Clinical Manifestations and Arsenic Methylation after a Rare Subacute Arsenic Poisoning Accident

One hundred and four workers ingested excessive levels of arsenic in an accident caused by leakage of pipeline in a copper-smelting factory. Clinical examinations were performed by physicians in a local hospital. Excreted urinary arsenic species were determined by cold trap hydride generation atomic...

Full description

Saved in:

Bibliographic Details
Published in	Toxicological sciences Vol. 103; no. 2; pp. 278 - 284
Main Authors	Xu, Yuanyuan, Wang, Yi, Zheng, Quanmei, Li, Bing, Li, Xin, Jin, Yaping, Lv, Xiuqiang, Qu, Guang, Sun, Guifan
Format	Journal Article
Language	English
Published	United States Oxford University Press 01.06.2008
Subjects	Accidents Adolescent Adult Aged Arsenic - adverse effects Arsenic - metabolism arsenic methylation Arsenic Poisoning - metabolism Arsenic Poisoning - pathology Arsenic Poisoning - physiopathology China DMPS Female Gastrointestinal Diseases - chemically induced Gastrointestinal Diseases - pathology Humans Leukopenia - chemically induced Leukopenia - pathology Male Methylation Middle Aged Occupational Exposure Peripheral Nervous System Diseases - chemically induced Peripheral Nervous System Diseases - pathology subacute arsenic poisoning urinary arsenic species Water Supply China subacute arsenic poisoning arsenic methylation urinary arsenic species DMPS
Online Access	Get full text
ISSN	1096-6080 1096-0929 1096-0929
DOI	10.1093/toxsci/kfn041

Cover

Abstract	One hundred and four workers ingested excessive levels of arsenic in an accident caused by leakage of pipeline in a copper-smelting factory. Clinical examinations were performed by physicians in a local hospital. Excreted urinary arsenic species were determined by cold trap hydride generation atomic absorption spectrometry. In the initial toxic phase, gastrointestinal symptoms were predominant (83 people, 79.8%). Most patients showed leucopenia (72 people, 69.2%), and increased serum alanine aminotransferase (84 people, 80.8%) and aspartate aminotransferase (58 people, 55.8%). Thirty-five patients (33.6%) had elevated red blood cells in urine. After 17 days of admission, many subjects (45 people, 43.3%) developed peripheral neuropathy and 25 of these 45 patients (24.0%) showed a decrease in motor and sensory nerve conduction velocity. In the comparison of urinary arsenic metabolites among subacute arsenic-poisoned, chronic high arsenic–exposed and control subjects, we found that subacute arsenic-poisoned patients had significantly elevated proportions of urinary inorganic arsenic (iAs) and methylarsonic acid (MMA) but reduced proportion of urinary dimethylarsinic acid (DMA) compared with chronic high arsenic–exposed and control subjects. Chronic exposed subjects excreted higher proportions of iAs and MMA but lower proportions of DMA in urine compared with control subjects. These results suggest that gastrointestinal symptoms, leucopenia, and hepatic and urinary injury are predominant in the initial phase of subacute arsenic poisoning. Peripheral neuropathy is the most frequent manifestation after the initial phase. The biomethylation of arsenic decreases in a dose rate–dependent manner.
