Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1,8-naphthyridin-2(1H)-one scaffold

CB2 receptor ligands are becoming increasingly attractive drugs due to the potential role of this receptor in several physiopathological processes. Using our previously described series of 1,8-naphthyridin-2(1H)-on-3-carboxamides as a lead class, several nitrogen heterocyclic derivatives, characteri...

Full description

Saved in:
Bibliographic Details
Published inEuropean journal of medicinal chemistry Vol. 52; pp. 284 - 294
Main Authors Manera, Clementina, Saccomanni, Giuseppe, Malfitano, Anna Maria, Bertini, Simone, Castelli, Francesca, Laezza, Chiara, Ligresti, Alessia, Lucchesi, Valentina, Tuccinardi, Tiziano, Rizzolio, Flavio, Bifulco, Maurizio, Di Marzo, Vincenzo, Giordano, Antonio, Macchia, Marco, Martinelli, Adriano
Format Journal Article
LanguageEnglish
Published ISSY-LES-MOULINEAUX Elsevier Masson SAS 01.06.2012
Elsevier
Subjects
Anti-proliferative
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - metabolism
Antineoplastic Agents - pharmacology
Biological and medical sciences
Cannabinoid
CB1 receptor
CB2 receptor
Cell Line, Tumor
Cell Proliferation - drug effects
Chemistry Techniques, Synthetic
Chemistry, Medicinal
Drug Design
Humans
Life Sciences & Biomedicine
Ligands
Medical sciences
Miscellaneous
Models, Molecular
Molecular Conformation
Naphthyridines - chemical synthesis
Naphthyridines - chemistry
Naphthyridines - metabolism
Naphthyridines - pharmacology
Pharmacology & Pharmacy
Pharmacology. Drug treatments
Receptor, Cannabinoid, CB1 - metabolism
Receptor, Cannabinoid, CB2 - metabolism
Science & Technology
Substrate Specificity
CB2 receptor
Anti-proliferative
Cannabinoid
CB1 receptor
LIVER-DISEASES
ENDOCANNABINOID SYSTEM
AMYOTROPHIC-LATERAL-SCLEROSIS
AGONISTS
MULTIPLE-SCLEROSIS
FUNCTIONAL EXPRESSION
MOUSE MODEL
BIOLOGICAL EVALUATION
1,8-NAPHTHYRIDIN-4(1H)-ON-3-CARBOXAMIDE
DERIVATIVES
Online AccessGet full text
ISSN0223-5234
1768-3254
1768-3254
DOI10.1016/j.ejmech.2012.03.031

Cover

Abstract CB2 receptor ligands are becoming increasingly attractive drugs due to the potential role of this receptor in several physiopathological processes. Using our previously described series of 1,8-naphthyridin-2(1H)-on-3-carboxamides as a lead class, several nitrogen heterocyclic derivatives, characterized by different central cores, were synthesized and tested for their affinity toward the human CB1 and CB2 cannabinoid receptors. The obtained results suggest that the new series of quinolin-2(1H)-on-3-carboxamides, 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamides and 1,2-dihydro-2-oxopyridine-3-carboxamides represent novel scaffolds very suitable for the development of promising CB2 ligands. Furthermore, the newly synthesized CB2 ligands inhibit proliferation of several cancer cell lines. In particular, it was demonstrated that in DU-145 cell line these ligands exert a CB2-mediated anti-proliferative action and decrease the CB2 receptor expression levels. [Display omitted] ► In this study we report the synthesis of new CB2R ligands. ► Some ligands possess high affinity and CB2/CB1 selectivity. ► The most active ligands are effective on different tumor cell lines.
AbstractList CB2 receptor ligands are becoming increasingly attractive drugs due to the potential role of this receptor in several physiopathological processes. Using our previously described series of 1,8-naphthyridin-2(1H)-on-3-carboxamides as a lead class, several nitrogen heterocyclic derivatives, characterized by different central cores, were synthesized and tested for their affinity toward the human CB1 and CB2 cannabinoid receptors. The obtained results suggest that the new series of quinolin-2(1H)-on-3-carboxamides, 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamides and 1,2-dihydro-2-oxopyridine-3-carboxamides represent novel scaffolds very suitable for the development of promising CB2 ligands. Furthermore, the newly synthesized CB2 ligands inhibit proliferation of several cancer cell lines. In particular, it was demonstrated that in DU-145 cell line these ligands exert a CB2-mediated anti-proliferative action and decrease the CB2 receptor expression levels. [Display omitted] ► In this study we report the synthesis of new CB2R ligands. ► Some ligands possess high affinity and CB2/CB1 selectivity. ► The most active ligands are effective on different tumor cell lines.
CB2 receptor ligands are becoming increasingly attractive drugs due to the potential role of this receptor in several physiopathological processes. Using our previously described series of 1,8-naphthyridin-2(1H)-on-3-carboxamides as a lead class, several nitrogen heterocyclic derivatives, characterized by different central cores, were synthesized and tested for their affinity toward the human CB1 and CB2 cannabinoid receptors. The obtained results suggest that the new series of quinolin-2(1H)-on-3-carboxamides, 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamides and 1,2-dihydro-2-oxopyridine-3-carboxamides represent novel scaffolds very suitable for the development of promising CB2 ligands. Furthermore, the newly synthesized CB2 ligands inhibit proliferation of several cancer cell lines. In particular, it was demonstrated that in DU-145 cell line these ligands exert a CB2-mediated anti-proliferative action and decrease the CB2 receptor expression levels.CB2 receptor ligands are becoming increasingly attractive drugs due to the potential role of this receptor in several physiopathological processes. Using our previously described series of 1,8-naphthyridin-2(1H)-on-3-carboxamides as a lead class, several nitrogen heterocyclic derivatives, characterized by different central cores, were synthesized and tested for their affinity toward the human CB1 and CB2 cannabinoid receptors. The obtained results suggest that the new series of quinolin-2(1H)-on-3-carboxamides, 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamides and 1,2-dihydro-2-oxopyridine-3-carboxamides represent novel scaffolds very suitable for the development of promising CB2 ligands. Furthermore, the newly synthesized CB2 ligands inhibit proliferation of several cancer cell lines. In particular, it was demonstrated that in DU-145 cell line these ligands exert a CB2-mediated anti-proliferative action and decrease the CB2 receptor expression levels.
CB2 receptor ligands are becoming increasingly attractive drugs due to the potential role of this receptor in several physiopathological processes. Using our previously described series of 1,8-naphthyridin-2(1H)-on-3-carboxamides as a lead class, several nitrogen heterocyclic derivatives, characterized by different central cores, were synthesized and tested for their affinity toward the human CB1 and CB2 cannabinoid receptors. The obtained results suggest that the new series of quinolin-2(1H)-on-3-carboxamides, 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamides and 1,2-dihydro-2-oxopyridine-3-carboxamides represent novel scaffolds very suitable for the development of promising CB2 ligands. Furthermore, the newly synthesized CB2 ligands inhibit proliferation of several cancer cell lines. In particular, it was demonstrated that in DU-145 cell line these ligands exert a CB2-mediated anti-proliferative action and decrease the CB2 receptor expression levels. (C) 2012 Elsevier Masson SAS. All rights reserved.
CB2 receptor ligands are becoming increasingly attractive drugs due to the potential role of this receptor in several physiopathological processes. Using our previously described series of 1,8-naphthyridin-2(1H)-on-3-carboxamides as a lead class, several nitrogen heterocyclic derivatives, characterized by different central cores, were synthesized and tested for their affinity toward the human CB1 and CB2 cannabinoid receptors. The obtained results suggest that the new series of quinolin-2(1H)-on-3-carboxamides, 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamides and 1,2-dihydro-2-oxopyridine-3-carboxamides represent novel scaffolds very suitable for the development of promising CB2 ligands. Furthermore, the newly synthesized CB2 ligands inhibit proliferation of several cancer cell lines. In particular, it was demonstrated that in DU-145 cell line these ligands exert a CB2-mediated anti-proliferative action and decrease the CB2 receptor expression levels.
