An Update on Neurosurgical Management of Primary CNS Lymphoma in Immunocompetent Patients
Primary central nervous system lymphomas (PCNSL) are rare CNS tumors that harbor a conspicuously longer diagnostic delay compared to other malignant brain tumors. The gold standard for diagnosis is stereotactic biopsy to acquire tissue for histopathological analysis and therefore neurosurgery plays...
Saved in:
| Published in | Frontiers in oncology Vol. 12; p. 884724 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
20.04.2022
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 2234-943X 2234-943X |
| DOI | 10.3389/fonc.2022.884724 |
Cover
| Abstract | Primary central nervous system lymphomas (PCNSL) are rare CNS tumors that harbor a conspicuously longer diagnostic delay compared to other malignant brain tumors. The gold standard for diagnosis is stereotactic biopsy to acquire tissue for histopathological analysis and therefore neurosurgery plays a central role when reducing the diagnostic period is mandated. However, histopathological diagnosis could be complicated if the patient was preoperatively exposed to corticosteroids. Besides the histopathological result, diagnosis of a PCNSL also requires full diagnostic workup to exclude cerebral metastatic disease of a systemic lymphoma. Most reviews of PCNSL discuss recent advancements in systemic treatment options from an (neuro-)oncologic viewpoint, whereas our intention was to discuss the optimization of the diagnostic period and therefore describe current standards of imaging, summarizing the diagnostic workup, discussing the surgical workup and future diagnostic prospects as well as the influence of preoperative corticosteroid therapy to reduce the diagnostic delay of PCNSL patients. |
|---|---|
| AbstractList | Primary central nervous system lymphomas (PCNSL) are rare CNS tumors that harbor a conspicuously longer diagnostic delay compared to other malignant brain tumors. The gold standard for diagnosis is stereotactic biopsy to acquire tissue for histopathological analysis and therefore neurosurgery plays a central role when reducing the diagnostic period is mandated. However, histopathological diagnosis could be complicated if the patient was preoperatively exposed to corticosteroids. Besides the histopathological result, diagnosis of a PCNSL also requires full diagnostic workup to exclude cerebral metastatic disease of a systemic lymphoma. Most reviews of PCNSL discuss recent advancements in systemic treatment options from an (neuro-)oncologic viewpoint, whereas our intention was to discuss the optimization of the diagnostic period and therefore describe current standards of imaging, summarizing the diagnostic workup, discussing the surgical workup and future diagnostic prospects as well as the influence of preoperative corticosteroid therapy to reduce the diagnostic delay of PCNSL patients. Primary central nervous system lymphomas (PCNSL) are rare CNS tumors that harbor a conspicuously longer diagnostic delay compared to other malignant brain tumors. The gold standard for diagnosis is stereotactic biopsy to acquire tissue for histopathological analysis and therefore neurosurgery plays a central role when reducing the diagnostic period is mandated. However, histopathological diagnosis could be complicated if the patient was preoperatively exposed to corticosteroids. Besides the histopathological result, diagnosis of a PCNSL also requires full diagnostic workup to exclude cerebral metastatic disease of a systemic lymphoma. Most reviews of PCNSL discuss recent advancements in systemic treatment options from an (neuro-)oncologic viewpoint, whereas our intention was to discuss the optimization of the diagnostic period and therefore describe current standards of imaging, summarizing the diagnostic workup, discussing the surgical workup and future diagnostic prospects as well as the influence of preoperative corticosteroid therapy to reduce the diagnostic delay of PCNSL patients.Primary central nervous system lymphomas (PCNSL) are rare CNS tumors that harbor a conspicuously longer diagnostic delay compared to other malignant brain tumors. The gold standard for diagnosis is stereotactic