The IGH locus relocalizes to a “recombination compartment” in the perinucleolar region of differentiating B-lymphocytes - Pichugin, Andrey; Iarovaia, Olga V.; Gavrilov, Alexey; Sklyar, Ilya; Barinova, Natalja; Barinov, Aleksandr; Ivashkin, Evgeny; Caron, Gersende; Aoufouchi, Said; Razin, Sergey V.; Fest, Thierry; Lipinski, Marc; et al. (Oncotarget, 2017)
Keywords: B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Cancer; Cell Differentiation - immunology; Cell Line, Tumor; Cell Nucleolus - immunology; Cell Nucleolus - metabolism; Cells, Cultured; Cytidine Deaminase - immunology; Cytidine Deaminase - metabolism; Germinal Center - cytology; Germinal Center - immunology; Germinal Center - metabolism; Humans; Immunoglobulin Class Switching - genetics; Immunoglobulin Class Switching - immunology; Immunoglobulin Heavy Chains - genetics; Immunoglobulin Heavy Chains - immunology; Immunoglobulin Heavy Chains - metabolism; Immunology; In Situ Hybridization, Fluorescence - methods; Life Sciences; Lymphocyte Activation - immunology; Microscopy, Confocal; Research Paper: Chromosome; Somatic Hypermutation, Immunoglobulin - genetics; Somatic Hypermutation, Immunoglobulin - immunology; differentiation; recombination; chromatin; Chromosome Section; immunoglobulin genes; CHROMATIN; Differentiation