Author Lucchesi, Valentina
Di Marzo, Vincenzo
Manera, Clementina
Castelli, Francesca
Laezza, Chiara
Ligresti, Alessia
Saccomanni, Giuseppe
Giordano, Antonio
Bertini, Simone
Bifulco, Maurizio
Martinelli, Adriano
Tuccinardi, Tiziano
Rizzolio, Flavio
Malfitano, Anna Maria
Macchia, Marco
Author_xml – sequence: 1
  givenname: Clementina
  surname: Manera
  fullname: Manera, Clementina
  email: manera@farm.unipi.it
  organization: Dipartimento di Scienze Farmaceutiche, Università di Pisa, via Bonanno 6, 56126 Pisa, Italy
– sequence: 2
  givenname: Giuseppe
  surname: Saccomanni
  fullname: Saccomanni, Giuseppe
  organization: Dipartimento di Scienze Farmaceutiche, Università di Pisa, via Bonanno 6, 56126 Pisa, Italy
– sequence: 3
  givenname: Anna Maria
  surname: Malfitano
  fullname: Malfitano, Anna Maria
  organization: Dipartimento di Scienze Farmaceutiche e biomediche, Università di Salerno, 84084 Fisciano (SA), Italy
– sequence: 4
  givenname: Simone
  surname: Bertini
  fullname: Bertini, Simone
  organization: Dipartimento di Scienze Farmaceutiche, Università di Pisa, via Bonanno 6, 56126 Pisa, Italy
– sequence: 5
  givenname: Francesca
  surname: Castelli
  fullname: Castelli, Francesca
  organization: Dipartimento di Scienze Farmaceutiche, Università di Pisa, via Bonanno 6, 56126 Pisa, Italy
– sequence: 6
  givenname: Chiara
  surname: Laezza
  fullname: Laezza, Chiara
  organization: Institute of Endocrinology and Experimental Oncology, IEOS, CNR, Naples, Italy
– sequence: 7
  givenname: Alessia
  surname: Ligresti
  fullname: Ligresti, Alessia
  organization: Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli, Napoli, Italy
– sequence: 8
  givenname: Valentina
  surname: Lucchesi
  fullname: Lucchesi, Valentina
  organization: Dipartimento di Scienze Farmaceutiche, Università di Pisa, via Bonanno 6, 56126 Pisa, Italy
– sequence: 9
  givenname: Tiziano
  surname: Tuccinardi
  fullname: Tuccinardi, Tiziano
  organization: Dipartimento di Scienze Farmaceutiche, Università di Pisa, via Bonanno 6, 56126 Pisa, Italy
– sequence: 10
  givenname: Flavio
  surname: Rizzolio
  fullname: Rizzolio, Flavio
  organization: Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicines, Centre for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
– sequence: 11
  givenname: Maurizio
  surname: Bifulco
  fullname: Bifulco, Maurizio
  organization: Dipartimento di Scienze Farmaceutiche e biomediche, Università di Salerno, 84084 Fisciano (SA), Italy
– sequence: 12
  givenname: Vincenzo
  surname: Di Marzo
  fullname: Di Marzo, Vincenzo
  organization: Dipartimento di Scienze Farmaceutiche e biomediche, Università di Salerno, 84084 Fisciano (SA), Italy
– sequence: 13
  givenname: Antonio
  surname: Giordano
  fullname: Giordano, Antonio
  organization: Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicines, Centre for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
– sequence: 14
  givenname: Marco
  surname: Macchia
  fullname: Macchia, Marco
  organization: Dipartimento di Scienze Farmaceutiche, Università di Pisa, via Bonanno 6, 56126 Pisa, Italy
– sequence: 15
  givenname: Adriano
  surname: Martinelli
  fullname: Martinelli, Adriano
  organization: Dipartimento di Scienze Farmaceutiche, Università di Pisa, via Bonanno 6, 56126 Pisa, Italy
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25868173$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/22483967$$D View this record in MEDLINE/PubMed
BookMark eNqNkl2LEzEUhgdZcT_0H4jkRlhxp-ZjMpPuhbAWdYUFQfQ6ZDIn25RpUpO0S3-Tf9LTbVfBCxUSZibzvO_J-TitjkIMUFXPGZ0wyto3iwkslmDnE04Zn1CBiz2qTljXqlpw2RxVJ5RzUUsumuPqNOcFpVS2lD6pjjlvlJi23Un144spPgYzkgGyvw0XJG9DmeN7JiYMuIuvVymO3kFCdAMEv1aQiodMoiMB7sjsHScZRrD3_60JwfQ-RD-QBBZWJSYy-lu0y5fkKhAfNpALHuwi7zwwHmEXqg5mNS_zbfKDDzU_Z9evasyZZGuci-PwtHrszJjh2eF5Vn378P7r7Lq--fzx0-zqprZiykvdsW6wtHdOdL2UVg1sANF3zDhJG2iNlZ1q5FRJaVrlmKGGN0K14LBcfeekOKvO976Y6fc1XlUvfbYwjiZAXGeN5aeNYo1oEH1xQNf9Ega9Sn5p0lY_FBiBlwfAYBqjSyZYn39zUrWKdQI5tefuoI8uWw_Bwi8MOydow6cM20e5mvlyX7tZXIeC0tf_L0X6ck_bFHNO4LQ9uJVk_IjJ7fJr9ULvx0vvxktTgYuhuPlD_BDmH7K3exlg1zYekj7ccvA4IEUP0f_d4CfSn-pR
CODEN EJMCA5
CitedBy_id crossref_primary_10_1021_acs_oprd_7b00313
crossref_primary_10_3389_fphar_2019_00621
crossref_primary_10_2174_1568026623666230502120956
crossref_primary_10_1002_jhet_4446
crossref_primary_10_1016_j_bmc_2013_09_040
crossref_primary_10_1016_j_ejmech_2013_10_070
crossref_primary_10_1016_j_tet_2021_132537
crossref_primary_10_1002_ddr_70059
crossref_primary_10_1371_journal_pone_0062511
crossref_primary_10_1039_C4GC01469C
crossref_primary_10_1002_ardp_201500237
crossref_primary_10_1016_j_ejmech_2020_112858
crossref_primary_10_3390_ijms19102975
crossref_primary_10_1021_co500120b
crossref_primary_10_1134_S1070428017080140
crossref_primary_10_1515_hc_2017_0068
crossref_primary_10_3390_molecules27093019
crossref_primary_10_1074_jbc_M115_649608
crossref_primary_10_3390_molecules23040777
crossref_primary_10_1002_anie_202206170
crossref_primary_10_1007_s10967_014_3407_4
crossref_primary_10_1016_j_biochi_2017_02_009
crossref_primary_10_1016_j_ejmech_2013_09_043
crossref_primary_10_1039_c3ob41200h
crossref_primary_10_1039_D1NA00036E
crossref_primary_10_1007_s13738_017_1152_7
crossref_primary_10_1002_cmdc_201600259
crossref_primary_10_1016_j_ejmech_2015_04_034
crossref_primary_10_1021_acs_jmedchem_0c01357
crossref_primary_10_1021_jm500807e
crossref_primary_10_1016_j_ejmech_2018_05_019
crossref_primary_10_3390_ijms19071958
crossref_primary_10_3390_ijms23063049
crossref_primary_10_1039_C7NJ03803H
crossref_primary_10_3390_molecules23071526
crossref_primary_10_1007_s11481_013_9494_0
crossref_primary_10_1021_acs_jmedchem_7b00155
crossref_primary_10_1186_s13065_017_0338_5
crossref_primary_10_1016_j_bmcl_2015_04_055
crossref_primary_10_1039_C8MD00448J
crossref_primary_10_1002_ange_202206170
crossref_primary_10_1039_D2RA05661E
Cites_doi 10.1021/jm200476p
10.1136/gut.2008.148791
10.1016/S0024-3205(97)00690-5
10.1021/jm100112j
10.1016/j.bmc.2004.09.050
10.1016/S0306-4522(03)00333-6
10.1038/sj.bjp.0706952
10.1016/j.bmc.2004.01.035
10.1196/annals.1369.052
10.1016/S0022-3565(24)37266-0
10.1016/j.ejphar.2006.05.025
10.1038/nrd1495
10.1021/jm801563d
10.1080/00397910500334371
10.2174/092986711795471374
10.1007/s00280-008-0788-5
10.1248/cpb.48.2003
10.1021/jo00276a023
10.1038/365061a0
10.1016/0006-2952(73)90196-2
10.1002/jcc.10189
10.1016/S0968-0896(99)00219-9
10.1161/STROKEAHA.107.488445
10.1038/sj.bjp.0707582
10.1124/jpet.106.105247
10.1016/j.bmcl.2007.09.089
10.1038/sj.bjp.0706406
10.2174/138955708783955935
10.1021/jm050875u
10.1038/sj.bjp.0706632
10.1002/ijc.23584
10.1007/s12035-007-0004-3
10.1038/346561a0
10.1080/10428190802239188
10.1038/sj.bjp.0707511
10.1038/sj.bjp.0707517
10.1007/s12035-007-0005-2
10.1111/j.1471-4159.2006.04346.x
10.1038/nprot.2006.179
10.1038/sj.bjp.0707531
10.1186/1471-2377-6-12
10.1021/jm0603466
10.1038/sj.bjp.0707486
10.2174/092986707780363023
10.1038/sj.bjp.0707493
ContentType Journal Article
Copyright 2012 Elsevier Masson SAS
2015 INIST-CNRS
Copyright © 2012 Elsevier Masson SAS. All rights reserved.
Copyright_xml – notice: 2012 Elsevier Masson SAS
– notice: 2015 INIST-CNRS
– notice: Copyright © 2012 Elsevier Masson SAS. All rights reserved.
