Late-Onset Focal Epilepsy: Electroclinical Features and Prognostic Role of Leukoaraiosis
The aim of this study was to describe the electroclinical and prognostic characteristics, and to investigate the role of leukoaraiosis in outpatients with new-onset elderly focal epilepsy aged ≥60 years, referred to a tertiary epilepsy center between 2005 and December 31, 2020. Among the 720 patient...
Saved in:
| Published in | Frontiers in neurology Vol. 13; p. 828493 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
23.02.2022
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1664-2295 1664-2295 |
| DOI | 10.3389/fneur.2022.828493 |
Cover
| Abstract | The aim of this study was to describe the electroclinical and prognostic characteristics, and to investigate the role of leukoaraiosis in outpatients with new-onset elderly focal epilepsy aged ≥60 years, referred to a tertiary epilepsy center between 2005 and December 31, 2020. Among the 720 patients who were referred to the center, we retrospectively selected 162 consecutive outpatients, with a first referral for recent-onset focal epilepsy of unknown cause (UC) or structural cause (SC), and collected a clinical and standard-Electroencephalogram (S-EEG), 24-h ambulatory EEG (A-EEG), and neuroimaging data. We also analyzed the seizure prognosis after titration of the first antiseizure medication (ASM). One hundred and four UC and 58 SC patients, followed up for 5.8 ± 5.3 years (mean ± SD), were included. Compared with the SC group, the patients with UC showed a predominance of focal seizures with impaired awareness (51.9% of cases) and focal to bilateral tonic-clonic seizures during sleep (25%); conversely, the SC group, more frequently, had focal to bilateral tonic-clonic seizures during wakefulness (39.6%) and focal aware seizures (25.8%) (
p
< 0.0001). Oral or gestural automatisms were prevalent in UC epilepsy (20.2 vs. 6.9% in the SC group,
p
= 0.04). In UC compared to patients with SC, interictal epileptiform discharges showed a preferential temporal lobe localization (
p
= 0.0007), low expression on S-EEG, and marked activation during deep Non-Rapid Eye Movement (NREM) sleep (
p
= 0.003). An overall good treatment response was found in the whole sample, with a probability of seizure freedom of 68.9% for 1 year. The cumulative probability of seizure freedom was significantly higher in the UC compared with the SC group (
p
< 0.0001). The prognosis was worsened by leukoaraiosis (
p
= 0.012). In the late-onset focal epilepsy of unknown cause, electroclinical findings suggest a temporal lobe origin of the seizures. This group showed a better prognosis compared with the patients with structural epilepsy. Leukoaraiosis,
per se
, negatively impacted on seizure prognosis. |
|---|---|
| AbstractList | The aim of this study was to describe the electroclinical and prognostic characteristics, and to investigate the role of leukoaraiosis in outpatients with new-onset elderly focal epilepsy aged ≥60 years, referred to a tertiary epilepsy center between 2005 and December 31, 2020. Among the 720 patients who were referred to the center, we retrospectively selected 162 consecutive outpatients, with a first referral for recent-onset focal epilepsy of unknown cause (UC) or structural cause (SC), and collected a clinical and standard-Electroencephalogram (S-EEG), 24-h ambulatory EEG (A-EEG), and neuroimaging data. We also analyzed the seizure prognosis after titration of the first antiseizure medication (ASM). One hundred and four UC and 58 SC patients, followed up for 5.8 ± 5.3 years (mean ± SD), were included. Compared with the SC group, the patients with UC showed a predominance of focal seizures with impaired awareness (51.9% of cases) and focal to bilateral tonic-clonic seizures during sleep (25%); conversely, the SC group, more frequently, had focal to bilateral tonic-clonic seizures during wakefulness (39.6%) and focal aware seizures (25.8%) (p < 0.0001). Oral or gestural automatisms were prevalent in UC epilepsy (20.2 vs. 6.9% in the SC group, p = 0.04). In UC compared to patients with SC, interictal epileptiform discharges showed a preferential temporal lobe localization (p = 0.0007), low expression on S-EEG, and marked activation during deep Non-Rapid Eye Movement (NREM) sleep (p = 0.003). An overall good treatment response was found in the whole sample, with a probability of seizure freedom of 68.9% for 1 year. The cumulative probability of seizure freedom was significantly higher in the UC compared with the SC group (p < 0.0001). The prognosis was worsened by leukoaraiosis (p = 0.012). In the late-onset focal epilepsy of unknown cause, electroclinical findings suggest a temporal lobe origin of the seizures. This group showed a better prognosis compared with the patients with structural epilepsy. Leukoaraiosis, per se, negatively impacted on seizure prognosis.The aim of this study was to describe the electroclinical and prognostic characteristics, and to investigate the role of leukoaraiosis in outpatients with new-onset elderly focal epilepsy aged ≥60 years, referred to a tertiary epilepsy center between 2005 and December 31, 2020. Among the 720 patients who were referred to the center, we retrospectively selected 162 consecutive outpatients, with a first referral for recent-onset focal epilepsy of unknown cause (UC) or structural cause (SC), and collected a clinical and standard-Electroencephalogram (S-EEG), 24-h ambulatory EEG (A-EEG), and neuroimaging data. We also analyzed the seizure prognosis after titration of the first antiseizure medication (ASM). One hundred and four UC and 58 SC patients, followed up for 5.8 ± 5.3 years (mean ± SD), were included. Compared with the SC group, the patients with UC showed a predominance of focal seizures with impaired awareness (51.9% of cases) and focal to bilateral tonic-clonic seizures during sleep (25%); conversely, the SC group, more frequently, had focal to bilateral tonic-clonic seizures during wakefulness (39.6%) and focal aware seizures (25.8%) (p < 0.0001). Oral or gestural automatisms were prevalent in UC epilepsy (20.2 vs. 6.9% in the SC group, p = 0.04). In UC compared to patients with SC, interictal epileptiform discharges showed a preferential temporal lobe localization (p = 0.0007), low expression on S-EEG, and marked activation during deep Non-Rapid Eye Movement (NREM) sleep (p = 0.003). An overall good treatment response was found in the whole sample, with a probability of seizure freedom of 68.9% for 1 year. The cumulative probability of seizure freedom was significantly higher in the UC compared with the SC group (p < 0.0001). The prognosis was worsened by leukoaraiosis (p = 0.012). In the late-onset focal epilepsy of unknown cause, electroclinical findings suggest a temporal lobe origin of the seizures. This group showed a better prognosis compared with the patients with structural epilepsy. Leukoaraiosis, per se, negatively impacted on seizure prognosis. The aim of this study was to describe the electroclinical and prognostic characteristics, and to investigate the role of leukoaraiosis in outpatients with new-onset elderly focal epilepsy aged ≥60 years, referred to a tertiary epilepsy center between 2005 and December 31, 2020. Among the 720 patients who were referred to the center, we retrospectively selected 162 consecutive outpatients, with a first referral for recent-onset focal epilepsy of unknown cause (UC) or structural cause (SC), and collected a clinical and standard-Electroencephalogram (S-EEG), 24-h ambulatory EEG (A-EEG), and neuroimaging data. We also analyzed the seizure prognosis after titration of the first antiseizure medication (ASM). One hundred and four UC and 58 SC patients, followed up for 5.8 ± 5.3 years (mean ± SD), were included. Compared with the SC group, the patients with UC showed a predominance of focal seizures with impaired awareness (51.9% of cases) and focal to bilateral tonic-clonic seizures during sleep (25%); conversely, the SC group, more frequently, had focal to bilateral tonic-clonic seizures during wakefulness (39.6%) and focal aware seizures (25.8%) (p < 0.0001). Oral or gestural automatisms were prevalent in UC epilepsy (20.2 vs. 6.9% in the SC group, p = 0.04). In UC compared to patients with SC, interictal epileptiform discharges showed a preferential temporal lobe localization (p = 0.0007), low expression on S-EEG, and marked activation during deep Non-Rapid Eye Movement (NREM) sleep (p = 0.003). An overall good treatment response was found in the whole