biopsy to acquire tissue for histopathological analysis and therefore neurosurgery plays a central role when reducing the diagnostic period is mandated. However, histopathological diagnosis could be complicated if the patient was preoperatively exposed to corticosteroids. Besides the histopathological result, diagnosis of a PCNSL also requires full diagnostic workup to exclude cerebral metastatic disease of a systemic lymphoma. Most reviews of PCNSL discuss recent advancements in systemic treatment options from an (neuro-)oncologic viewpoint, whereas our intention was to discuss the optimization of the diagnostic period and therefore describe current standards of imaging, summarizing the diagnostic workup, discussing the surgical workup and future diagnostic prospects as well as the influence of preoperative corticosteroid therapy to reduce the diagnostic delay of PCNSL patients. |
| Author | Marhold, Franz Popadic, Branko Freyschlag, Christian Franz Sherif, Camillo Scheichel, Florian Pinggera, Daniel |
| AuthorAffiliation | 1 Karl Landsteiner University of Health Sciences , Krems , Austria 2 Department of Neurosurgery, University Hospital St. Poelten , St. Poelten , Austria 3 Department of Neurosurgery, Medical University of Innsbruck , Innsbruck , Austria |
| AuthorAffiliation_xml | – name: 3 Department of Neurosurgery, Medical University of Innsbruck , Innsbruck , Austria – name: 1 Karl Landsteiner University of Health Sciences , Krems , Austria – name: 2 Department of Neurosurgery, University Hospital St. Poelten , St. Poelten , Austria |
| Author_xml | – sequence: 1 givenname: Florian surname: Scheichel fullname: Scheichel, Florian – sequence: 2 givenname: Daniel surname: Pinggera fullname: Pinggera, Daniel – sequence: 3 givenname: Branko surname: Popadic fullname: Popadic, Branko – sequence: 4 givenname: Camillo surname: Sherif fullname: Sherif, Camillo – sequence: 5 givenname: Franz surname: Marhold fullname: Marhold, Franz – sequence: 6 givenname: Christian Franz surname: Freyschlag fullname: Freyschlag, Christian Franz |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35515113$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kk1v1DAQhi1UREvpnRPykcsu_l7nglStCqy0lEpQCU7WxJlsXSV2yAdS_z0OaVGLhC9j2e88Y8-8L8lRTBEJec3ZWkpbvKtT9GvBhFhbqzZCPSMnQki1KpT8fvRof0zOhuGW5WU040y-IMdSa645lyfkx3mk110FI9IU6SVOfRqm_hA8NPQzRDhgi3GkqaZXfWihv6Pby690f9d2N6kFGiLdte0Uk09th-MsvYIx5Di8Is9raAY8u4-n5PrDxbftp9X-y8fd9ny_8rIQ40p7W6nNRlnusRDIVVUKW1nBFZcSa22YroxGplGDqIsNt9IriUwWaLA0Vp6S3cKtEty6bnmlSxDcn4PUHxz0Y_ANOlVkIgJUDAoFYMEIVQNn2qMsTVVm1vuF1U1li5XP_-iheQJ9ehPDjTukX67Ivc1DyYC394A-_ZxwGF0bBo9NAxHTNDhhDGdWMD5L3zyu9bfIw2yywCwCn2cy9Fg7H8bc3DSXDo3jzM0-cLMP3OwDt_ggJ7J_Eh_Y_035DTbJtss |
| CitedBy_id | crossref_primary_10_1007_s00115_022_01347_6 crossref_primary_10_1227_neu_0000000000002944 crossref_primary_10_1007_s00701_023_05742_z crossref_primary_10_46879_ukroj_2_2023_243_252 crossref_primary_10_1097_NRL_0000000000000475 crossref_primary_10_3389_fonc_2022_1034668 crossref_primary_10_1007_s00701_024_06138_3 crossref_primary_10_1093_neuonc_noae270 crossref_primary_10_7759_cureus_50912 crossref_primary_10_1007_s00117_022_01111_6 crossref_primary_10_1007_s11060_024_04695_2 crossref_primary_10_1016_j_bas_2023_101791 crossref_primary_10_35754_0234_5730_2024_69_3_368_383 crossref_primary_10_3390_curroncol31110491 crossref_primary_10_1016_j_anndiagpath_2023_152246 crossref_primary_10_1212_WNL_0000000000207386 |
| Cites_doi | 10.1111/ejh.12980 10.1186/s12885-021-08515-y 10.1016/S1470-2045(15)00076-5 10.3171/jns.2000.92.2.0261 10.1016/j.jocn.2008.10.029 10.1200/JCO.2008.17.7089 10.1007/s11060-009-9938-9 10.1215/15228517-2007-061 10.1016/S1470-2045(10)70229-1 10.5137/1019-5149.JTN.10594-14.1 10.3390/cancers13112580 10.3109/02688697.2013.817531 10.1016/j.critrevonc.2018.05.010 10.1016/S0065-230X(08)00406-5 10.1016/j.ccell.2017.04.012 10.1212/WNL.0000000000008900 10.1212/WNL.59.5.762 10.3174/ajnr.A1362 10.1080/08820530500350498 10.3174/ajnr.A2171 10.1111/j.1552-6569.2007.00231.x 10.1080/0284186X.2019.1599137 10.1111/cas.15133 10.1016/j.ejrad.2018.04.020 10.1016/j.ejso.2019.07.001 10.1016/S0303-8467(02)00105-1 10.1007/s11060-010-0457-5 