Blood biochemical parameters for assessment of COVID-19 in diabetic and non-diabetic subjects: a cross-sectional study

• Published in: International journal of environmental health research Vol. 32; no. 6; pp. 1344 - 1358
• Main Authors: Malik, Syeda Umme Fahmida, Chowdhury, Parveen Afroz, Hakim, Al, Islam, Mohammad Shahidul, Alam, Md Jahangir, Azad, Abul Kalam
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.06.2022; Taylor & Francis LLC
• Subjects: Biomarkers; Blood; Blood biochemical parameters; Calcium-binding protein; Coronaviruses; COVID-19; COVID-19 - diagnosis; Cross-Sectional Studies; Diabetes; Diabetes Mellitus; Dimers; Female; Ferritin; Ferritins; Glycated Hemoglobin A; Humans; Male; Males; SARS-CoV-2; Troponin; Troponin I; COVID-19; SARS-CoV-2; diabetes mellitus; Blood biochemical parameters
• ISSN: 0960-3123; 1369-1619; 1369-1619
• DOI: 10.1080/09603123.2021.1879741

This study aims to identify blood biomarkers for rapidly predicting progression and severity assessment of COVID-19 in type 2 diabetic (DM) and non-DM (NDM) patients. Among 211 hospitalized patients suspected of COVID-19, 98 were confirmed COVID-19 by rRT-PCR. The COVID-19 positive group contained 58 DM and 40 NDM patients with total death 9 of which 7 were males and 6 were DM, indicating males and DM individuals as more susceptible to COVID-19. Blood biomarkers notably serum ferritin, CRP, D-dimer, ALT, troponin I, and Hb1Ac were significantly (p < 0.05) higher in COVID-19 patients. Ferritin and HbA1c levels were significantly (p < 0.05) higher in DM than NDM COVID-19 patients. The present study suggests that ferritin and HbA1c levels for DM patients, and ferritin, D-dimer, ALT for NDM patients could be routinely used as biomarkers for progression and severity assessment of COVID-19. CRP and Troponin-I could be the predictor only for poor prognosis of COVID-19.