Overweight and obesity in children and adolescents with endocrine disorders
Obesity has become a serious medical condition where many factors can contribute to excess weight gain. The most common type of childhood obesity is simple obesity, which is due to gene-obesogenic environment interaction. Only a minority are due to pathological causes. Secondary causes of obesity, w...
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Published in | Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia Vol. 167; no. 4; pp. 328 - 334 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Czech Republic
Palacký University Olomouc, Faculty of Medicine and Dentistry
01.12.2023
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Subjects | |
Online Access | Get full text |
ISSN | 1213-8118 1804-7521 |
DOI | 10.5507/bp.2023.036 |
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Abstract | Obesity has become a serious medical condition where many factors can contribute to excess weight gain. The most common type of childhood obesity is simple obesity, which is due to gene-obesogenic environment interaction. Only a minority are due to pathological causes. Secondary causes of obesity, while less common, include these: genetic syndromes, drug-related obesity, as well as endocrine disorders (hypothyroidism, Cushing's syndrome, growth hormone deficiency, hypogonadism, pseudohypoparathyroidism type Ia, insulinoma, hypothalamic obesity and polycystic ovary syndrome). Given that some conditions may be treatable, physicians must be aware of obesity due to endocrinopathies and distinguish them from simple obesity, and treat them properly. Although rare among children, early detection of the endocrine cause of obesity leads to reduced morbidity and, in some cases, reduced mortality in these individuals. The aim of this review is to summarize the current findings on obesity-related endocrinopathies in children (illustrated by clinical examples), highlighting aspects of pathogenetic mechanisms, genetics, the clinical diagnosis, growth, body mass index and possible therapeutic approaches. Early detection and correction of endocrine obesity is of paramount importance for obese children who could benefit from timely diagnosis and an improved management of obesity as many disturbances related to obesity can be reversed at the early stage, if weight loss is achieved. |
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AbstractList | Obesity has become a serious medical condition where many factors can contribute to excess weight gain. The most common type of childhood obesity is simple obesity, which is due to gene-obesogenic environment interaction. Only a minority are due to pathological causes. Secondary causes of obesity, while less common, include these: genetic syndromes, drug-related obesity, as well as endocrine disorders (hypothyroidism, Cushing's syndrome, growth hormone deficiency, hypogonadism, pseudohypoparathyroidism type Ia, insulinoma, hypothalamic obesity and polycystic ovary syndrome). Given that some conditions may be treatable, physicians must be aware of obesity due to endocrinopathies and distinguish them from simple obesity, and treat them properly. Although rare among children, early detection of the endocrine cause of obesity leads to reduced morbidity and, in some cases, reduced mortality in these individuals. The aim of this review is to summarize the current findings on obesity-related endocrinopathies in children (illustrated by clinical examples), highlighting aspects of pathogenetic mechanisms, genetics, the clinical diagnosis, growth, body mass index and possible therapeutic approaches. Early detection and correction of endocrine obesity is of paramount importance for obese children who could benefit from timely diagnosis and an improved management of obesity as many disturbances related to obesity can be reversed at the early stage, if weight loss is achieved. |
Author | Paterova, Petra Pomahacova, Renata Sykora, Josef Sladkova, Eva Nykodymova, Eva Polak, Petr Skalicka, Eva |
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SubjectTerms | Adolescent Child cushing's syndrome Endocrine System Diseases - complications Endocrine System Diseases - diagnosis Female growth hormone deficiency Humans hypogonadism hypothalamic obesity Hypothyroidism insulinoma Obesity, Morbid Overweight - complications Pediatric Obesity - complications polycystic ovary syndrome pseudohypoparathyroidism type ia secondary obesity |
Title | Overweight and obesity in children and adolescents with endocrine disorders |
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