10.1002/1097-0142(197410)34:4<1293::aid-cncr2820340441>3.0.co;2-p 10.3389/fonc.2020.01151 10.1016/j.jocn.2019.10.010 10.1111/bjh.15661 10.3171/foc.2006.21.5.5 10.1038/bjc.2011.357 10.1002/cncr.10643 10.1200/JCO.2005.13.524 10.1007/s00292-013-1742-9 10.1016/j.jocn.2009.02.024 10.1111/j.1600-0609.2010.01516.x 10.1007/s10072-015-2353-4 10.1016/j.ymeth.2020.05.022 10.1186/s12883-021-02227-3 10.1002/ana.21366 10.1007/s00234-018-2091-4 10.1007/s11060-004-3390-7 10.1182/blood-2004-05-1982 10.1007/s11060-020-03547-z 10.3171/2013.9.JNS131076 10.1016/j.ctrv.2020.102106 10.3171/2020.9.JNS201980 10.3171/2018.3.FOCUS1859 10.1080/02841860500256272 10.4103/0028-3886.128272 10.1186/1470-7330-14-22 10.1016/j.beha.2011.12.001 10.1093/neuros/nyy096 10.1016/j.nicl.2019.101912 10.1093/neuonc/nos159 10.1007/s11060-016-2358-8 10.1007/s11060-020-03525-5 10.1016/S2352-3026(16)00036-3 10.1007/s00701-014-2145-2 10.1016/j.ejrad.2005.12.032 10.1212/wnl.40.1.80 10.1023/a:1005733416571 10.1007/s00330-018-5368-4 10.1093/nop/npz015 10.1111/bjh.15410 10.1002/jmri.27344 10.1210/me.2004-0528 10.1007/s00701-004-0282-8 10.1093/nop/npu029 |
| ContentType | Journal Article |
| Copyright | Copyright © 2022 Scheichel, Pinggera, Popadic, Sherif, Marhold and Freyschlag. Copyright © 2022 Scheichel, Pinggera, Popadic, Sherif, Marhold and Freyschlag 2022 Scheichel, Pinggera, Popadic, Sherif, Marhold and Freyschlag |
| Copyright_xml | – notice: Copyright © 2022 Scheichel, Pinggera, Popadic, Sherif, Marhold and Freyschlag. – notice: Copyright © 2022 Scheichel, Pinggera, Popadic, Sherif, Marhold and Freyschlag 2022 Scheichel, Pinggera, Popadic, Sherif, Marhold and Freyschlag |
| DBID | AAYXX CITATION NPM 7X8 5PM DOA |
| DOI | 10.3389/fonc.2022.884724 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2234-943X |
| ExternalDocumentID | oai_doaj_org_article_493efeaad0a94aa8a624fa105ce3b6db PMC9065338 35515113 10_3389_fonc_2022_884724 |
| Genre | Journal Article Review |
| GroupedDBID | 53G 5VS 9T4 AAFWJ AAKDD AAYXX ACGFO ACGFS ACXDI ADBBV ADRAZ AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK EBS EJD EMOBN GROUPED_DOAJ GX1 HYE KQ8 M48 M~E OK1 PGMZT RNS RPM IAO IEA IHR IHW IPNFZ NPM RIG 7X8 5PM |
| ID | FETCH-LOGICAL-c392t-5c8d477481ce92e14db28d8214133ef5605d65e05e5a2f97183c43e039e6eb683 |
| IEDL.DBID | M48 |
| ISSN | 2234-943X |
| IngestDate | Wed Aug 27 01:23:39 EDT 2025 Thu Aug 21 14:03:29 EDT 2025 Thu Sep 04 15:33:09 EDT 2025 Thu Jan 02 22:54:21 EST 2025 Tue Jul 01 02:46:35 EDT 2025 Thu Apr 24 22:58:39 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | diagnostic workup diagnostic delay corticosteroid therapy Primary central nervous system lymphoma (PCNSL) diagnostic yield |
| Language | English |
| License | Copyright © 2022 Scheichel, Pinggera, Popadic, Sherif, Marhold and Freyschlag. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c392t-5c8d477481ce92e14db28d8214133ef5605d65e05e5a2f97183c43e039e6eb683 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Edited by: Luca Ricciardi, Sapienza University of Rome, Italy Reviewed by: Antonella Mangraviti, Sant’Andrea Hospital, Italy; Giovanni Raffa, University of Messina, Italy This article was submitted to Neuro-Oncology and Neurosurgical Oncology, a section of the journal Frontiers in Oncology |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.3389/fonc.2022.884724 |
| PMID | 35515113 |
| PQID | 2661082018 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_493efeaad0a94aa8a624fa105ce3b6db pubmedcentral_primary_oai_pubmedcentral_nih_gov_9065338 proquest_miscellaneous_2661082018 pubmed_primary_35515113 crossref_citationtrail_10_3389_fonc_2022_884724 crossref_primary_10_3389_fonc_2022_884724 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2022-04-20 |
| PublicationDateYYYYMMDD | 2022-04-20 |
| PublicationDate_xml | – month: 04 year: 2022 text: 2022-04-20 day: 20 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland |
| PublicationTitle | Frontiers in oncology |
| PublicationTitleAlternate | Front Oncol |
