Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy?
A new coronavirus, referred to as SARS-CoV-2, is responsible for the recent outbreak of severe respiratory disease. This outbreak first detected in Wuhan, China in December 2019, has spread to other regions of China and to 25 other countries as of January, 2020. It has been known since the 2003 SARS...
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| Published in | Clinical science (1979) Vol. 134; no. 5; pp. 543 - 545 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
13.03.2020
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0143-5221 1470-8736 1470-8736 |
| DOI | 10.1042/CS20200163 |
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| Abstract | A new coronavirus, referred to as SARS-CoV-2, is responsible for the recent outbreak of severe respiratory disease. This outbreak first detected in Wuhan, China in December 2019, has spread to other regions of China and to 25 other countries as of January, 2020. It has been known since the 2003 SARS epidemic that the receptor critical for SARS-CoV entry into host cells is the angiotensin-converting enzyme 2 (ACE2). The S1 domain of the spike protein of SARS-CoV attaches the virus to its cellular receptor ACE2 on the host cells. We thought that it is timely to explain the connection between the SARS-CoV, SARS-CoV-2, ACE2 and the rationale for soluble ACE2 as a potential therapy. |
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| AbstractList | A new coronavirus, referred to as SARS-CoV-2, is responsible for the recent outbreak of severe respiratory disease. This outbreak first detected in Wuhan, China in December 2019, has spread to other regions of China and to 25 other countries as of January, 2020. It has been known since the 2003 SARS epidemic that the receptor critical for SARS-CoV entry into host cells is the angiotensin-converting enzyme 2 (ACE2). The S1 domain of the spike protein of SARS-CoV attaches the virus to its cellular receptor ACE2 on the host cells. We thought that it is timely to explain the connection between the SARS-CoV, SARS-CoV-2, ACE2 and the rationale for soluble ACE2 as a potential therapy. A new coronavirus, referred to as SARS-CoV-2, is responsible for the recent outbreak of severe respiratory disease. This outbreak first detected in Wuhan, China in December 2019, has spread to other regions of China and to 25 other countries as of January, 2020. It has been known since the 2003 SARS epidemic that the receptor critical for SARS-CoV entry into host cells is the angiotensin-converting enzyme 2 (ACE2). The S1 domain of the spike protein of SARS-CoV attaches the virus to its cellular receptor ACE2 on the host cells. We thought that it is timely to explain the connection between the SARS-CoV, SARS-CoV-2, ACE2 and the rationale for soluble ACE2 as a potential therapy.A new coronavirus, referred to as SARS-CoV-2, is responsible for the recent outbreak of severe respiratory disease. This outbreak first detected in Wuhan, China in December 2019, has spread to other regions of China and to 25 other countries as of January, 2020. It has been known since the 2003 SARS epidemic that the receptor critical for SARS-CoV entry into host cells is the angiotensin-converting enzyme 2 (ACE2). The S1 domain of the spike protein of SARS-CoV attaches the virus to its cellular receptor ACE2 on the host cells. We thought that it is timely to explain the connection between the SARS-CoV, SARS-CoV-2, ACE2 and the rationale for soluble ACE2 as a potential therapy. |
| Author | Wysocki, Jan Satchell, Karla Batlle, Daniel |
| Author_xml | – sequence: 1 givenname: Daniel orcidid: 0000-0002-5878-9046 surname: Batlle fullname: Batlle, Daniel organization: Department of Medicine/ Division of Nephrology/Hypertension, Northwestern University Feinberg School of Medicine, Chicago, IL, U.S.A – sequence: 2 givenname: Jan surname: Wysocki fullname: Wysocki, Jan organization: Department of Medicine/ Division of Nephrology/Hypertension, Northwestern University Feinberg School of Medicine, Chicago, IL, U.S.A – sequence: 3 givenname: Karla surname: Satchell fullname: Satchell, Karla organization: Department Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, U.S.A., Center for Structural Genomics of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, U.S.A |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32167153$$D View this record in MEDLINE/PubMed |
