Study of Alu sequences at the hypoxanthine phosphoribosyltransferase ( hprt) encoding region of man

The hypoxanthine phosphoribosyltransferase ( hprt) encoding region of man is considered rich in Alu sequences; with 49 sequences present within 57 kilobases. Subfamily classification of the Alu sequences and identification of flanking direct repeats has been carried out to detect past rearrangements...

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Published in	Gene Vol. 184; no. 2; pp. 155 - 162
Main Authors	Renwick, P.J, Birley, A.J, Hultén, M.A
Format	Journal Article
Language	English
Published	Netherlands Elsevier B.V 15.01.1997
Subjects	Base Sequence Direct repeats DNA Humans Hypoxanthine Phosphoribosyltransferase - genetics Insertion events Intragenic Molecular Sequence Data Novel sequences Recombination, Genetic Repetitive Sequences, Nucleic Acid SINES Subfamily classification Insertion events Subfamily classification Direct repeats Intragenic SINES Novel sequences kb, kilobase SINES, short interspersed repeated DNA sequences bp, base pair hprt, hypoxanthine phosphoribosyltransferase DNA, deoxyribonucleic acid
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ISSN	0378-1119 1879-0038
DOI	10.1016/S0378-1119(96)00588-4

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Abstract	The hypoxanthine phosphoribosyltransferase ( hprt) encoding region of man is considered rich in Alu sequences; with 49 sequences present within 57 kilobases. Subfamily classification of the Alu sequences and identification of flanking direct repeats has been carried out to detect past rearrangements associated with their insertion into the region. Members of the Alu-J and three Alu-S subfamilies are present, along with the existence of free left arm sequences. Using available data, a comparison is made of the Alu subfamilies present at different gene regions. The heterogeneity in the number of each subfamily present at different genes shows that no one particular subfamily attained saturation in the genome. Several adjacent insertions of Alu sequences are seen at the hprt region. Furthermore two novel sequences are described, there is an incident where one Alu sequence has inserted into the middle poly(A) tract of an existing sequence at the hprt region; while another resulted from an Alu/ Alu cross-over event elsewhere in the genome, before insertion into the hprt region. Once inserted, the Alu sequences are rarely subject to loss or rearrangement.
AbstractList	The hypoxanthine phosphoribosyltransferase (hprt) encoding region of man is considered rich in Alu sequences; with 49 sequences present within 57 kilobases. Subfamily classification of the Alu sequences and identification of flanking direct repeats has been carried out to detect past rearrangements associated with their insertion into the region. Members of the Alu-J and three Alu-S subfamilies are present, along with the existence of free left arm sequences. Using available data, a comparison is made of the Alu subfamilies present at different gene regions. The heterogeneity in the number of each subfamily present at different genes shows that no one particular subfamily attained saturation in the genome. Several adjacent insertions of Alu sequences are seen at the hprt region. Furthermore two novel sequences are described, there is an incident where one Alu sequence has inserted into the middle poly(A) tract of an existing sequence at the hprt region; while another resulted from an Alu/Alu cross-over event elsewhere in the genome, before insertion into the hprt region. Once inserted, the Alu sequences are rarely subject to loss or rearrangement. The hypoxanthine phosphoribosyltransferase (hprt) encoding region of man is considered rich in Alu sequences: with 49 sequences present within 57 kilobases. Subfamily classification of the Alu sequences and identification of flanking direct repeats has been carried out to detect past rearrangements associated with their insertion into the region. Members of the Alu-J and three Alu-S subfamilies are present, along with the existence of free left arm sequences. Using available data, a comparison is made of the Alu subfamilies present at different gene regions. The heterogeneity in the number of each subfamily present at different genes shows that no one particular subfamily attained saturation in the genome. Several adjacent insertions of Alu sequences are seen at the hprt region. Furthermore two novel sequences are described, there is an incident where one Alu sequence has inserted into the middle poly(A) tract of an existing sequence at the hprt region; while another result from an Alu/Alu cross-over event elsewhere in the genome, before insertion into the hprt region. Once inserted, the Alu sequences are rarely subject to loss or rearrangement. The hypoxanthine phosphoribosyltransferase (hprt) encoding region of man is considered rich in Alu sequences: with 49 sequences present within 57 kilobases. Subfamily classification of the Alu sequences and identification of flanking direct repeats has been carried out to detect past rearrangements associated with their insertion into the region. Members