| PublicationYear | 2022 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | Önder (B63) 2015; 8 Velasco (B13) 2020; 148 Schellekes (B57) 2021; 135 Brück (B62) 2013; 34 Manoj (B69) 2014; 62 Calli (B21) 2006; 58 Gliemroth (B20) 2003; 105 Wu (B55) 2021; 21 Chen (B27) 2020; 10 Bullis (B71) 2020; 72 Schroers (B38) 2010; 85 Kiesel (B47) 2018; 44 Khatab (B45) 2014; 156 Goh (B67) 2009; 16 Hasegawa (B65) 2009; 16 Suh (B26) 2018; 28 Yamamoto (B49) 2015; 25 Brainard (B46) 1997; 121 Xia (B29) 2021; 53 Cloney (B58) 2017; 132 Ferreri (B1) 2012; 25 Neuhauser (B7) 2019; 58 Bataille (B51) 2000; 92 Kong (B28) 2019; 23 Hegde (B36) 2005; 105 Lionakis (B43) 2017; 31 Mansour (B18) 2014; 14 Shaw (B72) 2014; 28 Hoang-Xuan (B9) 2015; 16 Zacharia (B22) 2008; 18 van Westrhenen (B40) 2018; 182 Cirillo (B41) 2020; 91 Roth (B59) 2015; 2 Ferreri (B10) 2016; 3 Seidel (B11) 2021; 13 Fox (B73) 2019; 184 Barajas (B23) 2009; 30 Rae (B56) 2019; 84 Pirotte (B64) 1997; 32 Porter (B70) 2008; 63 Wöhrer (B2) 2009; 95 Sionov (B60) 2008; 101 Hiemcke-jiwa (B39) 2018; 127 DeAngelis (B53) 1990; 40 Bromberg (B66) 2002; 59 Choi (B32) 2006; 21 Houillier (B8) 2020; 94 Eloranta (B3) 2018; 100 Mohile (B33) 2008; 10 Küker (B19) 2005; 72 Kim (B25) 2018; 60 Zaki (B68) 2004; 146 Scheichel (B44) 2021; 21 Villano (B4) 2011; 105 Go (B16) 2006; 21 Haldorsen (B17) 2011; 32 Morell (B35) 2019; 6 Thiel (B12) 2010; 11 Yamagishi (B42) 2021; 112 Grossman (B48) 2014; 120 Kadan-Lottick (B5) 2002; 95 Ibrahim (B30) 2021; 188 Henry (B52) 1974; 34 Bertaux (B34) 2020; 148 Bessell (B6) 2011; 104 Haldorsen (B14) 2005; 44 Cerqua (B15) 2016; 37 Zhou (B24) 2018; 104 Orfao (B37) 2009; 27 Abrey (B31) 2005; 23 Miller (B61) 2005; 19 Shofty (B50) 2019; 45 Weller (B54) 2012; 14 |
| References_xml | – volume: 100 year: 2018 ident: B3 article-title: Increasing Incidence of Primary Central Nervous System Lymphoma But No Improvement in Survival in Sweden 2000-2013 publication-title: Eur J Haematol doi: 10.1111/ejh.12980 – volume: 21 start-page: 754 year: 2021 ident: B44 article-title: Influence of Preoperative Corticosteroid Treatment on Rate of Diagnostic Surgeries in Primary Central Nervous System Lymphoma: A Multicenter Retrospective Study publication-title: BMC Cancer doi: 10.1186/s12885-021-08515-y – volume: 16 year: 2015 ident: B9 article-title: Diagnosis and Treatment of Primary CNS Lymphoma in Immunocompetent Patients: Guidelines From the European Association for Neuro-Oncology publication-title: Lancet Oncol doi: 10.1016/S1470-2045(15)00076-5 – volume: 92 year: 2000 ident: B51 article-title: Primary Intracerebral Malignant Lymphoma: Report of 248 Cases publication-title: J Neurosurg doi: 10.3171/jns.2000.92.2.0261 – volume: 16 year: 2009 ident: B67 article-title: Vanishing Glioblastoma After Corticosteroid Therapy publication-title: J Clin Neurosci doi: 10.1016/j.jocn.2008.10.029 – volume: 27 year: 2009 ident: B37 article-title: Identification of Leptomeningeal Disease in Aggressive B-Cell non-Hodgkin’s Lymphoma: Improved Sensitivity of Flow Cytometry publication-title: J Clin Oncol doi: 10.1200/JCO.2008.17.7089 – volume: 95 year: 2009 ident: B2 article-title: The Austrian Brain Tumour Registry: A Cooperative Way to Establish a Population-Based Brain Tumour Registry publication-title: J Neurooncol doi: 10.1007/s11060-009-9938-9 – volume: 10 year: 2008 ident: B33 article-title: The Utility of Body FDG PET in Staging Primary Central Nervous System Lymphoma publication-title: Neuro Oncol doi: 10.1215/15228517-2007-061 – volume: 11 year: 2010 ident: B12 article-title: High-Dose Methotrexate With or Without Whole Brain Radiotherapy for Primary CNS Lymphoma (G-PCNSL-SG-1): A Phase 3, Randomised, non-Inferiority Trial publication-title: Lancet Oncol doi: 10.1016/S1470-2045(10)70229-1 – volume: 25 start-page: 796 year: 2015 ident: B49 article-title: 5-Aminolevulinic Acid-Induced Fluorescence in Cerebellar Primary Central Nervous System Lymphoma: A Case Report and Literature Review publication-title: Turk Neurosurg doi: 10.5137/1019-5149.JTN.10594-14.1 – volume: 13 year: 2021 ident: B11 article-title: Is There an Indication for First Line Radiotherapy in Primary CNS Lymphoma publication-title: Cancers (Basel) doi: 10.3390/cancers13112580 – volume: 28 year: 2014 ident: B72 article-title: Diagnosis of Primary Cerebral Lymphomas: Possible Value of PCR Testing in Equivocal Cases Requiring Rebiopsy publication-title: Br J Neurosurg doi: 10.3109/02688697.2013.817531 – volume: 127 start-page: 56 year: 2018 ident: B39 article-title: Critical Reviews in Oncology / Hematology Molecular Analysis in Liquid Biopsies for Diagnostics of Primary Central Nervous System Lymphoma: Review of Literature and Future Opportunities publication-title: Crit Rev Oncol / Hematol doi: 10.1016/j.critrevonc.2018.05.010 – volume: 101 start-page: 127 year: 2008 ident: B60 article-title: Mechanisms Regulating the Susceptibility of Hematopoietic Malignancies to Glucocorticoid-Induced Apoptosis publication-title: Adv Cancer Res doi: 10.1016/S0065-230X(08)00406-5 – volume: 31 start-page: 833 year: 2017 ident: B43 article-title: Inhibition of B Cell Receptor Signaling by Ibrutinib in Primary CNS Lymphoma publication-title: Cancer Cell doi: 10.1016/j.ccell.2017.04.012 – volume: 94 year: 2020 ident: B8 article-title: Management and Outcome of Primary CNS Lymphoma in the Modern Era: An LOC Network Study publication-title: Neurology doi: 10.1212/WNL.0000000000008900 – volume: 59 year: 2002 ident: B66 article-title: Is a “Vanishing Tumor” Always a Lymphoma publication-title: Neurology doi: 10.1212/WNL.59.5.762 – volume: 30 year: 2009 ident: B23 article-title: Distinguishing Recurrent Intra-Axial Metastatic Tumor From Radiation Necrosis Following Gamma Knife Radiosurgery Using Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging publication-title: AJNR Am J Neuroradiol doi: 10.3174/ajnr.A1362 – volume: 21 year: 2006 ident: B32 article-title: Primary Intraocular Lymphoma: A Review publication-title: Semin Ophthalmol doi: 10.1080/08820530500350498 – volume: 32 year: 2011 ident: B17 article-title: Central Nervous System Lymphoma: Characteristic Findings on Traditional and Advanced Imaging publication-title: Am J Neuroradiol doi: 10.3174/ajnr.A2171 – volume: 18 year: 2008 ident: B22 article-title: Central Nervous System Lymphoma Characterization by Diffusion-Weighted Imaging and MR Spectroscopy publication-title: J Neuroimaging doi: 10.1111/j.1552-6569.2007.00231.x – volume: 58 year: 2019 ident: B7 article-title: Increasing Use of Immunotherapy and Prolonged Survival Among Younger Patients With Primary CNS Lymphoma: A Population-Based Study publication-title: Acta Oncol (Madr) doi: 10.1080/0284186X.2019.1599137 – volume: 112 year: 2021 ident: B42 article-title: Liquid Biopsy of Cerebrospinal Fluid for MYD88 L265P Mutation is Useful for Diagnosis of Central Nervous System Lymphoma publication-title: Cancer Sci doi: 10.1111/cas.15133 – volume: 104 start-page: 26 year: 2018 ident: B24 article-title: 18 F-FDG PET/CT in Immunocompetent Patients With Primary Central Nervous System Lymphoma: Differentiation From Glioblastoma and Correlation With DWI publication-title: Eur J Radiol doi: 10.1016/j.ejrad.2018.04.020 – volume: 45 year: 2019 ident: B50 article-title: 5-ALA-Assisted Stereotactic Brain Tumor Biopsy Improve Diagnostic Yield publication-title: Eur J Surg Oncol doi: 10.1016/j.ejso.2019.07.001 – volume: 105 start-page: 78 year: 2003 ident: B20 article-title: Neuroradiological Findings in Primary Cerebral Lymphomas of non-AIDS Patients publication-title: Clin Neurol Neurosurg doi: 10.1016/S0303-8467(02)00105-1 – volume: 104 year: 2011 ident: B6 article-title: Increasing Age at Diagnosis and Worsening Renal Function in Patients With Primary Central Nervous System Lymphoma publication-title: J Neurooncol doi: 10.1007/s11060-010-0457-5 – volume: 34 year: 1974 ident: B52 article-title: Primary Malignant Lymphomas of the Central Nervous System publication-title: Cancer doi: 10.1002/1097-0142(197410)34:4<1293::aid-cncr2820340441>3.0.co;2-p – volume: 10 year: 2020 ident: B27 article-title: Comparison of Radiomics-Based Machine-Learning Classifiers in Diagnosis of Glioblastoma From Primary Central Nervous System Lymphoma publication-title: Front Oncol doi: 10.3389/fonc.2020.01151 – volume: 72 year: 2020 ident: B71 article-title: Diagnostic Impact of Preoperative Corticosteroids in Primary Central Nervous System Lymphoma publication-title: J Clin Neurosci doi: 10.1016/j.jocn.2019.10.010 – volume: 184 year: 2019 ident: B73 article-title: Guidelines for the Diagnosis and Management of