AbstractList	One hundred and four workers ingested excessive levels of arsenic in an accident caused by leakage of pipeline in a copper-smelting factory. Clinical examinations were performed by physicians in a local hospital. Excreted urinary arsenic species were determined by cold trap hydride generation atomic absorption spectrometry. In the initial toxic phase, gastrointestinal symptoms were predominant (83 people, 79.8%). Most patients showed leucopenia (72 people, 69.2%), and increased serum alanine aminotransferase (84 people, 80.8%) and aspartate aminotransferase (58 people, 55.8%). Thirty-five patients (33.6%) had elevated red blood cells in urine. After 17 days of admission, many subjects (45 people, 43.3%) developed peripheral neuropathy and 25 of these 45 patients (24.0%) showed a decrease in motor and sensory nerve conduction velocity. In the comparison of urinary arsenic metabolites among subacute arsenic-poisoned, chronic high arsenic-exposed and control subjects, we found that subacute arsenic-poisoned patients had significantly elevated proportions of urinary inorganic arsenic (iAs) and methylarsonic acid (MMA) but reduced proportion of urinary dimethylarsinic acid (DMA) compared with chronic high arsenic-exposed and control subjects. Chronic exposed subjects excreted higher proportions of iAs and MMA but lower proportions of DMA in urine compared with control subjects. These results suggest that gastrointestinal symptoms, leucopenia, and hepatic and urinary injury are predominant in the initial phase of subacute arsenic poisoning. Peripheral neuropathy is the most frequent manifestation after the initial phase. The biomethylation of arsenic decreases in a dose rate-dependent manner.One hundred and four workers ingested excessive levels of arsenic in an accident caused by leakage of pipeline in a copper-smelting factory. Clinical examinations were performed by physicians in a local hospital. Excreted urinary arsenic species were determined by cold trap hydride generation atomic absorption spectrometry. In the initial toxic phase, gastrointestinal symptoms were predominant (83 people, 79.8%). Most patients showed leucopenia (72 people, 69.2%), and increased serum alanine aminotransferase (84 people, 80.8%) and aspartate aminotransferase (58 people, 55.8%). Thirty-five patients (33.6%) had elevated red blood cells in urine. After 17 days of admission, many subjects (45 people, 43.3%) developed peripheral neuropathy and 25 of these 45 patients (24.0%) showed a decrease in motor and sensory nerve conduction velocity. In the comparison of urinary arsenic metabolites among subacute arsenic-poisoned, chronic high arsenic-exposed and control subjects, we found that subacute arsenic-poisoned patients had significantly elevated proportions of urinary inorganic arsenic (iAs) and methylarsonic acid (MMA) but reduced proportion of urinary dimethylarsinic acid (DMA) compared with chronic high arsenic-exposed and control subjects. Chronic exposed subjects excreted higher proportions of iAs and MMA but lower proportions of DMA in urine compared with control subjects. These results suggest that gastrointestinal symptoms, leucopenia, and hepatic and urinary injury are predominant in the initial phase of subacute arsenic poisoning. Peripheral neuropathy is the most frequent manifestation after the initial phase. The biomethylation of arsenic decreases in a dose rate-dependent manner. One hundred and four workers ingested excessive levels of arsenic in an accident caused by leakage of pipeline in a copper-smelting factory. Clinical examinations were performed by physicians in a local hospital. Excreted urinary arsenic species were determined by cold trap hydride generation atomic absorption spectrometry. In the initial toxic phase, gastrointestinal symptoms were predominant (83 people, 79.8%). Most patients showed leucopenia (72 people, 69.2%), and increased serum alanine aminotransferase (84 people, 80.8%) and aspartate aminotransferase (58 people, 55.8%). Thirty-five patients (33.6%) had elevated red blood cells in urine. After 17 days of admission, many subjects (45 people, 43.3%) developed peripheral neuropathy and 25 of these 45 patients (24.0%) showed a decrease in motor and sensory nerve conduction velocity. In the comparison of urinary arsenic metabolites among subacute arsenic-poisoned, chronic high arsenic-exposed and control subjects, we found that subacute arsenic-poisoned patients had significantly elevated proportions of urinary inorganic arsenic (iAs) and methylarsonic acid (MMA) but reduced proportion of urinary dimethylarsinic acid (DMA) compared with chronic high arsenic-exposed and control subjects. Chronic exposed subjects excreted higher proportions of iAs and MMA but lower proportions of DMA in urine compared with control subjects. These results suggest that gastrointestinal symptoms, leucopenia, and hepatic and urinary injury are predominant in the initial phase of subacute arsenic poisoning. Peripheral neuropathy is the most frequent manifestation after the initial phase. The biomethylation of arsenic decreases in a dose rate-dependent manner.
