SHORT REPORT: THE ACTIVITY OF PAMAQUINE, AN 8-AMINOQUINOLINE DRUG, AGAINST SPOROZOITE-INDUCED INFECTIONS OF PLASMODIUM VIVAX (NEW GUINEA STRAINS)

It was reported in 1946 that the administration of pamaquine during the incubation period delayed but did not prevent primary attacks of a New Guinea strain of Plasmodium vivax malaria. The observation that none of the four test subjects in this study had relapses has not previously been published a...

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Published inThe American journal of tropical medicine and hygiene Vol. 71; no. 2; pp. 187 - 189
Main Authors SWEENEY, ANTHONY W, BLACKBURN, CHARLES R. B, RIECKMANN, KARL H
Format Journal Article
LanguageEnglish
Published United States ASTMH 01.08.2004
Subjects
Aminoquinolines - history
Aminoquinolines - therapeutic use
Animals
Antimalarials - history
Antimalarials - therapeutic use
Australia
Clinical Trials as Topic - history
History, 20th Century
Humans
Malaria, Vivax - drug therapy
Malaria, Vivax - history
Malaria, Vivax - prevention & control
Military Personnel - history
Plasmodium vivax - drug effects
Plasmodium vivax - growth & development
Secondary Prevention
Sporozoites - pathogenicity
Australia
Online AccessGet full text
ISSN0002-9637
1476-1645
1476-1645
DOI10.4269/ajtmh.2004.71.2.0700187

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Abstract It was reported in 1946 that the administration of pamaquine during the incubation period delayed but did not prevent primary attacks of a New Guinea strain of Plasmodium vivax malaria. The observation that none of the four test subjects in this study had relapses has not previously been published and may have important implications for the evaluation of other 8-aminoquinoline compounds against relapsing vivax malaria.
AbstractList It was reported in 1946 that the administration of pamaquine during the incubation period delayed but did not prevent primary attacks of a New Guinea strain of Plasmodium vivax malaria. The observation that none of the four test subjects in this study had relapses has not previously been published and may have important implications for the evaluation of other 8-aminoquinoline compounds against relapsing vivax malaria.
It was reported in 1946 that the administration of pamaquine during the incubation period delayed but did not prevent primary attacks of a New Guinea strain of Plasmodium vivax malaria. The observation that none of the four test subjects in this study had relapses has not previously been published and may have important implications for the evaluation of other 8-aminoquinoline compounds against relapsing vivax malaria.
It was reported in 1946 that the administration of pamaquine during the incubation period delayed but did not prevent primary attacks of a New Guinea strain of Plasmodium vivax malaria. The observation that none of the four test subjects in this study had relapses has not previously been published and may have important implications for the evaluation of other 8-aminoquinoline compounds against relapsing vivax malaria.It was reported in 1946 that the administration of pamaquine during the incubation period delayed but did not prevent primary attacks of a New Guinea strain of Plasmodium vivax malaria. The observation that none of the four test subjects in this study had relapses has not previously been published and may have important implications for the evaluation of other 8-aminoquinoline compounds against relapsing vivax malaria.
Author RIECKMANN, KARL H
SWEENEY, ANTHONY W
BLACKBURN, CHARLES R. B
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StartPage 187
SubjectTerms Aminoquinolines - history
Aminoquinolines - therapeutic use
Animals
Antimalarials - history
Antimalarials - therapeutic use
Australia
Clinical Trials as Topic - history
History, 20th Century
Humans
Malaria, Vivax - drug therapy
Malaria, Vivax - history
Malaria, Vivax - prevention & control
Military Personnel - history
Plasmodium vivax - drug effects
Plasmodium vivax - growth & development
Secondary Prevention
Sporozoites - pathogenicity
Title SHORT REPORT: THE ACTIVITY OF PAMAQUINE, AN 8-AMINOQUINOLINE DRUG, AGAINST SPOROZOITE-INDUCED INFECTIONS OF PLASMODIUM VIVAX (NEW GUINEA STRAINS)
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