A validated finite element model to reproduce Helmholtz’s theory of accommodation: a powerful tool to investigate presbyopia
Purpose To reproduce human in vivo accommodation numerically. For that purpose, a finite element model specific for a 29‐year‐old subject was designed. Once the proposed numerical model was validated, the decrease in accommodative amplitude with age was simulated according to data available in the l...
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| Published in | Ophthalmic & physiological optics Vol. 41; no. 6; pp. 1241 - 1253 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Wiley Subscription Services, Inc
01.11.2021
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0275-5408 1475-1313 1475-1313 |
| DOI | 10.1111/opo.12876 |
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| Abstract | Purpose
To reproduce human in vivo accommodation numerically. For that purpose, a finite element model specific for a 29‐year‐old subject was designed. Once the proposed numerical model was validated, the decrease in accommodative amplitude with age was simulated according to data available in the literature.
Methods
In contrast with previous studies, the non‐accommodated eye condition was the reference configuration. Consequently, two aspects were specifically highlighted: contraction of the ciliary muscle, which was simulated by a continuum electro‐mechanical model and incorporation of initial lens capsule stresses, which allowed the lens to become accommodated after releasing the resting zonular tension.
Results
The morphological changes and contraction of the ciliary muscle were calibrated accurately according to the experimental data from the literature. All dynamic optical and biometric lens measurements validated the model. With the proposed numerical model, presbyopia was successfully simulated.
Conclusions
The most widespread theory of accommodation, proposed by Helmholtz, was simulated accurately. Assuming the same initial stresses in the lens capsule over time, stiffening of the lens nucleus is the main cause of presbyopia. |
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| AbstractList | To reproduce human in vivo accommodation numerically. For that purpose, a finite element model specific for a 29-year-old subject was designed. Once the proposed numerical model was validated, the decrease in accommodative amplitude with age was simulated according to data available in the literature.
In contrast with previous studies, the non-accommodated eye condition was the reference configuration. Consequently, two aspects were specifically highlighted: contraction of the ciliary muscle, which was simulated by a continuum electro-mechanical model and incorporation of initial lens capsule stresses, which allowed the lens to become accommodated after releasing the resting zonular tension.
The morphological changes and contraction of the ciliary muscle were calibrated accurately according to the experimental data from the literature. All dynamic optical and biometric lens measurements validated the model. With the proposed numerical model, presbyopia was successfully simulated.
The most widespread theory of accommodation, proposed by Helmholtz, was simulated accurately. Assuming the same initial stresses in the lens capsule over time, stiffening of the lens nucleus is the main cause of presbyopia. Purpose To reproduce human in vivo accommodation numerically. For that purpose, a finite element model specific for a 29‐year‐old subject was designed. Once the proposed numerical model was validated, the decrease in accommodative amplitude with age was simulated according to data available in the literature. Methods In contrast with previous studies, the non‐accommodated eye condition was the reference configuration. Consequently, two aspects were specifically highlighted: contraction of the ciliary muscle, which was simulated by a continuum electro‐mechanical model and incorporation of initial lens capsule stresses, which allowed the lens to become accommodated after releasing the resting zonular tension. Results The morphological changes and contraction of the ciliary muscle were calibrated accurately according to the experimental data from the literature. All dynamic optical and biometric lens measurements validated the model. With the proposed numerical model, presbyopia was successfully simulated. Conclusions The most widespread theory of accommodation, proposed by Helmholtz, was simulated accurately. Assuming the same initial stresses in the lens capsule over time, stiffening of the lens nucleus is the main cause of presbyopia. PurposeTo reproduce human in vivo accommodation numerically. For that purpose, a finite element model specific for a 29‐year‐old subject was designed. Once the proposed numerical model was validated, the decrease in accommodative amplitude with age was simulated according to data available in the literature.MethodsIn contrast with previous studies, the non‐accommodated eye condition was the reference