Author	Wang, Yi Xu, Yuanyuan Zheng, Quanmei Jin, Yaping Lv, Xiuqiang Qu, Guang Sun, Guifan Li, Bing Li, Xin
Author_xml	– sequence: 1 givenname: Yuanyuan surname: Xu fullname: Xu, Yuanyuan organization: Department of Occupational and Environmental Health, College of Public Health, China Medical University, Shenyang, Liaoning, PR China 110001 – sequence: 2 givenname: Yi surname: Wang fullname: Wang, Yi organization: Department of Occupational and Environmental Health, College of Public Health, China Medical University, Shenyang, Liaoning, PR China 110001 – sequence: 3 givenname: Quanmei surname: Zheng fullname: Zheng, Quanmei organization: Department of Occupational and Environmental Health, College of Public Health, China Medical University, Shenyang, Liaoning, PR China 110001 – sequence: 4 givenname: Bing surname: Li fullname: Li, Bing organization: Department of Occupational and Environmental Health, College of Public Health, China Medical University, Shenyang, Liaoning, PR China 110001 – sequence: 5 givenname: Xin surname: Li fullname: Li, Xin organization: Department of Occupational and Environmental Health, College of Public Health, China Medical University, Shenyang, Liaoning, PR China 110001 – sequence: 6 givenname: Yaping surname: Jin fullname: Jin, Yaping organization: Department of Occupational and Environmental Health, College of Public Health, China Medical University, Shenyang, Liaoning, PR China 110001 – sequence: 7 givenname: Xiuqiang surname: Lv fullname: Lv, Xiuqiang organization: Department of Occupational and Environmental Health, College of Public Health, China Medical University, Shenyang, Liaoning, PR China 110001 – sequence: 8 givenname: Guang surname: Qu fullname: Qu, Guang organization: Department of Gastroenterology, The Central Hospital of Fuxin, Fuxin, Liaoning, PR China 123000 – sequence: 9 givenname: Guifan surname: Sun fullname: Sun, Guifan email: sungf@mail.cmu.edu.cn, To whom correspondence should be addressed at Department of Occupational and Environmental Health, College of Public Health, China Medical University, No. 92 Bei Er Road, Heping District, Shenyang 110001, PR China. Fax: +86-24-2326-1744. sungf@mail.cmu.edu.cn. organization: Department of Occupational and Environmental Health, College of Public Health, China Medical University, Shenyang, Liaoning, PR China 110001
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/18308700$$D View this record in MEDLINE/PubMed
BookMark	eNqFkU1v1DAQhq2qiH7AkSvyCXFJO443TnxcVoVW6goKtKp6MY4zaU2z9mI7Uvvva8iyByTUy3jkeebVzLwHZNd5h4S8YXDEQPLj5B-iscf3vYMZ2yH7-VMUIEu5u8kFNLBHDmL8CcCYAPmS7LGGQ1MD7JMfi8E6a_RAl9rZHmPSyXoXqXYdnYeIuUiXmO4ehz8FqvuEgWr6VQek38ZWmzHhlvzibfTOuls6N8Z26NIr8qLXQ8TXm_eQXH48-b44Lc4_fzpbzM8LwyVPxUwAlFWHJatLzkpoeduyXmKOXYtNabioTQ9iBrrSgvV5sxIMGqOrugRW80PybtJdB_9rzHuolY0Gh0E79GNUQjLJWdU8CzJZszwLZPDtBhzbFXZqHexKh0f193gZ4BNggo8xYK-Mnc6XgraDYqB-W6Qmi9RkUe4q_unaCv-Hfz_xflw_i26kbUz4sIV1uFei5nWlTq9v1PLi5gNcLaXi_AknfrMT
CitedBy_id	crossref_primary_10_1155_2013_984546 crossref_primary_10_1016_j_taap_2008_06_010 crossref_primary_10_1016_j_toxlet_2023_04_001 crossref_primary_10_1016_j_jhazmat_2013_02_017 crossref_primary_10_1016_j_tox_2014_09_002 crossref_primary_10_1038_jhg_2015_39 crossref_primary_10_1080_10408444_2019_1573804 crossref_primary_10_1002_tox_20731 crossref_primary_10_1016_j_cbi_2008_12_018 crossref_primary_10_1016_j_scitotenv_2022_159561 crossref_primary_10_1016_j_eti_2023_103040 crossref_primary_10_1001_dmp_2011_1 crossref_primary_10_1002_tox_20717 crossref_primary_10_1186_s40164_021_00205_6 crossref_primary_10_1016_j_tox_2013_07_008 crossref_primary_10_1039_b901500k crossref_primary_10_1007_s00204_009_0451_x crossref_primary_10_1093_toxsci_kfn184 crossref_primary_10_3389_fphar_2024_1338725 crossref_primary_10_1016_j_kjms_2011_05_005 crossref_primary_10_1016_j_kjms_2011_05_004 crossref_primary_10_1155_2013_817693 crossref_primary_10_1016_j_scitotenv_2011_08_055 crossref_primary_10_1039_b911133f crossref_primary_10_1038_srep44424 crossref_primary_10_1021_tx400123q crossref_primary_10_1016_j_chemosphere_2023_137735 crossref_primary_10_1016_j_cotox_2019_05_002 crossref_primary_10_3109_10408444_2013_827152 crossref_primary_10_5497_wjp_v3_i2_18 crossref_primary_10_7759_cureus_49177 crossref_primary_10_1007_s13530_015_0216_2 crossref_primary_10_1007_s11434_014_0150_8
