 end-page: 1488 ident: bb0405 article-title: Crystal and molecular structure of an Iodo derivative of the cyclic undecapeptide cyclosporin A publication-title: Helv. Chim. Acta – volume: 268 start-page: 20452 year: 1993 end-page: 20465 ident: bb0285 article-title: Substrate specificities of cyclosporin synthetase and peptolide SDZ 214-103 synthetase. Comparison of the substrate specificities of the related multifunctional polypeptides publication-title: J. Biol. Chem. – start-page: 279 year: 1997 end-page: 314 ident: bb0530 article-title: Biosynthesis of cyclosporins publication-title: Biotechnology of Antibiotics – volume: 125 start-page: 3 year: 1995 end-page: 14 ident: bb0480 article-title: Modular structure of genes encoding multifunctional peptide synthetases required for non-ribosomal peptide synthesis publication-title: FEMS Microbiol. Lett. – volume: 273 start-page: 22773 year: 1998 end-page: 22781 ident: bb0490 article-title: Peptide bond formation in nonribosomal peptide biosynthesis. Catalytic role of the condensation domain publication-title: J. Biol. Chem. – volume: 45 start-page: 133 year: 1992 end-page: 135 ident: bb0185 article-title: The preparation of [2-deutero-3-fluoro-D-Ala publication-title: J. Antibiot. – volume: 50 start-page: S379 year: 2009 ident: bb0320 article-title: Safety and antiviral efficacy of 14 publication-title: J. Hepatol. – volume: 13 start-page: 403 year: 2009 end-page: 417 ident: bb0125 article-title: Cyclophilin inhibitors publication-title: Clin. Liver Dis. – reference: M.A. Gregory, S.J. Moss, Wilkinson, B., Novel compound and methods for its production. US Patent Appl. US 2012/025181, 2012. URL: – reference: R.M. Wenger, M. Mutter, P. Garrouste, R. Lysex, O. Turpin, G. Vuagniaux, V. Nicolas, L.N. Zanolari and R. Crabbé (2010), Cycloundecadepsipeptide compounds and use of said compounds as a medicament. – volume: 343 start-page: 879 year: 2006 end-page: 884 ident: bb0135 article-title: Evaluation of the anti-hepatitis C virus effects of cyclophilin inhibitors, cyclosporine A, and NIM811 publication-title: Biochem. Biophys. Res. Commun. – volume: 52 start-page: 474 year: 1999 end-page: 479 ident: bb0085 article-title: Sanglifehrins A, B, C and D, novel cyclophilin-binding compounds isolated from publication-title: J. Antibiot. (Tokyo) – volume: 55 start-page: 1975 year: 2011 end-page: 1981 ident: bb0150 article-title: Preclinical characterization of naturally occurring polyketide cyclophilin inhibitors from the sanglifehrin family publication-title: Antimicrob. Agents Chemother. – volume: 42 start-page: 1283 year: 1989 end-page: 1289 ident: bb0295 article-title: Cell-free biosynthesis of new cyclosporins publication-title: J. Antibiot. (Tokyo) – volume: 121 start-page: 407 year: 1995 end-page: 412 ident: bb0450 article-title: Reversal of multidrug resistance (MDR) by novel publication-title: J. Cancer Res. Clin. Oncol. – reference: M. Hijikata, K. Shimotohno, Watashi, K., Use of modified cyclosporins for the treatment of HCV disorders. U. S. Patent Appl. US 7,968,518 B2, 2011. URL: – volume: 300 start-page: 395 year: 1994 end-page: 399 ident: bb0315 article-title: In vitro biosynthesis of ring-extended cyclosporins publication-title: Biochem. J. – start-page: 317 year: 2011 end-page: 328 ident: bb0335 article-title: Discovery of cyclophilin inhibitor NIM811 as a novel therapeutic agent for HCV publication-title: Antiviral Drugs From Basic Discovery Through Clinical Trials – volume: 337 start-page: 473 year: 1989 end-page: 475 ident: bb0520 article-title: Peptidyl-prolyl publication-title: Nature – volume: 74 start-page: 511 year: 1992 end-page: 516 ident: bb0310 article-title: Enzymatic biosynthesis of cyclosporin A and analogues publication-title: Biochimie – volume: 20 start-page: 579 year: 1995 end-page: 583 ident: bb0415 article-title: SDZ NIM 811. A novel nonimmunosuppressive natural cyclosporin with anti-HIV activity publication-title: Drugs Future – volume: 174 start-page: 850 year: 1996 end-page: 853 ident: bb0025 article-title: The use of cyclosporine, FK506, and SDZ NIM811 to prevent CD25-quiescent peripheral blood mononuclear cells from producing human immunodeficiency virus publication-title: J. Infect. Dis. – volume: 10 start-page: 4777 year: 1969 end-page: 4780 ident: bb0035 article-title: The roles of alanine, aspartate and glutamate in lawsone biosynthesis in Impatiens balsamina publication-title: Tetrahedron Lett. – volume: 92 start-page: 7839 year: 1995 end-page: 7843 ident: bb0455 article-title: The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 3 start-page: 239 year: 1985 end-page: 250 ident: bb0020 article-title: Immunological properties of ciclosporin (Sandimmune®) publication-title: Proc. Int. Conf., 3rd Meeting – volume: 57 start-page: 47 year: 2012 end-page: 54 ident: bb0205 article-title: The cyclophilin inhibitor SCY-635 suppresses viral replication and induces endogenous interferons in patients with chronic HCV genotype 1 infection publication-title: J. Hepatol. – volume: 26 start-page: 120 year: 1994 end-page: 125 ident: bb0585 article-title: The peptide synthetase catalyzing cyclosporine production in publication-title: Curr. Genet. – volume: 15 start-page: 407 year: 1976 end-page: 410 ident: bb0380 article-title: 1,4-Naphthoquinone, an intermediate in juglone (5-hydroxy-1,4-naphthoquinone) biosynthesis publication-title: Phytochemistry – volume: 7 start-page: 852 year: 2011 end-page: 861 ident: bb0410 article-title: Cloning, sequencing and characterization of the biosynthetic gene cluster of sanglifehrin A, a potent cyclophilin inhibitor publication-title: Mol. BioSyst. – volume: 172 start-page: 359 year: 2006 end-page: 404 ident: bb0075 article-title: Pharmacological targeting of catalyzed protein folding: the example of peptide bond publication-title: Handb. Exp. Pharmacol. – volume: 97 start-page: 2651 year: 1997 end-page: 2673 ident: bb0350 article-title: Modular peptide synthetases involved in nonribosomal peptide synthesis publication-title: Chem. Rev. – volume: 70 start-page: 13 year: 1987 end-page: 36 ident: bb0535 article-title: Neue Cyclosprine aus publication-title: Helv. Chim. Acta – volume: 77 start-page: 129 year: 2003 end-page: 137 ident: bb0555 article-title: Photoaffinity labelling of the publication-title: Photochem. Photobiol. – volume: 269 start-page: 12710 year: 1994 end-page: 12714 ident: bb9000 article-title: Purification and characterization of eucaryotic alanine racemase acting as key enzyme in cyclosporin biosynthesis publication-title: J. Biol. Chem. – volume: 312 start-page: 273 year: 2006 end-page: 276 ident: bb0265 article-title: Conformational switches modulate protein interactions in peptide antibiotic synthetases publication-title: Science – volume: 50 start-page: S260 year: 1991 end-page: S263 ident: bb0305 article-title: biosynthesis of [Thr