Primary Central Nervous System Diffuse Large B-Cell Lymphoma publication-title: Br J Haematol doi: 10.1111/bjh.15661 – volume: 21 start-page: 1 year: 2006 ident: B16 article-title: Imaging of Primary Central Nervous System Lymphoma publication-title: Neurosurg Focus doi: 10.3171/foc.2006.21.5.5 – volume: 105 year: 2011 ident: B4 article-title: Age, Gender, and Racial Differences in Incidence and Survival in Primary CNS Lymphoma publication-title: Br J Cancer doi: 10.1038/bjc.2011.357 – volume: 95 start-page: 193 year: 2002 ident: B5 article-title: Decreasing Incidence Rates of Primary Central Nervous System Lymphoma publication-title: Cancer doi: 10.1002/cncr.10643 – volume: 23 year: 2005 ident: B31 article-title: Report of an International Workshop to Standardize Baseline Evaluation and Response Criteria for Primary CNS Lymphoma publication-title: J Clin Oncol doi: 10.1200/JCO.2005.13.524 – volume: 121 year: 1997 ident: B46 article-title: Frozen Section Evaluation of Stereotactic Brain Biopsies: Diagnostic Yield at the Stereotactic Target Position in 188 Cases publication-title: Arch Pathol Lab Med – volume: 34 year: 2013 ident: B62 article-title: Differenzialdiagnose Lymphoider Infiltrate Im Zentralnervensystem: Erfahrungen Des Netzwerks Lymphome Und Lymphomatoide Läsionen Des Nervensystems publication-title: Pathologe doi: 10.1007/s00292-013-1742-9 – volume: 16 year: 2009 ident: B65 article-title: Glioblastoma Multiforme Fades on CT Imaging After Dexamethasone Therapy publication-title: J Clin Neurosci doi: 10.1016/j.jocn.2009.02.024 – volume: 85 year: 2010 ident: B38 article-title: Diagnosis of Leptomeningeal Disease in Diffuse Large B-Cell Lymphomas of the Central Nervous System by Flow Cytometry and Cytopathology publication-title: Eur J Haematol doi: 10.1111/j.1600-0609.2010.01516.x – volume: 37 year: 2016 ident: B15 article-title: Diagnostic Delay and Prognosis in Primary Central Nervous System Lymphoma Compared With Glioblastoma Multiforme publication-title: Neurol Sci doi: 10.1007/s10072-015-2353-4 – volume: 188 year: 2021 ident: B30 article-title: Radiomics for Precision Medicine: Current Challenges, Future Prospects, and the Proposal of a New Framework publication-title: Methods doi: 10.1016/j.ymeth.2020.05.022 – volume: 21 start-page: 1 year: 2021 ident: B55 article-title: The Role of Surgical Resection in Primary Central Nervous System Lymphoma: A Single-Center Retrospective Analysis of 70 Patients publication-title: BMC Neurol doi: 10.1186/s12883-021-02227-3 – volume: 63 year: 2008 ident: B70 article-title: Primary Central Nervous System Lymphoma can be Histologically Diagnosed After Previous Corticosteroid Use: A Pilot Study to Determine Whether Corticosteroids Prevent the Diagnosis of Primary Central Nervous System Lymphoma publication-title: Ann Neurol doi: 10.1002/ana.21366 – volume: 60 year: 2018 ident: B25 article-title: Radiomics Features to Distinguish Glioblastoma From Primary Central Nervous System Lymphoma on Multi-Parametric MRI publication-title: Neuroradiology doi: 10.1007/s00234-018-2091-4 – volume: 72 year: 2005 ident: B19 article-title: Primary Central Nervous System Lymphomas (PCNSL): MRI Features at Presentation in 100 Patients publication-title: J Neurooncol doi: 10.1007/s11060-004-3390-7 – volume: 105 start-page: 496 year: 2005 ident: B36 article-title: High Incidence of Occult Leptomeningeal Disease Detected by Flow Cytometry in Newly Diagnosed Aggressive B-Cell Lymphomas at Risk for Central Nervous System Involvement: The Role of Flow Cytometry Versus Cytology publication-title: Blood doi: 10.1182/blood-2004-05-1982 – volume: 148 year: 2020 ident: B13 article-title: Diagnostic Delay and Outcome in Immunocompetent Patients With Primary Central Nervous System Lymphoma in Spain: A Multicentric Study publication-title: J Neurooncol doi: 10.1007/s11060-020-03547-z – volume: 120 year: 2014 ident: B48 article-title: Intraoperative 5-Aminolevulinic Acid-Induced Fluorescence in Primary Central Nervous System Lymphoma publication-title: Evidence-Based Hematol doi: 10.3171/2013.9.JNS131076 – volume: 91 start-page: 1 year: 2020 ident: B41 article-title: Liquid Biopsy in Lymphoma: Molecular Methods