configuration. Consequently, two aspects were specifically highlighted: contraction of the ciliary muscle, which was simulated by a continuum electro‐mechanical model and incorporation of initial lens capsule stresses, which allowed the lens to become accommodated after releasing the resting zonular tension.ResultsThe morphological changes and contraction of the ciliary muscle were calibrated accurately according to the experimental data from the literature. All dynamic optical and biometric lens measurements validated the model. With the proposed numerical model, presbyopia was successfully simulated.ConclusionsThe most widespread theory of accommodation, proposed by Helmholtz, was simulated accurately. Assuming the same initial stresses in the lens capsule over time, stiffening of the lens nucleus is the main cause of presbyopia. To reproduce human in vivo accommodation numerically. For that purpose, a finite element model specific for a 29-year-old subject was designed. Once the proposed numerical model was validated, the decrease in accommodative amplitude with age was simulated according to data available in the literature.PURPOSETo reproduce human in vivo accommodation numerically. For that purpose, a finite element model specific for a 29-year-old subject was designed. Once the proposed numerical model was validated, the decrease in accommodative amplitude with age was simulated according to data available in the literature.In contrast with previous studies, the non-accommodated eye condition was the reference configuration. Consequently, two aspects were specifically highlighted: contraction of the ciliary muscle, which was simulated by a continuum electro-mechanical model and incorporation of initial lens capsule stresses, which allowed the lens to become accommodated after releasing the resting zonular tension.METHODSIn contrast with previous studies, the non-accommodated eye condition was the reference configuration. Consequently, two aspects were specifically highlighted: contraction of the ciliary muscle, which was simulated by a continuum electro-mechanical model and incorporation of initial lens capsule stresses, which allowed the lens to become accommodated after releasing the resting zonular tension.The morphological changes and contraction of the ciliary muscle were calibrated accurately according to the experimental data from the literature. All dynamic optical and biometric lens measurements validated the model. With the proposed numerical model, presbyopia was successfully simulated.RESULTSThe morphological changes and contraction of the ciliary muscle were calibrated accurately according to the experimental data from the literature. All dynamic optical and biometric lens measurements validated the model. With the proposed numerical model, presbyopia was successfully simulated.The most widespread theory of accommodation, proposed by Helmholtz, was simulated accurately. Assuming the same initial stresses in the lens capsule over time, stiffening of the lens nucleus is the main cause of presbyopia.CONCLUSIONSThe most widespread theory of accommodation, proposed by Helmholtz, was simulated accurately. Assuming the same initial stresses in the lens capsule over time, stiffening of the lens nucleus is the main cause of presbyopia. |
| Author | Calvo, Begoña Cabeza‐Gil, Iulen Grasa, Jorge |
| Author_xml | – sequence: 1 givenname: Iulen orcidid: 0000-0001-8219-2365 surname: Cabeza‐Gil fullname: Cabeza‐Gil, Iulen email: iulen@unizar.es organization: University of Zaragoza – sequence: 2 givenname: Jorge surname: Grasa fullname: Grasa, Jorge organization: Bioengineering, Biomaterials and Nanomedicine Networking Biomedical Research Centre (CIBER‐BBN) – sequence: 3 givenname: Begoña surname: Calvo fullname: Calvo, Begoña organization: Bioengineering, Biomaterials and Nanomedicine Networking Biomedical Research Centre (CIBER‐BBN) |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34463367$$D View this record in MEDLINE/PubMed |
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To reproduce human in vivo accommodation numerically. For that purpose, a finite element model specific for a 29‐year‐old subject was designed. Once... To reproduce human in vivo accommodation numerically. For that purpose, a finite element model specific for a 29-year-old subject was designed. Once the... PurposeTo reproduce human in vivo accommodation numerically. For that purpose, a finite element model specific for a 29‐year‐old subject was designed. Once the... |
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| SubjectTerms | Accommodation, Ocular accommodative change Adult Aging Ciliary Body Contraction Finite Element Analysis finite element method human eye accommodation Humans lens shape Lens, Crystalline Muscle contraction Presbyopia |
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| Title | A validated finite element model to reproduce Helmholtz’s theory of accommodation: a powerful tool to investigate presbyopia |
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