Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis

• Published in: The New England journal of medicine Vol. 380; no. 5; pp. 415 - 424
• Main Authors: Iversen, Kasper, Ihlemann, Nikolaj, Gill, Sabine U, Madsen, Trine, Elming, Hanne, Jensen, Kaare T, Bruun, Niels E, Høfsten, Dan E, Fursted, Kurt, Christensen, Jens J, Schultz, Martin, Klein, Christine F, Fosbøll, Emil L, Rosenvinge, Flemming, Schønheyder, Henrik C, Køber, Lars, Torp-Pedersen, Christian, Helweg-Larsen, Jannik, Tønder, Niels, Moser, Claus, Bundgaard, Henning
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 31.01.2019
• Subjects: Administration, Intravenous; Administration, Oral; Aged; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - adverse effects; Anti-Bacterial Agents - pharmacokinetics; Antibiotics; Bacteremia; Bacteremia - drug therapy; Cardiology; Coagulase; Endocarditis; Endocarditis, Bacterial - drug therapy; Endocarditis, Bacterial - microbiology; Endocarditis, Bacterial - mortality; Female; Heart; Heart surgery; Heart Valve Prosthesis - microbiology; Hospitals; Humans; Intention to Treat Analysis; Intravenous administration; Kaplan-Meier Estimate; Length of Stay; Male; Middle Aged; Patients; Recurrence; Society; Surgery; Denmark
• ISSN: 0028-4793; 1533-4406; 1533-4406
• DOI: 10.1056/NEJMoa1808312

In this randomized, controlled trial conducted at Danish cardiac centers, intravenous antibiotic therapy was compared with partial oral antibiotic therapy for the treatment of bacterial endocarditis. The outcomes were similar in the two groups.