Ultrasound-based fractional precipitation for the purification of (+)-dihydromyricetin

• Published in: The Korean journal of chemical engineering Vol. 38; no. 3; pp. 480 - 484
• Main Authors: Oh, Se-Rin, Kim, Jin-Hyun
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2021; Springer Nature B.V; 한국화학공학회
• Subjects: Biotechnology; Catalysis; Chemistry; Chemistry and Materials Science; Diffusion coefficient; Industrial Chemistry/Chemical Engineering; Materials Science; Purification; Rapid Communication; Temperature; Ultrasonic imaging; Ultrasound; 화학공학; (+)-Dihydromyricetin; Diffusion Coefficient; Kinetics; Fractional Precipitation; Ultrasound
• ISSN: 0256-1115; 1975-7220
• DOI: 10.1007/s11814-020-0734-8

The purification efficiency of (+)-dihydromyricetin, a bioactive plant flavonoid, was remarkably improved through ultrasound-based fractional precipitation. The precipitation time (up to 30 min) taken to obtain (+)-dihydromyricetin with high purity (87.01–91.66%) and yield (90.63–92.00%) through the ultrasonic fractional precipitation (ultrasonic power: 80–250 W) was shortened by 40-fold as compared to the conventional method (up to 1200 min). In addition, the precipitation rate constant was increased by 12- to 18-fold, but the activation energy was decreased to between −5,787 J/mol and −6,526 J/mol, and thereby the precipitation rate was improved. Furthermore, the size of the precipitate was reduced by 5.1- to 5.5-fold, while the diffusion coefficient was increased by 6.4- to 6.9-fold.