Cites_doi	10.1046/j.1365-4362.2002.01535_2.x 10.1016/j.forsciint.2005.01.018 10.1007/s002040000134 10.1016/0041-008X(84)90279-5 10.1146/annurev.pharmtox.37.1.397 10.1097/00007611-198002000-00021 10.1046/j.1365-2133.1999.03213.x 10.1016/S0300-483X(02)00444-4 10.1016/j.taap.2003.10.017 10.1007/s00204-002-0413-z 10.1016/S0736-4679(97)00241-2 10.1191/0960327104ht459cr 10.1081/CLT-100102005 10.1016/j.taap.2003.10.027 10.1097/00043764-200012000-00016 10.1021/jf0013297 10.1006/taap.1999.8872 10.1080/10590500701201695 10.1016/j.taap.2004.05.017 10.1136/pmj.79.933.391 10.1016/j.taap.2003.10.033 10.1016/0272-0590(84)90138-6 10.1520/JFS13302J 10.3816/CLM.2006.n.058 10.1016/0735-6757(95)90111-6 10.1177/096032719701600807 10.1081/CLT-120018263
ContentType	Journal Article
Copyright	The Author 2008. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org 2008
Copyright_xml	– notice: The Author 2008. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org 2008
DBID	BSCLL AAYXX CITATION CGR CUY CVF ECM EIF NPM 7T2 7TM 7TV 7U7 C1K 7X8
DOI	10.1093/toxsci/kfn041
DatabaseName	Istex CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Health and Safety Science Abstracts (Full archive) Nucleic Acids Abstracts Pollution Abstracts Toxicology Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Health & Safety Science Abstracts Pollution Abstracts Toxicology Abstracts Nucleic Acids Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE Health & Safety Science Abstracts
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine Public Health Pharmacy, Therapeutics, & Pharmacology
EISSN	1096-0929
EndPage	284
ExternalDocumentID	18308700 10_1093_toxsci_kfn041 10.1093/toxsci/kfn041 ark_67375_HXZ_MQZB0VM9_3
Genre	Research Support, Non-U.S. Gov't Journal Article
GeographicLocations	China
GeographicLocations_xml	– name: China
GroupedDBID	--- -E4 .2P .I3 .ZR 0R~ 123 18M 1~5 29Q 2WC 4.4 48X 4G. 53G 5RE 5VS 5WA 5WD 7-5 70D A8Z AABZA AACZT AAHBH AAIMJ AAJKP AAJQQ AAMDB AAMVS AAOGV AAPNW AAPQZ AAPXW AARHZ AAUAY AAUQX AAVAP AAVLN AAYWO ABDFA ABEJV ABEUO ABGNP ABIXL ABJNI ABKDP ABMNT ABNGD ABNHQ ABNKS ABPQP ABPTD ABQLI ABVGC ABWST ABXVV ABXZS ABZBJ ACGFO ACGFS ACUFI ACUKT ACUTO ADBBV ADEYI ADEZT ADGKP ADGZP ADHKW ADHZD ADIPN ADNBA ADOCK ADQBN ADRTK ADVEK ADYVW ADZTZ ADZXQ AEGPL AEGXH AEJOX AEKSI AELWJ AEMDU AENEX AENZO AEPUE AETBJ AEWNT AFFZL AFGWE AFIYH AFOFC AGINJ AGKEF AGORE AGQPQ AGQXC AGSYK AHMMS AHXPO AIJHB AJBYB AJEEA AJNCP AKHUL AKRWK AKWXX ALMA_UNASSIGNED_HOLDINGS ALUQC ALXQX APIBT APWMN ARIXL ATGXG AXUDD AYOIW AZFZN BAWUL BAYMD BCRHZ BEYMZ BHONS BQDIO BSCLL BSWAC BTRTY BVRKM CAG CDBKE COF CS3 CZ4 DAKXR DIK DILTD DU5 D~K E3Z EBS EDH EE~ EJD EMOBN ESTFP F5P F9B FDB FHSFR FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H13 H5~ HAR HH5 HW0 HZ~ I-F IOX JXSIZ KAQDR KBUDW KOP KQ8 KSI KSN M-Z N9A NGC NLBLG NOMLY NOYVH NQ- NU- NVLIB O-L O0~ O9- OAWHX OBOKY OCZFY ODMLO OJQWA OJZSN OPAEJ OWPYF P2P PAFKI PB- PEELM Q1. Q5Y R44 RD5 ROL ROX RUSNO RW1 RXO SV3 TJX TLC TR2 W8F WOQ X7H YAYTL YKOAZ YXANX ZKX ~02 ~91 --K 1B1 1TH AACTN AAEDT AALRI AAQXK AASNB AAWDT AAXUO ABMAC ABQTQ ACFRR ACMRT ACUTJ ADJQC ADMUD ADRIX AFXEN ANFBD AQDSO ASPBG ATTQO AVWKF DM4 EBD ELUNK FEDTE FGOYB FIRID HVGLF IHE J21 KC5 LG5 M49 NTWIH OHT OK1 O~Y R2- RIG RNI RPZ RZO SSZ UHS XPP YCJ ZGI ZMT ZXP AAYXX ABIME ABWVN ACRPL ADNMO AEHUL AHGBF CITATION CGR CUY CVF ECM EIF NPM 7T2 7TM 7TV 7U7 C1K 7X8