publication-title: Biomed. Biophys. Acta – volume: 30 start-page: 5789 year: 1991 end-page: 5796 ident: bb0385 article-title: Biosynthesis of the immunosuppressant immunomycin: the enzymology of pipecolate incorporation publication-title: Biochemistry – reference: S.Y. Ko, H. Kobel, B. Risenwirth, D. Seebach, R.P. Traber, R. Wenger and P. Bollinger (1991), Cyclosporine. – volume: 18 start-page: 464 year: 2011 end-page: 475 ident: bb0570 article-title: Characterization of the publication-title: Chem. Biol. – reference: . EP 0 484 281 B1. URL: – volume: 89 start-page: 238 year: 2011 end-page: 245 ident: bb0325 article-title: Safety, pharmacokinetics, and antiviral activity of the cyclophilin inhibitor NIM811 alone or in combination with pegylated interferon in HCV-infected patients receiving 14 publication-title: Antivir. Res. – volume: 49 start-page: 1460 year: 2009 end-page: 1468 ident: bb0105 article-title: The cyclophilin inhibitor Debio 025 combined with PEG IFNα2a significantly reduces viral load in treatment-naïve hepatitis C patients publication-title: Hepatology – volume: 176 start-page: 285 year: 2001 end-page: 293 ident: bb0210 article-title: Structure and localization of cyclosporin synthetase, the key enzyme of cyclosporin biosynthesis in publication-title: Arch. Microbiol. – volume: 68 start-page: 661 year: 1985 end-page: 681 ident: bb0240 article-title: Peptide conformations. Part 30. Assignment of the publication-title: Helv. Chim. Acta – reference: . WO 2012/131377 A1. URL: – volume: 64 start-page: 51 year: 2011 end-page: 57 ident: bb0400 article-title: Hutchinson's legacy: keeping on polyketide biosynthesis publication-title: J. Antibiot. (Tokyo) – volume: 59 start-page: 1075 year: 1976 end-page: 1092 ident: bb0425 article-title: Cyclosporine A ein immunsuppressiv wirksamer Peptidmetabolit aus publication-title: Helv. Chim. Acta – volume: 38 start-page: 1763 year: 1994 end-page: 1772 ident: bb9005 article-title: Inhibition of human immunodeficiency virus type 1 replication by SDZ NIM 811, a nonimmunosuppressive cyclosporine analog publication-title: Antimicrob. Agents Chemother. – volume: 84 start-page: 439 year: 1996 end-page: 443 ident: bb0260 article-title: : publication-title: Exp. Parasitol. – volume: 43 start-page: 1101 year: 1984 end-page: 1111 ident: bb0090 article-title: Nachweis einer Enzymkatalyse für die publication-title: Biomed. Biochim. Acta – volume: 50 start-page: S219 year: 1991 end-page: S224 ident: bb0245 article-title: Cell-free biosynthesis of cyclosporin A and analogues publication-title: Biomed. Biophys. Acta – volume: 45 start-page: 4598 year: 2002 end-page: 4612 ident: bb0340 article-title: Cyclosporins: structure–activity relationships for the inhibition of the human publication-title: J. Med. Chem. – volume: 57 start-page: 7145 year: 2014 end-page: 7159 ident: bb0515 article-title: From chemical tools to clinical medicines: nonimmunosuppressive cyclophilin inhibitors derived from the cyclosporin and sanglifehrin scaffolds publication-title: J. Med. Chem. – volume: 33 start-page: 53 year: 1996 end-page: 97 ident: bb0280 article-title: Biosynthesis and mechanism of action of cyclosporins publication-title: Prog. Med. Chem. – volume: 171 start-page: 542 year: 2003 end-page: 546 ident: bb0500 article-title: Cutting edge: sanglifehrin A, a novel cyclophilin-binding immunosuppressant blocks bioactive IL-12 production by human dendritic cells publication-title: J. Immunol. – volume: 69 start-page: 2451 year: 1995 end-page: 2461 ident: bb0015 article-title: Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus (HIV) type 1: interference with HIV protein–cyclophilin A interactions publication-title: J. Virol. – volume: 265 start-page: 11355 year: 1990 end-page: 11360 ident: bb0290 article-title: Cyclosporin synthetase. The most complex peptide synthesizing multienzyme polypeptide so far described publication-title: J. Biol. Chem. – volume: 16 start-page: 4174 year: 1997 end-page: 4183 ident: bb0045 article-title: Structural basis for the activation of phenylalanine in the non-ribosomal biosynthesis of gramicidin S publication-title: EMBO J. – volume: 270 start-page: 6163 year: 1995 end-page: 6169 ident: bb0475 article-title: Modular structure of peptide synthetases revealed by dissection of the multifunctional enzyme GrsA publication-title: J. Biol. Chem. – volume: 45 start-page: 275 year: 2006 end-page: 287 ident: bb0565 article-title: An improved purification procedure for cyclosporin synthetase publication-title: Protein Expr. Purif. – reference: -[EtVal] – volume: 15 start-page: 4415 year: 2003 end-page: 4419 ident: bb0080 article-title: Synthesis of non-immunosuppressive cyclophilin-binding cyclosporin A derivatives as potential anti-HIV-1 drugs publication-title: Bioorg. Med. Chem. Lett. – volume: 43 start-page: 2551 year: 2004 end-page: 2553 ident: bb0145 article-title: Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by publication-title: Angew. Chem. Int. Ed. Engl. – volume: 69 start-page: 814 year: 1995 end-page: 824 ident: bb0495 article-title: Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus type 1 (HIV-1): interference with early and late events in HIV-1 replication publication-title: J. Virol. – volume: 38 start-page: 841 year: 2010 end-page: 860 ident: bb0160 article-title: A pore way to die: the role of mitochondria in reperfusion injury and cardioprotection publication-title: Biochem. Soc. Trans. – volume: 54 start-page: 660 year: 2010 end-page: 672 ident: bb0200 article-title: SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication publication-title: Antimicrob. Agents Chemother. – volume: 529 start-page: 55 year: 2013 end-page: 65 ident: bb0055 article-title: Alanine racemase from publication-title: Arch. Biochem. Biophys. – volume: 226 start-page: 544 year: 1984 end-page: 547 ident: bb0165 article-title: Cyclophilin: a specific cytosolic binding protein for cyclosporin A publication-title: Science – volume: 29 start-page: 418 year: 2011 end-page: 435 ident: bb0505 article-title: Cyclosporin A — a review on fermentative production, downstream processing and pharmacological applications publication-title: Biotechnol. Adv. – volume: 128 start-page: 3838 year: 2006 end-page: 3847 ident: bb0130 article-title: Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster publication-title: J. Am. Chem. Soc. – volume: 9 start-page: 522 year: 2002 end-page: 526 ident: bb0235 article-title: The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains publication-title: Nat. Struct. Biol. – reference: S.J. Moss, B. Wilkinson and M.A. Gregory (2012b), Macrocyclic compounds and methods for their production. – volume: 78 start-page: 825 year: 1997 end-page: 835 ident: bb0365 article-title: The non-immunosuppressive cyclosporin A analogue SDZ NIM 811 inhibits cyclophilin A incorporation into virions and virus