sample, with a probability of seizure freedom of 68.9% for 1 year. The cumulative probability of seizure freedom was significantly higher in the UC compared with the SC group (p < 0.0001). The prognosis was worsened by leukoaraiosis (p = 0.012). In the late-onset focal epilepsy of unknown cause, electroclinical findings suggest a temporal lobe origin of the seizures. This group showed a better prognosis compared with the patients with structural epilepsy. Leukoaraiosis, per se, negatively impacted on seizure prognosis. The aim of this study was to describe the electroclinical and prognostic characteristics, and to investigate the role of leukoaraiosis in outpatients with new-onset elderly focal epilepsy aged ≥60 years, referred to a tertiary epilepsy center between 2005 and December 31, 2020. Among the 720 patients who were referred to the center, we retrospectively selected 162 consecutive outpatients, with a first referral for recent-onset focal epilepsy of unknown cause (UC) or structural cause (SC), and collected a clinical and standard-Electroencephalogram (S-EEG), 24-h ambulatory EEG (A-EEG), and neuroimaging data. We also analyzed the seizure prognosis after titration of the first antiseizure medication (ASM). One hundred and four UC and 58 SC patients, followed up for 5.8 ± 5.3 years (mean ± SD), were included. Compared with the SC group, the patients with UC showed a predominance of focal seizures with impaired awareness (51.9% of cases) and focal to bilateral tonic-clonic seizures during sleep (25%); conversely, the SC group, more frequently, had focal to bilateral tonic-clonic seizures during wakefulness (39.6%) and focal aware seizures (25.8%) ( < 0.0001). Oral or gestural automatisms were prevalent in UC epilepsy (20.2 vs. 6.9% in the SC group, = 0.04). In UC compared to patients with SC, interictal epileptiform discharges showed a preferential temporal lobe localization ( = 0.0007), low expression on S-EEG, and marked activation during deep Non-Rapid Eye Movement (NREM) sleep ( = 0.003). An overall good treatment response was found in the whole sample, with a probability of seizure freedom of 68.9% for 1 year. The cumulative probability of seizure freedom was significantly higher in the UC compared with the SC group ( < 0.0001). The prognosis was worsened by leukoaraiosis ( = 0.012). In the late-onset focal epilepsy of unknown cause, electroclinical findings suggest a temporal lobe origin of the seizures. This group showed a better prognosis compared with the patients with structural epilepsy. Leukoaraiosis, , negatively impacted on seizure prognosis. The aim of this study was to describe the electroclinical and prognostic characteristics, and to investigate the role of leukoaraiosis in outpatients with new-onset elderly focal epilepsy aged ≥60 years, referred to a tertiary epilepsy center between 2005 and December 31, 2020. Among the 720 patients who were referred to the center, we retrospectively selected 162 consecutive outpatients, with a first referral for recent-onset focal epilepsy of unknown cause (UC) or structural cause (SC), and collected a clinical and standard-Electroencephalogram (S-EEG), 24-h ambulatory EEG (A-EEG), and neuroimaging data. We also analyzed the seizure prognosis after titration of the first antiseizure medication (ASM). One hundred and four UC and 58 SC patients, followed up for 5.8 ± 5.3 years (mean ± SD), were included. Compared with the SC group, the patients with UC showed a predominance of focal seizures with impaired awareness (51.9% of cases) and focal to bilateral tonic-clonic seizures during sleep (25%); conversely, the SC group, more frequently, had focal to bilateral tonic-clonic seizures during wakefulness (39.6%) and focal aware seizures (25.8%) ( p < 0.0001). Oral or gestural automatisms were prevalent in UC epilepsy (20.2 vs. 6.9% in the SC group, p = 0.04). In UC compared to patients with SC, interictal epileptiform discharges showed a preferential temporal lobe localization ( p = 0.0007), low expression on S-EEG, and marked activation during deep Non-Rapid Eye Movement (NREM) sleep ( p = 0.003). An overall good treatment response was found in the whole sample, with a probability of seizure freedom of 68.9% for 1 year. The cumulative probability of seizure freedom was significantly higher in the UC compared with the SC group ( p < 0.0001). The prognosis was worsened by leukoaraiosis ( p = 0.012). In the late-onset focal epilepsy of unknown cause, electroclinical findings suggest a temporal lobe origin of the seizures. This group showed a better prognosis compared with the patients with structural epilepsy. Leukoaraiosis, per se , negatively impacted on seizure prognosis. |
