Triclocarban-induced change in intracellular Ca2+ level in rat thymocytes: Cytometric analysis with Fluo-3 under Zn2+-free conditions
•Triclocarban is an antimicrobial used in personal health care products.•Triclocarban is reportedly detected in human blood.•Triclocarban initially released Ca2+ from intracellular store in murine cells.•Triclocarban lately induced Ca2+ influx through store-operated Ca2+ channels.•Triclocarban may d...
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| Published in | Environmental toxicology and pharmacology Vol. 37; no. 2; pp. 563 - 570 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.03.2014
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1382-6689 1872-7077 1872-7077 |
| DOI | 10.1016/j.etap.2014.01.013 |
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| Abstract | •Triclocarban is an antimicrobial used in personal health care products.•Triclocarban is reportedly detected in human blood.•Triclocarban initially released Ca2+ from intracellular store in murine cells.•Triclocarban lately induced Ca2+ influx through store-operated Ca2+ channels.•Triclocarban may disturb intracellular Ca2+ signaling in human cells.
Triclocarban (TCC) is an antimicrobial used in personal hygiene products. Recent health concerns arose after TCC was detected in the blood of human subjects who showered with soap containing TCC. In this study, the effect of TCC on intracellular Ca2+ concentration in rat thymocytes was examined using Fluo-3, an indicator of intracellular Ca2+. TCC at concentrations ranging from 0.1μM to 3μM increased intracellular Ca2+ concentration biphasically: first by releasing Ca2+ from intracellular Ca2+ stores and then inducing Ca2+ influx through store-operated Ca2+ channels. The threshold TCC concentration to increase intracellular Ca2+ concentration in this study was lower than the maximum TCC concentrations reported in human blood samples. Therefore, we anticipate that TCC at concentrations reported in human blood samples might disturb intracellular Ca2+ signaling in human lymphocytes. |
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| AbstractList | Highlights • Triclocarban is an antimicrobial used in personal health care products. • Triclocarban is reportedly detected in human blood. • Triclocarban initially released Ca2+ from intracellular store in murine cells. • Triclocarban lately induced Ca2+ influx through store-operated Ca2+ channels. • Triclocarban may disturb intracellular Ca2+ signaling in human cells. Triclocarban (TCC) is an antimicrobial used in personal hygiene products. Recent health concerns arose after TCC was detected in the blood of human subjects who showered with soap containing TCC. In this study, the effect of TCC on intracellular Ca(2+) concentration in rat thymocytes was examined using Fluo-3, an indicator of intracellular Ca(2+). TCC at concentrations ranging from 0.1 μM to 3 μM increased intracellular Ca(2+) concentration biphasically: first by releasing Ca(2+) from intracellular Ca(2+) stores and then inducing Ca(2+) influx through store-operated Ca(2+) channels. The threshold TCC concentration to increase intracellular Ca(2+) concentration in this study was lower than the maximum TCC concentrations reported in human blood samples. Therefore, we anticipate that TCC at concentrations reported in human blood samples might disturb intracellular Ca(2+) signaling in human lymphocytes. •Triclocarban is an antimicrobial used in personal health care products.•Triclocarban is reportedly detected in human blood.•Triclocarban initially released Ca2+ from intracellular store in murine cells.•Triclocarban lately induced Ca2+ influx through store-operated Ca2+ channels.•Triclocarban may disturb intracellular Ca2+ signaling in human cells. Triclocarban (TCC) is an antimicrobial used in personal hygiene products. Recent health concerns arose after TCC was detected in the blood of human subjects who showered with soap containing TCC. In this study, the effect of TCC on intracellular Ca2+ concentration in rat thymocytes was examined using Fluo-3, an indicator of intracellular Ca2+. TCC at concentrations ranging from 0.1μM to 3μM increased intracellular Ca2+ concentration biphasically: first by releasing Ca2+ from intracellular Ca2+ stores and then inducing Ca2+ influx through store-operated Ca2+ channels. The threshold TCC concentration to increase intracellular Ca2+ concentration in this study was lower than the maximum TCC concentrations reported in human blood samples. Therefore, we anticipate that TCC at concentrations reported in human blood samples might disturb intracellular Ca2+ signaling in human lymphocytes. Triclocarban (TCC) is an antimicrobial used in personal hygiene products. Recent health concerns arose after TCC was detected in the blood of human subjects who showered with soap containing TCC. In this study, the effect of TCC on intracellular Ca(2+) concentration in rat thymocytes was examined using Fluo-3, an indicator of intracellular Ca(2+). TCC at concentrations ranging from 0.1 μM to 3 μM increased intracellular Ca(2+) concentration biphasically: first by releasing Ca(2+) from intracellular Ca(2+) stores and then inducing Ca(2+) influx through store-operated Ca(2+) channels. The threshold TCC concentration to increase intracellular Ca(2+) concentration in this study was lower than the maximum TCC concentrations reported in human blood samples. Therefore, we anticipate that TCC at concentrations reported in human blood samples might disturb intracellular Ca(2+) signaling in human lymphocytes.Triclocarban (TCC) is an antimicrobial used in personal hygiene products. Recent health concerns arose after TCC was detected in the blood of human subjects who showered with soap containing TCC. In this study, the effect of TCC on intracellular Ca(2+) concentration in rat thymocytes was examined using Fluo-3, an indicator of intracellular Ca(2+). TCC at concentrations ranging from 0.1 μM to 3 μM increased intracellular Ca(2+) concentration biphasically: first by releasing Ca(2+) from intracellular Ca(2+) stores and then inducing Ca(2+) influx through store-operated Ca(2+) channels. The threshold TCC concentration to increase intracellular Ca(2+) concentration in this study was lower than the maximum TCC concentrations reported in human blood samples. Therefore, we anticipate that TCC at concentrations reported in human blood samples might disturb intracellular Ca(2+) signaling in human lymphocytes. |
| Author | Satoh, Masaya Oyama, Yasuo Sun, Yuanzhi Enkhjargal, Molomjamts Kuroda, Keiko Yamada, Saki Chen, Xiaohui Miura, Yukari Sugihara, Aya |
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| CitedBy_id | crossref_primary_10_1002_tox_22675 crossref_primary_10_1016_j_watres_2023_119736 crossref_primary_10_1088_2058_6272_aa9479 |
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| Keywords | Triclocarban Cytotoxicity Intracellular Ca2 Lymphocyte Zn2 Intracellular Ca 2 Zn 2 Intracellular Ca(2+) Zn(2+) |
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| Snippet | •Triclocarban is an antimicrobial used in personal health care products.•Triclocarban is reportedly detected in human blood.•Triclocarban initially released... Highlights • Triclocarban is an antimicrobial used in personal health care products. • Triclocarban is reportedly detected in human blood. • Triclocarban... Triclocarban (TCC) is an antimicrobial used in personal hygiene products. Recent health concerns arose after TCC was detected in the blood of human subjects... |
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| SubjectTerms | Aniline Compounds Animals Anti-Infective Agents, Local - toxicity Calcium - metabolism Carbanilides - toxicity Cells, Cultured Cytotoxicity Emergency Fluorescent Dyes Intracellular Ca2 Lymphocyte Male Rats Thymocytes - drug effects Thymocytes - metabolism Triclocarban Water Pollutants, Chemical - toxicity Xanthenes Zinc Zn2 |
| Title | Triclocarban-induced change in intracellular Ca2+ level in rat thymocytes: Cytometric analysis with Fluo-3 under Zn2+-free conditions |
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