replication in human immunodeficiency virus type 1-infected primary and growth-arrested T cells publication-title: J. Gen. Virol. – volume: 125 start-page: 3849 year: 2003 end-page: 3859 ident: bb0460 article-title: Sanglifehrin–cyclophilin interaction: degradation work, synthetic macrocyclic analogues, X-ray crystal structure, and binding data publication-title: J. Am. Chem. Soc. – volume: 25 start-page: 1 year: 1988 end-page: 33 ident: bb0575 article-title: Cyclosporines, fungal metabolites with immunosuppressive activities publication-title: Prog. Med. Chem. – volume: 21 start-page: 375 year: 2012 end-page: 382 ident: bb0110 article-title: Update on alisporivir in treatment of viral hepatitis C publication-title: Expert Opin. Investig. Drugs – start-page: 65 year: 2014 end-page: 88 ident: bb0560 article-title: Cyclosporines: biosynthesis and beyond publication-title: Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites – volume: 454 start-page: 903 year: 2008 end-page: 906 ident: bb0115 article-title: Dynamic thiolation–thioesterase structure of a non-ribosomal peptide synthetase publication-title: Nature – reference: . WO 2010/052559 A1. URL: – volume: 397 start-page: 43 year: 2010 end-page: 55 ident: bb0120 article-title: Multiple cyclophilins involved in different cellular pathways mediate HCV replication publication-title: Virology – volume: 9 start-page: e1003496 year: 2013 ident: bb0030 article-title: The genome of publication-title: PLoS Genet. – volume: 15 start-page: 781 year: 2007 end-page: 792 ident: bb0430 article-title: Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase publication-title: Structure – reference: . 1989, 111, 152146a. URL: – volume: 341 start-page: 758 year: 1989 end-page: 760 ident: bb0170 article-title: A receptor for the immunosuppressant FK506 is a publication-title: Nature – reference: H.P. Kocher, E. Schneider-Scherzer, K. Schoergendorfer and G. Weber (1994), Recombinant Alanine Racemase and GAPDH from Tolypocladium. – reference: . WO 2006/038088 A1. URL: – volume: 37 start-page: 5953 year: 1998 end-page: 5960 ident: bb0180 article-title: Selective inactivation of parvulin-like peptidyl-prolyl cis/trans isomerases by juglone publication-title: Biochemistry – volume: 35 start-page: 8401 year: 1996 end-page: 8412 ident: bb0395 article-title: Biosynthesis of the unusual amino acid (4 publication-title: Biochemistry – volume: 247 start-page: 526 year: 1997 end-page: 534 ident: bb0270 article-title: The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin–nucleotide sequence analysis, disruption and heterologous expression of rapP from publication-title: Eur. J. Biochem. – volume: 26 start-page: 602 year: 2009 end-page: 609 ident: bb0140 article-title: Recent advances in the chemistry, biosynthesis and pharmacology of rapamycin analogs publication-title: Nat. Prod. Rep. – reference: P. Scalfaro, J.-M. Dumont, G. Vuagniaux and R.-Y. Mauvernay (03. 10. 2005), Use of [D-MeAla] – volume: 40 start-page: 585 year: 1996 end-page: 592 ident: bb0525 article-title: Conformational polymorphism in peptidic and nonpeptidic drug molecules publication-title: Pept. Sci. – volume: 251 start-page: 81 year: 2000 end-page: 90 ident: bb0605 article-title: The FK520 gene cluster of publication-title: Gene – volume: 78 start-page: 12800 year: 2004 end-page: 12808 ident: bb0470 article-title: Target cell cyclophilin A modulates human immunodeficiency virus type 1 infectivity publication-title: J. Virol. – volume: 268 start-page: 26127 year: 1993 end-page: 26134 ident: bb0390 article-title: Biosynthesis of the unusual amino acid (4 publication-title: J. Biol. Chem. – volume: 99 start-page: 12120 year: 2002 end-page: 12125 ident: bb0355 article-title: Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 4 start-page: 2558 year: 2012 end-page: 2577 ident: bb0195 article-title: Cyclophilin inhibitors: an emerging class of therapeutics for the treatment of chronic hepatitis C infection publication-title: Viruses – volume: 266 start-page: 15567 year: 1991 end-page: 15570 ident: bb0300 article-title: biosynthesis of [Thr publication-title: J. Biol. Chem. – volume: 199 start-page: 653 year: 1991 end-page: 658 ident: bb0465 article-title: Selective publication-title: Eur. J. Biochem. – reference: . EP 0 296 123 A2 (1989); – volume: 17 start-page: 129 year: 2013 end-page: 139 ident: bb0360 article-title: Cyclophilin inhibitors for hepatitis C therapy publication-title: Clin. Liver Dis. – volume: 50 start-page: S229 year: 2009 ident: bb0225 article-title: Saftey, and tolerability of NIM811, a novel cyclophilin inhibitor for HCV, following single and multiple ascending doses in healthy volunteers and HCV-infected patients publication-title: J. Hepatol. – volume: 23 start-page: 259 year: 1968 end-page: 268 ident: bb0330 article-title: Zur Biogenese von 5-Hydroxy-1,4-napthoquinone (Juglon) in publication-title: Z. Naturforsch. B – volume: 63 start-page: 26 year: 2006 end-page: 34 ident: bb0175 article-title: Immunosuppressive activity of the immunophilin-binding drug sanglifehrin A in human whole blood: potent inhibition of interleukin-6 produced by lymphocytes and monocytes publication-title: Scand. J. Immunol. – volume: 307 start-page: 355 year: 1992 end-page: 360 ident: bb0445 article-title: Cyclosporin synthetase is a 1.4 publication-title: FEBS Lett. – volume: 41 start-page: 7139 year: 2000 end-page: 7276 ident: bb0215 article-title: Synthetic routes to NEtXaa publication-title: Tetrahedron Lett. – reference: -cyclosporin for the treatment of hepatitis C infection and pharmaceutical composition comprising said [D-MeAla] – reference: . – volume: 84 start-page: 125 year: 2006 end-page: 146 ident: bb0580 article-title: Peptidyl-prolyl isomerase inhibitors publication-title: Pept. Sci. – volume: 9 start-page: 151 year: 2003 end-page: 197 ident: bb0545 article-title: Nonribosomal peptide synthetases as technological platforms for the synthesis of highly modified peptide bioeffectors — cyclosporin synthetase as a complex example publication-title: Biotechnol. Annu. Rev. – volume: 8 start-page: 407 year: 2000 end-page: 418 ident: bb0590 article-title: Solution structure of PCP, a prototype for the peptidyl carrier domains of modular peptide synthetases publication-title: Structure – reference: M.M. Dreyfuss, M.H. Schreier, H. Tscherter and R. Wenger (15.06.1988), Cyclosporin peptolides, their preparation by fermentation or chemical synthesis and their use as pharmaceuticals. – volume: Vol.7 start-page: 535 year: 1997 end-page: 591 ident: bb0220 article-title: Cyclosporins: recent developments in biosynthesis, pharmacology and biology, and clinical applications publication-title: Biotechnology – volume: 52 start-page: 466 year: 1999 end-page: 473 ident: bb0435 article-title: Sanglifehrins A, B, C and D, novel cyclophilin-binding compounds isolated from