DBID AAYXX
CITATION
17B
1KM
BLEPL
DTL
EGQ
GKHJH
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
7X8
DOI 10.1016/j.ejmech.2012.03.031
DatabaseName CrossRef
Web of Knowledge
Index Chemicus
Web of Science Core Collection
Science Citation Index Expanded
Web of Science Primary (SCIE, SSCI & AHCI)
Web of Science - Science Citation Index Expanded - 2012
Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
DatabaseTitle CrossRef
Web of Science
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic
Web of Science
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 1KM
  name: Index Chemicus
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/woscc/search-with-editions?editions=WOS.IC
  sourceTypes:
    Enrichment Source
    Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
Pharmacy, Therapeutics, & Pharmacology
EISSN 1768-3254
EndPage 294
ExternalDocumentID 22483967
25868173
000304291600028
10_1016_j_ejmech_2012_03_031
S0223523412001936
Genre Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: National Interest Research Projects (PRIN)
– fundername: FISM - Fondazione Italiana Sclerosi Multipla; Fondazione Italiana Sclerosi Multipla (FISM)
  grantid: 2009/R/3/C1
GroupedDBID ---
--K
--M
.~1
0R~
1B1
1RT
1~.
1~5
29G
4.4
457
4G.
53G
5GY
5VS
7-5
71M
8P~
9JM
9JN
AACTN
AAEDT
AAEDW
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AARLI
AATCM
AAXUO
AAYOK
ABFNM
ABFRF
ABGSF
ABJNI
ABMAC
ABOCM
ABUDA
ABXDB
ABYKQ
ABZDS
ACDAQ
ACGFO
ACIUM
ACNNM
ACRLP
ADBBV
ADECG
ADEZE
ADMUD
ADUVX
AEBSH
AEFWE
AEHWI
AEKER
AENEX
AFKWA
AFTJW
AFXIZ
AFZHZ
AGHFR
AGRDE
AGUBO
AGYEJ
AHHHB
AIEXJ
AIKHN
AITUG
AJBFU
AJOXV
AJSZI
ALCLG
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLXMC
CS3
DOVZS
DU5
EBS
EFJIC
EFLBG
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FLBIZ
FNPLU
FYGXN
G-2
G-Q
GBLVA
HMS
HMT
HVGLF
HZ~
IHE
J1W
KOM
M2Y
M34
M41
MO0
N9A
O-L
O9-
OAUVE
OGGZJ
OZT
P-8
P-9
P2P
PC.
Q38
R2-
RIG
ROL
RPZ
SCB
SCC
SDF
SDG
SES
SEW
SOC
SPC
SPCBC
SPT
SSK
SSP
SSU
SSZ
T5K
WUQ
~G-
AATTM
AAXKI
AAYWO
AAYXX
ABWVN
ACRPL
ACVFH
ADCNI
ADNMO
AEIPS
AEUPX
AFJKZ
AFPUW
AGCQF
AGQPQ
AGRNS
AIGII
AIIUN
AKBMS
AKRWK
AKYEP
ANKPU
APXCP
BNPGV
CITATION
EFKBS
17B
1KM
BLEPL
DTL
GROUPED_WOS_SCIENCE_CITATION_INDEX_EXPANDED
GROUPED_WOS_WEB_OF_SCIENCE
IQODW
SSH
CGR
CUY
CVF
ECM
EIF
NPM
PKN
7X8
ACLOT
~HD
ID FETCH-LOGICAL-c392t-717dc0bff37b55c8d1de3b71af504e6ac578459855a68f1a0a24386ef022b7f53
IEDL.DBID AIKHN
ISICitedReferencesCount 51
ISICitedReferencesURI https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=CitingArticles&UT=000304291600028
ISSN 0223-5234
1768-3254
IngestDate Sat Sep 27 20:03:29 EDT 2025
Wed Feb 19 01:51:16 EST 2025
Mon Jul 21 09:14:42 EDT 2025
Wed Aug 06 08:46:31 EDT 2025
Fri Sep 26 20:18:33 EDT 2025
Thu Apr 24 22:58:00 EDT 2025
Tue Aug 05 11:57:37 EDT 2025
Fri Feb 23 02:33:45 EST 2024
IsPeerReviewed true
IsScholarly true
Keywords CB2 receptor
Anti-proliferative
Cannabinoid
CB1 receptor
LIVER-DISEASES
ENDOCANNABINOID SYSTEM
AMYOTROPHIC-LATERAL-SCLEROSIS
AGONISTS
MULTIPLE-SCLEROSIS
FUNCTIONAL EXPRESSION
MOUSE MODEL
BIOLOGICAL EVALUATION
1,8-NAPHTHYRIDIN-4(1H)-ON-3-CARBOXAMIDE
DERIVATIVES
Language English
License https://www.elsevier.com/tdm/userlicense/1.0
CC BY 4.0
Copyright © 2012 Elsevier Masson SAS. All rights reserved.
LinkModel DirectLink
LogoURL https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg
MergedId FETCHMERGED-LOGICAL-c392t-717dc0bff37b55c8d1de3b71af504e6ac578459855a68f1a0a24386ef022b7f53
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-1490-3070
0000-0002-5959-016X
0000-0002-6205-4069
0000-0002-3400-4363
0000-0002-6193-2835
0000-0002-7197-0552
0000-0003-1787-3900
0000-0002-1771-4531
PMID 22483967
PQID 1010481434
PQPubID 23479
PageCount 11
ParticipantIDs pubmed_primary_22483967
crossref_citationtrail_10_1016_j_ejmech_2012_03_031
elsevier_sciencedirect_doi_10_1016_j_ejmech_2012_03_031
proquest_miscellaneous_1010481434
pascalfrancis_primary_25868173
webofscience_primary_000304291600028CitationCount
crossref_primary_10_1016_j_ejmech_2012_03_031
webofscience_primary_000304291600028
PublicationCentury 2000
PublicationDate 2012-06-01
PublicationDateYYYYMMDD 2012-06-01
PublicationDate_xml – month: 06
  year: 2012
  text: 2012-06-01
  day: 01
PublicationDecade 2010
PublicationPlace ISSY-LES-MOULINEAUX
PublicationPlace_xml – name: ISSY-LES-MOULINEAUX
– name: Kidlington
– name: France
PublicationTitle European journal of medicinal chemistry
PublicationTitleAbbrev EUR J MED CHEM
PublicationTitleAlternate Eur J Med Chem
PublicationYear 2012
Publisher Elsevier Masson SAS
Elsevier
Publisher_xml – name: Elsevier Masson SAS
– name: Elsevier
References Dittel (bib16) 2008; 153
Grimaldi, Capasso (bib25) 2011; 18
Price, Helesic, Parghi, Hargreaves, Flores (bib5) 2003; 120
Pasquini, De Rosa, Pedani, Mugnaini, Guida, Luongo, De Chiaro, Maione, Dragoni, Frosini, Ligresti, Di Marzo, Corelli (bib43) 2011; 54
Whiteside, Lee, Valenzano (bib14) 2007; 14
Ligresti, Moriello, Starowicz, Matias, Pisanti, De Petrocellis, Laezza, Portella, Bifulco, Di Marzo (bib35) 2006; 318
Pertwee (bib15) 2007; 36
Tuccinardi, Ferrarini, Manera, Ortore, Saccomanni, Martinelli (bib34) 2006; 49
Thored, Wood, Arvidsson, Cammenga, Kokaia, Lindvall (bib11) 2007; 38
Cossi, Rega, Scalmani, Barone (bib50) 2003; 24
Izzo, Camilleri (bib23) 2008; 57
Kim, Moore, Makriyannis, Abood (bib17) 2006; 542
Shoemaker, Seely, Reed, Crow, Prather (bib18) 2007; 101
Pacher, Hasko (bib20) 2008; 153
Ferrarini, Calderone, Cavallini, Manera, Saccomanni, Pani, Ruiu, Gessa (bib30) 2004; 12
Manera, Tuccinardi, Martinelli (bib12) 2008; 8
Galve-Roperh, Sánchez, Cortés, Gómez del Pulgar, Izquierdo, Guzmán (bib36) 2003; 6
Matsuda, Lolait, Brownstein, Young, Bonner (bib4) 1990; 346
Gustafsson, Wang, Severa, Eriksson, Kimby, Merup, Christensson, Flygare, Sander (bib29) 2008; 123
Rhee, Kim (bib45) 2002; 3
Guindon, Hohmann (bib13) 2008; 153
Krasavin, Shkavrov, Kravchenko (bib38) 2006; 36
Liu, Scott, Shamash, Joel, Powles (bib28) 2008; 49
Cheng, Prusoff (bib48) 1973; 22
Gatley, Lan, Pyatt, Gifford, Volkow, Makriyannis (bib46) 1997; 61
Lotersztajn, Teixeira-Clerc, Julien, Deveaux, Ichigotani, Manin, Tran-Van-Nhieu, Karsak, Zimmer, Mallat (bib24) 2008; 153
