Application of Advanced Statistics in Ophthalmology
Statistics is an integral part of research in ophthalmology. The application of appropriate statistical strategies allows clinicians to realize the full potential in analyzing data from paired ocular measurements, longitudinal design, and genome-wide association study (GWAS). The increasing populari...
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| Published in | Investigative ophthalmology & visual science Vol. 52; no. 9; p. 6059 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.08.2011
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1552-5783 0146-0404 1552-5783 |
| DOI | 10.1167/iovs.10-7108 |
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| Abstract | Statistics is an integral part of research in ophthalmology. The application of appropriate statistical strategies allows clinicians to realize the full potential in analyzing data from paired ocular measurements, longitudinal design, and genome-wide association study (GWAS). The increasing popularity of longitudinal follow-up in either clinical or epidemiologic study demands advanced statistical methodologies. This article describes robust statistical models that can cope with correlated components for both paired-eye data and repeated measurements over time. Also highlight are the statistical challenges and corresponding strategies available for testing multiple hypotheses with paired-eye data in GWAS, which has been the subject of intense interest for the past 5 years within the ophthalmology community in investigating the genetic etiology of eye disorders. |
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| AbstractList | Statistics is an integral part of research in ophthalmology. The application of appropriate statistical strategies allows clinicians to realize the full potential in analyzing data from paired ocular measurements, longitudinal design, and genome-wide association study (GWAS). The increasing popularity of longitudinal follow-up in either clinical or epidemiologic study demands advanced statistical methodologies. This article describes robust statistical models that can cope with correlated components for both paired-eye data and repeated measurements over time. Also highlight are the statistical challenges and corresponding strategies available for testing multiple hypotheses with paired-eye data in GWAS, which has been the subject of intense interest for the past 5 years within the ophthalmology community in investigating the genetic etiology of eye disorders.Statistics is an integral part of research in ophthalmology. The application of appropriate statistical strategies allows clinicians to realize the full potential in analyzing data from paired ocular measurements, longitudinal design, and genome-wide association study (GWAS). The increasing popularity of longitudinal follow-up in either clinical or epidemiologic study demands advanced statistical methodologies. This article describes robust statistical models that can cope with correlated components for both paired-eye data and repeated measurements over time. Also highlight are the statistical challenges and corresponding strategies available for testing multiple hypotheses with paired-eye data in GWAS, which has been the subject of intense interest for the past 5 years within the ophthalmology community in investigating the genetic etiology of eye disorders. Statistics is an integral part of research in ophthalmology. The application of appropriate statistical strategies allows clinicians to realize the full potential in analyzing data from paired ocular measurements, longitudinal design, and genome-wide association study (GWAS). The increasing popularity of longitudinal follow-up in either clinical or epidemiologic study demands advanced statistical methodologies. This article describes robust statistical models that can cope with correlated components for both paired-eye data and repeated measurements over time. Also highlight are the statistical challenges and corresponding strategies available for testing multiple hypotheses with paired-eye data in GWAS, which has been the subject of intense interest for the past 5 years within the ophthalmology community in investigating the genetic etiology of eye disorders. |
| Author | Saw, Seang-Mei Teo, Yik-Ying Fan, Qiao |
| Author_xml | – sequence: 1 givenname: Qiao surname: Fan fullname: Fan, Qiao organization: From the Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine and – sequence: 2 givenname: Yik-Ying surname: Teo fullname: Teo, Yik-Ying organization: From the Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine and the 2Department of Statistics and Applied Probability, National University of Singapore, Singapore; and – sequence: 3 givenname: Seang-Mei surname: Saw fullname: Saw, Seang-Mei organization: From the Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine and the 3Singapore Eye Research Institute, Singapore National Eye Center, Singapore |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21807933$$D View this record in MEDLINE/PubMed |
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