The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells - Lennon, Jennifer C.; Bright, Sandra A.; Carroll, Eilis; Butini, Stefania; Campiani, Giuseppe; O’Meara, Anne; Williams, D. Clive; Zisterer, Daniela M. (Biochemical pharmacology, 2014)
Keywords: Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Apoptosis; Apoptosis - drug effects; Apoptosis - physiology; Carboplatin; Carboplatin - pharmacology; Carboplatin - therapeutic use; Cell Line, Tumor; Drug Resistance, Multiple - drug effects; Drug Resistance, Multiple - physiology; Drug Resistance, Neoplasm - drug effects; Drug Resistance, Neoplasm - physiology; Drug Synergism; Humans; Neuroblastoma; Neuroblastoma - drug therapy; Neuroblastoma - pathology; Oxazepines - pharmacology; Oxazepines - therapeutic use; PBOX-6; Pyrroles - pharmacology; Pyrroles - therapeutic use; Synergy; Up-Regulation - drug effects; Up-Regulation - physiology; Bcl-2; BCRP; MRP1; CML; DTT; FAC; PARP; Neuroblastoma; PBOX-6; Mcl-1; FBS; Carboplatin; MDR; Synergy; MTA; PBOX; Apoptosis