publication-title: J. Antibiot. (Tokyo) – reference: -cyclosporin. – volume: 9 start-page: 1521 year: 2000 end-page: 1541 ident: bb0510 article-title: From Norway to Novartis: Cyclosporin from publication-title: Biodivers. Conserv. – volume: 269 start-page: 69 year: 1995 end-page: 72 ident: bb0485 article-title: Rational design of peptide antibiotics by targeted replacement of bacterial and fungal domains publication-title: Science – ident: 10.1016/j.bbagen.2014.12.009_bb0070 – volume: 18 start-page: 464 year: 2011 ident: 10.1016/j.bbagen.2014.12.009_bb0570 article-title: Characterization of the N-methyltransferase activitie(s) of the multifunctional polypeptide cyclosporin synthetase publication-title: Chem. Biol. doi: 10.1016/j.chembiol.2011.01.017 – volume: 99 start-page: 12120 year: 2002 ident: 10.1016/j.bbagen.2014.12.009_bb0355 article-title: Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.182156699 – volume: 199 start-page: 653 year: 1991 ident: 10.1016/j.bbagen.2014.12.009_bb0465 article-title: Selective 13C-labelling of cyclosporine A publication-title: Eur. J. Biochem. doi: 10.1111/j.1432-1033.1991.tb16167.x – volume: 89 start-page: 238 year: 2011 ident: 10.1016/j.bbagen.2014.12.009_bb0325 article-title: Safety, pharmacokinetics, and antiviral activity of the cyclophilin inhibitor NIM811 alone or in combination with pegylated interferon in HCV-infected patients receiving 14days of therapy publication-title: Antivir. Res. doi: 10.1016/j.antiviral.2011.01.003 – volume: 128 start-page: 3838 year: 2006 ident: 10.1016/j.bbagen.2014.12.009_bb0130 article-title: Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster publication-title: J. Am. Chem. Soc. doi: 10.1021/ja0587603 – volume: Vol.7 start-page: 535 year: 1997 ident: 10.1016/j.bbagen.2014.12.009_bb0220 article-title: Cyclosporins: recent developments in biosynthesis, pharmacology and biology, and clinical applications – volume: 47 start-page: 817 year: 2008 ident: 10.1016/j.bbagen.2014.12.009_bb0100 article-title: The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus publication-title: Hepatology doi: 10.1002/hep.22131 – volume: 68 start-page: 661 year: 1985 ident: 10.1016/j.bbagen.2014.12.009_bb0240 article-title: Peptide conformations. Part 30. Assignment of the 1H-, 13C-, and 15N-NMR spectra of cyclosporin A in CDCl3 and C6D6 by a combination of homo- and heteronuclear two-dimensional techniques publication-title: Helv. Chim. Acta doi: 10.1002/hlca.19850680318 – volume: 278 start-page: 1137 year: 2003 ident: 10.1016/j.bbagen.2014.12.009_bb0550 article-title: Mapping of S-adenosyl-l-methionine binding site in the N-methyltransferase domain(s) of the multienzyme polypeptide cyclosporin synthetase publication-title: J. Biol. Chem. doi: 10.1074/jbc.M209719200 – volume: 84 start-page: 125 year: 2006 ident: 10.1016/j.bbagen.2014.12.009_bb0580 article-title: Peptidyl-prolyl isomerase inhibitors publication-title: Pept. Sci. doi: 10.1002/bip.20240 – volume: 13 start-page: 403 year: 2009 ident: 10.1016/j.bbagen.2014.12.009_bb0125 article-title: Cyclophilin inhibitors publication-title: Clin. Liver Dis. doi: 10.1016/j.cld.2009.05.002 – volume: 70 start-page: 13 year: 1987 ident: 10.1016/j.bbagen.2014.12.009_bb0535 article-title: Neue Cyclosprine aus Tolypocladium inflatum. Die Cyclosporine K–Z publication-title: Helv. Chim. Acta doi: 10.1002/hlca.19870700103 – volume: 9 start-page: e1003496 year: 2013 ident: 10.1016/j.bbagen.2014.12.009_bb0030 article-title: The genome of Tolypocladium inflatum: evolution, organization, and expression of the cyclosporine biosynthetic gene cluster publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1003496 – volume: 159 start-page: 831 year: 2014 ident: 10.1016/j.bbagen.2014.12.009_bb0230 article-title: Current and future therapies for hepatitis C virus infection: from viral proteins to host targets publication-title: Arch. Virol. doi: 10.1007/s00705-013-1803-7 – start-page: 65 year: 2014 ident: 10.1016/j.bbagen.2014.12.009_bb0560 article-title: Cyclosporines: biosynthesis and beyond – volume: 7 start-page: 1315 year: 1996 ident: 10.1016/j.bbagen.2014.12.009_bb0600 article-title: Apoptosis induced by inhibitors of the plasma membrane NADH-oxidase involves Bcl-2 and calcineurin publication-title: Cell Growth Differ. – volume: 265 start-page: 11355 year: 1990 ident: 10.1016/j.bbagen.2014.12.009_bb0290 article-title: Cyclosporin synthetase. The most complex peptide synthesizing multienzyme polypeptide so far described publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)38600-4 – volume: 57 start-page: 47 year: 2012 ident: 10.1016/j.bbagen.2014.12.009_bb0205 article-title: The cyclophilin inhibitor SCY-635 suppresses viral replication and induces endogenous interferons in patients with chronic HCV genotype 1 infection publication-title: J. Hepatol. doi: 10.1016/j.jhep.2012.02.024 – volume: 74 start-page: 511 year: 1992 ident: 10.1016/j.bbagen.2014.12.009_bb0310 article-title: Enzymatic biosynthesis of cyclosporin A and analogues publication-title: Biochimie doi: 10.1016/0300-9084(92)90092-S – ident: 10.1016/j.bbagen.2014.12.009_bb0250 – volume: Vol.7 start-page: 129 year: 2002 ident: 10.1016/j.bbagen.2014.12.009_bb0275 article-title: Immunosuppressants – volume: 30 start-page: 5789 year: 1991 ident: 10.1016/j.bbagen.2014.12.009_bb0385 article-title: Biosynthesis of the immunosuppressant immunomycin: the enzymology of pipecolate incorporation publication-title: Biochemistry doi: 10.1021/bi00237a023 – volume: 33 start-page: 53 year: 1996 ident: 10.1016/j.bbagen.2014.12.009_bb0280 article-title: Biosynthesis and mechanism of action of cyclosporins publication-title: Prog. Med. Chem. doi: 10.1016/S0079-6468(08)70303-5 – volume: 50 start-page: S229 year: 2009 ident: 10.1016/j.bbagen.2014.12.009_bb0225 article-title: Saftey, and tolerability of NIM811, a novel cyclophilin inhibitor for HCV, following single and multiple ascending doses in healthy volunteers and HCV-infected patients publication-title: J. Hepatol. doi: 10.1016/S0168-8278(09)60624-3 – ident: 10.1016/j.bbagen.2014.12.009_bb0155 – volume: 174 start-page: 850 year: 1996 ident: 10.1016/j.bbagen.2014.12.009_bb0025 article-title: The use of cyclosporine, FK506, and SDZ NIM811 to prevent CD25-quiescent peripheral blood mononuclear cells from producing human immunodeficiency virus publication-title: J. Infect. Dis. doi: 10.1093/infdis/174.4.850 – volume: 42 start-page: 1283 year: 1989 ident: 10.1016/j.bbagen.2014.12.009_bb0295 article-title: Cell-free biosynthesis of new cyclosporins publication-title: J. Antibiot. (Tokyo) doi: 10.7164/antibiotics.42.1283 – ident: 10.1016/j.bbagen.2014.12.009_bb0050 – volume: 176 start-page: 285 year: 2001 ident: 10.1016/j.bbagen.2014.12.009_bb0210 article-title: Structure and localization of cyclosporin synthetase, the key enzyme of cyclosporin biosynthesis in Tolypocladium