Nemorubicin and doxorubicin bind the G-quadruplex sequences of the human telomeres and of the c-MYC promoter element Pu22 - Scaglioni, Leonardo; Mondelli, Rosanna; Artali, Roberto; Sirtori, Federico Riccardi; Mazzini, Stefania (Biochimica et biophysica acta, 2016)
Keywords: adenine; antineoplastic activity; Antineoplastic Agents - chemistry; c-MYC; Daunomycins; DNA; DNA-binding drugs; doxorubicin; Doxorubicin - analogs & derivatives; Doxorubicin - chemistry; electrospray ionization mass spectrometry; G-quadruplex; G-Quadruplexes; gene overexpression; Genes, myc; guanine; humans; ligands; Magnetic Resonance Spectroscopy; mechanism of action; Models, Molecular; Molecular modeling; NMR; nuclear magnetic resonance spectroscopy; oncogenes; promoter regions; Promoter Regions, Genetic; Spectrometry, Mass, Electrospray Ionization; Telomere; telomeres; transcription (genetics); A; DNA-binding drugs; c-MYC; G; G-quadruplex; nemo; TOCSY; doxo; daunomycins; DOSY; Q; NMR; R=[drug]/[DNA]; T; Molecular modeling; ESI–MS; NOESY; HSQC; Daunomycins