| Author | Paoletti, Matteo Scanziani, Sofia Galimberti, Carlo Andrea Micalizzi, Elisa Ballante, Elena Tartara, Elena |
| AuthorAffiliation | 2 Department of Brain and Behavioral Sciences, University of Pavia , Pavia , Italy 3 BioData Center, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Mondino Foundation , Pavia , Italy 1 Epilepsy Center, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Mondino Foundation , Pavia , Italy 5 Department of Neuroradiology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Mondino Foundation , Pavia , Italy 4 Department of Mathematics, University of Pavia , Pavia , Italy |
| AuthorAffiliation_xml | – name: 3 BioData Center, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Mondino Foundation , Pavia , Italy – name: 1 Epilepsy Center, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Mondino Foundation , Pavia , Italy – name: 5 Department of Neuroradiology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Mondino Foundation , Pavia , Italy – name: 2 Department of Brain and Behavioral Sciences, University of Pavia , Pavia , Italy – name: 4 Department of Mathematics, University of Pavia , Pavia , Italy |
| Author_xml | – sequence: 1 givenname: Elena surname: Tartara fullname: Tartara, Elena – sequence: 2 givenname: Elisa surname: Micalizzi fullname: Micalizzi, Elisa – sequence: 3 givenname: Sofia surname: Scanziani fullname: Scanziani, Sofia – sequence: 4 givenname: Elena surname: Ballante fullname: Ballante, Elena – sequence: 5 givenname: Matteo surname: Paoletti fullname: Paoletti, Matteo – sequence: 6 givenname: Carlo Andrea surname: Galimberti fullname: Galimberti, Carlo Andrea |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35295838$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kl1rFDEUhoNUbK39Ad7IXHoz20kyk0m8EKTsamGhIgrehbPJmTU1m6xJptB_70y3La1gLpLD-XjeA3lfk6MQAxLyljYLzqU6HwKOacEaxhaSyVbxF-SECtHWjKnu6El8TM5yvm6mw5Xigr8ix7yb8pLLE_JzDQXrq5CxVKtowFfLvfO4z7cfqqVHU1I03gU3V1YIZUyYKwi2-priNsRcnKm-RY9VHKo1jr8jJHAxu_yGvBzAZzy7f0_Jj9Xy-8WXen31-fLi07o2XHWl7qkcODdUdqZjyDpgXPZWSNq2hvHBtNb2w8bawW4USMkUdFZ0FIAywXtQ_JRcHrg2wrXeJ7eDdKsjOH2XiGmrIU1betQbsQE1sEaAaFvRDpJZRTk2k7ZRyOzE-nhg7cfNDq3BUBL4Z9DnleB-6W280VJRJVQ_Ad7fA1L8M2IueueyQe8hYByzZqJt-HSpee93T7UeRR6-ZmroDw0mxZwTDtq4AsXFWdp5TRs9-0Df-UDPPtAHH0yT9J_JB_j_Z_4CJ1W36A |
| CitedBy_id | crossref_primary_10_1007_s00415_023_11828_6 crossref_primary_10_1016_j_yebeh_2024_109926 crossref_primary_10_1111_epi_17994 |
| Cites_doi | 10.1111/epi.13709 10.1212/WNL.0000000000007010 10.1046/j.1528-1157.2001.0420081025.x 10.1111/j.1528-1157.1997.tb01075.x 10.1016/j.nicl.2015.07.016 10.1111/j.1528-1167.2007.01164.x 10.1016/j.eplepsyres.2014.10.012 10.1016/j.clinimag.2017.06.011 10.1016/j.yebeh.2019.06.039 10.1016/j.seizure.2013.06.005 10.1016/j.seizure.2019.02.004 10.1016/j.clineuro.2012.07.009 10.1212/WNL.62.5_suppl_2.S24 10.1001/jamaneurol.2018.1935 10.1016/j.yebeh.2005.11.007 10.1111/j.1528-1157.1997.tb01219.x 10.1016/j.eplepsyres.2013.08.009 10.1111/j.1528-1167.2009.02303.x 10.1016/0013-4694(80)90396-X 10.1111/j.1528-1157.1996.tb00007.x 10.1016/j.eplepsyres.2016.08.023 10.1111/ane.12398 10.1016/j.clinph.2014.10.155 10.1016/j.seizure.2016.03.011 10.1212/WNL.43.2.425 10.1111/j.1528-1157.1998.tb01329.x 10.1212/WNL.41.2_Part_1.290 10.1111/j.1528-1167.2009.02285.x 10.1177/155005949903000403 10.1016/j.seizure.2004.09.003 10.1111/j.1528-1157.1992.tb06222.x 10.1017/S0317167100035411 10.1097/MD.0000000000007682 10.1016/j.yebeh.2012.11.041 10.1016/j.biopsych.2008.03.024 10.1111/epi.13670 10.1016/S0013-4694(97)00158-2 10.1007/s10072-019-03913-4 10.1016/S1059-1311(05)80005-6 10.1155/2017/8724503 10.2307/2530904 10.1016/S1388-2457(00)00404-1 10.1111/j.1468-1331.2006.01205.x 10.1111/j.0013-9580.2004.29003.x 10.1177/1073858412462747 |
| ContentType | Journal Article |
