Parotid Gland Tumors: A Comparison of Postoperative Radiotherapy Techniques Using Three Dimensional (3D) Dose Distributions and Dose-Volume Histograms (DVHs)
Purpose: To compare different treatment techniques for unilateral treatment of parotid gland tumors. Methods and Materials: The CT-scans of a representative parotid patient were used. The field size was 9 × 11 cm, the separation was 15.5 cm, and the prescription depth was 4.5 cm. Using 3D dose distr...
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          | Published in | International journal of radiation oncology, biology, physics Vol. 40; no. 1; pp. 43 - 49 | 
|---|---|
| Main Authors | , , , , | 
| Format | Journal Article Conference Proceeding | 
| Language | English | 
| Published | 
        New York, NY
          Elsevier Inc
    
        1998
     Elsevier  | 
| Subjects | |
| Online Access | Get full text | 
| ISSN | 0360-3016 1879-355X  | 
| DOI | 10.1016/S0360-3016(97)00484-7 | 
Cover
| Abstract | Purpose: To compare different treatment techniques for unilateral treatment of parotid gland tumors.
Methods and Materials: The CT-scans of a representative parotid patient were used. The field size was 9 × 11 cm, the separation was 15.5 cm, and the prescription depth was 4.5 cm. Using 3D dose distributions, tissue inhomogeneity corrections, scatter integration (for photons) and pencil beam (for electrons) algorithms and dose-volume histogram (DVH), nine treatment techniques were compared. [1] unilateral 6 MV photons [2] unilateral 12 MeV electrons [3] unilateral 16 MeV electrons [4] an ipsilateral wedge pair technique using 6 MV photons [5] a 3-field AP (wedged), PA (wedged) and lateral portal technique using 6 MV photons [6] a mixed beam technique using 6 MV photons and 12 MeV electrons (1:4 weighting) [7] a mixed beam technique using 6 MV photons and 16 MeV electrons (1:4 weighting) [8] a mixed beam technique using 18 MV photons and 20 MeV electrons (2:3 weighting) [9] a mixed beam technique using 18 MV photons and 20 MeV electrons (1:1 weighting).
Results: Using dose-volume histograms to evaluate the dose to the contralateral parotid gland, the percentage of contralateral parotid volume receiving ≥ 30% of the prescribed dose was 100% for techniques [1], [8] and [9], and < 5% for techniques [2] through [7]. Evaluating the “hottest” 5 cc of the ipsilateral mandible and temporal lobes, the hot spots were: 152% and 150% for technique [2], 132% and 130% for technique [6]. Comparing the exit doses, techniques [1], [8] and [9] contributed to ≥ 50% of the prescribed dose to the contralateral mandible and the temporal lobes. Only techniques [2] and [6] kept the highest point doses to both the brain stem and the spinal cord below 50% of the prescribed dose.
Conclusion: The single photon lateral field [1] and the mixed electron-photon beams [8] and [9] are not recommended treatment techniques for unilateral parotid irradiation because of high doses delivered to the contralateral parotid gland and high exit doses which are associated with Xerostomia. The
en face
electron beam technique [2] and the mixed electron-photon beam technique [6] are unacceptable due to the excessive dose heterogeneity to the contiguous normal structures. In spite of optimal dose fall-off achieved using the
en face
technique [3], most patients cannot tolerate the resulting high skin doses. We conclude that the ipsilateral wedge pair [4], the 3-field [5], and the mixed electron-photon beam [7] techniques are optimal techniques in providing relatively homogeneous dose distributions within the target area and for minimizing dose to the relevant normal structures. | 
    