ID	FETCH-LOGICAL-c393t-460025de21723120b3bb1f9ebb1dbe82c367cf0640a5a61f09620cecca5720173
ISSN	1096-6080 1096-0929
IngestDate	Thu Sep 04 23:25:38 EDT 2025 Fri Sep 05 02:42:45 EDT 2025 Mon Jul 21 05:23:40 EDT 2025 Tue Jul 01 02:57:21 EDT 2025 Thu Apr 24 23:04:04 EDT 2025 Wed Aug 28 03:25:25 EDT 2024 Sat Sep 20 11:01:44 EDT 2025
IsPeerReviewed	true
IsScholarly	true
Issue	2
Keywords	subacute arsenic poisoning arsenic methylation urinary arsenic species DMPS
Language	English
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c393t-460025de21723120b3bb1f9ebb1dbe82c367cf0640a5a61f09620cecca5720173
Notes	ark:/67375/HXZ-MQZB0VM9-3 istex:2A437B6A0CEA00F6DF67B24F4A7B652B2EE9542A ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
PMID	18308700
PQID	19710020
PQPubID	23462
PageCount	7
ParticipantIDs	proquest_miscellaneous_69193158 proquest_miscellaneous_19710020 pubmed_primary_18308700 crossref_citationtrail_10_1093_toxsci_kfn041 crossref_primary_10_1093_toxsci_kfn041 oup_primary_10_1093_toxsci_kfn041 istex_primary_ark_67375_HXZ_MQZB0VM9_3
ProviderPackageCode	CITATION AAYXX
PublicationCentury	2000
PublicationDate	2008-06-01
PublicationDateYYYYMMDD	2008-06-01
PublicationDate_xml	– month: 06 year: 2008 text: 2008-06-01 day: 01
PublicationDecade	2000
PublicationPlace	United States
PublicationPlace_xml	– name: United States
PublicationTitle	Toxicological sciences
PublicationTitleAlternate	Toxicol Sci
PublicationYear	2008
Publisher	Oxford University Press
Publisher_xml	– name: Oxford University Press
References	( key 20170508154014_bib9) 2004; 201 ( key 20170508154014_bib19) 2005; 151 ( key 20170508154014_bib2) 1997; 37 ( key 20170508154014_bib32) 1999 ( key 20170508154014_bib6) 2006; 7 ( key 20170508154014_bib25) 1993; 52 ( key 20170508154014_bib26) 2000; 163 ( key 20170508154014_bib10) 2002 ( key 20170508154014_bib33) 2007; 115 ( key 20170508154014_bib4) 2004; 198 ( key 20170508154014_bib24) 1997; 16 ( key 20170508154014_bib7) 2003; 183 ( key 20170508154014_bib29) 1980; 73 ( key 20170508154014_bib37) 1984; 74 ( key 20170508154014_bib35) 2007; 25 ( key 20170508154014_bib1) 2000; 42 ( key 20170508154014_bib18) 2004; 198 ( key 20170508154014_bib3) 1984; 4 ( key 20170508154014_bib12) 1998; 16 ( key 20170508154014_bib17) 2004; 23 ( key 20170508154014_bib11) 2002 ( key 20170508154014_bib34) 2004; 198 ( key 20170508154014_bib36) 2000; 112–113 ( key 20170508154014_bib20) 1995; 13 ( key 20170508154014_bib30) 2002; 41 ( key 20170508154014_bib15) 1994; 268 ( key 20170508154014_bib8) 2001; 49 ( key 20170508154014_bib28) 2003; 79 ( key 20170508154014_bib21) 1998; 96 ( key 20170508154014_bib27) 1992; 37 ( key 20170508154014_bib13) 2003; 41 ( key 20170508154014_bib14) 2003; 77 IARC ( key 20170508154014_bib16) 2004; 84 ( key 20170508154014_bib23) 2000; 38 ( key 20170508154014_bib31) 2000; 74 ( key 20170508154014_bib5) 1999; 141 ( key 20170508154014_bib22) 2001
References_xml	– volume: 41 start-page: 399 year: 2002 ident: key 20170508154014_bib30 article-title: Mees’ lines in a patient following acute arsenic intoxication publication-title: Int. J. Dermatol. doi: 10.1046/j.1365-4362.2002.01535_2.x – volume: 151 start-page: 273 year: 2005 ident: key 20170508154014_bib19 article-title: Massive acute arsenic poisonings publication-title: Forensic Sci. Int. doi: 10.1016/j.forsciint.2005.01.018 – volume: 74 start-page: 289 year: 2000 ident: key 20170508154014_bib31 article-title: Comparative toxicity of trivalent and pentavalent inorganic and methylated Asals in rat and human cells publication-title: Arch. Toxicol. doi: 10.1007/s002040000134 – volume: 74 start-page: 134 year: 1984 ident: key 20170508154014_bib37 article-title: Metabolism and excretion of orally administered dimethylarsinic acid in the hamster publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/0041-008X(84)90279-5 – volume: 37 