Associations of sarcopenia with graft failure and mortality in patients undergoing living donor liver transplantation
Recent studies have reported that sarcopenia influences morbidity and mortality in surgical patients. However, few studies have investigated the associations of sarcopenia with short‐term and long‐term graft failure in recipients after living donor liver transplantation (LDLT). In this study, we inv...
Saved in:
| Published in | Liver transplantation Vol. 28; no. 8; pp. 1345 - 1355 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Wolters Kluwer Health, Inc
01.08.2022
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1527-6465 1527-6473 1527-6473 |
| DOI | 10.1002/lt.26447 |
Cover
| Abstract | Recent studies have reported that sarcopenia influences morbidity and mortality in surgical patients. However, few studies have investigated the associations of sarcopenia with short‐term and long‐term graft failure in recipients after living donor liver transplantation (LDLT). In this study, we investigated the associations between sarcopenia and graft failure/mortality in patients undergoing LDLT. We retrospectively examined 2816 recipients who underwent LDLT between January 2008 and January 2018. Cox regression analysis was performed to evaluate the associations between sarcopenia and graft failure/mortality in recipients at 60 days, 180 days, and 1 year and overall. Sarcopenia in the recipient was significantly associated with 60‐day graft failure (adjusted hazard ratio [HR], 1.98; 95% confidence interval [CI], 1.09–3.61; p = 0.03), 180‐day graft failure (HR, 1.85; 95% CI, 1.19–2.88; p = 0.01), 1‐year graft failure (HR, 1.45; 95% CI, 1.01–2.17; p = 0.05), and overall graft failure (HR, 1.42; 95% CI, 1.08–1.87; p = 0.01). In addition, recipient sarcopenia was associated with 180‐day mortality (HR, 1.88; 95% CI, 1.17–3.01; p = 0.01), 1‐year mortality (HR, 1.53; 95% CI, 1.01–2.29; p = 0.04), and overall mortality (HR, 1.43; 95% CI, 1.08–1.90; p = 0.01). Preoperative sarcopenia was associated with high rates of graft failure and mortality in LDLT recipients. Therefore, preoperative sarcopenia may be a strong predictor of the surgical prognosis in LDLT recipients. |
|---|---|
| AbstractList | Recent studies have reported that sarcopenia influences morbidity and mortality in surgical patients. However, few studies have investigated the associations of sarcopenia with short‐term and long‐term graft failure in recipients after living donor liver transplantation (LDLT). In this study, we investigated the associations between sarcopenia and graft failure/mortality in patients undergoing LDLT. We retrospectively examined 2816 recipients who underwent LDLT between January 2008 and January 2018. Cox regression analysis was performed to evaluate the associations between sarcopenia and graft failure/mortality in recipients at 60 days, 180 days, and 1 year and overall. Sarcopenia in the recipient was significantly associated with 60‐day graft failure (adjusted hazard ratio [HR], 1.98; 95% confidence interval [CI], 1.09–3.61; p = 0.03), 180‐day graft failure (HR, 1.85; 95% CI, 1.19–2.88; p = 0.01), 1‐year graft failure (HR, 1.45; 95% CI, 1.01–2.17; p = 0.05), and overall graft failure (HR, 1.42; 95% CI, 1.08–1.87; p = 0.01). In addition, recipient sarcopenia was associated with 180‐day mortality (HR, 1.88; 95% CI, 1.17–3.01; p = 0.01), 1‐year mortality (HR, 1.53; 95% CI, 1.01–2.29; p = 0.04), and overall mortality (HR, 1.43; 95% CI, 1.08–1.90; p = 0.01). Preoperative sarcopenia was associated with high rates of graft failure and mortality in LDLT recipients. Therefore, preoperative sarcopenia may be a strong predictor of the surgical prognosis in LDLT recipients. Recent studies have reported that sarcopenia influences morbidity and mortality in surgical patients. However, few studies have investigated the associations of sarcopenia with short‐term and long‐term graft failure in recipients after living donor liver transplantation (LDLT). In this study, we investigated the associations between sarcopenia and graft failure/mortality in patients undergoing LDLT. We retrospectively examined 2816 recipients who underwent LDLT between January 2008 and January 2018. Cox regression analysis was performed to evaluate the associations between sarcopenia and graft failure/mortality in recipients at 60 days, 180 days, and 1 year and overall. Sarcopenia in the recipient was significantly associated with 60‐day graft failure (adjusted