|---|---|
| AbstractList | To compare different treatment techniques for unilateral treatment of parotid gland tumors.PURPOSETo compare different treatment techniques for unilateral treatment of parotid gland tumors.The CT-scans of a representative parotid patient were used. The field size was 9 x 11 cm, the separation was 15.5 cm, and the prescription depth was 4.5 cm. Using 3D dose distributions, tissue inhomogeneity corrections, scatter integration (for photons) and pencil beam (for electrons) algorithms and dose-volume histogram (DVH), nine treatment techniques were compared. [1] unilateral 6 MV photons [2] unilateral 12 MeV electrons [3] unilateral 16 MeV electrons [4] an ipsilateral wedge pair technique using 6 MV photons [5] a 3-field AP (wedged), PA (wedged) and lateral portal technique using 6 MV photons [6] a mixed beam technique using 6 MV photons and 12 MeV electrons (1:4 weighting) [7] a mixed beam technique using 6 MV photons and 16 MeV electrons (1:4 weighting) [8] a mixed beam technique using 18 MV photons and 20 MeV electrons (2:3 weighting) [9] a mixed beam technique using 18 MV photons and 20 MeV electrons (1:1 weighting).METHODS AND MATERIALSThe CT-scans of a representative parotid patient were used. The field size was 9 x 11 cm, the separation was 15.5 cm, and the prescription depth was 4.5 cm. Using 3D dose distributions, tissue inhomogeneity corrections, scatter integration (for photons) and pencil beam (for electrons) algorithms and dose-volume histogram (DVH), nine treatment techniques were compared. [1] unilateral 6 MV photons [2] unilateral 12 MeV electrons [3] unilateral 16 MeV electrons [4] an ipsilateral wedge pair technique using 6 MV photons [5] a 3-field AP (wedged), PA (wedged) and lateral portal technique using 6 MV photons [6] a mixed beam technique using 6 MV photons and 12 MeV electrons (1:4 weighting) [7] a mixed beam technique using 6 MV photons and 16 MeV electrons (1:4 weighting) [8] a mixed beam technique using 18 MV photons and 20 MeV electrons (2:3 weighting) [9] a mixed beam technique using 18 MV photons and 20 MeV electrons (1:1 weighting).Using dose-volume histograms to evaluate the dose to the contralateral parotid gland, the percentage of contralateral parotid volume receiving > or = 30% of the prescribed dose was 100% for techniques [1], [8] and [9], and < 5% for techniques [2] through [7]. Evaluating the "hottest" 5 cc of the ipsilateral mandible and temporal lobes, the hot spots were: 152% and 150% for technique [2], 132% and 130% for technique [6]. Comparing the exit doses, techniques [1], [8] and [9] contributed to > or = 50% of the prescribed dose to the contralateral mandible and the temporal lobes. Only techniques [2] and [6] kept the highest point doses to both the brain stem and the spinal cord below 50% of the prescribed dose.RESULTSUsing dose-volume histograms to evaluate the dose to the contralateral parotid gland, the percentage of contralateral parotid volume receiving > or = 30% of the prescribed dose was 100% for techniques [1], [8] and [9], and < 5% for techniques [2] through [7]. Evaluating the "hottest" 5 cc of the ipsilateral mandible and temporal lobes, the hot spots were: 152% and 150% for technique [2], 132% and 130% for technique [6]. Comparing the exit doses, techniques [1], [8] and [9] contributed to > or = 50% of the prescribed dose to the contralateral mandible and the temporal lobes. Only techniques [2] and [6] kept the highest point doses to both the brain stem and the spinal cord below 50% of the prescribed dose.The single photon lateral field [1] and the mixed electron-photon beams [8] and [9] are not recommended treatment techniques for unilateral parotid irradiation because of high doses delivered to the contralateral parotid gland and high exit doses which are associated with Xerostomia. The en face electron beam technique [2] and the mixed electron-photon beam technique [6] are unacceptable due to the excessive dose heterogeneity to the contiguous normal structures. In spite of optimal dose fall-off achieved using the en face technique [3], most patients cannot tolerate the resulting high skin doses. We conclude that the ipsilateral wedge pair [4], the 3-field [5], and the mixed electron-photon beam [7] techniques are optimal techniques in providing relatively homogeneous dose distributions within the target area and for minimizing dose to the relevant normal structures.CONCLUSIONThe single photon lateral field [1] and the mixed electron-photon beams [8] and [9] are not recommended treatment techniques for unilateral parotid irradiation because of high doses delivered to the contralateral parotid gland and high exit doses which are associated with Xerostomia. The en face electron beam technique [2] and the mixed electron-photon beam technique [6] are unacceptable due to the excessive dose heterogeneity to the contiguous normal structures. In spite of optimal dose fall-off achieved using the en face technique [3], most patients cannot tolerate the resulting high skin doses. We conclude that the ipsilateral wedge pair [4], the 3-field [5], and the mixed electron-photon beam [7] techniques are optimal techniques in providing relatively homogeneous dose distributions within the target area and for minimizing dose to the relevant normal