| Copyright | Copyright © 2022 Tartara, Micalizzi, Scanziani, Ballante, Paoletti and Galimberti. Copyright © 2022 Tartara, Micalizzi, Scanziani, Ballante, Paoletti and Galimberti. 2022 Tartara, Micalizzi, Scanziani, Ballante, Paoletti and Galimberti |
| Copyright_xml | – notice: Copyright © 2022 Tartara, Micalizzi, Scanziani, Ballante, Paoletti and Galimberti. – notice: Copyright © 2022 Tartara, Micalizzi, Scanziani, Ballante, Paoletti and Galimberti. 2022 Tartara, Micalizzi, Scanziani, Ballante, Paoletti and Galimberti |
| DBID | AAYXX CITATION NPM 7X8 5PM DOA |
| DOI | 10.3389/fneur.2022.828493 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ: Directory of Open Access Journal (DOAJ) |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed CrossRef |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1664-2295 |
| ExternalDocumentID | oai_doaj_org_article_b6ba9f206a64464f82d913e085cc9e2d PMC8919697 35295838 10_3389_fneur_2022_828493 |
| Genre | Journal Article |
| GroupedDBID | 53G 5VS 9T4 AAFWJ AAKDD AAYXX ACGFO ACGFS ACXDI ADBBV ADRAZ AENEX AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK E3Z EMOBN F5P GROUPED_DOAJ GX1 HYE KQ8 M48 M~E O5R O5S OK1 P2P PGMZT RNS RPM IAO IEA IHR IHW IPNFZ NPM RIG 7X8 5PM |
| ID | FETCH-LOGICAL-c395t-718f33c185c52e25a2387d68144c23fc4dd7fbddfdb9a8829a5d651aa12637a93 |
| IEDL.DBID | M48 |
| ISSN | 1664-2295 |
| IngestDate | Wed Aug 27 01:26:23 EDT 2025 Thu Aug 21 14:07:23 EDT 2025 Fri Sep 05 07:30:12 EDT 2025 Thu Jan 02 22:55:11 EST 2025 Thu Apr 24 23:01:16 EDT 2025 Tue Jul 01 04:27:51 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | epilepsy sleep interictal epileptiform discharges leukoaraiosis elderly |
| Language | English |
| License | Copyright © 2022 Tartara, Micalizzi, Scanziani, Ballante, Paoletti and Galimberti. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c395t-718f33c185c52e25a2387d68144c23fc4dd7fbddfdb9a8829a5d651aa12637a93 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 European Reference Network for Rare and Complex Epilepsies (ERN EpiCARE) Full Member Reviewed by: Vincenzo Belcastro, Lodi Hospital, Italy; Melissa Barker-Haliski, University of Washington, United States These authors have contributed equally to this work This article was submitted to Epilepsy, a section of the journal Frontiers in Neurology Edited by: Filippo Sean Giorgi, University of Pisa, Italy |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.3389/fneur.2022.828493 |
| PMID | 35295838 |
| PQID | 2640326499 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_b6ba9f206a64464f82d913e085cc9e2d pubmedcentral_primary_oai_pubmedcentral_nih_gov_8919697 proquest_miscellaneous_2640326499 pubmed_primary_35295838 crossref_citationtrail_10_3389_fneur_2022_828493 crossref_primary_10_3389_fneur_2022_828493 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2022-02-23 |
| PublicationDateYYYYMMDD | 2022-02-23 |
| PublicationDate_xml | – month: 02 year: 2022 text: 2022-02-23 day: 23 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland |
| PublicationTitle | Frontiers in neurology |
| PublicationTitleAlternate | Front Neurol |
| PublicationYear | 2022 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | Gasparini (B14) 2015; 109 Malow (B30) 1998; 39 Johnson (B47) 2019; 92 Lawn (B9) 2013; 107 Drury (B26) 1998; 106 Sammaritano (B29) 1991; 41 Johnson (B44) 2018; 75 Tinuper (B2) 1996; 37 Belcastro (B41) 2007; 48 Belcastro (B40) 2010; 51 Besocke (B8) 2013; 27 Beghi (B22) 2010; 51 Lin (B38) 2017; 96 Kales (B20) 1968 Emsley (B12) 2020; 104 Lindsten (B33) 2002; 42 Li (B43) 1997; 38 Hanby (B15) 2015; 9 Ferrillo (B31) 2000; 111 Marchi (B46) 2013; 19 Del Bene (B39) 2015; 132 Naka (B37) 2006; 13 Lieb (B28) 1980; 49 Bruun (B35) 2016; 127 Huang (B6) 2016; 38 Rudilosso (B18) 2017; 46 Park (B24) 1998; 7 Kim (B17) 2008; 64 Kellinghaus (B3) 2004; 45 Lin (B36) 2017; 2017 Maxwell (B13) 2013; 115 Abraira (B16) 2019; 66 Clemens (B32) 2005; 14 Cockerell (B34) 1997; 38 Link (B21) 1984; 40 Stephen (B7) 2006; 8 Gasparini (B45) 2019; 40 Ng (B42) 1993; 43 Ramsay (B5) 2004; 62 Fisher (B19) 2017; 58 Young (B23) 1985; 12 Hauser (B1) 1992; 33 Scheffer (B11) 2017; 58 Galimberti (B25) 2003 Tanaka (B10) 2013; 22 Hughes (B27) 1999; 30 Arbasino (B4) 2015; 126 |