inflatum publication-title: Arch. Microbiol. doi: 10.1007/s002030100324 – volume: 125 start-page: 3 year: 1995 ident: 10.1016/j.bbagen.2014.12.009_bb0480 article-title: Modular structure of genes encoding multifunctional peptide synthetases required for non-ribosomal peptide synthesis publication-title: FEMS Microbiol. Lett. doi: 10.1111/j.1574-6968.1995.tb07328.x – volume: 9 start-page: 151 year: 2003 ident: 10.1016/j.bbagen.2014.12.009_bb0545 article-title: Nonribosomal peptide synthetases as technological platforms for the synthesis of highly modified peptide bioeffectors — cyclosporin synthetase as a complex example publication-title: Biotechnol. Annu. Rev. doi: 10.1016/S1387-2656(03)09002-1 – volume: 125 start-page: 3849 year: 2003 ident: 10.1016/j.bbagen.2014.12.009_bb0460 article-title: Sanglifehrin–cyclophilin interaction: degradation work, synthetic macrocyclic analogues, X-ray crystal structure, and binding data publication-title: J. Am. Chem. Soc. doi: 10.1021/ja021327y – ident: 10.1016/j.bbagen.2014.12.009_bb0255 – volume: 277 start-page: 34793 year: 2002 ident: 10.1016/j.bbagen.2014.12.009_bb0040 article-title: Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilin-D at a different site from cyclosporin A publication-title: J. Biol. Chem. doi: 10.1074/jbc.M202191200 – ident: 10.1016/j.bbagen.2014.12.009_bb0190 – volume: 5 start-page: 331 year: 1994 ident: 10.1016/j.bbagen.2014.12.009_bb0540 article-title: [MeIle4]cyclosporin, a novel natural cyclosporin with anti-HIV activity: structure elucidation and biosynthesis publication-title: Antivir. Chem. Chemother. doi: 10.1177/095632029400500507 – volume: 38 start-page: 1763 year: 1994 ident: 10.1016/j.bbagen.2014.12.009_bb9005 article-title: Inhibition of human immunodeficiency virus type 1 replication by SDZ NIM 811, a nonimmunosuppressive cyclosporine analog publication-title: Antimicrob. Agents Chemother. doi: 10.1128/AAC.38.8.1763 – volume: 37 start-page: 5953 year: 1998 ident: 10.1016/j.bbagen.2014.12.009_bb0180 article-title: Selective inactivation of parvulin-like peptidyl-prolyl cis/trans isomerases by juglone publication-title: Biochemistry doi: 10.1021/bi973162p – volume: 26 start-page: 120 year: 1994 ident: 10.1016/j.bbagen.2014.12.009_bb0585 article-title: The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame publication-title: Curr. Genet. doi: 10.1007/BF00313798 – volume: 25 start-page: 1 year: 1988 ident: 10.1016/j.bbagen.2014.12.009_bb0575 article-title: Cyclosporines, fungal metabolites with immunosuppressive activities publication-title: Prog. Med. Chem. doi: 10.1016/S0079-6468(08)70276-5 – volume: 69 start-page: 2451 year: 1995 ident: 10.1016/j.bbagen.2014.12.009_bb0015 article-title: Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus (HIV) type 1: interference with HIV protein–cyclophilin A interactions publication-title: J. Virol. doi: 10.1128/JVI.69.4.2451-2461.1995 – volume: 77 start-page: 129 year: 2003 ident: 10.1016/j.bbagen.2014.12.009_bb0555 article-title: Photoaffinity labelling of the N-methyltransferase domains of cyclosporin synthetase publication-title: Photochem. Photobiol. doi: 10.1562/0031-8655(2003)077<0129:PLOTNM>2.0.CO;2 – volume: 343 start-page: 879 year: 2006 ident: 10.1016/j.bbagen.2014.12.009_bb0135 article-title: Evaluation of the anti-hepatitis C virus effects of cyclophilin inhibitors, cyclosporine A, and NIM811 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2006.03.059 – volume: 172 start-page: 359 year: 2006 ident: 10.1016/j.bbagen.2014.12.009_bb0075 article-title: Pharmacological targeting of catalyzed protein folding: the example of peptide bond cis/trans isomerases publication-title: Handb. Exp. Pharmacol. doi: 10.1007/3-540-29717-0_15 – volume: 10 start-page: 4777 year: 1969 ident: 10.1016/j.bbagen.2014.12.009_bb0035 article-title: The roles of alanine, aspartate and glutamate in lawsone biosynthesis in Impatiens balsamina publication-title: Tetrahedron Lett. doi: 10.1016/S0040-4039(01)88807-9 – volume: 45 start-page: 275 year: 2006 ident: 10.1016/j.bbagen.2014.12.009_bb0565 article-title: An improved purification procedure for cyclosporin synthetase publication-title: Protein Expr. Purif. doi: 10.1016/j.pep.2005.07.012 – volume: 7 start-page: 852 year: 2011 ident: 10.1016/j.bbagen.2014.12.009_bb0410 article-title: Cloning, sequencing and characterization of the biosynthetic gene cluster of sanglifehrin A, a potent cyclophilin inhibitor publication-title: Mol. BioSyst. doi: 10.1039/C0MB00234H – volume: 20 start-page: 579 year: 1995 ident: 10.1016/j.bbagen.2014.12.009_bb0415 article-title: SDZ NIM 811. A novel nonimmunosuppressive natural cyclosporin with anti-HIV activity publication-title: Drugs Future doi: 10.1358/dof.1995.020.06.300693 – volume: 64 start-page: 51 year: 2011 ident: 10.1016/j.bbagen.2014.12.009_bb0400 article-title: Hutchinson's legacy: keeping on polyketide biosynthesis publication-title: J. Antibiot. (Tokyo) doi: 10.1038/ja.2010.126 – volume: 16 start-page: 4174 year: 1997 ident: 10.1016/j.bbagen.2014.12.009_bb0045 article-title: Structural basis for the activation of phenylalanine in the non-ribosomal biosynthesis of gramicidin S publication-title: EMBO J. doi: 10.1093/emboj/16.14.4174 – volume: 21 start-page: 375 year: 2012 ident: 10.1016/j.bbagen.2014.12.009_bb0110 article-title: Update on alisporivir in treatment of viral hepatitis C publication-title: Expert Opin. Investig. Drugs doi: 10.1517/13543784.2012.658641 – volume: 3 start-page: 944 year: 2012 ident: 10.1016/j.bbagen.2014.12.009_bb0370 article-title: Sangamides, a new class of cyclophilin-inhibiting host-targeted antivirals for treatment of HCV infection publication-title: Med. Chem. Commun. doi: 10.1039/C1MD00227A – volume: 121 start-page: 407 year: 1995 ident: 10.1016/j.bbagen.2014.12.009_bb0450 article-title: Reversal of multidrug resistance (MDR) by novel in vitro biosynthesized cyclosporin A analogues and the cyclopeptolide SDZ 214-103 publication-title: J. Cancer Res. Clin. Oncol. doi: 10.1007/BF01212947 – volume: 171 start-page: 542 year: 2003 ident: 10.1016/j.bbagen.2014.12.009_bb0500 article-title: Cutting edge: sanglifehrin A, a novel cyclophilin-binding immunosuppressant blocks bioactive IL-12 production by human dendritic cells publication-title: J. Immunol. doi: 10.4049/jimmunol.171.2.542 – volume: 341 start-page: 758 year: 1989 ident: 10.1016/j.bbagen.2014.12.009_bb0170 article-title: A receptor for the immunosuppressant FK506 is a cis–trans peptidyl-prolyl isomerase publication-title: Nature doi: 10.1038/341758a0 – volume: 269 start-page: 69 year: 1995 ident: 10.1016/j.bbagen.2014.12.009_bb0485 article-title: Rational design of peptide antibiotics by targeted replacement of bacterial and fungal domains publication-title: Science doi: 10.1126/science.7604280 – volume: 40 start-page: 585 year: 1996 ident: 10.1016/j.bbagen.2014.12.009_bb0525 