structures. Purpose: To compare different treatment techniques for unilateral treatment of parotid gland tumors. Methods and Materials: The CT-scans of a representative parotid patient were used. The field size was 9 × 11 cm, the separation was 15.5 cm, and the prescription depth was 4.5 cm. Using 3D dose distributions, tissue inhomogeneity corrections, scatter integration (for photons) and pencil beam (for electrons) algorithms and dose-volume histogram (DVH), nine treatment techniques were compared. [1] unilateral 6 MV photons [2] unilateral 12 MeV electrons [3] unilateral 16 MeV electrons [4] an ipsilateral wedge pair technique using 6 MV photons [5] a 3-field AP (wedged), PA (wedged) and lateral portal technique using 6 MV photons [6] a mixed beam technique using 6 MV photons and 12 MeV electrons (1:4 weighting) [7] a mixed beam technique using 6 MV photons and 16 MeV electrons (1:4 weighting) [8] a mixed beam technique using 18 MV photons and 20 MeV electrons (2:3 weighting) [9] a mixed beam technique using 18 MV photons and 20 MeV electrons (1:1 weighting). Results: Using dose-volume histograms to evaluate the dose to the contralateral parotid gland, the percentage of contralateral parotid volume receiving ≥ 30% of the prescribed dose was 100% for techniques [1], [8] and [9], and < 5% for techniques [2] through [7]. Evaluating the “hottest” 5 cc of the ipsilateral mandible and temporal lobes, the hot spots were: 152% and 150% for technique [2], 132% and 130% for technique [6]. Comparing the exit doses, techniques [1], [8] and [9] contributed to ≥ 50% of the prescribed dose to the contralateral mandible and the temporal lobes. Only techniques [2] and [6] kept the highest point doses to both the brain stem and the spinal cord below 50% of the prescribed dose. Conclusion: The single photon lateral field [1] and the mixed electron-photon beams [8] and [9] are not recommended treatment techniques for unilateral parotid irradiation because of high doses delivered to the contralateral parotid gland and high exit doses which are associated with Xerostomia. The en face electron beam technique [2] and the mixed electron-photon beam technique [6] are unacceptable due to the excessive dose heterogeneity to the contiguous normal structures. In spite of optimal dose fall-off achieved using the en face technique [3], most patients cannot tolerate the resulting high skin doses. We conclude that the ipsilateral wedge pair [4], the 3-field [5], and the mixed electron-photon beam [7] techniques are optimal techniques in providing relatively homogeneous dose distributions within the target area and for minimizing dose to the relevant normal structures. To compare different treatment techniques for unilateral treatment of parotid gland tumors. The CT-scans of a representative parotid patient were used. The field size was 9 x 11 cm, the separation was 15.5 cm, and the prescription depth was 4.5 cm. Using 3D dose distributions, tissue inhomogeneity corrections, scatter integration (for photons) and pencil beam (for electrons) algorithms and dose-volume histogram (DVH), nine treatment techniques were compared. [1] unilateral 6 MV photons [2] unilateral 12 MeV electrons [3] unilateral 16 MeV electrons [4] an ipsilateral wedge pair technique using 6 MV photons [5] a 3-field AP (wedged), PA (wedged) and lateral portal technique using 6 MV photons [6] a mixed beam technique using 6 MV photons and 12 MeV electrons (1:4 weighting) [7] a mixed beam technique using 6 MV photons and 16 MeV electrons (1:4 weighting) [8] a mixed beam technique using 18 MV photons and 20 MeV electrons (2:3 weighting) [9] a mixed beam technique using 18 MV photons and 20 MeV electrons (1:1 weighting). Using dose-volume histograms to evaluate the dose to the contralateral parotid gland, the percentage of contralateral parotid volume receiving > or = 30% of the prescribed dose was 100% for techniques [1], [8] and [9], and < 5% for techniques [2] through [7]. Evaluating the "hottest" 5 cc of the ipsilateral mandible and temporal lobes, the hot spots were: 152% and 150% for technique [2], 132% and 130% for technique [6]. Comparing the exit doses, techniques [1], [8] and [9] contributed to > or = 50% of the prescribed dose to the contralateral mandible and the temporal lobes. Only techniques [2] and [6] kept the highest point doses to both the brain stem and the spinal cord below 50% of the prescribed dose. The single photon lateral field [1] and the mixed electron-photon beams [8] and [9] are not recommended treatment techniques for unilateral parotid irradiation because of high doses delivered to the contralateral parotid gland and high exit doses which are associated with Xerostomia. The en face electron beam technique [2] and the mixed electron-photon beam technique [6] are unacceptable due to the excessive dose heterogeneity to the contiguous normal structures. In spite of optimal dose fall-off achieved using the en face technique [3], most patients cannot tolerate the resulting high skin doses. We conclude that the ipsilateral wedge pair [4], the 3-field [5], and the mixed electron-photon beam [7] techniques are optimal techniques in providing relatively homogeneous dose distributions within the target area and for minimizing dose to the relevant normal structures.  | 
    
