Eugenol disrupts Plasmodium falciparum intracellular development during the erythrocytic cycle and protects against cerebral malaria - Pontes, Kesley A.O.; Silva, Leandro S.; Santos, Edgleyson C.; Pinheiro, Alessandro S.; Teixeira, Douglas E.; Peruchetti, Diogo B.; Silva-Aguiar, Rodrigo P.; Wendt, Camila H.C.; Miranda, Kildare R.; Coelho-de-Souza, Andrelina N.; Leal-Cardoso, José Henrique; Caruso-Neves, Celso; et al. (Biochimica et biophysica acta. General subjects, 2021)
Keywords: animal models; Animals; Antimalarials; Antimalarials - pharmacology; artemisinin; Blood-Brain Barrier - drug effects; Blood-Brain Barrier - metabolism; Blood-Brain Barrier - parasitology; Brain Edema - drug therapy; Brain Edema - parasitology; cerebral malaria; cloves; Disease Models, Animal; dose response; edema; electron microscopy; erythrocytes; Erythrocytes - drug effects; Erythrocytes - parasitology; Erythrocytic cycle; Essential oil; eugenol; Eugenol - pharmacology; evolution; Humans; Inhibitory Concentration 50; Life Cycle Stages - drug effects; Life Cycle Stages - physiology; Malaria; Malaria, Cerebral - drug therapy; Malaria, Cerebral - parasitology; Malaria, Falciparum - drug therapy; Malaria, Falciparum - parasitology; Male; Mice; Mice, Inbred C57BL; nuclear membrane; parasitemia; Plasmodium berghei - drug effects; Plasmodium berghei - growth & development; Plasmodium berghei - parasitology; Plasmodium falciparum; Plasmodium falciparum - drug effects; Plasmodium falciparum - growth & development; Plasmodium falciparum - pathogenicity; therapeutics; vacuoles; Antimalarials; Plasmodium falciparum; Erythrocytic cycle; Essential oil; Malaria