| References_xml | – volume: 58 start-page: 512 year: 2017 ident: B11 article-title: ILAE classification of the epilepsies: position paper of the ILAE commission for classification and terminology publication-title: Epilepsia. doi: 10.1111/epi.13709 – volume: 92 start-page: e988 year: 2019 ident: B47 article-title: Association between white matter hyperintensities, cortical volumes, and late-onset epilepsy publication-title: Neurology. doi: 10.1212/WNL.0000000000007010 – volume: 42 start-page: 1025 year: 2002 ident: B33 article-title: Remission of seizures in a population-based adult cohort with a newly diagnosed unprovoked epileptic seizure publication-title: Epilepsia. doi: 10.1046/j.1528-1157.2001.0420081025.x – volume: 38 start-page: 31 year: 1997 ident: B34 article-title: Prognosis of epilepsy: a review and further analysis of the first nine years of the british national general practice study of epilepsy, a prospective population-based study publication-title: Epilepsia. doi: 10.1111/j.1528-1157.1997.tb01075.x – volume: 9 start-page: 128 year: 2015 ident: B15 article-title: Structural and physiological MRI correlates of occult cerebrovascular disease in late-onset epilepsy publication-title: NeuroImage Clin. doi: 10.1016/j.nicl.2015.07.016 – volume: 48 start-page: 1990 year: 2007 ident: B41 article-title: Antiepileptic drugs and MTHFR polymorphisms influence hyper-homocysteinemia recurrence in epileptic patients publication-title: Epilepsia. doi: 10.1111/j.1528-1167.2007.01164.x – volume: 109 start-page: 1 year: 2015 ident: B14 article-title: Epilepsy associated with leukoaraiosis mainly affects temporal lobe: a casual or causal relationship? publication-title: Epilepsy Res. doi: 10.1016/j.eplepsyres.2014.10.012 – volume: 46 start-page: 24 year: 2017 ident: B18 article-title: Evaluation of white matter hypodensities on computed tomography in stroke patients using the Fazekas score publication-title: Clin Imaging. doi: 10.1016/j.clinimag.2017.06.011 – volume: 104 start-page: 106396 year: 2020 ident: B12 article-title: Seizures in the context of occult cerebrovascular disease publication-title: Epilepsy Behav. doi: 10.1016/j.yebeh.2019.06.039 – volume: 22 start-page: 772 year: 2013 ident: B10 article-title: Clinical characteristics and treatment responses in new-onset epilepsy in the elderly publication-title: Seizure. doi: 10.1016/j.seizure.2013.06.005 – volume: 66 start-page: 31 year: 2019 ident: B16 article-title: Cerebrovascular disease burden in late-onset non-lesional focal epilepsy publication-title: Seizure. doi: 10.1016/j.seizure.2019.02.004 – volume: 115 start-page: 591 year: 2013 ident: B13 article-title: Prevalence and subtypes of radiological cerebrovascular disease in late-onset isolated seizures and epilepsy publication-title: Clin Neurol Neurosurg. doi: 10.1016/j.clineuro.2012.07.009 – volume: 62 start-page: S24 year: 2004 ident: B5 article-title: Special considerations in treating the elderly patient with epilepsy publication-title: Neurology. doi: 10.1212/WNL.62.5_suppl_2.S24 – volume: 75 start-page: 1375 year: 2018 ident: B44 article-title: Association between midlife risk factors and late-onset epilepsy publication-title: JAMA Neurol. doi: 10.1001/jamaneurol.2018.1935 – volume: 8 start-page: 434 year: 2006 ident: B7 article-title: Pharmacological outcomes in older people with newly diagnosed epilepsy publication-title: Epilepsy Behav. doi: 10.1016/j.yebeh.2005.11.007 – volume: 38 start-page: 1216 year: 1997 ident: B43 article-title: Vascular determinants of epilepsy: the rotterdam study publication-title: Epilepsia. doi: 10.1111/j.1528-1157.1997.tb01219.x – volume: 107 start-page: 109 year: 2013 ident: B9 article-title: First seizure in the older patient: clinical features and prognosis publication-title: Epilepsy Res. doi: 10.1016/j.eplepsyres.2013.08.009 – volume: 51 start-page: 274 year: 2010 ident: B40 article-title: Hyperhomocysteinemia in epileptic patients on new antiepileptic drugs publication-title: Epilepsia. doi: 10.1111/j.1528-1167.2009.02303.x – volume: 49 start-page: 538 year: 1980 ident: B28 article-title: Sleep state and seizure foci related to depth spike activity in patients with temporal lobe epilepsy publication-title: Electroencephalogr Clin Neurophysiol. doi: 10.1016/0013-4694(80)90396-X – volume: 37 start-page: 162 year: 1996 ident: B2 