ROLE OF HUMAN CYTOCHROME P450 (CYP) IN THE METABOLIC ACTIVATION OF NITROSAMINE DERIVATIVES: APPLICATION OF GENETICALLY ENGINEERED SALMONELLA EXPRESSING HUMAN CYP - Kamataki, Tetsuya; Fujita, Ken-ichi; Nakayama, Kazuo; Yamazaki, Yoshiyuki; Miyamoto, Masami; Ariyoshi, Noritaka (Drug metabolism reviews, 2002)
Keywords: Aryl Hydrocarbon Hydroxylases - genetics; Aryl Hydrocarbon Hydroxylases - metabolism; Cytochrome P-450 CYP2A6; Epidemiology; Gene Expression Regulation; Genetic Engineering; Genetic Predisposition to Disease; Humans; Japan; Lung cancer; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Mixed Function Oxygenases - genetics; Mixed Function Oxygenases - metabolism; Mutation assay; NADPH-Ferrihemoprotein Reductase - genetics; NADPH-Ferrihemoprotein Reductase - metabolism; Nitrosamines - chemistry; Nitrosamines - metabolism; Polymorphism; Polymorphism, Genetic; Risk Factors; Salmonella typhimurium - genetics; Tobacco Products; Tobacco smoke