Functional characterization of a slow and tight-binding inhibitor of plasmin isolated from Russell's viper venom - Cheng, An-Chun; Tsai, Inn-Ho (Biochimica et biophysica acta, 2014)
Keywords: Amino Acid Sequence; Animals; Antifibrinolytic agent; Antifibrinolytic Agents - pharmacology; Aprotinin - chemistry; Blood Coagulation - drug effects; Blotting, Far-Western; chymotrypsin; Daboia; Daboia russelii; dose response; drugs; Elapid Venoms - chemistry; fibrin; Fibrin - metabolism; Fibrin Clot Lysis Time; Fibrinolysin - antagonists & inhibitors; Fibrinolysin - metabolism; hemorrhage; Kinetics; Kunitz-type protease inhibitor; Mice; Mice, Inbred ICR; Molecular Sequence Data; nitroprusside; Plasmin; Protease Inhibitors - pharmacology; Prothrombin Time; Russell's viper venom; screening; Sequence Homology, Amino Acid; snakes; tail; Tight-binding inhibition; Time-dependent inhibition; trypsin; venoms; Viper Venoms - pharmacology; Western blotting; DrKIn-II; tPA; PT; uPA; Plasmin; Kunitz-type protease inhibitor; APTT; Tight-binding inhibition; Antifibrinolytic agent; RVV; FDP; Time-dependent inhibition; Russell's viper venom; BPTI; HPLC; tissue plasminogen activator; prothrombin time; urokinase plasminogen activator; Daboia russelii Kunitz Inhibitor-II; high performance liquid chromatography; activated partial thromboplastin time; bovine pancreatic trypsin inhibitor; fibrin/fibrinogen degradation product