Bromocriptine and amantadine in cocaine detoxification

The effects of bromocriptine and amantadine in treating cocaine withdrawal were compared. Withdrawal symptoms are thought to be due to central dopamine depletion. Both bromocriptine and amantadine are dopamine agonists previously reported to diminish withdrawal symptoms. Thirty subjects were withdra...

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Published inPsychiatry research Vol. 29; no. 1; pp. 11 - 16
Main Authors Giannini, A.James, Folts, David J., Feather, John N., Sullivan, Brian S.
Format Journal Article
LanguageEnglish
Published Shannon Elsevier Ireland Ltd 01.07.1989
Elsevier
Subjects
Adult
amantadine
Amantadine - adverse effects
Amantadine - therapeutic use
Biological and medical sciences
Brain - drug effects
bromocriptine
Bromocriptine - adverse effects
Bromocriptine - therapeutic use
Clinical Trials as Topic
Cocaine
Cocaine - adverse effects
dopamine
Drug addictions
Humans
Male
Medical sciences
Random Allocation
Receptors, Dopamine - drug effects
Substance Withdrawal Syndrome - rehabilitation
Substance-Related Disorders - rehabilitation
Toxicology
withdrawal
Cocaine
withdrawal
bromocriptine
amantadine
dopamine
Bromocryptine
Human
Drug abuse
Chemotherapy
Dopamine
Treatment
Withdrawal
Dopamine agonist
Withdrawal syndrome
Comparative study
Online AccessGet full text
ISSN0165-1781
1872-7123
DOI10.1016/0165-1781(89)90182-0

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Abstract The effects of bromocriptine and amantadine in treating cocaine withdrawal were compared. Withdrawal symptoms are thought to be due to central dopamine depletion. Both bromocriptine and amantadine are dopamine agonists previously reported to diminish withdrawal symptoms. Thirty subjects were withdrawn for 30 days with amantadine, bromocriptine, or placebo. Bromocriptine and amantadine were more effective than placebo for 15 days. Amantadine's effectiveness then declined so that it was no more effective than placebo by experiment's end. Bromocriptine was significantly more effective than both throughout the latter phase of the study. Amantadine's decline in effectiveness is hypothesized to be due to stimulation of dopamine release.
AbstractList The effects of bromocriptine and amantadine in treating cocaine withdrawal were compared. Withdrawal symptoms are thought to be due to central dopamine depletion. Both bromocriptine and amantadine are dopamine agonists previously reported to diminish withdrawal symptoms. Thirty subjects were withdrawn for 30 days with amantadine, bromocriptine, or placebo. Bromocriptine and amantadine were more effective than placebo for 15 days. Amantadine's effectiveness then declined so that it was no more effective than placebo by experiment's end. Bromocriptine was significantly more effective than both throughout the latter phase of the study. Amantadine's decline in effectiveness is hypothesized to be due to stimulation of dopamine release.The effects of bromocriptine and amantadine in treating cocaine withdrawal were compared. Withdrawal symptoms are thought to be due to central dopamine depletion. Both bromocriptine and amantadine are dopamine agonists previously reported to diminish withdrawal symptoms. Thirty subjects were withdrawn for 30 days with amantadine, bromocriptine, or placebo. Bromocriptine and amantadine were more effective than placebo for 15 days. Amantadine's effectiveness then declined so that it was no more effective than placebo by experiment's end. Bromocriptine was significantly more effective than both throughout the latter phase of the study. Amantadine's decline in effectiveness is hypothesized to be due to stimulation of dopamine release.
The effects of bromocriptine and amantadine in treating cocaine withdrawal were compared. Withdrawal symptoms are thought to be due to central dopamine depletion. Both bromocriptine and amantadine are dopamine agonists previously reported to diminish withdrawal symptoms. Thirty subjects were withdrawn for 30 days with amantadine, bromocriptine, or placebo. Bromocriptine and amantadine were more effective than placebo for 15 days. Amantadine's effectiveness then declined so that it was no more effective than placebo by experiment's end. Bromocriptine was significantly more effective than both throughout the latter phase of the study. Amantadine's decline in effectiveness is hypothesized to be due to stimulation of dopamine release.
Author Folts, David J.
Sullivan, Brian S.
Giannini, A.James
Feather, John N.
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Issue 1
Keywords Cocaine
withdrawal
bromocriptine
amantadine
dopamine
Bromocryptine
Human
Drug abuse
Chemotherapy
Dopamine
Treatment
Withdrawal
Dopamine agonist
Withdrawal syndrome
Comparative study
Language English
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Snippet The effects of bromocriptine and amantadine in treating cocaine withdrawal were compared. Withdrawal symptoms are thought to be due to central dopamine...
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StartPage 11
SubjectTerms Adult
amantadine
Amantadine - adverse effects
Amantadine - therapeutic use
Biological and medical sciences
Brain - drug effects
bromocriptine
Bromocriptine - adverse effects
Bromocriptine - therapeutic use
Clinical Trials as Topic
Cocaine
Cocaine - adverse effects
dopamine
Drug addictions
Humans
Male
Medical sciences
Random Allocation
Receptors, Dopamine - drug effects
Substance Withdrawal Syndrome - rehabilitation
Substance-Related Disorders - rehabilitation
Toxicology
withdrawal
Title Bromocriptine and amantadine in cocaine detoxification
URI https://dx.doi.org/10.1016/0165-1781(89)90182-0
https://www.ncbi.nlm.nih.gov/pubmed/2672061
https://www.proquest.com/docview/79197822
Volume 29
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