BMP9 promotes methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in non-obese mice by enhancing NF-κB dependent macrophage polarization - Jiang, Qianqian; Li, Qi; Liu, Beibei; Li, Guixin; Riedemann, Gabriel; Gaitantzi, Haristi; Breitkopf-Heinlein, Katja; Zeng, Ajuan; Ding, Huiguo; Xu, Keshu (International immunopharmacology, 2021)
Keywords: Adenoviridae - genetics; Animals; Bisphosphonates; Bone morphogenetic protein 9; Bone morphogenetic protein 9 (BMP9); CD86 antigen; Cell Differentiation; Choline; Choline - metabolism; Clodronic acid; Cytokines - metabolism; Depletion; Diet; Disease Models, Animal; Gene expression; Gene Expression Regulation; Genetic Vectors - genetics; Growth Differentiation Factor 2 - genetics; Growth Differentiation Factor 2 - metabolism; Humans; Immunohistochemistry; Inflammation; Interleukin 1; Interleukin 6; Lipopolysaccharides; Liposomes; Liver; Macrophages; Macrophages - immunology; Male; Methionine; Methionine - metabolism; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; Monocyte chemoattractant protein 1; Monocytes; NF-kappa B - metabolism; NF-κB; NF-κB protein; Nitric-oxide synthase; Non-alcoholic Fatty Liver Disease - immunology; Non-alcoholic Fatty Liver Disease - metabolism; Nonalcoholic fatty liver disease (NAFLD); Nonalcoholic steatohepatitis (NASH); Nuclear transport; Nutrient deficiency; Polarization; RAW 264.7 Cells; Th1 Cells - immunology; TLR4 protein; Toll-like receptors; Translocation; Triglycerides; Tumor necrosis factor-α; Unmanned aerial vehicles; Western blotting; NF-κB; Inflammation; Nonalcoholic fatty liver disease (NAFLD); Bone morphogenetic protein 9 (BMP9); Nonalcoholic steatohepatitis (NASH)