N. Fujii, Y. Oguro, S. Sasaki, Kondo S. PCT Int. Appl. WO 2009/107850, 2009.
Wright, Duncan, Sharkey (bib22) 2008; 153
Vichai, Kirtikara (bib49) 2006; 1
Manera, Saccomanni, Adinolfi, Benetti, Ligresti, Cascio, Tuccinardi, Lucchesi, Martinelli, Nieri, Masini, Di Marzo, Ferrarini (bib33) 2009; 52
Bissantz, Kuhn, Stahl (bib44) 2010; 53
Gustafsson, Lindgren, Jonsson, Jacobsson (bib27) 2009; 63
Onaivi, Ishiguro, Gong, Patel, Perchuk, Meozzi, Myers, Mora, Tagliaferro, Gardner, Brusco, Akinshola, Liu, Hope, Iwasaki, Arinami, Teasenfitz, Uhl (bib9) 2006; 1074
Taylor, Wong (bib40) 1989; 54
Sagredo, García-Arencibia, de Lago, Finetti, Decio, Fernández-Ruiz (bib19) 2007; 36
Mach, Montecucco, Steffens (bib21) 2008; 153
Rinaldi-Carmona, Barth, Millan, Derocq, Casellas, Congy, Oustric, Sarran, Bouaboula, Calandra, Portier, Shire, Brelie`re, Le Fur (bib41) 1998; 284
Piomelli (bib1) 2005; 6
Bifulco, Laezza, Pisanti, Gazzerro (bib26) 2006; 148
Munro, Thomas, Abu-Shaar (bib8) 1993; 365
Yiangou, Facer, Durrenberger, Chessell, Naylor, Bountra, Banati, Anand (bib10) 2006; 6
Huffman, Zengin, Wu, Lu, Hynd, Bushell, Thompson, Bushell, Tartal, Hurst, Reggio, Selley, Cassidy, Wiley, Martin (bib47) 2005; 13
Manera, Benetti, Castelli, Cavallini, Lazzarotti, Pibiri, Saccomanni, Tuccinardi, Vannacci, Martinelli, Ferrarini (bib31) 2006; 49
Huffman, Liddle, Yu, Aung, Abood, Wiley, Martin (bib42) 1999; 7
Di Marzo, Bifulco, De Petrocellis (bib3) 2004; 3
Pertwee (bib2) 2006; 147
Tokanovic, Malone, Ventura (bib6) 2007; 150
Manera, Cascio, Benetti, Allara, Tuccinardi, Martinelli, Saccomanni, Vivoli, Ghelardini, Di Marzo, Ferrarini (bib32) 2007; 17
Szabo, Schlicker (bib7) 2005
Suzuki, Ohuchi, Asanuma, Kaneko, Yokomori, Ito, Isobe, Muramatsu (bib37) 2000; 48
Mach (10.1016/j.ejmech.2012.03.031_bib21) 2008; 153
Yiangou (10.1016/j.ejmech.2012.03.031_bib10) 2006; 6
Guindon (10.1016/j.ejmech.2012.03.031_bib13) 2008; 153
Whiteside (10.1016/j.ejmech.2012.03.031_bib14) 2007; 14
Grimaldi (10.1016/j.ejmech.2012.03.031_bib25) 2011; 18
Thored (10.1016/j.ejmech.2012.03.031_bib11) 2007; 38
Sagredo (10.1016/j.ejmech.2012.03.031_bib19) 2007; 36
Di Marzo (10.1016/j.ejmech.2012.03.031_bib3) 2004; 3
Cossi (10.1016/j.ejmech.2012.03.031_bib50) 2003; 24
Lotersztajn (10.1016/j.ejmech.2012.03.031_bib24) 2008; 153
Galve-Roperh (10.1016/j.ejmech.2012.03.031_bib36) 2003; 6
Suzuki (10.1016/j.ejmech.2012.03.031_bib37) 2000; 48
Tokanovic (10.1016/j.ejmech.2012.03.031_bib6) 2007; 150
Manera (10.1016/j.ejmech.2012.03.031_bib32) 2007; 17
Krasavin (10.1016/j.ejmech.2012.03.031_bib38) 2006; 36
Kim (10.1016/j.ejmech.2012.03.031_bib17) 2006; 542
Manera (10.1016/j.ejmech.2012.03.031_bib12) 2008; 8
Szabo (10.1016/j.ejmech.2012.03.031_bib7) 2005
Izzo (10.1016/j.ejmech.2012.03.031_bib23) 2008; 57
Tuccinardi (10.1016/j.ejmech.2012.03.031_bib34) 2006; 49
Gatley (10.1016/j.ejmech.2012.03.031_bib46) 1997; 61
Rinaldi-Carmona (10.1016/j.ejmech.2012.03.031_bib41) 1998; 284
Huffman (10.1016/j.ejmech.2012.03.031_bib47) 2005; 13
Ligresti (10.1016/j.ejmech.2012.03.031_bib35) 2006; 318
Matsuda (10.1016/j.ejmech.2012.03.031_bib4) 1990; 346
Pacher (10.1016/j.ejmech.2012.03.031_bib20) 2008; 153
Rhee (10.1016/j.ejmech.2012.03.031_bib45) 2002; 3
Taylor (10.1016/j.ejmech.2012.03.031_bib40) 1989; 54
Vichai (10.1016/j.ejmech.2012.03.031_bib49) 2006; 1
Pasquini (10.1016/j.ejmech.2012.03.031_bib43) 2011; 54
Bifulco (10.1016/j.ejmech.2012.03.031_bib26) 2006; 148
Gustafsson (10.1016/j.ejmech.2012.03.031_bib29) 2008; 123
Ferrarini (10.1016/j.ejmech.2012.03.031_bib30) 2004; 12
Gustafsson (10.1016/j.ejmech.2012.03.031_bib27) 2009; 63
Pertwee (10.1016/j.ejmech.2012.03.031_bib2) 2006; 147
Pertwee (10.1016/j.ejmech.2012.03.031_bib15) 2007; 36
Manera (10.1016/j.ejmech.2012.03.031_bib33) 2009; 52
Wright (10.1016/j.ejmech.2012.03.031_bib22) 2008; 153
Onaivi (10.1016/j.ejmech.2012.03.031_bib9) 2006; 1074
10.1016/j.ejmech.2012.03.031_bib39
Dittel (10.1016/j.ejmech.2012.03.031_bib16) 2008; 153
Bissantz (10.1016/j.ejmech.2012.03.031_bib44) 2010; 53
Liu (10.1016/j.ejmech.2012.03.031_bib28) 2008; 49
Munro (10.1016/j.ejmech.2012.03.031_bib8) 1993; 365
Price (10.1016/j.ejmech.2012.03.031_bib5) 2003; 120
Cheng (10.1016/j.ejmech.2012.03.031_bib48) 1973; 22
Huffman (10.1016/j.ejmech.2012.03.031_bib42) 1999; 7
Manera (10.1016/j.ejmech.2012.03.031_bib31) 2006; 49
Piomelli (10.1016/j.ejmech.2012.03.031_bib1) 2005; 6
Shoemaker (10.1016/j.ejmech.2012.03.031_bib18) 2007; 101
Sagredo, O (WOS:000250121100010) 2007; 36
Price, TJ (WOS:000184257500015) 2003; 120
TAYLOR, EC (WOS:A1989AH03900023) 1989; 54
Rinaldi-Carmona, M (WOS:000071929100030) 1998; 284
Manera, C (WOS:000267180600005) 2009; 52
Grimaldi, C (WOS:000289975200002) 2011; 18
Manera, C (WOS:000240826200011) 2006; 49
Izzo, AA (WOS:000257646200024) 2008; 57
Shoemaker, JL (WOS:000244885600008) 2007; 101
Kim, K (WOS:000239467800014) 2006; 542
Whiteside, GT (WOS:000244879100005) 2007; 14
Pasquini, S (WOS:000293419400016) 2011; 54
Tuccinardi, T (WOS:000235826300017) 2006; 49
Bissantz, C (WOS:000279787200001) 2010; 53
Piomelli, Daniele (MEDLINE:16044662) 2005; 6
Gustafsson, SB (WOS:000264114300014) 2009; 63
Guindon, J (WOS:000252883900017) 2008; 153
Suzuki, M (WOS:000165673800032) 2000; 48
Pacher, P (WOS:000252883900009) 2008; 153
Thored, P (WOS:000250518300026) 2007; 38
Huffman, JW (WOS:000225939200009) 2005; 13
Dittel, BN (WOS:000252883900011) 2008; 153
Krasavin, M (WOS:000234544600007) 2006; 36
Cossi, M (WOS:000181993100001) 2003; 24
Galve-Roperh, I. (000304291600028.9) 2003; 6
Szabo, B (CCC:000229801000011) 2005; 168
Tokanovic, S (WOS:000244386700013) 2007; 150
MATSUDA, LA (WOS:A1990DT67900072) 1990; 346
Di Marzo, V (WOS:000223654800020) 2004; 3
Gustafsson, K (WOS:000258243300006) 2008; 123
Lotersztajn, S (WOS:000252883900013) 2008; 153
Onaivi, ES (WOS:000242168100052) 2006; 1074
Manera, C (WOS:000253489000020) 2007; 17
Vichai, V (WOS:000251155400005) 2006; 1
Gatley, SJ (WOS:A1997XV26900013) 1997; 61
Ligresti, A (WOS:000239878900053) 2006; 318
Wright, KL (WOS:000252883900010) 2008; 153
Yiangou, Y (WOS:000236272700001) 2006; 6
(000304291600028.1) 2009
Huffman, JW (WOS:000084527300026) 1999; 7
CHENG, Y (WOS:A1973R295300018) 1973; 22
Rhee, Man-Hee (MEDLINE:12514329) 2002; 3
Mach, F (WOS:000252883900014) 2008; 153
Pertwee, RG (WOS:000250121100006) 2007; 36
MUNRO, S (WOS:A1993LV64600054) 1993; 365
Manera, C (WOS:000256195900006) 2008; 8
Pertwee, RG (WOS:000235087400020) 2006; 147
Bifulco, M (WOS:000237806600001) 2006; 148
Liu, WM (WOS:000259240500024) 2008; 49
Ferrarini, PL (WOS:000220754600010) 2004; 12
References_xml – volume: 6
  start-page: 672
  year: 2005
  end-page: 679
  ident: bib1
  publication-title: Curr. Opin. Invest. Drugs
– volume: 12
  start-page: 1921
  year: 2004
  end-page: 1933
  ident: bib30
  publication-title: Bioorg. Med. Chem.