article-title: Conformational polymorphism in peptidic and nonpeptidic drug molecules publication-title: Pept. Sci. doi: 10.1002/(SICI)1097-0282(1996)40:5<585::AID-BIP16>3.0.CO;2-G – volume: 397 start-page: 43 year: 2010 ident: 10.1016/j.bbagen.2014.12.009_bb0120 article-title: Multiple cyclophilins involved in different cellular pathways mediate HCV replication publication-title: Virology doi: 10.1016/j.virol.2009.10.043 – volume: 270 start-page: 6163 year: 1995 ident: 10.1016/j.bbagen.2014.12.009_bb0475 article-title: Modular structure of peptide synthetases revealed by dissection of the multifunctional enzyme GrsA publication-title: J. Biol. Chem. doi: 10.1074/jbc.270.11.6163 – volume: 15 start-page: 407 year: 1976 ident: 10.1016/j.bbagen.2014.12.009_bb0380 article-title: 1,4-Naphthoquinone, an intermediate in juglone (5-hydroxy-1,4-naphthoquinone) biosynthesis publication-title: Phytochemistry doi: 10.1016/S0031-9422(00)86833-8 – volume: 63 start-page: 26 year: 2006 ident: 10.1016/j.bbagen.2014.12.009_bb0175 article-title: Immunosuppressive activity of the immunophilin-binding drug sanglifehrin A in human whole blood: potent inhibition of interleukin-6 produced by lymphocytes and monocytes publication-title: Scand. J. Immunol. doi: 10.1111/j.1365-3083.2006.01702.x – volume: 268 start-page: 26127 year: 1993 ident: 10.1016/j.bbagen.2014.12.009_bb0390 article-title: Biosynthesis of the unusual amino acid (4R)-4-[(E)-2-butenyl]-4-methyl-l-threonine of cyclosporine A. Identification of 3(R)-hydroxy-4(R)-methyl-6(E)-octenoic acid as a key intermediate by enzymatic in vitro synthesis and by in vivo labeling techniques publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)74290-2 – start-page: 49 year: 1994 ident: 10.1016/j.bbagen.2014.12.009_bb0065 article-title: Potential of fungi in the discovery of novel, low-molecular weight pharmaceuticals – volume: 50 start-page: S219 year: 1991 ident: 10.1016/j.bbagen.2014.12.009_bb0245 article-title: Cell-free biosynthesis of cyclosporin A and analogues publication-title: Biomed. Biophys. Acta – start-page: 317 year: 2011 ident: 10.1016/j.bbagen.2014.12.009_bb0335 article-title: Discovery of cyclophilin inhibitor NIM811 as a novel therapeutic agent for HCV – volume: 3 start-page: 239 year: 1985 ident: 10.1016/j.bbagen.2014.12.009_bb0020 article-title: Immunological properties of ciclosporin (Sandimmune®) – volume: 43 start-page: 1101 year: 1984 ident: 10.1016/j.bbagen.2014.12.009_bb0090 article-title: Nachweis einer Enzymkatalyse für die cis–trans-Isomerisierung der Peptidbindung in prolinhaltigen Peptiden publication-title: Biomed. Biochim. Acta – volume: 15 start-page: 4415 year: 2003 ident: 10.1016/j.bbagen.2014.12.009_bb0080 article-title: Synthesis of non-immunosuppressive cyclophilin-binding cyclosporin A derivatives as potential anti-HIV-1 drugs publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/j.bmcl.2003.09.042 – volume: 266 start-page: 15567 year: 1991 ident: 10.1016/j.bbagen.2014.12.009_bb0300 article-title: In vitro biosynthesis of [Thr2, Leu5, D-Hiv8, Leu10]-cyclosporin, a cyclosporin-related peptolide with immunosuppressive activity by a multienzyme polypeptide publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)98439-5 – volume: 312 start-page: 273 year: 2006 ident: 10.1016/j.bbagen.2014.12.009_bb0265 article-title: Conformational switches modulate protein interactions in peptide antibiotic synthetases publication-title: Science doi: 10.1126/science.1122928 – volume: 78 start-page: 825 year: 1997 ident: 10.1016/j.bbagen.2014.12.009_bb0365 article-title: The non-immunosuppressive cyclosporin A analogue SDZ NIM 811 inhibits cyclophilin A incorporation into virions and virus replication in human immunodeficiency virus type 1-infected primary and growth-arrested T cells publication-title: J. Gen. Virol. doi: 10.1099/0022-1317-78-4-825 – volume: 26 start-page: 602 year: 2009 ident: 10.1016/j.bbagen.2014.12.009_bb0140 article-title: Recent advances in the chemistry, biosynthesis and pharmacology of rapamycin analogs publication-title: Nat. Prod. Rep. doi: 10.1039/b804602f – volume: 52 start-page: 466 year: 1999 ident: 10.1016/j.bbagen.2014.12.009_bb0435 article-title: Sanglifehrins A, B, C and D, novel cyclophilin-binding compounds isolated from Streptomyces sp. A92-308110. I. Taxonomy, fermentation, isolation and biological activity publication-title: J. Antibiot. (Tokyo) doi: 10.7164/antibiotics.52.466 – volume: 15 start-page: 781 year: 2007 ident: 10.1016/j.bbagen.2014.12.009_bb0430 article-title: Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase publication-title: Structure doi: 10.1016/j.str.2007.05.008 – volume: 300 start-page: 395 year: 1994 ident: 10.1016/j.bbagen.2014.12.009_bb0315 article-title: In vitro biosynthesis of ring-extended cyclosporins publication-title: Biochem. J. doi: 10.1042/bj3000395 – volume: 9 start-page: 1521 year: 2000 ident: 10.1016/j.bbagen.2014.12.009_bb0510 article-title: From Norway to Novartis: Cyclosporin from Tolypocladium inflatum in an open access bioprospecting regime publication-title: Biodivers. Conserv. doi: 10.1023/A:1008990919682 – volume: 45 start-page: 4598 year: 2002 ident: 10.1016/j.bbagen.2014.12.009_bb0340 article-title: Cyclosporins: structure–activity relationships for the inhibition of the human MDR1 P-glycoprotein ABC transporter publication-title: J. Med. Chem. doi: 10.1021/jm0109863 – volume: 57 start-page: 7145 year: 2014 ident: 10.1016/j.bbagen.2014.12.009_bb0515 article-title: From chemical tools to clinical medicines: nonimmunosuppressive cyclophilin inhibitors derived from the cyclosporin and sanglifehrin scaffolds publication-title: J. Med. Chem. doi: 10.1021/jm500223x – volume: 45 start-page: 133 year: 1992 ident: 10.1016/j.bbagen.2014.12.009_bb0185 article-title: The preparation of [2-deutero-3-fluoro-D-Ala8]cyclosporin A by directed biosynthesis publication-title: J. Antibiot. doi: 10.7164/antibiotics.45.133 – volume: 431 start-page: 386 year: 1998 ident: 10.1016/j.bbagen.2014.12.009_bb0010 article-title: Peptidyl-prolyl-cis/trans-isomerase activity may be necessary for memory formation publication-title: FEBS Lett. doi: 10.1016/S0014-5793(98)00795-9 – volume: 268 start-page: 20452 year: 1993 ident: 10.1016/j.bbagen.2014.12.009_bb0285 article-title: Substrate specificities of cyclosporin synthetase and peptolide SDZ 214-103 synthetase. Comparison of the substrate specificities of the related multifunctional polypeptides publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(20)80748-0 – volume: 337 start-page: 476 year: 1989 ident: 10.1016/j.bbagen.2014.12.009_bb0095 article-title: Cyclophilin and peptidyl-prolyl cis–trans isomerase are probably identical proteins publication-title: Nature doi: 10.1038/337476a0 – volume: 92 start-page: 7839 year: 1995 ident: 10.1016/j.bbagen.2014.12.009_bb0455 article-title: The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.92.17.7839 – volume: 50 start-page: S379 year: 2009 ident: 10.1016/j.bbagen.2014.12.009_bb0320 article-title: Safety and antiviral efficacy of 14days of the cyclophilin inhibitor NIM811 in combination with pegylated interferon α2a in relapsed genotype 1 HCV infected patients publication-title: J. Hepatol. doi: 10.1016/S0168-8278(09)61047-3 – volume: 55 start-page: 1975 year: 2011 ident: 10.1016/j.bbagen.2014.12.009_bb0150 article-title: Preclinical characterization of naturally occurring polyketide cyclophilin inhibitors from the sanglifehrin family publication-title: Antimicrob. Agents Chemother. doi: 10.1128/AAC.01627-10 – volume: 8 start-page: 407 year: 2000 ident: 10.1016/j.bbagen.2014.12.009_bb0590 article-title: Solution structure of PCP, a prototype for the peptidyl carrier domains of modular peptide synthetases publication-title: Structure doi: 10.1016/S0969-2126(00)00120-9 – volume: 108 start-page: 4776 year: 2011 ident: 10.1016/j.bbagen.2014.12.009_bb0005 article-title: Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1015773108 – volume: 23 start-page: 259 year: 1968 ident: 10.1016/j.bbagen.2014.12.009_bb0330 article-title: Zur Biogenese von 5-Hydroxy-1,4-napthoquinone (Juglon) in Juglans regia L. [On the biogenesis of 5-hydroxy-1,4-napthoquinone (juglone) in Juglans regia L.] publication-title: Z. Naturforsch. B doi: 10.1515/znb-1968-0224 – volume: 50 start-page: S260 year: 1991 ident: 10.1016/j.bbagen.2014.12.009_bb0305 article-title: In vitro biosynthesis of [Thr2, Leu5, D-Hiv8, Leu10]-cyclosporin, a cyclosporin-related immunosuppressive peptolide publication-title: Biomed. Biophys. Acta – ident: 10.1016/j.bbagen.2014.12.009_bb0595 – volume: 247 start-page: 526 year: 1997 ident: 10.1016/j.bbagen.2014.12.009_bb0270 article-title: The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin–nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus publication-title: Eur. J. Biochem. doi: 10.1111/j.1432-1033.1997.00526.x – volume: 38 start-page: 841 year: 2010 ident: 10.1016/j.bbagen.2014.12.009_bb0160 article-title: A pore way to die: the role of mitochondria in reperfusion injury and cardioprotection publication-title: Biochem. Soc. Trans. doi: 10.1042/BST0380841 – volume: 78 start-page: 12800 year: 2004 ident: 10.1016/j.bbagen.2014.12.009_bb0470 article-title: Target cell cyclophilin A modulates human immunodeficiency virus type 1 infectivity publication-title: J. Virol. doi: 10.1128/JVI.78.23.12800-12808.2004 – volume: 59 start-page: 1480 year: 1976 ident: 10.1016/j.bbagen.2014.12.009_bb0405 article-title: Crystal and molecular structure of an Iodo derivative of the cyclic undecapeptide cyclosporin A publication-title: Helv. Chim. Acta doi: 10.1002/hlca.19760590509 – volume: 4 start-page: 2558 year: 2012 ident: 10.1016/j.bbagen.2014.12.009_bb0195 article-title: Cyclophilin inhibitors: an emerging class of therapeutics for the treatment of chronic hepatitis C infection publication-title: Viruses doi: 10.3390/v4112558 – volume: 454 start-page: 903 year: 2008 ident: 10.1016/j.bbagen.2014.12.009_bb0115 article-title: Dynamic thiolation–thioesterase structure of a non-ribosomal peptide synthetase publication-title: Nature doi: 10.1038/nature07162 – volume: 307 start-page: 355 year: 1992 ident: 10.1016/j.bbagen.2014.12.009_bb0445 article-title: Cyclosporin synthetase is a 1.4MDa multienzyme polypeptide. Re-evaluation of the molecular mass of various peptide synthetases publication-title: FEBS Lett. doi: 10.1016/0014-5793(92)80712-P – volume: 84 start-page: 439 year: 1996 ident: 10.1016/j.bbagen.2014.12.009_bb0260 article-title: Plasmodium vivax: in vitro antiparasitic effect of cyclosporines publication-title: Exp. Parasitol. doi: 10.1006/expr.1996.0132 – ident: 10.1016/j.bbagen.2014.12.009_bb0440 – volume: 529 start-page: 55 year: 2013 ident: 10.1016/j.bbagen.2014.12.009_bb0055 article-title: Alanine racemase from Tolypocladium inflatum: a key PLP-dependent enzyme in cyclosporin biosynthesis and a model of catalytic promiscuity publication-title: Arch. Biochem. Biophys. doi: 10.1016/j.abb.2012.11.011 – volume: 69 start-page: 814 year: 1995 ident: 10.1016/j.bbagen.2014.12.009_bb0495 article-title: Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus type 1 (HIV-1): interference with early and late events in HIV-1 replication publication-title: J. Virol. doi: 10.1128/JVI.69.2.814-824.1995 – volume: 29 start-page: 418 year: 2011 ident: 10.1016/j.bbagen.2014.12.009_bb0505 article-title: Cyclosporin A — a review on fermentative production, downstream processing and pharmacological applications publication-title: Biotechnol. Adv. doi: 10.1016/j.biotechadv.2011.03.004 – volume: 52 start-page: 474 year: 1999 ident: 10.1016/j.bbagen.2014.12.009_bb0085 article-title: Sanglifehrins A, B, C and D, novel cyclophilin-binding compounds isolated from Streptomyces sp. A92-308110. II. Structure elucidation, stereochemistry and physico-chemical properties publication-title: J. Antibiot. (Tokyo) doi: 10.7164/antibiotics.52.474 – volume: 273 start-page: 22773 year: 1998 ident: 10.1016/j.bbagen.2014.12.009_bb0490 article-title: Peptide bond formation in nonribosomal peptide biosynthesis. Catalytic role of the condensation domain publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.35.22773 – volume: 54 start-page: 660 year: 2010 ident: 10.1016/j.bbagen.2014.12.009_bb0200 article-title: SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro publication-title: Antimicrob. Agents Chemother. doi: 10.1128/AAC.00660-09 – volume: 9 start-page: 522 year: 2002 ident: 10.1016/j.bbagen.2014.12.009_bb0235 article-title: The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains publication-title: Nat. Struct. Biol. – start-page: 279 year: 1997 ident: 10.1016/j.bbagen.2014.12.009_bb0530 article-title: Biosynthesis of cyclosporins – volume: 269 start-page: 12710 year: 1994 ident: 10.1016/j.bbagen.2014.12.009_bb9000 article-title: Purification and characterization of eucaryotic alanine racemase acting as key enzyme in cyclosporin biosynthesis publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)99934-5 – volume: 380 start-page: 544 year: 1996 ident: 10.1016/j.bbagen.2014.12.009_bb0345 article-title: A human peptidyl-prolyl isomerase essential for regulation of mitosis publication-title: Nature doi: 10.1038/380544a0 – volume: 337 start-page: 473 year: 1989 ident: 10.1016/j.bbagen.2014.12.009_bb0520 article-title: Peptidyl-prolyl cis–trans isomerase is the cyclosporin A-binding protein cyclophilin publication-title: Nature doi: 10.1038/337473a0 – volume: 226 start-page: 544 year: 1984 ident: 10.1016/j.bbagen.2014.12.009_bb0165 article-title: Cyclophilin: a specific cytosolic binding protein for cyclosporin A publication-title: Science doi: 10.1126/science.6238408 – volume: 269 start-page: 2841 year: 1994 ident: 