article-title: Partial epilepsy of long duration: changing semiology with age publication-title: Epilepsia. doi: 10.1111/j.1528-1157.1996.tb00007.x – volume: 127 start-page: 60 year: 2016 ident: B35 article-title: Outcome of initial antiepileptic drug treatment in elderly patients with newly diagnosed epilepsy publication-title: Epilepsy Res. doi: 10.1016/j.eplepsyres.2016.08.023 – volume: 132 start-page: 147 year: 2015 ident: B39 article-title: Is type 2 diabetes related to leukoaraiosis? an updated review publication-title: Acta Neurol Scand. doi: 10.1111/ane.12398 – volume: 126 start-page: 1498 year: 2015 ident: B4 article-title: Interictal spiking in adult newly-diagnosed focal epilepsy of unknown cause: the effect of age publication-title: Clin Neurophysiol. doi: 10.1016/j.clinph.2014.10.155 – volume: 38 start-page: 26 year: 2016 ident: B6 article-title: Clinical features and prognosis of epilepsy in the elderly in western China publication-title: Seizure. doi: 10.1016/j.seizure.2016.03.011 – volume: 43 start-page: 425 year: 1993 ident: B42 article-title: Hypertension and the risk of new-onset unprovoked seizures publication-title: Neurology. doi: 10.1212/WNL.43.2.425 – volume: 39 start-page: 1309 year: 1998 ident: B30 article-title: Interictal spiking increases with sleep depth in temporal lobe epilepsy publication-title: Epilepsia. doi: 10.1111/j.1528-1157.1998.tb01329.x – volume: 41 start-page: 290 year: 1991 ident: B29 article-title: Interictal spiking during wakefulness and sleep and the localization of foci in temporal lobe epilepsy publication-title: Neurology. doi: 10.1212/WNL.41.2_Part_1.290 – volume: 51 start-page: 671 year: 2010 ident: B22 article-title: Recommendation for a definition of acute symptomatic seizure publication-title: Epilepsia. doi: 10.1111/j.1528-1167.2009.02285.x – volume-title: A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. year: 1968 ident: B20 – volume: 30 start-page: 126 year: 1999 ident: B27 article-title: EEG and epilepsy in the elderly compared to a younger group publication-title: Clin Electroencephalogr. doi: 10.1177/155005949903000403 – volume: 14 start-page: 52 year: 2005 ident: B32 article-title: Factors affecting spiking related to sleep and wake states in temporal lobe epilepsy (TLE) publication-title: Seizure. doi: 10.1016/j.seizure.2004.09.003 – volume: 33 start-page: 6 year: 1992 ident: B1 article-title: Seizure disorders: the changes with age publication-title: Epilepsia. doi: 10.1111/j.1528-1157.1992.tb06222.x – volume: 12 start-page: 317 year: 1985 ident: B23 article-title: Differential aspects of sleep epilepsy publication-title: Can J Neurol Sci. doi: 10.1017/S0317167100035411 – volume: 96 start-page: e7682 year: 2017 ident: B38 article-title: Incidence and risk factors of leukoaraiosis from 4683 hospitalized patients publication-title: Medicine doi: 10.1097/MD.0000000000007682 – volume: 27 start-page: 29 year: 2013 ident: B8 article-title: del C, Gonorazky SE, Romano LM. Outcome of newly-diagnosed epilepsy in older patients publication-title: Epilepsy Behav. doi: 10.1016/j.yebeh.2012.11.041 – volume: 64 start-page: 273 year: 2008 ident: B17 article-title: Classification of white matter lesions on magnetic resonance imaging in elderly persons publication-title: Biol Psychiatry. doi: 10.1016/j.biopsych.2008.03.024 – volume: 58 start-page: 522 year: 2017 ident: B19 article-title: Operational classification of seizure types by the international league against epilepsy: position paper of the ILAE commission for classification and terminology publication-title: Epilepsia. doi: 10.1111/epi.13670 – volume: 106 start-page: 369 year: 1998 ident: B26 article-title: Interictal epileptiform activity in elderly patients with epilepsy publication-title: Electroencephalogr Clin Neurophysiol. doi: 10.1016/S0013-4694(97)00158-2 – volume: 40 start-page: 1775 year: 2019 ident: B45 article-title: Hypertension, seizures, and epilepsy: a review on pathophysiology and management publication-title: Neurol Sci. doi: 10.1007/s10072-019-03913-4 – volume: 7 start-page: 369 year: 1998 ident: B24 article-title: Clinical courses of pure sleep epilepsies publication-title: Seizure. doi: 10.1016/S1059-1311(05)80005-6 – volume: 2017 start-page: 1 year: 2017 ident: B36 article-title: Multiple factors involved in the pathogenesis of white matter lesions publication-title: Biomed Res Int. doi: 10.1155/2017/8724503 – volume: 40 start-page: 601 year: 1984 ident: B21 article-title: Confidence intervals for the survival function using cox's proportional- hazard model with covariates publication-title: Biometrics. doi: 10.2307/2530904 – volume: 111 start-page: S65 year: 2000 ident: B31 article-title: Sleep EEG synchronization mechanisms and activation of interictal epileptic spikes publication-title: Clin Neurophysiol. doi: 10.1016/S1388-2457(00)00404-1 – volume: 13 start-page: 261 year: 2006 ident: B37 article-title: Plasma total homocysteine levels are associated with advanced leukoaraiosis but not with asymptomatic microbleeds on T2*-weighted MRI in patients with stroke publication-title: Eur J Neurol. doi: 10.1111/j.1468-1331.2006.01205.x – volume: 45 start-page: 263 year: 2004 ident: B3 article-title: Seizure semiology in the elderly: a video analysis publication-title: Epilepsia. doi: 10.1111/j.0013-9580.2004.29003.x – volume-title: The Landscape of Epilepsy in the Elderly Outpatients - Abstract From the 25th International Epilepsy Congress year: 2003 ident: B25 – volume: 19 start-page: 304 year: 2013 ident: B46 article-title: Cerebrovascular remodeling and epilepsy publication-title: Neurosci. doi: 10.1177/1073858412462747 |
| SSID | ssj0000399363 |
| Score | 2.292996 |
| Snippet | The aim of this study was to describe the electroclinical and prognostic characteristics, and to investigate the role of leukoaraiosis in outpatients with... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 828493 |
| SubjectTerms | elderly epilepsy interictal epileptiform discharges leukoaraiosis Neurology sleep |
| SummonAdditionalLinks | – databaseName: DOAJ: Directory of Open Access Journal (DOAJ) dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYlh9JL6bvuIyjQU8GNLdmS1Vtbdgkhj1Ia2JuQpRFdGuxlvXvIv8-M7V12S0guvdqyLEYjfd_HSDOMfTI5OA2FTLWsfFpElac1wk5aIPv1DrQxQELx_EKdXBWns3K2U-qLzoQN6YEHwx3XqnYmikw5RG5VxEoEk0tApuC9ARFo981MtiOm-j2YcFfJIYyJKswcR8oPiXpQiC8oMgoj94Coz9d_F8n896zkDvhMn7GnI2vk34bRPmePoHnBHp-PcfGXbHaGlDG9bDpY8SmhE58scLkvupuvfDIUutlcgeRE-tYosrlrAv-5bOmkHXbLf7XXwNvIz2D9t3VLN2-7efeKXU0nv3-cpGPNhNRLU65ShJoopUcU9qUAUTqEZB1UhbrJCxl9EYKOdQgx1MYhuzauDKrMncuFktoZ-ZodNG0DbxkHJEem0jX2CIXwKIxE5nUGoDRUGfiEZRsDWj8mFKe6FtcWhQXZ3PY2t2RzO9g8YZ-3nyyGbBr3Nf5Os7JtSImw-wfoHnZ0D_uQeyTsaDOnFhcORUNcA-26s8gEM-SuqPgS9maY4-2vJIU_K1klTO_N_t5Y9t808z99cu7KUMIh_e5_DP49e0L26G_Qyw_sYLVcw0fkQKv6sHf3W9q5BZo priority: 102 providerName: Directory of Open Access Journals |
| Title | Late-Onset Focal Epilepsy: Electroclinical Features and Prognostic Role of Leukoaraiosis |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/35295838 https://www.proquest.com/docview/2640326499 https://pubmed.ncbi.nlm.nih.gov/PMC8919697 https://doaj.org/article/b6ba9f206a64464f82d913e085cc9e2d |
| Volume | 13 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3fi9QwEA7nCeKLnL97nkcEn4SebdImzcEhKrsccqsiLuxbSZPpubi0e-0ueP-9M213cWURX9s0aWeSfN_XJDOMvTYxWA2JDLXMXJiUKg4LhJ0wQfbrLGhjgITi5LO6nCafZunsgG3SWw0GbPdKO8onNW0WZ79ubt_hgL8gxYl4-7ak0I8o9YQ4Q_2QGHmH3UVgUqTFJgPb7yZmAuMut1qsVBJSIut-nXN_LTtI1QX038dC_95M-Qc6jY_Yg4FW8vd9P3jIDqB6xO5NhoXzx2x2hZwy_FK1sOJjgi8-WuJ8sGxvz_moz4SzOSPJiRWuUYVzW3n-talpKx5Wy7_VC-B1ya9g_bO2jZ3X7bx9wqbj0fePl-GQVCF00qSrELGolNIhTLtUgEgtYrb2KkNh5YQsXeK9LgvvS18Yi_Tb2NSrNLY2Fkpqa-RTdljVFTxnHJA9mUwXWCMkwqFyEpHTEYDSkEXgAhZtDJi7IeI4Jb5Y5Kg8yOZ5Z_OcbJ73Ng_Ym-0jyz7cxr8KfyCvbAtSpOzuQt1c58PAywtVWFOKSFlkfiopM-FNLAGZpnMGhA_Yq41PcxxZtFxiK6jXbY5UMUJyi5IwYM96H2-bkrQ-msksYHrH-zvvsnunmv_oondnhiIS6eP_aPcFu0-f252glyfscNWs4SVyoFVx2v07OO36928K_wXL |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Late-Onset+Focal+Epilepsy%3A+Electroclinical+Features+and+Prognostic+Role+of+Leukoaraiosis&rft.jtitle=Frontiers+in+neurology&rft.au=Tartara%2C+Elena&rft.au=Micalizzi%2C+Elisa&rft.au=Scanziani%2C+Sofia&rft.au=Ballante%2C+Elena&rft.date=2022-02-23&rft.issn=1664-2295&rft.eissn=1664-2295&rft.volume=13&rft.spage=828493&rft_id=info:doi/10.3389%2Ffneur.2022.828493&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1664-2295&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1664-2295&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1664-2295&client=summon |