– volume: 52
  start-page: 3644
  year: 2009
  end-page: 3651
  ident: bib33
  publication-title: J. Med. Chem.
– start-page: 327
  year: 2005
  end-page: 365
  ident: bib7
  article-title: Effects of cannabinoids on neurotransmission
  publication-title: Cannabinoids
– volume: 6
  start-page: 12
  year: 2006
  ident: bib10
  publication-title: BMC Neurol.
– volume: 1074
  start-page: 514
  year: 2006
  end-page: 536
  ident: bib9
  publication-title: Ann. N.Y. Acad. Sci.
– volume: 284
  start-page: 644
  year: 1998
  end-page: 650
  ident: bib41
  publication-title: J. Pharmacol. Exp. Ther.
– volume: 36
  start-page: 82
  year: 2007
  end-page: 91
  ident: bib19
  publication-title: Mol. Neurobiol.
– volume: 120
  start-page: 155
  year: 2003
  end-page: 162
  ident: bib5
  publication-title: Neuroscience
– volume: 153
  start-page: 290
  year: 2008
  end-page: 298
  ident: bib21
  publication-title: Br. J. Pharmacol.
– volume: 153
  start-page: 252
  year: 2008
  end-page: 262
  ident: bib20
  publication-title: Br. J. Pharmacol.
– volume: 54
  start-page: 3618
  year: 1989
  ident: bib40
  publication-title: J. Org. Chem.
– volume: 53
  start-page: 5061
  year: 2010
  end-page: 5084
  ident: bib44
  publication-title: J. Med. Chem.
– volume: 150
  start-page: 227
  year: 2007
  end-page: 234
  ident: bib6
  publication-title: Br. J. Pharmacol.
– volume: 57
  start-page: 1140
  year: 2008
  end-page: 1155
  ident: bib23
  publication-title: Gut
– volume: 48
  start-page: 2003
  year: 2000
  end-page: 2008
  ident: bib37
  publication-title: Chem. Pharm. Bull.
– volume: 54
  start-page: 5444
  year: 2011
  end-page: 5453
  ident: bib43
  publication-title: J. Med. Chem.
– volume: 61
  start-page: 191
  year: 1997
  end-page: 197
  ident: bib46
  publication-title: Life Sci.
– volume: 147
  start-page: 163
  year: 2006
  end-page: 171
  ident: bib2
  publication-title: Br. J Pharmacol.
– volume: 153
  start-page: 271
  year: 2008
  end-page: 276
  ident: bib16
  publication-title: Br. J. Pharmacol.
– volume: 49
  start-page: 984
  year: 2006
  end-page: 994
  ident: bib34
  publication-title: J. Med. Chem.
– volume: 123
  start-page: 1025
  year: 2008
  end-page: 1033
  ident: bib29
  publication-title: Int. J. Cancer
– volume: 36
  start-page: 181
  year: 2006
  end-page: 186
  ident: bib38
  publication-title: Synth. Comm.
– volume: 24
  start-page: 669
  year: 2003
  end-page: 681
  ident: bib50
  publication-title: J. Comp. Chem.
– volume: 18
  start-page: 1575
  year: 2011
  end-page: 1583
  ident: bib25
  publication-title: Curr. Med. Chem.
– volume: 148
  start-page: 123
  year: 2006
  end-page: 135
  ident: bib26
  publication-title: Br. J. Pharmacol.
– volume: 153
  start-page: 286
  year: 2008
  end-page: 289
  ident: bib24
  publication-title: Br. J. Pharmacol.
– volume: 1
  start-page: 1112
  year: 2006
  end-page: 1116
  ident: bib49
  publication-title: Nat. Protoc.
– volume: 17
  start-page: 6505
  year: 2007
  end-page: 6510
  ident: bib32
  publication-title: Bioorg. Med. Chem. Lett.
– volume: 542
  start-page: 100
  year: 2006
  end-page: 105
  ident: bib17
  publication-title: Eur. J. Pharmacol.
– volume: 101
  start-page: 87
  year: 2007
  end-page: 98
  ident: bib18
  publication-title: J. Neurochem.
– volume: 13
  start-page: 89
  year: 2005
  end-page: 112
  ident: bib47
  publication-title: Bioorg. Med. Chem.
– volume: 153
  start-page: 263
  year: 2008
  end-page: 270
  ident: bib22
  publication-title: Br. J. Pharmacol.
– volume: 153
  start-page: 319
  year: 2008
  end-page: 334
  ident: bib13
  publication-title: Br. J. Pharmacol.
– volume: 7
  start-page: 2905
  year: 1999
  end-page: 2914
  ident: bib42
  publication-title: Bioorg. Med. Chem.
– volume: 318
  start-page: 1375
  year: 2006
  end-page: 1387
  ident: bib35
  publication-title: J. Pharmacol. Exp. Ther.
– reference: N. Fujii, Y. Oguro, S. Sasaki, Kondo S. PCT Int. Appl. WO 2009/107850, 2009.
– volume: 49
  start-page: 5947
  year: 2006
  end-page: 5957
  ident: bib31
  publication-title: J. Med. Chem.
– volume: 6
  start-page: 13
  year: 2003
  end-page: 319
  ident: bib36
  publication-title: Nat. Med.
– volume: 365
  start-page: 61
  year: 1993
  end-page: 65
  ident: bib8
  publication-title: Nature
– volume: 8
  start-page: 370
  year: 2008
  end-page: 387
  ident: bib12
  publication-title: Mini Rev. Med. Chem.
– volume: 346
  start-page: 561
  year: 1990
  end-page: 564
  ident: bib4
  publication-title: Nature
– volume: 22
  start-page: 3099
  year: 1973
  end-page: 3108
  ident: bib48
  publication-title: Biochem. Pharmacol.
– volume: 14
  start-page: 917
  year: 2007
  end-page: 936
  ident: bib14
  publication-title: Curr. Med. Chem.
– volume: 36
  start-page: 45
  year: 2007
  end-page: 59
  ident: bib15
  publication-title: Mol. Neurobiol.
– volume: 49
  start-page: 1800
  year: 2008
  end-page: 1809
  ident: bib28
  publication-title: Leuk. Lymphoma
– volume: 3
  start-page: 179
  year: 2002
  end-page: 184
  ident: bib45
  publication-title: J. Vet. Sci.
– volume: 3
  start-page: 771
  year: 2004
  end-page: 784
  ident: bib3
  publication-title: Nat. Rev. Drug Discov.
– volume: 38
  start-page: 3032
  year: 2007
  end-page: 3039
  ident: bib11
  publication-title: Stroke
– volume: 63
  start-page: 691
  year: 2009
  end-page: 701
  ident: bib27
  publication-title: Cancer Chemother. Pharmacol.
– volume: 6
  start-page: 13
  year: 2003
  ident: 10.1016/j.ejmech.2012.03.031_bib36
  publication-title: Nat. Med.
– volume: 6
  start-page: 672
  year: 2005
  ident: 10.1016/j.ejmech.2012.03.031_bib1
  publication-title: Curr. Opin. Invest. Drugs
– volume: 54
  start-page: 5444
  year: 2011
  ident: 10.1016/j.ejmech.2012.03.031_bib43
  publication-title: J. Med. Chem.
  doi: 10.1021/jm200476p
– volume: 57
  start-page: 1140
  year: 2008
  ident: 10.1016/j.ejmech.2012.03.031_bib23
  publication-title: Gut
  doi: 10.1136/gut.2008.148791
– volume: 61
  start-page: 191
  year: 1997
  ident: 10.1016/j.ejmech.2012.03.031_bib46
  publication-title: Life Sci.
  doi: 10.1016/S0024-3205(97)00690-5
– volume: 53
  start-page: 5061
  year: 2010
  ident: 10.1016/j.ejmech.2012.03.031_bib44
  publication-title: J. Med. Chem.
  doi: 10.1021/jm100112j
– volume: 13
  start-page: 89
  year: 2005
  ident: 10.1016/j.ejmech.2012.03.031_bib47
  publication-title: Bioorg. Med. Chem.
  doi: 10.1016/j.bmc.2004.09.050
– volume: 120
  start-page: 155
  year: 2003
  ident: 10.1016/j.ejmech.2012.03.031_bib5
  publication-title: Neuroscience
  doi: 10.1016/S0306-4522(03)00333-6
– volume: 150
  start-page: 227
  year: 2007
  ident: 10.1016/j.ejmech.2012.03.031_bib6
  publication-title: Br. J. Pharmacol.