of the Alu-J and three Alu-S subfamilies are present, along with the existence of free left arm sequences. Using available data, a comparison is made of the Alu subfamilies present at different gene regions. The heterogeneity in the number of each subfamily present at different genes shows that no one particular subfamily attained saturation in the genome. Several adjacent insertions of Alu sequences are seen at the hprt region. Furthermore two novel sequences are described, there is an incident where one Alu sequence has inserted into the middle poly(A) tract of an existing sequence at the hprt region; while another result from an Alu/Alu cross-over event elsewhere in the genome, before insertion into the hprt region. Once inserted, the Alu sequences are rarely subject to loss or rearrangement.The hypoxanthine phosphoribosyltransferase (hprt) encoding region of man is considered rich in Alu sequences: with 49 sequences present within 57 kilobases. Subfamily classification of the Alu sequences and identification of flanking direct repeats has been carried out to detect past rearrangements associated with their insertion into the region. Members of the Alu-J and three Alu-S subfamilies are present, along with the existence of free left arm sequences. Using available data, a comparison is made of the Alu subfamilies present at different gene regions. The heterogeneity in the number of each subfamily present at different genes shows that no one particular subfamily attained saturation in the genome. Several adjacent insertions of Alu sequences are seen at the hprt region. Furthermore two novel sequences are described, there is an incident where one Alu sequence has inserted into the middle poly(A) tract of an existing sequence at the hprt region; while another result from an Alu/Alu cross-over event elsewhere in the genome, before insertion into the hprt region. Once inserted, the Alu sequences are rarely subject to loss or rearrangement. The hypoxanthine phosphoribosyltransferase ( hprt) encoding region of man is considered rich in Alu sequences; with 49 sequences present within 57 kilobases. Subfamily classification of the Alu sequences and identification of flanking direct repeats has been carried out to detect past rearrangements associated with their insertion into the region. Members of the Alu-J and three Alu-S subfamilies are present, along with the existence of free left arm sequences. Using available data, a comparison is made of the Alu subfamilies present at different gene regions. The heterogeneity in the number of each subfamily present at different genes shows that no one particular subfamily attained saturation in the genome. Several adjacent insertions of Alu sequences are seen at the hprt region. Furthermore two novel sequences are described, there is an incident where one Alu sequence has inserted into the middle poly(A) tract of an existing sequence at the hprt region; while another resulted from an Alu/ Alu cross-over event elsewhere in the genome, before insertion into the hprt region. Once inserted, the Alu sequences are rarely subject to loss or rearrangement.
Author	Hultén, M.A Renwick, P.J Birley, A.J
Author_xml	– sequence: 1 givenname: P.J surname: Renwick fullname: Renwick, P.J organization: Regional Genetic Laboratory and Consultancy Services, Birmingham Heartlands Hospital NHS Trust, Birmingham B9 5PX UK – sequence: 2 givenname: A.J surname: Birley fullname: Birley, A.J organization: Population and Environmental Research Group, School of Biological Sciences, The University of Birmingham, Birmingham B15 2TT UK – sequence: 3 givenname: M.A surname: Hultén fullname: Hultén, M.A organization: Regional Genetic Laboratory and Consultancy Services, Birmingham Heartlands Hospital NHS Trust, Birmingham B9 5PX UK
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Keywords	Insertion events Subfamily classification Direct repeats Intragenic SINES Novel sequences kb, kilobase SINES, short interspersed repeated DNA sequences bp, base pair hprt, hypoxanthine phosphoribosyltransferase DNA, deoxyribonucleic acid
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Snippet	The hypoxanthine phosphoribosyltransferase ( hprt) encoding region of man is considered rich in Alu sequences; with 49 sequences present within 57 kilobases.... The hypoxanthine phosphoribosyltransferase (hprt) encoding region of man is considered rich in Alu sequences: with 49 sequences present within 57 kilobases.... The hypoxanthine phosphoribosyltransferase (hprt) encoding region of man is considered rich in Alu sequences; with 49 sequences present within 57 kilobases....
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SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	155
SubjectTerms	Base Sequence Direct repeats DNA Humans Hypoxanthine Phosphoribosyltransferase - genetics Insertion events Intragenic Molecular Sequence Data Novel sequences Recombination, Genetic Repetitive Sequences, Nucleic Acid SINES Subfamily classification
Title	Study of Alu sequences at the hypoxanthine phosphoribosyltransferase ( hprt) encoding region of man
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