start-page: 397 year: 1997 ident: key 20170508154014_bib2 article-title: Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity publication-title: Annu. Rev. Pharmacol. Toxicol. doi: 10.1146/annurev.pharmtox.37.1.397 – volume: 268 start-page: 662 year: 1994 ident: key 20170508154014_bib15 article-title: Determination and metabolism of dithiol chelating agents XVI: Pharmacokinetics of 2,3-dimercapto-1-propanesulfonate after intravenous administration to human volunteers publication-title: J. Pharmacol. Exp. Ther. – start-page: 649 volume-title: Principles and Methods of Toxicology year: 2001 ident: key 20170508154014_bib22 article-title: Metals – volume: 84 start-page: 269 year: 2004 ident: key 20170508154014_bib16 article-title: Some drinking water disinfectants and contaminants, including arsenic publication-title: IARC Monogr. Eval. Carcinog. Risk Hum – start-page: 1183 volume-title: Goldfrank's Toxicologic Emergencies year: 2002 ident: key 20170508154014_bib10 article-title: Arsenic – volume: 73 start-page: 198 year: 1980 ident: key 20170508154014_bib29 article-title: Arsenic poisoning publication-title: South Med. J. doi: 10.1097/00007611-198002000-00021 – volume: 141 start-page: 1106 year: 1999 ident: key 20170508154014_bib5 article-title: Acute arsenic poisoning: Clinical and histopathological features publication-title: Br. J. Dermatol. doi: 10.1046/j.1365-2133.1999.03213.x – volume: 112–113 start-page: 209 year: 2000 ident: key 20170508154014_bib36 article-title: Genetic polymorphism in the biotransformation of inorganic arsenic and its role in toxicity publication-title: Toxicol. Lett. – volume: 183 start-page: 77 year: 2003 ident: key 20170508154014_bib7 article-title: Dose-dependent biotransformation of arsenite in rats-not S—Adenosylmethionine depletion impairs arsenic methylation at high dose publication-title: Toxicology doi: 10.1016/S0300-483X(02)00444-4 – volume: 198 start-page: 268 year: 2004 ident: key 20170508154014_bib34 article-title: Arsenic contamination and arsenicosis in China publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2003.10.017 – volume: 77 start-page: 63 year: 2003 ident: key 20170508154014_bib14 article-title: Arsenic species excretion after dimercaptopropanesulfonic acid (DMPS) treatment of an acute arsenic trioxide poisoning publication-title: Arch. Toxicol. doi: 10.1007/s00204-002-0413-z – volume: 16 start-page: 45 year: 1998 ident: key 20170508154014_bib12 article-title: Heavy metal toxicity. Part I: Arsenic and mercury publication-title: J. Emerg. Med. doi: 10.1016/S0736-4679(97)00241-2 – volume: 23 start-page: 359 year: 2004 ident: key 20170508154014_bib17 article-title: Arsenic trioxide poisoning: A description of two acute overdoses publication-title: Hum. Exp. Toxicol. doi: 10.1191/0960327104ht459cr – volume: 38 start-page: 471 year: 2000 ident: key 20170508154014_bib23 article-title: Repetitive endoscopy and continuous alkaline gastric irrigation in a case of arsenic poisoning publication-title: J. Toxicol. Clin. Toxicol. doi: 10.1081/CLT-100102005 – volume: 198 start-page: 327 year: 2004 ident: key 20170508154014_bib4 article-title: A review of the enzymology of As metabolism and a new potential role of hydrogen peroxide in detoxication of the trivalent As species publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2003.10.027 – start-page: 811 volume-title: Cassarett and Doull's Toxicology year: 2002 ident: key 20170508154014_bib11 article-title: Toxic effects of metals – volume: 42 start-page: 1195 year: 2000 ident: key 20170508154014_bib1 article-title: Associations between drinking water and urinary arsenic levels and skin lesions in Bangladesh publication-title: J. Occup. Environ. Med. doi: 10.1097/00043764-200012000-00016 – volume: 49 start-page: 2272 year: 2001 ident: key 20170508154014_bib8 article-title: Effect of cooking