  doi: 10.1038/sj.bjp.0706952
– volume: 12
  start-page: 1921
  year: 2004
  ident: 10.1016/j.ejmech.2012.03.031_bib30
  publication-title: Bioorg. Med. Chem.
  doi: 10.1016/j.bmc.2004.01.035
– volume: 1074
  start-page: 514
  year: 2006
  ident: 10.1016/j.ejmech.2012.03.031_bib9
  publication-title: Ann. N.Y. Acad. Sci.
  doi: 10.1196/annals.1369.052
– volume: 284
  start-page: 644
  year: 1998
  ident: 10.1016/j.ejmech.2012.03.031_bib41
  publication-title: J. Pharmacol. Exp. Ther.
  doi: 10.1016/S0022-3565(24)37266-0
– volume: 542
  start-page: 100
  year: 2006
  ident: 10.1016/j.ejmech.2012.03.031_bib17
  publication-title: Eur. J. Pharmacol.
  doi: 10.1016/j.ejphar.2006.05.025
– volume: 3
  start-page: 771
  year: 2004
  ident: 10.1016/j.ejmech.2012.03.031_bib3
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd1495
– volume: 52
  start-page: 3644
  year: 2009
  ident: 10.1016/j.ejmech.2012.03.031_bib33
  publication-title: J. Med. Chem.
  doi: 10.1021/jm801563d
– volume: 36
  start-page: 181
  year: 2006
  ident: 10.1016/j.ejmech.2012.03.031_bib38
  publication-title: Synth. Comm.
  doi: 10.1080/00397910500334371
– volume: 18
  start-page: 1575
  year: 2011
  ident: 10.1016/j.ejmech.2012.03.031_bib25
  publication-title: Curr. Med. Chem.
  doi: 10.2174/092986711795471374
– volume: 63
  start-page: 691
  year: 2009
  ident: 10.1016/j.ejmech.2012.03.031_bib27
  publication-title: Cancer Chemother. Pharmacol.
  doi: 10.1007/s00280-008-0788-5
– volume: 48
  start-page: 2003
  year: 2000
  ident: 10.1016/j.ejmech.2012.03.031_bib37
  publication-title: Chem. Pharm. Bull.
  doi: 10.1248/cpb.48.2003
– volume: 54
  start-page: 3618
  year: 1989
  ident: 10.1016/j.ejmech.2012.03.031_bib40
  publication-title: J. Org. Chem.
  doi: 10.1021/jo00276a023
– volume: 365
  start-page: 61
  year: 1993
  ident: 10.1016/j.ejmech.2012.03.031_bib8
  publication-title: Nature
  doi: 10.1038/365061a0
– volume: 22
  start-page: 3099
  year: 1973
  ident: 10.1016/j.ejmech.2012.03.031_bib48
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/0006-2952(73)90196-2
– volume: 24
  start-page: 669
  year: 2003
  ident: 10.1016/j.ejmech.2012.03.031_bib50
  publication-title: J. Comp. Chem.
  doi: 10.1002/jcc.10189
– volume: 7
  start-page: 2905
  year: 1999
  ident: 10.1016/j.ejmech.2012.03.031_bib42
  publication-title: Bioorg. Med. Chem.
  doi: 10.1016/S0968-0896(99)00219-9
– volume: 38
  start-page: 3032
  year: 2007
  ident: 10.1016/j.ejmech.2012.03.031_bib11
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.107.488445
– volume: 153
  start-page: 252
  year: 2008
  ident: 10.1016/j.ejmech.2012.03.031_bib20
  publication-title: Br. J. Pharmacol.
  doi: 10.1038/sj.bjp.0707582
– volume: 318
  start-page: 1375
  year: 2006
  ident: 10.1016/j.ejmech.2012.03.031_bib35
  publication-title: J. Pharmacol. Exp. Ther.
  doi: 10.1124/jpet.106.105247
– volume: 17
  start-page: 6505
  year: 2007
  ident: 10.1016/j.ejmech.2012.03.031_bib32
  publication-title: Bioorg. Med. Chem. Lett.
  doi: 10.1016/j.bmcl.2007.09.089
– volume: 147
  start-page: 163
  year: 2006
  ident: 10.1016/j.ejmech.2012.03.031_bib2
  publication-title: Br. J Pharmacol.
  doi: 10.1038/sj.bjp.0706406
– ident: 10.1016/j.ejmech.2012.03.031_bib39
– volume: 8
  start-page: 370
  year: 2008
  ident: 10.1016/j.ejmech.2012.03.031_bib12
  publication-title: Mini Rev. Med. Chem.
  doi: 10.2174/138955708783955935
– volume: 49
  start-page: 984
  year: 2006
  ident: 10.1016/j.ejmech.2012.03.031_bib34
  publication-title: J. Med. Chem.
  doi: 10.1021/jm050875u
– volume: 148
  start-page: 123
  year: 2006
  ident: 10.1016/j.ejmech.2012.03.031_bib26
  publication-title: Br. J. Pharmacol.
  doi: 10.1038/sj.bjp.0706632
– volume: 123
  start-page: 1025
  year: 2008
  ident: 10.1016/j.ejmech.2012.03.031_bib29
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.23584
– volume: 36
  start-page: 82
  year: 2007
  ident: 10.1016/j.ejmech.2012.03.031_bib19
  publication-title: Mol. Neurobiol.
  doi: 10.1007/s12035-007-0004-3
– volume: 3
  start-page: 179
  year: 2002
  ident: 10.1016/j.ejmech.2012.03.031_bib45
  publication-title: J. Vet. Sci.
– volume: 346
  start-page: 561
  year: 1990
  ident: 10.1016/j.ejmech.2012.03.031_bib4
  publication-title: Nature
  doi: 10.1038/346561a0
– volume: 49
  start-page: 1800
  year: 2008
  ident: 10.1016/j.ejmech.2012.03.031_bib28
  publication-title: Leuk. Lymphoma
  doi: 10.1080/10428190802239188
– volume: 153
  start-page: 286
  year: 2008
  ident: 10.1016/j.ejmech.2012.03.031_bib24
  publication-title: Br. J. Pharmacol.
  doi: 10.1038/sj.bjp.0707511
– volume: 153
  start-page: 290
  year: 2008
  ident: 10.1016/j.ejmech.2012.03.031_bib21
  publication-title: Br. J. Pharmacol.
  doi: 10.1038/sj.bjp.0707517
– volume: 36
  start-page: 45
  year: 2007
  ident: 10.1016/j.ejmech.2012.03.031_bib15
  publication-title: Mol. Neurobiol.
  doi: 10.1007/s12035-007-0005-2
– volume: 101
  start-page: 87
  year: 2007
  ident: 10.1016/j.ejmech.2012.03.031_bib18
  publication-title: J. Neurochem.
  doi: 10.1111/j.1471-4159.2006.04346.x
– volume: 1
  start-page: 1112
  year: 2006
  ident: 10.1016/j.ejmech.2012.03.031_bib49
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2006.179
– start-page: 327
  year: 2005
  ident: 10.1016/j.ejmech.2012.03.031_bib7
  article-title: Effects of cannabinoids on neurotransmission
– volume: 153
  start-page: 319
  year: 2008
  ident: 10.1016/j.ejmech.2012.03.031_bib13
  publication-title: Br. J. Pharmacol.
  doi: 10.1038/sj.bjp.0707531
– volume: 6
  start-page: 12
  year: 2006
  ident: 10.1016/j.ejmech.2012.03.031_bib10
  publication-title: BMC Neurol.
  doi: 10.1186/1471-2377-6-12
– volume: 49
  start-page: 5947
  year: 2006
  ident: 10.1016/j.ejmech.2012.03.031_bib31
  publication-title: J. Med. Chem.
  doi: 10.1021/jm0603466
– volume: 153
  start-page: 263
  year: 2008
  ident: 10.1016/j.ejmech.2012.03.031_bib22
  publication-title: Br. J. Pharmacol.
  doi: 10.1038/sj.bjp.0707486
– volume: 14
  start-page: 917
  year: 2007
  ident: 10.1016/j.ejmech.2012.03.031_bib14
  publication-title: Curr. Med. Chem.
  doi: 10.2174/092986707780363023
– volume: 153
  start-page: 271
  year: 2008
  ident: 10.1016/j.ejmech.2012.03.031_bib16
  publication-title: Br. J. Pharmacol.
