In Vitro Anti- Malassezia Activity of Castanea crenata Shell and Oil-Soluble Glycyrrhiza Extracts

• Published in: Annals of dermatology Vol. 29; no. 3; pp. 321 - 326
• Main Authors: Han, Song Hee, Hur, Min Seok, Kim, Min Jung, Jung, Won Hee, Park, Minji, Kim, Jeong Hwan, Shin, Hong Ju, Choe, Yong Beom, Ahn, Kyu Joong, Lee, Yang Won
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Dermatological Association; The Korean Society for Investigative Dermatology 01.06.2017; 대한피부과학회
• Subjects: Original; 피부과학; Shampoo; Seborrheic dermatitis; Malassezia; Oil-soluble Glycyrrhiza extract; Castanea crenata shell extract
• ISSN: 1013-9087; 2005-3894
• DOI: 10.5021/ad.2017.29.3.321

A new shampoo with anti- properties obtained from various plants is required to provide seborrheic dermatitis patients with a wider range of treatment options. The aim of this study was to obtain susceptibility profiles of and , the most important pathogenic organisms in the development of seborrheic dermatitis, to the plant extracts used in commercial anti-dandruff shampoos. Minimal inhibitory concentrations (MICs) were determined for eight candidate plant extracts and two plant-derived natural products diluted with Leeming and Notman medium to final concentrations of 0.016 to 1 mg/ml. shell, leaf, and oil-soluble extracts presented relatively low MIC values (≤0.5 mg/ml) against both strains. The shell and oil-soluble extracts demonstrated especially high activity, suggesting their potential use in the treatment of seborrheic dermatitis. The extracts also showed fungistatic activity against other common facultative pathogenic yeasts, and . shell and oil-soluble extracts could potentially be used as active ingredients in anti-seborrheic and anti-dandruff shampoo formulations. They could be helpful for repeated treatments and regular prophylaxis of scalp seborrheic dermatitis.