Dynamic simulation of insulin-glucose interaction in type 1 diabetes with MATLAB Simulink

• Published in: IOP conference series. Materials Science and Engineering Vol. 778; no. 1; pp. 12147 - 12156
• Main Authors: Mufti Azis, Muhammad, Kristanto, Jonas, Sarto
• Format: Journal Article
• Language: English
• Published: Bristol IOP Publishing 01.04.2020
• Subjects: Chemical engineering; Diabetes; dynamic; Engineering education; Glucose; Homeostasis; Hyperglycemia; Insulin; minimal model; Pancreas; Process controls; Simulation; State space models
• ISSN: 1757-8981; 1757-899X
• DOI: 10.1088/1757-899X/778/1/012147

Diabetes is a complex multifactorial disease where a person endures hyperglycemia in a long period. There have been large interest to perform dynamic simulation of insulin-glucose interaction to obtain a new insight of glucose homeostasis in a diabetic patient. Type 1 diabetes is characterized by the inability of β-cell in the pancreas to produce insulin and hence type 1 diabetes patient needs continuous insulin injection throughout their lives. Here, an educational module for process control in chemical engineering education has been developed to describe the insulin-glucose interaction. The model used an extended version of the minimal model (Bergman model) to simulate the interaction of insulin-glucose using state-space and SIMULINK. The state-space model development through classic linearization method followed by open-loop as well as a closed-loop simulation in SIMULINK was presented. The model was then used to simulate the meal disturbance over 24 h of simulation time. Various PI parameters were compared based on ITAE tuning methods in order to evaluate the dynamics of insulin-glucose interaction.