Prediction of airway deformation effect on pulmonary air-particle dynamics: A numerical study
Most existing whole lung models neglect the airway deformation kinematics and assume the lung airways are static. However, neglecting the airway deformation effect on pulmonary air-particle flow dynamics significantly limits the modeling capability under disease-specific lung conditions. Therefore,...
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| Published in | Physics of Fluids Vol. 33; no. 10 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
AIP Publishing
01.10.2021
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| Online Access | Get full text |
| ISSN | 1070-6631 1089-7666 |
| DOI | 10.1063/5.0065309 |
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| Abstract | Most existing whole lung models neglect the airway deformation kinematics and assume the
lung airways are static. However, neglecting the airway deformation effect on pulmonary
air-particle flow dynamics significantly limits the modeling capability under
disease-specific lung conditions. Therefore, a novel elastic truncated whole-lung (TWL)
modeling framework has been developed to simulate the disease-specific airway deformation
kinematics simultaneously with pulmonary air-particle flow dynamics using one-way coupled
Euler–Lagrange method plus the dynamic mesh method. Specifically, the deformation
kinematics of the elastic TWL model was calibrated with clinical data and pulmonary
function test results for both healthy lung and lungs with chronic obstructive pulmonary
diseases (COPDs). The transport dynamics of spherical sub micrometer and micrometer
particles were investigated. Results show that noticeable differences in air-particle flow
predictions between static and elastic lung models can be found, which demonstrates the
necessity to model airway deformation kinematics in whole-lung models. The elastic TWL
model predicted lower deposition fraction in mouth-throat regions and higher deposition
fraction in lower airways. The effect of disease-specific airway deformation kinematics on
particle transport and deposition in the whole lung was investigated, with a focus on the
targeted drug delivery efficiency in small airways from generation (G8) to alveoli as the
designated lung sites for COPD treatment using inhalation therapy. Simulation results
indicate that with the exacerbation of COPD disease conditions, the highest delivery
efficiency of the inhaled drug particles decreases which indicates that delivering
aerosolized medications to small airways to treat COPD is more challenging for patients
with severe disease conditions. |
|---|---|
| AbstractList | Most existing whole lung models neglect the airway deformation kinematics and assume the
lung airways are static. However, neglecting the airway deformation effect on pulmonary
air-particle flow dynamics significantly limits the modeling capability under
disease-specific lung conditions. Therefore, a novel elastic truncated whole-lung (TWL)
modeling framework has been developed to simulate the disease-specific airway deformation
kinematics simultaneously with pulmonary air-particle flow dynamics using one-way coupled
Euler–Lagrange method plus the dynamic mesh method. Specifically, the deformation
kinematics of the elastic TWL model was calibrated with clinical data and pulmonary
function test results for both healthy lung and lungs with chronic obstructive pulmonary
diseases (COPDs). The transport dynamics of spherical sub micrometer and micrometer
particles were investigated. Results show that noticeable differences in air-particle flow
predictions between static and elastic lung models can be found, which demonstrates the
necessity to model airway deformation kinematics in whole-lung models. The elastic TWL
model predicted lower deposition fraction in mouth-throat regions and higher deposition
fraction in lower airways. The effect of disease-specific airway deformation kinematics on
particle transport and deposition in the whole lung was investigated, with a focus on the
targeted drug delivery efficiency in small airways from generation (G8) to alveoli as the
designated lung sites for COPD treatment using inhalation therapy. Simulation results
indicate that with the exacerbation of COPD disease conditions, the highest delivery
efficiency of the inhaled drug particles decreases which indicates that delivering
aerosolized medications to small airways to treat COPD is more challenging for patients
with severe disease conditions. Most existing whole lung models neglect the airway deformation kinematics and assume the lung airways are static. However, neglecting the airway deformation effect on pulmonary air-particle flow dynamics significantly limits the modeling capability under disease-specific lung conditions. Therefore, a novel elastic truncated whole-lung (TWL) modeling framework has been developed to simulate the disease-specific airway deformation kinematics simultaneously with pulmonary air-particle flow dynamics using one-way coupled Euler–Lagrange method plus the dynamic mesh method. Specifically, the deformation kinematics of the elastic TWL model was calibrated with clinical data and pulmonary function test results for both healthy lung and lungs with chronic obstructive pulmonary diseases (COPDs). The transport dynamics of spherical sub micrometer and micrometer particles were investigated. Results show that noticeable differences in air-particle flow predictions between static and elastic lung models can be found, which demonstrates the necessity to model airway deformation kinematics in whole-lung models. The elastic TWL model predicted lower deposition fraction in mouth-throat regions and higher deposition fraction in lower airways. The effect of disease-specific airway deformation kinematics on particle transport and deposition in the whole lung was investigated, with a focus on the targeted drug delivery efficiency in small airways from generation (G8) to alveoli as the designated lung sites for COPD treatment using inhalation therapy. Simulation results indicate that with the exacerbation of COPD disease conditions, the highest delivery efficiency of the inhaled drug particles decreases which indicates that delivering aerosolized medications to small airways to treat COPD is more challenging for patients with severe disease conditions. |
| Author | Yu Feng Huimin Wu Jianan Zhao Kenichiro Koshiyama |
| Author_xml | – sequence: 1 givenname: Jianan orcidid: 0000-0001-6276-8961 surname: Zhao fullname: Zhao, Jianan – sequence: 2 givenname: Yu orcidid: 0000-0003-2908-0625 surname: Feng fullname: Feng, Yu – sequence: 3 givenname: Kenichiro orcidid: 0000-0003-2023-6742 surname: Koshiyama fullname: Koshiyama, Kenichiro – sequence: 4 givenname: Huimin orcidid: 0000-0001-7023-8362 surname: Wu fullname: Wu, Huimin |
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