temperatures on chemical changes in species of organic arsenic in seafood publication-title: J. Agric. Food Chem. doi: 10.1021/jf0013297 – volume: 163 start-page: 203 year: 2000 ident: key 20170508154014_bib26 article-title: Monomethylarsonous acid (MMA(III)) is more toxic than arsenite in Chang human hepatocytes publication-title: Toxicol. Appl. Pharmacol. doi: 10.1006/taap.1999.8872 – volume: 25 start-page: 1 year: 2007 ident: key 20170508154014_bib35 article-title: Arsenic methylation, urinary arsenic metabolites and human diseases: Current perspective publication-title: J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev. doi: 10.1080/10590500701201695 – volume: 52 start-page: 258 year: 1993 ident: key 20170508154014_bib25 article-title: Arsenic toxicity in Hawaii: A case report and review publication-title: Hawaii Med. J. – start-page: 311 volume-title: Arsenic Exposure and Health Effects. Proceedings of the Third International Conference on Arsenic Exposure and Health Effects year: 1999 ident: key 20170508154014_bib32 article-title: Metabolism and toxicity of arsenicals in cultured cells – volume: 201 start-page: 156 year: 2004 ident: key 20170508154014_bib9 article-title: Uptake of inorganic and organic derivatives of arsenic associated with induced cytotoxic and genotoxic effects in Chinese hamster ovary (CHO) cells publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2004.05.017 – volume: 79 start-page: 391 year: 2003 ident: key 20170508154014_bib28 article-title: Acute and chronic arsenic toxicity publication-title: Postgrad. Med. J. doi: 10.1136/pmj.79.933.391 – volume: 198 start-page: 297 year: 2004 ident: key 20170508154014_bib18 article-title: Arsenic speciation in human urine: Are we all the same? publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2003.10.033 – volume: 4 start-page: 58 year: 1984 ident: key 20170508154014_bib3 article-title: DMSA, DMPS, and DMPA—As arsenic antidotes publication-title: Fundam. Appl. Toxicol. doi: 10.1016/0272-0590(84)90138-6 – volume: 115 start-page: 647 year: 2007 ident: key 20170508154014_bib33 article-title: Urinary arsenic metabolites in children and adults exposed to arsenic in drinking water in Inner Mongolia, China publication-title: Environ. Health Perspect. – volume: 96 start-page: 4 year: 1998 ident: key 20170508154014_bib21 article-title: Chronic arsenic toxicity in west Bengal—The worst calamity in the world publication-title: JAMA – volume: 37 start-page: 1163 year: 1992 ident: key 20170508154014_bib27 article-title: Acute arsenic intoxication: Forensic and toxicologic aspects (an observation) publication-title: J. Forensic Sci. doi: 10.1520/JFS13302J – volume: 7 start-page: 192 year: 2006 ident: key 20170508154014_bib6 article-title: Arsenic compounds in the treatment of multiple myeloma: A new role for a historical remedy publication-title: Clin. Lymphoma Myeloma doi: 10.3816/CLM.2006.n.058 – volume: 13 start-page: 244 year: 1995 ident: key 20170508154014_bib20 article-title: Wholebowel irrigation as an adjunct in the treatment of radiopaque arsenic publication-title: Am. J. Emerg. Med. doi: 10.1016/0735-6757(95)90111-6 – volume: 16 start-page: 460 year: 1997 ident: key 20170508154014_bib24 article-title: Are we ready to replace dimercaprol (BAL) as an arsenic antidote? publication-title: Hum. Exp. Toxicol. doi: 10.1177/096032719701600807 – volume: 41 start-page: 1 year: 2003 ident: key 20170508154014_bib13 article-title: Acute arsenic poisoning treated by intravenous dimercaptosuccinic acid (DMSA) and combined extrarenal epuration techniques publication-title: J. Toxicol. Clin. Toxicol. doi: 10.1081/CLT-120018263
SSID	ssj0011609
Score	2.0944755
Snippet	One hundred and four workers ingested excessive levels of arsenic in an accident caused by leakage of pipeline in a copper-smelting factory. Clinical...