10.1016/j.bbagen.2014.12.009_bb0060 article-title: Mechanism of biosynthesis of cyclosporin A: evidence for synthesis via a single linear undecapeptide precursor publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)42019-9 – volume: 251 start-page: 81 year: 2000 ident: 10.1016/j.bbagen.2014.12.009_bb0605 article-title: The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units publication-title: Gene doi: 10.1016/S0378-1119(00)00171-2 – volume: 97 start-page: 2651 year: 1997 ident: 10.1016/j.bbagen.2014.12.009_bb0350 article-title: Modular peptide synthetases involved in nonribosomal peptide synthesis publication-title: Chem. Rev. doi: 10.1021/cr960029e – volume: 41 start-page: 7139 year: 2000 ident: 10.1016/j.bbagen.2014.12.009_bb0215 article-title: Synthetic routes to NEtXaa4-cyclosporin A derivatives as potential anti-HIV I drugs publication-title: Tetrahedron Lett. doi: 10.1016/S0040-4039(00)01267-3 – volume: 17 start-page: 129 year: 2013 ident: 10.1016/j.bbagen.2014.12.009_bb0360 article-title: Cyclophilin inhibitors for hepatitis C therapy publication-title: Clin. Liver Dis. doi: 10.1016/j.cld.2012.09.008 – ident: 10.1016/j.bbagen.2014.12.009_bb0375 – volume: 35 start-page: 8401 year: 1996 ident: 10.1016/j.bbagen.2014.12.009_bb0395 article-title: Biosynthesis of the unusual amino acid (4R)-4-[(E)-2-butenyl]-4-methyl-l-threonine of cyclosporine A: enzymatic analysis of the reaction sequence including identification of the methylation precursor in a polyketide pathway publication-title: Biochemistry doi: 10.1021/bi960224n – volume: 59 start-page: 1075 year: 1976 ident: 10.1016/j.bbagen.2014.12.009_bb0425 article-title: Cyclosporine A ein immunsuppressiv wirksamer Peptidmetabolit aus Trichoderma polysporum (LINK ex PERS.) Rifai publication-title: Helv. Chim. Acta doi: 10.1002/hlca.19760590412 – volume: 49 start-page: 1460 year: 2009 ident: 10.1016/j.bbagen.2014.12.009_bb0105 article-title: The cyclophilin inhibitor Debio 025 combined with PEG IFNα2a significantly reduces viral load in treatment-naïve hepatitis C patients publication-title: Hepatology doi: 10.1002/hep.22835 – volume: 43 start-page: 2551 year: 2004 ident: 10.1016/j.bbagen.2014.12.009_bb0145 article-title: Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus publication-title: Angew. Chem. Int. Ed. Engl. doi: 10.1002/anie.200453764 |
| SSID | ssj0000595 ssj0025309 |
| Score | 2.2475715 |
| SecondaryResourceType | review_article |
| Snippet | Peptidyl-prolyl-cis/trans-isomerases (PPIases) are ubiquitously expressed and have been implicated in a wide range of biological functions. Their inhibition is... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 2111 |
| SubjectTerms | antiviral agents autoimmune diseases biosynthesis catalysts cyclophilins Cyclosporin analogues Cyclosporin synthetase Cyclosporine - metabolism cyclosporins engineering Enzyme Inhibitors - metabolism immunosuppression Juglone ligases neoplasms Peptide Biosynthesis, Nucleic Acid-Independent - physiology peptidylprolyl isomerase Peptidylprolyl Isomerase - antagonists & inhibitors Peptidylprolyl Isomerase - metabolism polyketide synthases Protozoa Rapamycin and analoges Sanglifehrins SDZ 214-103 synthesis |
| Title | Biosynthesis of cyclosporins and other natural peptidyl prolyl cis/trans isomerase inhibitors |
| URI | https://dx.doi.org/10.1016/j.bbagen.2014.12.009 https://www.ncbi.nlm.nih.gov/pubmed/25497210 https://www.proquest.com/docview/1708903071 https://www.proquest.com/docview/2000216279 |
| Volume | 1850 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Baden-Württemberg Complete Freedom Collection (Elsevier) customDbUrl: eissn: 1872-8006 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000595 issn: 0304-4165 databaseCode: GBLVA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier Science Direct Journals customDbUrl: eissn: 1872-8006 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000595 issn: 0304-4165 databaseCode: AIKHN dateStart: 19950118 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier SD Complete Freedom Collection [SCCMFC] customDbUrl: eissn: 1872-8006 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000595 issn: 0304-4165 databaseCode: ACRLP dateStart: 19950118 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection customDbUrl: eissn: 1872-8006 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000595 issn: 0304-4165 databaseCode: .~1 dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 1872-8006 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0025309 issn: 0304-4165 databaseCode: AKRWK dateStart: 19470101 isFulltext: true providerName: Library Specific Holdings – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 1872-8006 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000595 issn: 0304-4165 databaseCode: AKRWK dateStart: 19640113 isFulltext: true providerName: Library Specific Holdings |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR1daxQxMJSK6Ito_WrVsoKv8W43X5vHclhOD_ugFvsiIZ8YOXaP7vXhXvztndmPimAp-JTdkIQwM8nMZL4IecdrUQPj9FTXXlPOuKIODhaNwierLFe1wEDhz2dyec4_XYiLPbKYYmHQrXK8-4c7vb-tx57ZCM3ZJufZVzTqgTgBHB8pUWNEOWb_App-__uPmweID2KwJHCKo6fwud7Hyzk4tJgFteT9oyC6Jf6bPd0mfvZs6PQxeTTKj8XJsMUnZC82B-T-UFFyd0AeLKYCbk_JD-jtdg1IeF3uijYVfufXLaqxuekK24Sij74q-tyesOYGHVzCDj4u2zU0PnezLbKyInctvl11scjNz-wyVuh5Rs5PP3xbLOlYTYF6psWWquiV1bVQodJJ2hR1lCzB-bNMlSFZ55N0suLRSltxJVysrNUhhoSmzJjYc7LftE18iXHeTARZR6kY475yeg7Yquo5D6C_lWU4JGwCovFjqnGseLE2k0_ZLzOA3iDoTVkZAP0hoTezNkOqjTvGqwk_5i-SMcAN7pj5dkKnAZygicQ2sb3qTKnmtcZ7r7x9DAY3VaWsFKzzYqCFm_2iug069fzov_f2ijyEPzH4C74m-9vLq_gG5J6tO-4J-5jcO_m4Wp5hu_ryfXUNEKIEmg |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR3JatwwVKQTSnopbbqlbVIXehUz1modw9Aw2ebSBHIpQpupy2AP8eQwf9_3vKQUGgI52WhDvPf0FukthHwThSxAcAZqimCo4EJTDweLJhlKp53QhcRA4culWlyLsxt5s0PmYywMulUOvL_n6R23HlqmAzSn66qa_sBHPVAnQOIjJRr9jOwKCTx5QnaPT88Xy78MWXbFV3A8xQljBF3n5uU9nFtMhJqL7l4QPRP_L6Ee0kA7SXTyirwcVMjsuN_la7KT6n3yvC8qud0ne_Oxhtsb8hNa220NSl5btVlTZmEbVg1aslXdZq6OWReAlXXpPWHNNfq4xC383DYr-ISqnW5QmmVV2-D1VZuyqv5V-QqL9Lwl1yffr-YLOhRUoIEbuaE6Be1MIXVkplSuTCYpXsIRdFznsXQ-lMorJpJTjgktfWLOmZhiia-ZqeTvyKRu6vQBQ725jKpISnMuAvNmBghjxUxEMOHyPB4QPgLRhiHbOBa9WNnRrey37UFvEfQ2ZxZAf0Do_ax1n23jkfF6xI_9h2osCIRHZn4d0WkBJ_hK4urU3LU217PCIOvLHx6D8U0sV0zDOu97WrjfL1rcYFbPPj55b1_I3uLq8sJenC7PP5EX0CN798HPZLK5vUuHoAZt_NFA5n8At3sFog |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Biosynthesis+of+cyclosporins+and+other+natural+peptidyl+prolyl+cis%2Ftrans+isomerase+inhibitors&rft.jtitle=Biochimica+et+biophysica+acta.+General+subjects&rft.au=Lawen%2C+Alfons&rft.date=2015-10-01&rft.issn=0304-4165&rft.volume=1850+p.2111-2120&rft.spage=2111&rft.epage=2120&rft_id=info:doi/10.1016%2Fj.bbagen.2014.12.009&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0304-4165&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0304-4165&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0304-4165&client=summon |