  doi: 10.1038/sj.bjp.0707493
– volume: 123
  start-page: 1025
  year: 2008
  ident: WOS:000258243300006
  article-title: Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: Growth inhibition by receptor activation
  publication-title: INTERNATIONAL JOURNAL OF CANCER
  doi: 10.1002/ijc.23584
– volume: 153
  start-page: 271
  year: 2008
  ident: WOS:000252883900011
  article-title: Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor
  publication-title: BRITISH JOURNAL OF PHARMACOLOGY
  doi: 10.1038/sj.bjp.0707493
– volume: 57
  start-page: 1140
  year: 2008
  ident: WOS:000257646200024
  article-title: Emerging role of cannabinoids in gastrointestinal and liver diseases: basic and clinical aspects
  publication-title: GUT
  doi: 10.1136/gut.2008.148791
– volume: 38
  start-page: 3032
  year: 2007
  ident: WOS:000250518300026
  article-title: Long-term neuroblast migration along blood vessels in an area with transient angiogenesis and increased vascularization after stroke
  publication-title: STROKE
  doi: 10.1161/STROKEAHA.107.488445
– volume: 7
  start-page: 2905
  year: 1999
  ident: WOS:000084527300026
  article-title: 3-(1 ',1 '-dimethylbutyl)-1-deoxy-Delta(8)-THC and related compounds: Synthesis of selective ligands for the CB2 receptor
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY
– volume: 147
  start-page: S163
  year: 2006
  ident: WOS:000235087400020
  article-title: Cannabinoid pharmacology: the first 66 years
  publication-title: BRITISH JOURNAL OF PHARMACOLOGY
  doi: 10.1038/sj.bjp.0706406
– volume: 18
  start-page: 1575
  year: 2011
  ident: WOS:000289975200002
  article-title: The Endocannabinoid System in the Cancer Therapy: An Overview
  publication-title: CURRENT MEDICINAL CHEMISTRY
– volume: 49
  start-page: 1800
  year: 2008
  ident: WOS:000259240500024
  article-title: Enhancing the in vitro cytotoxic activity of Delta(9)-tetrahydrocannabinol in leukemic cells through a combinatorial approach
  publication-title: LEUKEMIA & LYMPHOMA
  doi: 10.1080/10428190802239188
– volume: 346
  start-page: 561
  year: 1990
  ident: WOS:A1990DT67900072
  article-title: STRUCTURE OF A CANNABINOID RECEPTOR AND FUNCTIONAL EXPRESSION OF THE CLONED CDNA
  publication-title: NATURE
– volume: 284
  start-page: 644
  year: 1998
  ident: WOS:000071929100030
  article-title: SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor
  publication-title: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
– volume: 53
  start-page: 5061
  year: 2010
  ident: WOS:000279787200001
  article-title: A Medicinal Chemist's Guide to Molecular Interactions
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
  doi: 10.1021/jm100112j
– volume: 36
  start-page: 82
  year: 2007
  ident: WOS:000250121100010
  article-title: Cannabinoids and neuroprotection in basal ganglia disorders
  publication-title: MOLECULAR NEUROBIOLOGY
  doi: 10.1007/s12035-007-0004-3
– volume: 3
  start-page: 179
  year: 2002
  ident: MEDLINE:12514329
  article-title: SR144528 as inverse agonist of CB2 cannabinoid receptor.
  publication-title: Journal of veterinary science
– volume: 36
  start-page: 45
  year: 2007
  ident: WOS:000250121100006
  article-title: Cannabinoids and multiple sclerosis
  publication-title: MOLECULAR NEUROBIOLOGY
  doi: 10.1007/s12035-007-0005-2
– volume: 542
  start-page: 100
  year: 2006
  ident: WOS:000239467800014
  article-title: AM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis
  publication-title: EUROPEAN JOURNAL OF PHARMACOLOGY
  doi: 10.1016/j.ejphar.2006.05.025
– volume: 24
  start-page: 669
  year: 2003
  ident: WOS:000181993100001
  article-title: Energies, structures, and electronic properties of molecules in solution with the C-PCM solvation model
  publication-title: JOURNAL OF COMPUTATIONAL CHEMISTRY
– volume: 150
  start-page: 227
  year: 2007
  ident: WOS:000244386700013
  article-title: Stimulation of epithelial CB1 receptors inhibits contractions of the rat prostate gland
  publication-title: BRITISH JOURNAL OF PHARMACOLOGY
  doi: 10.1038/sj.bjp.0706952
– volume: 8
  start-page: 370
  year: 2008
  ident: WOS:000256195900006
  article-title: Indoles and related compounds as cannabinoid ligands
  publication-title: MINI-REVIEWS IN MEDICINAL CHEMISTRY
– volume: 6
  start-page: 672
  year: 2005
  ident: MEDLINE:16044662
  article-title: The endocannabinoid system: a drug discovery perspective.
  publication-title: Current opinion in investigational drugs (London, England : 2000)
– volume: 6
  start-page: ARTN 12
  year: 2006
  ident: WOS:000236272700001
  article-title: COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord
  publication-title: BMC NEUROLOGY
  doi: 10.1186/1471-2377-6-12
– volume: 153
  start-page: 286
  year: 2008
  ident: WOS:000252883900013
  article-title: CB2 receptors as new therapeutic targets for liver diseases
  publication-title: BRITISH JOURNAL OF PHARMACOLOGY
  doi: 10.1038/sj.bjp.0707511
– volume: 48
  start-page: 2003
  year: 2000
  ident: WOS:000165673800032
  article-title: Synthesis and evaluation of novel 2-oxo-1,2-dihydro-3-quinolinecarboxamide derivatives as serotonin 5-HT4 receptor agonists
  publication-title: CHEMICAL & PHARMACEUTICAL BULLETIN
– volume: 3
  start-page: 771
  year: 2004
  ident: WOS:000223654800020
  article-title: The endocannabinoid system and its therapeutic exploitation
  publication-title: NATURE REVIEWS DRUG DISCOVERY
  doi: 10.1038/nrd1495
– volume: 17
  start-page: 6505
  year: 2007
  ident: WOS:000253489000020
  article-title: New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  doi: 10.1016/j.bmcl.2007.09.089
– volume: 49
  start-page: 984
  year: 2006
  ident: WOS:000235826300017
  article-title: Cannabinoid CB2/CB1 selectivity. Receptor modeling and automated docking analysis
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
  doi: 10.1021/jm050875u
– year: 2009
  ident: 000304291600028.1
  publication-title: Kondo S. PCT Int. Appl.
– volume: 168
  start-page: 327
  year: 2005
  ident: CCC:000229801000011
  article-title: Effects of cannabinoids on neurotransmission
  publication-title: CANNABINOID S
– volume: 148
  start-page: 123
  year: 2006
  ident: WOS:000237806600001
  article-title: Cannabinoids and cancer: pros and cons of an antitumour strategy
  publication-title: BRITISH JOURNAL OF PHARMACOLOGY
  doi: 10.1038/sj.bjp.0706632
– volume: 153
  start-page: 252
  year: 2008
  ident: WOS:000252883900009
  article-title: Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioning
  publication-title: BRITISH JOURNAL OF PHARMACOLOGY
  doi: 10.1038/sj.bjp.0707582
– volume: 61
  start-page: PL191
  year: 1997
  ident: WOS:A1997XV26900013
  article-title: Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors
  publication-title: LIFE SCIENCES
– volume: 153
  start-page: 263
  year: 2008
  ident: WOS:000252883900010
  article-title: Cannabinoid CB2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation
  publication-title: BRITISH JOURNAL OF PHARMACOLOGY
  doi: 10.1038/sj.bjp.0707486
– volume: 6
  start-page: 13
  year: 2003
  ident: 000304291600028.9
  publication-title: Nat. Med.
