Ischemia increases tissue and decreases extracellular levels of acid dopamine metabolites in the rat striatum: Further evidence for active transport of metabolites

During 30 minutes of global forebrain ischemia in rats, striatal intracellular levels of dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) increase at the same time extracellular levels, measured by microdialysis, decrease. If DOPAC and HVA were free to diffuse out of cells, these chang...

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Published inLife sciences (1973) Vol. 56; no. 13; pp. 1135 - 1141
Main Authors Phebus, Lee A, Mincy, Ronald E, Clemens, James A
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 17.02.1995
Subjects
3,4-Dihydroxyphenylacetic Acid - metabolism
active transport
Animals
Biological Transport, Active
Brain Ischemia - metabolism
Corpus Striatum - blood supply
Corpus Striatum - metabolism
dihydrophenylacetic acid
Dopamine - analogs & derivatives
Dopamine - metabolism
global ischemia
homovanillic acid
Homovanillic Acid - metabolism
Male
Membrane Potentials
microdialysis
Rats
Rats, Wistar
global ischemia
homovanillic acid
dihydrophenylacetic acid
microdialysis
active transport
Online AccessGet full text
ISSN0024-3205
1879-0631
DOI10.1016/0024-3205(95)00051-7

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Abstract During 30 minutes of global forebrain ischemia in rats, striatal intracellular levels of dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) increase at the same time extracellular levels, measured by microdialysis, decrease. If DOPAC and HVA were free to diffuse out of cells, these changes in opposite directions should not occur. These data support the theory that a membrane potential-dependent active transport system is required for DOPAC and HVA to leave striatal cells. During ischemia and subsequent to ATP depletion, neurons and glia depolarize and active transport systems fail. DOPAC and HVA, which are still being produced inside neurons and possibly glia, can not be transported out of these cells and accumulate intracellularly.
AbstractList During 30 minutes of global forebrain ischemia in rats, striatal intracellular levels of dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) increase at the same time extracellular levels, measured by microdialysis, decrease. If DOPAC and HVA were free to diffuse out of cells, these changes in opposite directions should not occur. These data support the theory that a membrane potential-dependent active transport system is required for DOPAC and HVA to leave striatal cells. During ischemia and subsequent to ATP depletion, neurons and glia depolarize and active transport systems fail. DOPAC and HVA, which are still being produced inside neurons and possibly glia, can not be transported out of these cells and accumulate intracellularly.
During 30 minutes of global forebrain ischemia in rats, striatal intracellular levels of dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) increase at the same time extracellular levels, measured by microdialysis, decrease. If DOPAC and HVA were free to diffuse out of cells, these changes in opposite directions should not occur. These data support the theory that a membrane potential-dependent active transport system is required for DOPAC and HVA to leave striatal cells. During ischemia and subsequent to ATP depletion, neurons and glia depolarize and active transport systems fail. DOPAC and HVA, which are still being produced inside neurons and possibly glia, can not be transported out of these cells and accumulate intracellularly.During 30 minutes of global forebrain ischemia in rats, striatal intracellular levels of dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) increase at the same time extracellular levels, measured by microdialysis, decrease. If DOPAC and HVA were free to diffuse out of cells, these changes in opposite directions should not occur. These data support the theory that a membrane potential-dependent active transport system is required for DOPAC and HVA to leave striatal cells. During ischemia and subsequent to ATP depletion, neurons and glia depolarize and active transport systems fail. DOPAC and HVA, which are still being produced inside neurons and possibly glia, can not be transported out of these cells and accumulate intracellularly.
Author Clemens, James A
Phebus, Lee A
Mincy, Ronald E
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Issue 13
Keywords global ischemia
homovanillic acid
dihydrophenylacetic acid
microdialysis
active transport
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Snippet During 30 minutes of global forebrain ischemia in rats, striatal intracellular levels of dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)...
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SubjectTerms 3,4-Dihydroxyphenylacetic Acid - metabolism
active transport
Animals
Biological Transport, Active
Brain Ischemia - metabolism
Corpus Striatum - blood supply
Corpus Striatum - metabolism
dihydrophenylacetic acid
Dopamine - analogs & derivatives
Dopamine - metabolism
global ischemia
homovanillic acid
Homovanillic Acid - metabolism
Male
Membrane Potentials
microdialysis
Rats
Rats, Wistar
Title Ischemia increases tissue and decreases extracellular levels of acid dopamine metabolites in the rat striatum: Further evidence for active transport of metabolites
URI https://dx.doi.org/10.1016/0024-3205(95)00051-7
https://www.ncbi.nlm.nih.gov/pubmed/9001448
https://www.proquest.com/docview/16731946
https://www.proquest.com/docview/77946669
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