and Clinical Applications publication-title: Cancer Treat Rev doi: 10.1016/j.ctrv.2020.102106 – volume: 135 year: 2021 ident: B57 article-title: Resection of Primary Central Nervous System Lymphoma: Impact of Patient Selection on Overall Survival publication-title: J Neurosurg doi: 10.3171/2020.9.JNS201980 – volume: 44 year: 2018 ident: B47 article-title: 5-ALA–induced Fluorescence as a Marker for Diagnostic Tissue in Stereotactic Biopsies of Intracranial Lymphomas: Experience in 41 Patients publication-title: Neurosurg Focus doi: 10.3171/2018.3.FOCUS1859 – volume: 44 year: 2005 ident: B14 article-title: Diagnostic Delay in Primary Central Nervous System Lymphoma publication-title: Acta Oncol (Madr) doi: 10.1080/02841860500256272 – volume: 62 start-page: 19 year: 2014 ident: B69 article-title: Central Nervous System Lymphoma: Patterns of Incidence in Indian Population and Effect of Steroids on Stereotactic Biopsy Yield publication-title: Neurol India doi: 10.4103/0028-3886.128272 – volume: 14 start-page: 1 year: 2014 ident: B18 article-title: MR Imaging Features of Intracranial Primary CNS Lymphoma in Immune Competent Patients publication-title: Cancer Imaging doi: 10.1186/1470-7330-14-22 – volume: 25 year: 2012 ident: B1 article-title: Primary CNS Lymphoma publication-title: Best Pract Res Clin Haematol doi: 10.1016/j.beha.2011.12.001 – volume: 84 year: 2019 ident: B56 article-title: Craniotomy and Survival for Primary Central Nervous System Lymphoma publication-title: Clin Neurosurg doi: 10.1093/neuros/nyy096 – volume: 23 year: 2019 ident: B28 article-title: 18f-FDG-PET-Based Radiomics Features to Distinguish Primary Central Nervous System Lymphoma From Glioblastoma publication-title: NeuroImage Clin doi: 10.1016/j.nicl.2019.101912 – volume: 14 year: 2012 ident: B54 article-title: Surgery for Primary CNS Lymphoma? Challenging a Paradigm publication-title: Neuro Oncol doi: 10.1093/neuonc/nos159 – volume: 132 year: 2017 ident: B58 article-title: The Safety of Resection for Primary Central Nervous System Lymphoma: A Single Institution Retrospective Analysis publication-title: J Neurooncol doi: 10.1007/s11060-016-2358-8 – volume: 148 year: 2020 ident: B34 article-title: Use of FDG-PET/CT for Systemic Assessment of Suspected Primary Central Nervous System Lymphoma: A LOC Study publication-title: J Neurooncol doi: 10.1007/s11060-020-03525-5 – volume: 3 year: 2016 ident: B10 article-title: Chemoimmunotherapy With Methotrexate, Cytarabine, Thiotepa, and Rituximab (MATRix Regimen) in Patients With Primary CNS Lymphoma: Results of the First Randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) Phase 2 Trial publication-title: Lancet Haematol doi: 10.1016/S2352-3026(16)00036-3 – volume: 156 year: 2014 ident: B45 article-title: Frameless Image-Guided Stereotactic Brain Biopsies: Emphasis on Diagnostic Yield publication-title: Acta Neurochir (Wien) doi: 10.1007/s00701-014-2145-2 – volume: 58 start-page: 394 year: 2006 ident: B21 article-title: Perfusion and Diffusion MR Imaging in Enhancing Malignant Cerebral Tumors publication-title: Eur J Radiol doi: 10.1016/j.ejrad.2005.12.032 – volume: 40 year: 1990 ident: B53 article-title: Primary CNS Lymphoma: Combined Treatment With Chemotherapy and Radiotherapy publication-title: Neurology doi: 10.1212/wnl.40.1.80 – volume: 32 year: 1997 ident: B64 article-title: Glucocorticoid-Induced Long-Term Remission in Primary Cerebral Lymphoma: Case Report and Review of the Literature publication-title: J Neurooncol doi: 10.1023/a:1005733416571 – volume: 28 year: 2018 ident: B26 article-title: Primary Central Nervous System Lymphoma and Atypical Glioblastoma: Differentiation Using Radiomics Approach publication-title: Eur Radiol doi: 10.1007/s00330-018-5368-4 – volume: 6 year: 2019 ident: B35 article-title: Diagnosis of Primary Central Nervous System Lymphoma: A Systematic Review of the Utility of CSF Screening and the Role of Early Brain Biopsy publication-title: Neuro-Oncol Pract doi: 10.1093/nop/npz015 – volume: 182 start-page: 384 year: 2018 ident: B40 article-title: Diagnostic Markers for CNS Lymphoma in Blood and Cerebrospinal Fluid: A Systematic Review publication-title: Br J Haematol doi: 