Oligodendrocytes in amyotrophic lateral sclerosis and frontotemporal dementia: the new players on stage

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal adult-onset neurodegenerative disorders that share clinical, neuropathological and genetic features, which forms part of a multi-system disease spectrum. The pathological process leading to ALS and FTD is the result of t...

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Published inFrontiers in molecular neuroscience Vol. 17; p. 1375330
Main Authors Jamet, Marguerite, Dupuis, Luc, Gonzalez De Aguilar, Jose-Luis
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 22.03.2024
Frontiers Media S.A
Subjects
Amyotrophic lateral sclerosis
Animal models
Autophagy
Dementia
Dementia disorders
Disease
Family medical history
Frontotemporal dementia
Glial cells
Glycoproteins
Localization
Mutation
Myelin
Neurodegeneration
neurodegenerative disease
Neurodegenerative diseases
Neuronal-glial interactions
Neurons
oligodendrocyte
Oligodendrocytes
Proteins
Spinal cord
myelin
frontotemporal dementia
neurodegenerative disease
amyotrophic lateral sclerosis
oligodendrocyte
Online AccessGet full text
ISSN1662-5099
1662-5099
DOI10.3389/fnmol.2024.1375330

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Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal adult-onset neurodegenerative disorders that share clinical, neuropathological and genetic features, which forms part of a multi-system disease spectrum. The pathological process leading to ALS and FTD is the result of the combination of multiple mechanisms that operate within specific populations of neurons and glial cells. The implication of oligodendrocytes has been the subject of a number of studies conducted on patients and related animal models. In this review we summarize our current knowledge on the alterations specific to myelin and the oligodendrocyte lineage occurring in ALS and FTD. We also consider different ways by which specific oligodendroglial alterations influence neurodegeneration and highlight the important role of oligodendrocytes in these two intrinsically associated neurodegenerative diseases.
AbstractList Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal adult-onset neurodegenerative disorders that share clinical, neuropathological and genetic features, which forms part of a multi-system disease spectrum. The pathological process leading to ALS and FTD is the result of the combination of multiple mechanisms that operate within specific populations of neurons and glial cells. The implication of oligodendrocytes has been the subject of a number of studies conducted on patients and related animal models. In this review we summarize our current knowledge on the alterations specific to myelin and the oligodendrocyte lineage occurring in ALS and FTD. We also consider different ways by which specific oligodendroglial alterations influence neurodegeneration and highlight the important role of oligodendrocytes in these two intrinsically associated neurodegenerative diseases.Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal adult-onset neurodegenerative disorders that share clinical, neuropathological and genetic features, which forms part of a multi-system disease spectrum. The pathological process leading to ALS and FTD is the result of the combination of multiple mechanisms that operate within specific populations of neurons and glial cells. The implication of oligodendrocytes has been the subject of a number of studies conducted on patients and related animal models. In this review we summarize our current knowledge on the alterations specific to myelin and the oligodendrocyte lineage occurring in ALS and FTD. We also consider different ways by which specific oligodendroglial alterations influence neurodegeneration and highlight the important role of oligodendrocytes in these two intrinsically associated neurodegenerative diseases.
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal adult-onset neurodegenerative disorders that share clinical, neuropathological and genetic features, which forms part of a multi-system disease spectrum. The pathological process leading to ALS and FTD is the result of the combination of multiple mechanisms that operate within specific populations of neurons and glial cells. The implication of oligodendrocytes has been the subject of a number of studies conducted on patients and related animal models. In this review we summarize our current knowledge on the alterations specific to myelin and the oligodendrocyte lineage occurring in ALS and FTD. We also consider different ways by which specific oligodendroglial alterations influence neurodegeneration and highlight the important role of oligodendrocytes in these two intrinsically associated neurodegenerative diseases.
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal adult-onset neurodegenerative disorders that share clinical, neuropathological and genetic features, which forms part of a multi-system disease spectrum. The pathological process leading to ALS and FTD is the result of the combination of multiple mechanisms that operate within specific populations of neurons and glial cells. The implication of oligodendrocytes has been the subject to a number of studies conducted on patients and related animal models. In this review we summarize our current knowledge on the alterations specific to myelin and the oligodendrocyte lineage occurring in ALS and FTD. We also consider different ways by which specific oligondendroglial alterations influence neurodegeneration and highlight the important role of oligodendrocytes in these two intrinsically associated neurodegenerative diseases.
Author Jamet, Marguerite
Gonzalez De Aguilar, Jose-Luis
Dupuis, Luc
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frontotemporal dementia
neurodegenerative disease
amyotrophic lateral sclerosis
oligodendrocyte
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Snippet Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal adult-onset neurodegenerative disorders that share clinical, neuropathological...
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SubjectTerms Amyotrophic lateral sclerosis
Animal models
Autophagy
Dementia
Dementia disorders
Disease
Family medical history
Frontotemporal dementia
Glial cells
Glycoproteins
Localization
Mutation
Myelin
Neurodegeneration
neurodegenerative disease
Neurodegenerative diseases
Neuronal-glial interactions
Neurons
oligodendrocyte
Oligodendrocytes
Proteins
Spinal cord
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Title Oligodendrocytes in amyotrophic lateral sclerosis and frontotemporal dementia: the new players on stage
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