– volume: 52
  start-page: 3644
  year: 2009
  ident: WOS:000267180600005
  article-title: Rational Design, Synthesis, and Pharmacological Properties of New 1,8-Naphthyridin-2(1H)-on-3-Carboxamide Derivatives as Highly Selective Cannabinoid-2 Receptor Agonists
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
  doi: 10.1021/jm801563d
– volume: 120
  start-page: 155
  year: 2003
  ident: WOS:000184257500015
  article-title: The neuronal distribution of cannabinoid receptor type 1 in the trigeminal ganglion of the rat
  publication-title: NEUROSCIENCE
  doi: 10.1016/S0306-4522(03)00333-6
– volume: 54
  start-page: 5444
  year: 2011
  ident: WOS:000293419400016
  article-title: Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 4. Identification of New Potent and Selective Ligands for the Cannabinoid Type 2 Receptor with Diverse Substitution Patterns and Antihyperalgesic Effects in Mice
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
  doi: 10.1021/jm200476p
– volume: 13
  start-page: 89
  year: 2005
  ident: WOS:000225939200009
  article-title: Structure-activity relationships for 1-alkyl-3-(l-naphthoyl)indoles at the cannabinoid CB1 and CB2 receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB2 receptor agonists
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY
  doi: 10.1016/j.bmc.2004.09.050
– volume: 153
  start-page: 290
  year: 2008
  ident: WOS:000252883900014
  article-title: Cannabinoid receptors in acute and chronic complications of atherosclerosis
  publication-title: BRITISH JOURNAL OF PHARMACOLOGY
  doi: 10.1038/sj.bjp.0707517
– volume: 153
  start-page: 319
  year: 2008
  ident: WOS:000252883900017
  article-title: Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain
  publication-title: BRITISH JOURNAL OF PHARMACOLOGY
  doi: 10.1038/sj.bjp.0707531
– volume: 63
  start-page: 691
  year: 2009
  ident: WOS:000264114300014
  article-title: Cannabinoid receptor-independent cytotoxic effects of cannabinoids in human colorectal carcinoma cells: synergism with 5-fluorouracil
  publication-title: CANCER CHEMOTHERAPY AND PHARMACOLOGY
  doi: 10.1007/s00280-008-0788-5
– volume: 22
  start-page: 3099
  year: 1973
  ident: WOS:A1973R295300018
  article-title: RELATIONSHIP BETWEEN INHIBITION CONSTANT (K1) AND CONCENTRATION OF INHIBITOR WHICH CAUSES 50 PER CENT INHIBITION (I50) OF AN ENZYMATIC-REACTION
  publication-title: BIOCHEMICAL PHARMACOLOGY
– volume: 14
  start-page: 917
  year: 2007
  ident: WOS:000244879100005
  article-title: The role of the cannabinoid CB2 receptor in pain transmission and therapeutic potential of small molecule CB2 receptor agonists
  publication-title: CURRENT MEDICINAL CHEMISTRY
– volume: 36
  start-page: 181
  year: 2006
  ident: WOS:000234544600007
  article-title: Preparation and chemical behavior of 2-(tert-butoxycarbonyl)amino-3-bromomethyl pyridine, a novel alkylating agent
  publication-title: SYNTHETIC COMMUNICATIONS
  doi: 10.1080/00397910500334371
– volume: 49
  start-page: 5947
  year: 2006
  ident: WOS:000240826200011
  article-title: Design, synthesis, and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
  doi: 10.1021/jm0603466
– volume: 365
  start-page: 61
  year: 1993
  ident: WOS:A1993LV64600054
  article-title: MOLECULAR CHARACTERIZATION OF A PERIPHERAL RECEPTOR FOR CANNABINOIDS
  publication-title: NATURE
– volume: 12
  start-page: 1921
  year: 2004
  ident: WOS:000220754600010
  article-title: Synthesis and biological evaluation of 1,8-naphthyridin-4(1H)-on-3-carboxamide derivatives as new ligands of cannabinoid receptors
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY
  doi: 10.1016/j.bmc.2004.01.035
– volume: 101
  start-page: 87
  year: 2007
  ident: WOS:000244885600008
  article-title: The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset
  publication-title: JOURNAL OF NEUROCHEMISTRY
  doi: 10.1111/j.1471-4159.2006.04346.x
– volume: 54
  start-page: 3618
  year: 1989
  ident: WOS:A1989AH03900023
  article-title: CONVERGENT AND EFFICIENT PALLADIUM-EFFECTED SYNTHESIS OF 5,10-DIDEAZA-5,6,7,8-TETRAHYDROFOLIC ACID (DDATHF)
  publication-title: JOURNAL OF ORGANIC CHEMISTRY
– volume: 1
  start-page: 1112
  year: 2006
  ident: WOS:000251155400005
  article-title: Sulforhodamine B colorimetric assay for cytotoxicity screening
  publication-title: NATURE PROTOCOLS
  doi: 10.1038/nprot.2006.179
– volume: 1074
  start-page: 514
  year: 2006
  ident: WOS:000242168100052
  article-title: Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain
  publication-title: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY: COCAINE, GHB, AND SUBSTITUTED AMPHETAMINES
  doi: 10.1196/annals.1369.052
– volume: 318
  start-page: 1375
  year: 2006
  ident: WOS:000239878900053
  article-title: Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
  publication-title: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
  doi: 10.1124/jpet.106.105247
SSID ssj0005600
Score 2.2621424
Snippet CB2 receptor ligands are becoming increasingly attractive drugs due to the potential role of this receptor in several physiopathological processes. Using our...
Source Web of Science
SourceID proquest
pubmed
pascalfrancis
webofscience
crossref
elsevier
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 284
SubjectTerms Anti-proliferative
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - metabolism
Antineoplastic Agents - pharmacology
Biological and medical sciences
Cannabinoid
CB1 receptor
CB2 receptor
Cell Line, Tumor
Cell Proliferation - drug effects
Chemistry Techniques, Synthetic
Chemistry, Medicinal
Drug Design
Humans
Life Sciences & Biomedicine
Ligands
Medical sciences
Miscellaneous
Models, Molecular
Molecular Conformation
Naphthyridines - chemical synthesis
Naphthyridines - chemistry
Naphthyridines - metabolism
Naphthyridines - pharmacology
Pharmacology & Pharmacy
Pharmacology. Drug treatments
Receptor, Cannabinoid, CB1 - metabolism
Receptor, Cannabinoid, CB2 - metabolism
Science & Technology
Substrate Specificity
Title Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1,8-naphthyridin-2(1H)-one scaffold
URI https://dx.doi.org/10.1016/j.ejmech.2012.03.031
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=FullRecord&UT=000304291600028
https://www.ncbi.nlm.nih.gov/pubmed/22483967
https://www.proquest.com/docview/1010481434
Volume 52
WOS 000304291600028
WOSCitedRecordID wos000304291600028
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9RAFD602wcFEa23eFlGKEVhx80kk0ni27pYVsVStIW-hcxkRlPWJGzSh33xD_knPZPLroVKRUgeksxkyJkv5zJzLgAHikmmlFRUaxOggcIklUppKr0Yf3NPaV_aHd3Px2Jxxj-eB-c7MB9iYaxbZc_7O57ecuv-zrSn5rTK8-lXlD6oPSAXtm5BsS92Yc9DaR-NYG_24dPieOvpIbpIFGxv7S4-RNC1bl764odudyXsoqCPB_ubhLpTpTXSzXQFL67TSK8VXq2gOroHd3sNk8y6j7gPO7rYh1vzobDbPhyedOmq1xNyuo2-qifkkJxsE1mvH8CvL_1KIclaP48JqdcFKox1XpO0yPBsclrZsj9GdwnESWXX9lc2SSspDUGVnczfeaRui-3Y5ziRRYrGeJlnBOmuKzT5yTL_ZgOO35JZQfJt3o-ysO_A8QibRLRIq-8IqlWOwpZ6r9jiNS0LTZBWxpTL7CGcHb0_nS9oX9yBKpykhqIZmSlXGuOHMghUlLEMcRGy1AQu1yJVyEp4EEdBkIrIsNRNPe5HQhucRhmawH8EowLHeQJExEYbxlnMM8ZV6sWu5EKFrpFSx0poB_xhQhPVZz63BTiWyeDidpF0MEgsDBLXx4M5QDe9qi7zxw3twwEryRUEJyicbug5vgKtzXBeEImIhb4DLwesJYgVu6WTFrq8rO07bcIf7nMHHncg3Pb2OGq_InTg4E9Ubp635jCqI0y0a6wOsH9pNu8JaFMmNE__-5ufwW171TndPYdRs7rUL1C9a-QYdt_8ZOP-J_4NEY1RfA
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9swFD506UMHY2zdzbt0GpSyQUQsW5btvWVhJV3bULYW-mYsWdpcMtvE6UN-0_7kjnxJVujoGNgvlmTho8_nIp0LwL5ikiklFdXaBGigMEmlUppKL8bf3FPal_ZE93Qmphf8y2VwuQWTPhbGulV2vL_l6Q237p6MOmqOqjwffUPpg9oDcmHrFhT74h5sc1vUegDb46Pj6Wzj6SHaSBTsb-0u3kfQNW5e-uqnbk4l7Kagjxf7m4R6UKU10s20BS9u00hvFV6NoDp8BA87DZOM2494DFu62IWdSV_YbRcOztp01ashOd9EX9VDckDONomsV0_g19dup5BkjZ_HkNSrAhXGOq9JWmR4L3Na2bI_RrcJxEll9_YXNkkrKQ1BlZ1MPnmkbort2HZcyCJFY7zMM4J01xWa_GSef7cBxx_JuCD5Ju9HWdh34HyEDSNapNUPBNUiR2FLvfds-oGWhSZIK2PKefYULg4_n0-mtCvuQBWqZEuKZmSmXGmMH8ogUFHGMsRFyFITuFyLVCEr4UEcBUEqIsNSN_W4HwltcBllaAL_GQwKnOcFEBEbbRhnMc8YV6kXu5ILFbpGSh0roR3w-wVNVJf53BbgmCe9i9tV0sIgsTBIXB8v5gBdj6razB939A97rCQ3EJygcLpj5N4NaK2n84JIRCz0HXjXYy1BrNgjnbTQ5XVt32kT_nCfO_C8BeFmtMdR-xWhA_t_onLd3pjDqI4w0eyxOsD-pdukI6BNmbB8-d_f_BZ2puenJ8nJ0ez4Fdy3La0D3msYLBfX-g2qeku51_3KvwH8klNi
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Rational+design%2C+synthesis+and+anti-proliferative+properties+of+new+CB2+selective+cannabinoid+receptor+ligands%3A+an+investigation+of+the+1%2C8-naphthyridin-2%281H%29-one+scaffold&rft.jtitle=European+journal+of+medicinal+chemistry&rft.au=Manera%2C+Clementina&rft.au=Saccomanni%2C+Giuseppe&rft.au=Malfitano%2C+Anna+Maria&rft.au=Bertini%2C+Simone&rft.date=2012-06-01&rft.eissn=1768-3254&rft.volume=52&rft.spage=284&rft_id=info:doi/10.1016%2Fj.ejmech.2012.03.031&rft_id=info%3Apmid%2F22483967&rft.externalDocID=22483967
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0223-5234&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0223-5234&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0223-5234&client=summon