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| Keywords | angiotensin converting enzyme 2 Coronavirus 2019 Novel Coronavirus |
| Language | English |
| License | 2020 The Author(s). cc-by |
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| References | Du (2021113011105008100_B4) 2009; 7 Menachery (2021113011105008100_B6) 2015; 21 Imai (2021113011105008100_B12) 2010; 74 Wysocki (2021113011105008100_B7) 2010; 55 Ksiazek (2021113011105008100_B9) 2003; 348 Serfozo (2021113011105008100_B1) 2020; 75 Lu (2021113011105008100_B5) 2020; 395 Zhao (2021113011105008100_B3) 2020 Wysocki (2021113011105008100_B13) 2019; 9 Lei (2021113011105008100_B10) 2020 Wrapp (2021113011105008100_B11) 2020 Hamming (2021113011105008100_B2) 2004; 203 Li (2021113011105008100_B8) 2003; 426 |
| References_xml | – volume: 75 start-page: 173 year: 2020 ident: 2021113011105008100_B1 article-title: Ang ii (angiotensin ii) conversion to angiotensin-(1-7) in the circulation is pop (prolyloligopeptidase)-dependent and ace2 (angiotensin-converting enzyme 2)-independent publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.119.14071 – volume: 426 start-page: 450 year: 2003 ident: 2021113011105008100_B8 article-title: Angiotensin-converting enzyme 2 is a functional receptor for the sars coronavirus publication-title: Nature doi: 10.1038/nature02145 – volume: 348 start-page: 1953 year: 2003 ident: 2021113011105008100_B9 article-title: A novel coronavirus associated with severe acute respiratory syndrome publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa030781 – year: 2020 ident: 2021113011105008100_B11 article-title: Cryo-em structure of the 2019-ncov spike in the prefusion conformation publication-title: Science doi: 10.1126/science.abb2507 – volume: 203 start-page: 631 year: 2004 ident: 2021113011105008100_B2 article-title: Tissue distribution of ace2 protein, the functional receptor for sars coronavirus. A first step in understanding sars pathogenesis publication-title: J. Pathol. doi: 10.1002/path.1570 – volume: 395 start-page: 565 year: 2020 ident: 2021113011105008100_B5 article-title: Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding publication-title: Lancet doi: 10.1016/S0140-6736(20)30251-8 – volume: 74 start-page: 405 year: 2010 ident: 2021113011105008100_B12 article-title: Angiotensin-converting enzyme 2 (ace2) in disease pathogenesis publication-title: Circ. J. doi: 10.1253/circj.CJ-10-0045 – volume: 55 start-page: 90 year: 2010 ident: 2021113011105008100_B7 article-title: Targeting the degradation of angiotensin ii with recombinant angiotensin-converting enzyme 2: Prevention of angiotensin ii-dependent hypertension publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.109.138420 – year: 2020 ident: 2021113011105008100_B10 article-title: Potent neutralization of 2019 novel coronavirus by recombinant ace2-ig publication-title: bioRxiv doi: 10.1101/2020.02.01.929976 – volume: 7 start-page: 226 year: 2009 ident: 2021113011105008100_B4 article-title: The spike protein of sars-cov–a target for vaccine and therapeutic development publication-title: Nat. Rev. Microbiol. doi: 10.1038/nrmicro2090 – volume: 21 start-page: 1508 year: 2015 ident: 2021113011105008100_B6 article-title: A sars-like cluster of circulating bat coronaviruses shows potential for human emergence publication-title: Nat. Med. doi: 10.1038/nm.3985 – volume: 9 year: 2019 ident: 2021113011105008100_B13 article-title: Novel variants of angiotensin converting enzyme-2 of shorter molecular size to target the kidney renin angiotensin system publication-title: Biomolecules doi: 10.3390/biom9120886 – year: 2020 ident: 2021113011105008100_B3 article-title: Single-cell rna expression profiling of ace2, the putative receptor of wuhan 2019-ncov publication-title: bioRxiv doi: 10.1101/2020.01.26.919985 |
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| SubjectTerms | Animals Betacoronavirus - pathogenicity Cell Line Coronavirus Infections - drug therapy Haplorhini Humans Peptidyl-Dipeptidase A - physiology Pneumonia, Viral - drug therapy Recombinant Proteins - therapeutic use SARS Virus - pathogenicity Solubility Virus Attachment Virus Replication |
| Title | Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy? |
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