Handling of computational in vitro/in vivo correlation problems by Microsoft Excel: I. principles and some general algorithms
Most computations in the field of in vitro/in vivo correlations can be handled directly by Excel worksheets, without the need for specialized software. Following a summary of Excel features, applications are illustrated for numerical computation of AUC and Mean, Wagner–Nelson and Loo–Riegelman absor...
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| Published in | European journal of pharmaceutics and biopharmaceutics Vol. 53; no. 1; pp. 1 - 7 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier B.V
2002
Elsevier Science |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0939-6411 1873-3441 |
| DOI | 10.1016/S0939-6411(01)00214-4 |
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| Abstract | Most computations in the field of in vitro/in vivo correlations can be handled directly by Excel worksheets, without the need for specialized software. Following a summary of Excel features, applications are illustrated for numerical computation of AUC and Mean, Wagner–Nelson and Loo–Riegelman absorption plots, and polyexponential curve fitting. |
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| AbstractList | Most computations in the field of in vitro/in vivo correlations can be handled directly by Excel worksheets, without the need for specialized software. Following a summary of Excel features, applications are illustrated for numerical computation of AUC and Mean, Wagner–Nelson and Loo–Riegelman absorption plots, and polyexponential curve fitting. Most computations in the field of in vitro/in vivo correlations can be handled directly by Excel worksheets, without the need for specialized software. Following a summary of Excel features, applications are illustrated for numerical computation of AUC and Mean, Wagner-Nelson and Loo-Riegelman absorption plots, and polyexponential curve fitting.Most computations in the field of in vitro/in vivo correlations can be handled directly by Excel worksheets, without the need for specialized software. Following a summary of Excel features, applications are illustrated for numerical computation of AUC and Mean, Wagner-Nelson and Loo-Riegelman absorption plots, and polyexponential curve fitting. |
| Author | Langenbucher, Frieder |
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| Cites_doi | 10.1002/jps.2600570602 10.1002/jps.2600740724 10.1002/jps.2600720738 10.1002/jps.2600520629 |
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| Keywords | Mean Excel SAS WinNonlin In vitro/in vivo correlations Kinetica Moments Correlation in vitro/in vivo Wagner–Nelson Loo–Riegelman AUC Mathematical function Mathematical formula In vivo Correlation Investigation method Mathematical analysis Computer Software Pharmacokinetics In vitro Computing method |
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| References | Carstensen (BIB3) 1996 Proost (BIB17) 1985; 74 Dietrich, Stahl (BIB12) 1978 Microsoft Excel 2000, Microsoft Press, Redmont, WA, 1999. (BIB8) 1985 WinNonlin 3.1, Pharsight Corp., Mountain View, CA, 1999. Brockmeier (BIB13) 1986; 32 Loo, Riegelman (BIB15) 1968; 57 Lee, Amidon (BIB4) 1996 J. Gabrielsson, D. Weiner, Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Swed. Pharm. Press, 679: Stockholm, Sweden, 1997. Shargel, Yu (BIB6) 1999 Guidance (BIB2) 1997 Wagner (BIB16) 1983; 72 Young, Devane, Butler (BIB7) 1997 Kinetika 2000, Innaphase Corp., Philadelphia, PA, 2000. In vitro and in vivo evaluations of dosage forms, United States Pharmacopoeia, 23rd edition, Rockville MD, 1995, pp. 1924-1929. Wagner, Nelson (BIB14) 1963; 52 10.1016/S0939-6411(01)00214-4_BIB11 10.1016/S0939-6411(01)00214-4_BIB10 Brockmeier (10.1016/S0939-6411(01)00214-4_BIB13) 1986; 32 10.1016/S0939-6411(01)00214-4_BIB5 Loo (10.1016/S0939-6411(01)00214-4_BIB15) 1968; 57 Guidance (10.1016/S0939-6411(01)00214-4_BIB2) 1997 10.1016/S0939-6411(01)00214-4_BIB9 Wagner (10.1016/S0939-6411(01)00214-4_BIB14) 1963; 52 Carstensen (10.1016/S0939-6411(01)00214-4_BIB3) 1996 10.1016/S0939-6411(01)00214-4_BIB1 Proost (10.1016/S0939-6411(01)00214-4_BIB17) 1985; 74 (10.1016/S0939-6411(01)00214-4_BIB8) 1985 Lee (10.1016/S0939-6411(01)00214-4_BIB4) 1996 Dietrich (10.1016/S0939-6411(01)00214-4_BIB12) 1978 Young (10.1016/S0939-6411(01)00214-4_BIB7) 1997 Shargel (10.1016/S0939-6411(01)00214-4_BIB6) 1999 Wagner (10.1016/S0939-6411(01)00214-4_BIB16) 1983; 72 |