SourceID	proquest pubmed crossref oup istex
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	278
SubjectTerms	Accidents Adolescent Adult Aged Arsenic - adverse effects Arsenic - metabolism arsenic methylation Arsenic Poisoning - metabolism Arsenic Poisoning - pathology Arsenic Poisoning - physiopathology China DMPS Female Gastrointestinal Diseases - chemically induced Gastrointestinal Diseases - pathology Humans Leukopenia - chemically induced Leukopenia - pathology Male Methylation Middle Aged Occupational Exposure Peripheral Nervous System Diseases - chemically induced Peripheral Nervous System Diseases - pathology subacute arsenic poisoning urinary arsenic species Water Supply
Title	Clinical Manifestations and Arsenic Methylation after a Rare Subacute Arsenic Poisoning Accident
URI	https://api.istex.fr/ark:/67375/HXZ-MQZB0VM9-3/fulltext.pdf https://www.ncbi.nlm.nih.gov/pubmed/18308700 https://www.proquest.com/docview/19710020 https://www.proquest.com/docview/69193158
Volume	103
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbKJiEkhKDcytVIqC8sm-Nc_bhNoHIJ6lAHZS8hcRxpGrSoTaWOB34758SO0-4iBi9RZB0ncs6X4-NzJeQlehdj5pdOFpeB4xdF4Qhf-Q4vCp_noVCRxHzn5GM4OPTfjYNxp_N7NbukyrflrwvzSv6HqzAGfMUs2X_grH0oDMA98BeuwGG4XonH-01aY5JhiMq8MnFtaAzfnc0VNrdJFLBCB7yZhuDZq08Y7gUiI5MYJdBQDqcYWVSbSaTEXqNrZvvRdHksraQ0G6dVyMeLWpYvQLQsWrx9Mcbor8etfVrpoQMg-6Hs-Ic6qGCv2UcbM0TchksZyQlnISdkui3TtmrHmDAmjUbcMm8FV3xVeOpmPmYf5rp13DkRr8tfVdMlrBRuTsoJ06Wz1otpn9nkbOihdrp7qX5AqqdfI5s8At0Lleq3760Xyg3rECG7NFOjFabv6Ok7evqaTrOJv-fyTL7kuWNLrb6MbpNb5txBdzWI7pCOmnTJ9cREVnRJf6hrmJ9u0VGbkjffon06bKubn3bJTW3opTp_7S751oCQroOQAgipgRZdASGtQUgziiCkDQgtpQUhbUB4jxy-eT3aHzimbYcjPeFVjo-u3qBQ2PrMcznLvTx3S6HgWuQq5tILI1miBzkLstAt4etyJlGUBBGoo5F3n2xMphP1kFBeotc8yD2uQl_GIgcB4roik2UQs1LkPbLVfPhUmpr22Frle3ohm3ukb8l_6mIulxLWXLRU2ewEIyCjIB2Mj9Lk4GiPfU5E6vXIC2Dz3x72vAFBCrIbHXLZRE0X89QVWFuLs8spQgEHLDeIe-SBRk_7qhhreTL26KprekxutP_tE7JRzRbqKSjUVf6sRv0fol7RYg
linkProvider	Flying Publisher
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Clinical+Manifestations+and+Arsenic+Methylation+after+a+Rare+Subacute+Arsenic+Poisoning+Accident&rft.jtitle=Toxicological+sciences&rft.au=Xu%2C+Yuanyuan&rft.au=Wang%2C+Yi&rft.au=Zheng%2C+Quanmei&rft.au=Li%2C+Bing&rft.date=2008-06-01&rft.issn=1096-6080&rft.eissn=1096-0929&rft.volume=103&rft.issue=2&rft.spage=278&rft.epage=284&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfn041&rft.externalDBID=n%2Fa&rft.externalDocID=10_1093_toxsci_kfn041
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1096-6080&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1096-6080&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1096-6080&client=summon