Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage

Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually categorized as: lobar (mostly related to cerebral amyloid angiopathy) and nonlob...

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Published inInternational journal of molecular sciences Vol. 23; no. 12; p. 6479
Main Authors Giralt-Steinhauer, Eva, Jiménez-Balado, Joan, Fernández-Pérez, Isabel, Rey Álvarez, Lucía, Rodríguez-Campello, Ana, Ois, Ángel, Cuadrado-Godia, Elisa, Jiménez-Conde, Jordi, Roquer, Jaume
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 09.06.2022
MDPI
Subjects
Blood pressure
Blood vessels
Cholesterol
Epigenetics
Genetics
Genomes
Health risk assessment
Hematoma
Hemorrhage
High density lipoprotein
Hypertension
Mortality
Mutation
Review
Risk factors
Traumatic brain injury
White people
Online AccessGet full text
ISSN1422-0067
1661-6596
1422-0067
DOI10.3390/ijms23126479

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Abstract Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually categorized as: lobar (mostly related to cerebral amyloid angiopathy) and nonlobar (hypertension-related vasculopathy) ICH. Accurate phenotyping aims to reflect these biological differences in the underlying mechanisms and has been demonstrated to be crucial to the success of genetic studies in this field. This review summarizes how current knowledge on genetics and epigenetics of this devastating stroke subtype are contributing to improve the understanding of ICH pathophysiology and their potential role in developing therapeutic strategies.
AbstractList Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually categorized as: lobar (mostly related to cerebral amyloid angiopathy) and nonlobar (hypertension-related vasculopathy) ICH. Accurate phenotyping aims to reflect these biological differences in the underlying mechanisms and has been demonstrated to be crucial to the success of genetic studies in this field. This review summarizes how current knowledge on genetics and epigenetics of this devastating stroke subtype are contributing to improve the understanding of ICH pathophysiology and their potential role in developing therapeutic strategies.
Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually categorized as: lobar (mostly related to cerebral amyloid angiopathy) and nonlobar (hypertension-related vasculopathy) ICH. Accurate phenotyping aims to reflect these biological differences in the underlying mechanisms and has been demonstrated to be crucial to the success of genetic studies in this field. This review summarizes how current knowledge on genetics and epigenetics of this devastating stroke subtype are contributing to improve the understanding of ICH pathophysiology and their potential role in developing therapeutic strategies.Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually categorized as: lobar (mostly related to cerebral amyloid angiopathy) and nonlobar (hypertension-related vasculopathy) ICH. Accurate phenotyping aims to reflect these biological differences in the underlying mechanisms and has been demonstrated to be crucial to the success of genetic studies in this field. This review summarizes how current knowledge on genetics and epigenetics of this devastating stroke subtype are contributing to improve the understanding of ICH pathophysiology and their potential role in developing therapeutic strategies.
Author Giralt-Steinhauer, Eva
Rodríguez-Campello, Ana
Roquer, Jaume
Fernández-Pérez, Isabel
Jiménez-Balado, Joan
Ois, Ángel
Jiménez-Conde, Jordi
Rey Álvarez, Lucía
Cuadrado-Godia, Elisa
AuthorAffiliation Neurovascular Research Group, Neurology Department, Hospital de Mar, 08003 Barcelona, Spain; ifernandezperez@psmar.cat (I.F.-P.); lrey@imim.es (L.R.Á.); arodriguezc@psmar.cat (A.R.-C.); aois@psmar.cat (Á.O.); ecuadrardo@psmar.cat (E.C.-G.); jjimenez@imim.es (J.J.-C.); jroquer@psmar.cat (J.R.)
AuthorAffiliation_xml – name: Neurovascular Research Group, Neurology Department, Hospital de Mar, 08003 Barcelona, Spain; ifernandezperez@psmar.cat (I.F.-P.); lrey@imim.es (L.R.Á.); arodriguezc@psmar.cat (A.R.-C.); aois@psmar.cat (Á.O.); ecuadrardo@psmar.cat (E.C.-G.); jjimenez@imim.es (J.J.-C.); jroquer@psmar.cat (J.R.)
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Snippet Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation...
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SubjectTerms Blood pressure
Blood vessels
Cholesterol
Epigenetics
Genetics
Genomes
Health risk assessment
Hematoma
Hemorrhage
High density lipoprotein
Hypertension
Mortality
Mutation
Review
Risk factors
Traumatic brain injury
White people
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Title Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage
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