| References_xml | – year: 1985 ident: BIB8 publication-title: SAS/IML User's Guide for Personal Computers – year: 1999 ident: BIB6 publication-title: Applied Biopharmaceutics and Pharmacokinetics – reference: Kinetika 2000, Innaphase Corp., Philadelphia, PA, 2000. – volume: 72 start-page: 838 year: 1983 end-page: 842 ident: BIB16 article-title: Pharmacokinetic absorption plots from oral data alone or oral/intravenous data and an exact Loo–Riegelman equation publication-title: J. Pharm. Sci. – year: 1978 ident: BIB12 publication-title: Matrizen und Determinanten und ihre Anwendungen in Technik und Oekonomie – volume: 32 start-page: 164 year: 1986 end-page: 174 ident: BIB13 article-title: In vitro/in vivo correlation of dissolution using moments of dissolution and transit times publication-title: Acta Pharm. Technol. – year: 1996 ident: BIB3 publication-title: Modeling and Data Treatment in the Pharmaceutical Sciences – year: 1997 ident: BIB7 publication-title: In Vitro–In Vivo Correlations – volume: 57 start-page: 918 year: 1968 end-page: 928 ident: BIB15 article-title: New method for calculating the intrinsic absorption rate of drugs publication-title: J. Pharm. Sci. – year: 1996 ident: BIB4 publication-title: Pharmacokinetic Analysis; a Practical Approach – reference: WinNonlin 3.1, Pharsight Corp., Mountain View, CA, 1999. – reference: In vitro and in vivo evaluations of dosage forms, United States Pharmacopoeia, 23rd edition, Rockville MD, 1995, pp. 1924-1929. – start-page: 23 year: 1997 end-page: 32 ident: BIB2 article-title: for Industry publication-title: Extended release oral dosage forms: development, evaluation and application of in vitro/in vivo correlations, Dissol. Technol. – volume: 74 start-page: 793 year: 1985 end-page: 794 ident: BIB17 article-title: Wagner's exact Loo–Riegelman equation: the need for a criterion to choose between the linear and logarithmic trapezoidal rule publication-title: J. Pharm. Sci. – volume: 52 start-page: 610 year: 1963 end-page: 611 ident: BIB14 article-title: Percent absorbed time plots derived from blood level and/or urinary excretion data publication-title: J. Pharm. Sci. – reference: J. Gabrielsson, D. Weiner, Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Swed. Pharm. Press, 679: Stockholm, Sweden, 1997. – reference: Microsoft Excel 2000, Microsoft Press, Redmont, WA, 1999. – ident: 10.1016/S0939-6411(01)00214-4_BIB5 – year: 1996 ident: 10.1016/S0939-6411(01)00214-4_BIB3 – volume: 57 start-page: 918 year: 1968 ident: 10.1016/S0939-6411(01)00214-4_BIB15 article-title: New method for calculating the intrinsic absorption rate of drugs publication-title: J. Pharm. Sci. doi: 10.1002/jps.2600570602 – ident: 10.1016/S0939-6411(01)00214-4_BIB1 – ident: 10.1016/S0939-6411(01)00214-4_BIB9 – year: 1996 ident: 10.1016/S0939-6411(01)00214-4_BIB4 – volume: 74 start-page: 793 year: 1985 ident: 10.1016/S0939-6411(01)00214-4_BIB17 article-title: Wagner's exact Loo–Riegelman equation: the need for a criterion to choose between the linear and logarithmic trapezoidal rule publication-title: J. Pharm. Sci. doi: 10.1002/jps.2600740724 – year: 1978 ident: 10.1016/S0939-6411(01)00214-4_BIB12 – start-page: 23 year: 1997 ident: 10.1016/S0939-6411(01)00214-4_BIB2 article-title: for Industry publication-title: Extended release oral dosage forms: development, evaluation and application of in vitro/in vivo correlations, Dissol. Technol. – year: 1985 ident: 10.1016/S0939-6411(01)00214-4_BIB8 – volume: 32 start-page: 164 year: 1986 ident: 10.1016/S0939-6411(01)00214-4_BIB13 article-title: In vitro/in vivo correlation of dissolution using moments of dissolution and transit times publication-title: Acta Pharm. Technol. – volume: 72 start-page: 838 year: 1983 ident: 10.1016/S0939-6411(01)00214-4_BIB16 article-title: Pharmacokinetic absorption plots from oral data alone or oral/intravenous data and an exact Loo–Riegelman equation publication-title: J. Pharm. Sci. doi: 10.1002/jps.2600720738 – year: 1997 ident: 10.1016/S0939-6411(01)00214-4_BIB7 – ident: 10.1016/S0939-6411(01)00214-4_BIB10 – ident: 10.1016/S0939-6411(01)00214-4_BIB11 – volume: 52 start-page: 610 year: 1963 ident: 10.1016/S0939-6411(01)00214-4_BIB14 article-title: Percent absorbed time plots derived from blood level and/or urinary excretion data publication-title: J. Pharm. Sci. doi: 10.1002/jps.2600520629 – year: 1999 ident: 10.1016/S0939-6411(01)00214-4_BIB6 |
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| SubjectTerms | Algorithms AUC Biological and medical sciences Correlation in vitro/in vivo Excel General pharmacology In vitro/in vivo correlations Kinetica Loo–Riegelman Mathematical Computing Mean Medical sciences Models, Statistical Moments Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments SAS Software - statistics & numerical data Wagner–Nelson WinNonlin |
| Title | Handling of computational in vitro/in vivo correlation problems by Microsoft Excel: I. principles and some general algorithms |
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