10.1111/bjh.15410 – volume: 8 year: 2015 ident: B63 article-title: Corticosteroid Pre-Treated Primary CNS Lymphoma: A Detailed Analysis of Stereotactic Biopsy Findings and Consideration of Interobserver Variability publication-title: Int J Clin Exp Pathol – volume: 53 year: 2021 ident: B29 article-title: Multiparametric-MRI-Based Radiomics Model for Differentiating Primary Central Nervous System Lymphoma From Glioblastoma: Development and Cross-Vendor Validation publication-title: J Magn Reson Imaging doi: 10.1002/jmri.27344 – volume: 19 year: 2005 ident: B61 article-title: P38 Mitogen-Activated Protein Kinase (MAPK) is a Key Mediator in Glucocorticoid-Induced Apoptosis of Lymphoid Cells: Correlation Between P38 MAPK Activation and Site-Specific Phosphorylation of the Human Glucocorticoid Receptor at Serine 211 publication-title: Mol Endocrinol doi: 10.1210/me.2004-0528 – volume: 146 year: 2004 ident: B68 article-title: Vanishing Contrast Enhancement in Malignant Glioma After Corticosteroid Treatment publication-title: Acta Neurochir (Wien) doi: 10.1007/s00701-004-0282-8 – volume: 2 start-page: 6 year: 2015 ident: B59 article-title: Corticosteroid Use in Neuro-Oncology: An Update publication-title: Neuro-Oncol Pract doi: 10.1093/nop/npu029 |
| SSID | ssj0000650103 |
| Score | 2.36031 |
| SecondaryResourceType | review_article |
| Snippet | Primary central nervous system lymphomas (PCNSL) are rare CNS tumors that harbor a conspicuously longer diagnostic delay compared to other malignant brain... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 884724 |
| SubjectTerms | corticosteroid therapy diagnostic delay diagnostic workup diagnostic yield Oncology Primary central nervous system lymphoma (PCNSL) |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1NT9wwELUQB8QFAQUaoJUr9cIhWsd2svaRoiKKACHBSnCynGSiIhUHsbsH_j0zcVh2ESoXrvm0Z8aeN5rxG8Z-NmAFBmw2Fd5CSh4rtdJT2V8BZU69kjI6jXx-UZyM9OlNfjPX6otqwiI9cBTcQFsFDXhf48e098YXUjceUUEFqizqknZfYcVcMBX34JwaGMS8JEZhdtC0gRgLpUTT0EOpF_xQR9f_HsZ8Wyo553uO19laDxr5YRzsBluCsMlWzvu0-Bd2exj46IFid94G3vFtjKeP3Z7GX-tbeNvwy0guwY8urvjZE2qyvff8LvA_dEykrXoQPeGXkW51vMVGx7-vj07SvmdCWiHSmaR5ZWqNkM5kFVgJma5LaWojM3RWKEjEN3ld5CByyL1sLHomVWkFQllA5RRGbbPl0Ab4yrgXDcKvoYRho7TQWSl9WRpDhOyZx8WbsMGLBF3VE4pTX4t_DgMLkrkjmTuSuYsyT9jB7I2HON__PPuLlDJ7jmiwuwtoHK43DveRcSTsx4tKHS4byoX4AO107AiXdOjHJGwnqnj2K5og4lCVsOGC8hfGsngn3P3tqLktUf0qs_sZg99jqyQPSl1Jsc-WJ49T-IYIaFJ-74z9Ge-VBXY priority: 102 providerName: Directory of Open Access Journals |
| Title | An Update on Neurosurgical Management of Primary CNS Lymphoma in Immunocompetent Patients |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/35515113 https://www.proquest.com/docview/2661082018 https://pubmed.ncbi.nlm.nih.gov/PMC9065338 https://doaj.org/article/493efeaad0a94aa8a624fa105ce3b6db |
| Volume | 12 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB5BkapeEG_CozISFw6hie1k7QNCpaIURKtKsNJyspxkUioVp-xDov-eGSe7ZdGKA5ccEluJZ2zPN5nxNwAvW7QZOWw2zbzFlC1WaqXntL8Sq4JrJeV8Gvn4pDwa60-TYnJ9PHoQ4Gyja8f1pMbTi9e_fl69pQX_hj1Osrd7bReYjFBK0roeSX0TbsVoESfyDWC_35cLLmrQxyo3dtyBbTK_ZANztWamIpv_Jgj6dyblH6bp8A7cHjCl2O8nwV24geEebB8PUfP78G0_iPElu_aiCyLSccwW07jliev0F9G14rTnnhAHJ1_E5ytSdPfDi_MgPvIpkq4eMPZcnPZsrLMHMD58__XgKB1KKqQ1AaF5WtSm0YT4TF6jlZjrppKmMTIneSlsCf4UTVlgVmDhZWvJcKlaK8yURdJdadRD2ApdwMcgfNYSOhtJHLVKZzqvpK8qY5ivPfe0thPYW0rQ1QPfOJe9uHDkd7D4HYvfsfhdL_4EXq16XPbj_Ufbd6yUVTtmyY43uumZGxad05bGhN43NBG198aXUreeEGWNqiqbKoEXS5U6WlUcKvEBu8XMMWyJ4Mgk8KhX8epVyymSwGhN-Wvfsv4knH-PzN2WmYCVefLfPZ_CDguBw1kyewZb8-kCnxMqmle78W8CXT9M8t048X8DHAMNvw |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=An+Update+on+Neurosurgical+Management+of+Primary+CNS+Lymphoma+in+Immunocompetent+Patients&rft.jtitle=Frontiers+in+oncology&rft.au=Scheichel%2C+Florian&rft.au=Pinggera%2C+Daniel&rft.au=Popadic%2C+Branko&rft.au=Sherif%2C+Camillo&rft.date=2022-04-20&rft.pub=Frontiers+Media+S.A&rft.eissn=2234-943X&rft.volume=12&rft_id=info:doi/10.3389%2Ffonc.2022.884724&rft_id=info%3Apmid%2F35515113&rft.externalDocID=PMC9065338 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2234-943X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2234-943X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2234-943X&client=summon |