| Author | Fontenla, Doracy P Beitler, Jonathan J Boselli, Lucia R Yaparpalvi, Ravindra Tyerech, Sangeeta K  | 
    
| Author_xml | – sequence: 1 givenname: Ravindra surname: Yaparpalvi fullname: Yaparpalvi, Ravindra organization: Department of Radiation Oncology, Montefiore Medical Center, The University Hospital for the Albert Einstein College of Medicine, Bronx, NY USA – sequence: 2 givenname: Doracy P surname: Fontenla fullname: Fontenla, Doracy P organization: Department of Radiation Oncology, Montefiore Medical Center, The University Hospital for the Albert Einstein College of Medicine, Bronx, NY USA – sequence: 3 givenname: Sangeeta K surname: Tyerech fullname: Tyerech, Sangeeta K organization: Department of Radiation Oncology, Montefiore Medical Center, The University Hospital for the Albert Einstein College of Medicine, Bronx, NY USA – sequence: 4 givenname: Lucia R surname: Boselli fullname: Boselli, Lucia R organization: Department of Radiation Oncology, Montefiore Medical Center, The University Hospital for the Albert Einstein College of Medicine, Bronx, NY USA – sequence: 5 givenname: Jonathan J surname: Beitler fullname: Beitler, Jonathan J organization: Department of Radiation Oncology, Montefiore Medical Center, The University Hospital for the Albert Einstein College of Medicine, Bronx, NY USA  | 
    
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| Keywords | Dose-volume histograms Temporal lobe necrosis Osteoradionecrosis of the mandible Radiation therapy 3D dose distributions Treatment planning Xerostomia Parotid gland tumors Endocrinopathy Dose repartition Human Postoperative Radiotherapy Prevention Three dimensional representation Parathyroid diseases Volume Surgery Radiation injury Parathyroid glands Tumor Technique Comparative study  | 
    
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| References | Wheeler (BIB17) 1985; 1 Dobrowsky, Schlappack, Karcher, Pavelka, Kment (BIB2) 1986; 6 Tapley, N. duV. Malignant tumors of the salivary glands. In: Clinical Applications of the Electron Beam. New York: John Wiley and Sons; 1976:141–171. Shui, Hogstrom (BIB13) 1991; 21 McNaney, McNeese, Guillamondegui, Fletcher, Oswald (BIB8) 1983; 9 Million, R. R.; Cassisi, J. N.; Mancuso, A. A. Major salivary gland tumors. In: Cancer: A Multidisciplinary Approach. Philadelphia; PA: Lippincott Co; 1994:711–735. Ostwald, Cooper, Denham, Hamilton (BIB10) 1994; 33 Spiro, Wang, Montogmery (BIB14) 1993; 71 Drzymala, Mohan, Brewster, Chu, Goitein, Harms, Urie (BIB3) 1991; 21 Liu, Fleming, Toth, Keene (BIB6) 1990; 70 Cooper, Fu, Marks, Silverman (BIB1) 1995; 31 Lee, Duhon, North, Lam (BIB5) 1990; 19 Prasad, S. C.; Ames, T. E.; Howard, T. B.; Bassano, D. A.; Chung, T. C.; King, G. A.; Sagerman, R. H. Dose enhancement in bone in electron beam therapy. Radiology 151:513–516. Sanger, Matloub, Yousif, Larson (BIB12) 1993; 20 Tapley (BIB16) 1977; 56 Marks, Davis, Goltsman, Purdy, Lee (BIB7) 1981; 7 Jacob (BIB4) 1993; 20  | 
    
| References_xml | – volume: 19 start-page: 244 year: 1990 ident: BIB5 article-title: Radiotherapy treatment planning for parotid carcinoma publication-title: Int. J. Radiat. Oncol. Biol. Phys. – volume: 20 start-page: 517 year: 1993 end-page: 530 ident: BIB12 article-title: Management of the osteoradionecrosis of the mandible publication-title: Clinics in Plastic Surgery – volume: 20 start-page: 507 year: 1993 end-page: 516 ident: BIB4 article-title: Management of Xerostomia in the irradiated patient publication-title: Clinics in Plastic Surgery – volume: 9 start-page: 1289 year: 1983 end-page: 1295 ident: BIB8 article-title: Postoperative irradiation in malignant epithelial tumors of the parotid publication-title: Int. J. Radiat. Oncol. Biol. Phys. – volume: 21 start-page: 695 year: 1991 end-page: 702 ident: BIB13 article-title: Dose in bone and tissue near bone-tissue interface from electron beam publication-title: Int. J. Radiat. Oncol. Biol. Phys. – volume: 1 start-page: 74 year: 1985 end-page: 80 ident: BIB17 article-title: Retrograde amnesia produced by electron beam exposure publication-title: Radiat. Res. – volume: 31 start-page: 1141 year: 1995 end-page: 1164 ident: BIB1 article-title: Late effects of RT in the head and neck region publication-title: Int. J. Radiat. Oncol. Biol. Phys. – volume: 70 start-page: 724 year: 1990 end-page: 729 ident: BIB6 article-title: Salivary flow rates in patients with head and neck cancer 0.5 to 25 years after radiotherapy publication-title: Oral Surg. Oral Med. Oral Pathol. – volume: 33 start-page: 148 year: 1994 end-page: 156 ident: BIB10 article-title: Dosimetry of high energy electron therapy to the parotid region publication-title: Radiother. Oncol. – reference: Prasad, S. C.; Ames, T. E.; Howard, T. B.; Bassano, D. A.; Chung, T. C.; King, G. A.; Sagerman, R. H. Dose enhancement in bone in electron beam therapy. Radiology 151:513–516. – reference: Tapley, N. duV. Malignant tumors of the salivary glands. In: Clinical Applications of the Electron Beam. New York: John Wiley and Sons; 1976:141–171. – reference: Million, R. R.; Cassisi, J. N.; Mancuso, A. A. Major salivary gland tumors. In: Cancer: A Multidisciplinary Approach. Philadelphia; PA: Lippincott Co; 1994:711–735. – volume: 71 start-page: 2699 year: 1993 end-page: 2705 ident: BIB14 article-title: Carcinoma of the parotid gland publication-title: Cancer. – volume: 21 start-page: 71 year: 1991 end-page: 78 ident: BIB3 article-title: Dose-volume histograms publication-title: Int. J. Radiat. Oncol. Biol. Phys. – volume: 7 start-page: 1013 year: 1981 end-page: 1019 ident: BIB7 article-title: The effects of radiation on the parotid salivary function publication-title: Int. J. Radiat. Oncol. Biol. Phys. – volume: 56 start-page: 110 year: 1977 end-page: 114 ident: BIB16 article-title: Irradiation treatment of malignant tumors of the salivary glands publication-title: Ear Nose Throat J. – volume: 6 start-page: 293 year: 1986 end-page: 299 ident: BIB2 article-title: Electron beam therapy in treatment of parotid neoplasm publication-title: Radioth. Oncol.  | 
    
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| Snippet | Purpose: To compare different treatment techniques for unilateral treatment of parotid gland tumors.
Methods and Materials: The CT-scans of a representative... To compare different treatment techniques for unilateral treatment of parotid gland tumors. The CT-scans of a representative parotid patient were used. The... To compare different treatment techniques for unilateral treatment of parotid gland tumors.PURPOSETo compare different treatment techniques for unilateral...  | 
    
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| SubjectTerms | 3D dose distributions Biological and medical sciences Brain Diseases - etiology Dose-Response Relationship, Radiation Dose-volume histograms Electrons - therapeutic use Endocrinopathies Humans Mandibular Diseases - etiology Medical sciences Necrosis Non tumoral diseases. Target tissue resistance. Benign neoplasms Osteoradionecrosis - etiology Osteoradionecrosis of the mandible Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases) Parotid Gland - radiation effects Parotid gland tumors Parotid Neoplasms - radiotherapy Parotid Neoplasms - surgery Photons - therapeutic use Radiation therapy Radiotherapy - methods Radiotherapy Dosage Salivation - radiation effects Temporal Lobe - pathology Temporal Lobe - radiation effects Temporal lobe necrosis Treatment planning Xerostomia  | 
    
| Title | Parotid Gland Tumors: A Comparison of Postoperative Radiotherapy Techniques Using Three Dimensional (3D) Dose Distributions and Dose-Volume Histograms (DVHs) | 
    
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