hazard ratio [HR], 1.98; 95% confidence interval [CI], 1.09–3.61; p = 0.03), 180‐day graft failure (HR, 1.85; 95% CI, 1.19–2.88; p = 0.01), 1‐year graft failure (HR, 1.45; 95% CI, 1.01–2.17; p = 0.05), and overall graft failure (HR, 1.42; 95% CI, 1.08–1.87; p = 0.01). In addition, recipient sarcopenia was associated with 180‐day mortality (HR, 1.88; 95% CI, 1.17–3.01; p = 0.01), 1‐year mortality (HR, 1.53; 95% CI, 1.01–2.29; p = 0.04), and overall mortality (HR, 1.43; 95% CI, 1.08–1.90; p = 0.01). Preoperative sarcopenia was associated with high rates of graft failure and mortality in LDLT recipients. Therefore, preoperative sarcopenia may be a strong predictor of the surgical prognosis in LDLT recipients. Recent studies have reported that sarcopenia influences morbidity and mortality in surgical patients. However, few studies have investigated the associations of sarcopenia with short‐term and long‐term graft failure in recipients after living donor liver transplantation (LDLT). In this study, we investigated the associations between sarcopenia and graft failure/mortality in patients undergoing LDLT. We retrospectively examined 2816 recipients who underwent LDLT between January 2008 and January 2018. Cox regression analysis was performed to evaluate the associations between sarcopenia and graft failure/mortality in recipients at 60 days, 180 days, and 1 year and overall. Sarcopenia in the recipient was significantly associated with 60‐day graft failure (adjusted hazard ratio [HR], 1.98; 95% confidence interval [CI], 1.09–3.61; p = 0.03), 180‐day graft failure (HR, 1.85; 95% CI, 1.19–2.88; p = 0.01), 1‐year graft failure (HR, 1.45; 95% CI, 1.01–2.17; p = 0.05), and overall graft failure (HR, 1.42; 95% CI, 1.08–1.87; p = 0.01). In addition, recipient sarcopenia was associated with 180‐day mortality (HR, 1.88; 95% CI, 1.17–3.01; p = 0.01), 1‐year mortality (HR, 1.53; 95% CI, 1.01–2.29; p = 0.04), and overall mortality (HR, 1.43; 95% CI, 1.08–1.90; p = 0.01). Preoperative sarcopenia was associated with high rates of graft failure and mortality in LDLT recipients. Therefore, preoperative sarcopenia may be a strong predictor of the surgical prognosis in LDLT recipients. Recent studies have reported that sarcopenia influences morbidity and mortality in surgical patients. However, few studies have investigated the associations of sarcopenia with short-term and long-term graft failure in recipients after living donor liver transplantation (LDLT). In this study, we investigated the associations between sarcopenia and graft failure/mortality in patients undergoing LDLT. We retrospectively examined 2816 recipients who underwent LDLT between January 2008 and January 2018. Cox regression analysis was performed to evaluate the associations between sarcopenia and graft failure/mortality in recipients at 60 days, 180 days, and 1 year and overall. Sarcopenia in the recipient was significantly associated with 60-day graft failure (adjusted hazard ratio [HR], 1.98; 95% confidence interval [CI], 1.09-3.61; p = 0.03), 180-day graft failure (HR, 1.85; 95% CI, 1.19-2.88; p = 0.01), 1-year graft failure (HR, 1.45; 95% CI, 1.01-2.17; p = 0.05), and overall graft failure (HR, 1.42; 95% CI, 1.08-1.87; p = 0.01). In addition, recipient sarcopenia was associated with 180-day mortality (HR, 1.88; 95% CI, 1.17-3.01; p = 0.01), 1-year mortality (HR, 1.53; 95% CI, 1.01-2.29; p = 0.04), and overall mortality (HR, 1.43; 95% CI, 1.08-1.90; p = 0.01). Preoperative sarcopenia was associated with high rates of graft failure and mortality in LDLT recipients. Therefore, preoperative sarcopenia may be a strong predictor of the surgical prognosis in LDLT recipients.Recent studies have reported that sarcopenia influences morbidity and mortality in surgical patients. However, few studies have investigated the associations of sarcopenia with short-term and long-term graft failure in recipients after living donor liver transplantation (LDLT). In this study, we investigated the associations between sarcopenia and graft failure/mortality in patients undergoing LDLT. We retrospectively examined 2816 recipients who underwent LDLT between January 2008 and January 2018. Cox regression analysis was performed to evaluate the associations between sarcopenia and graft failure/mortality in recipients at 60 days, 180 days, and 1 year and overall. Sarcopenia in the recipient was significantly associated with 60-day graft failure (adjusted hazard ratio [HR], 1.98; 95% confidence interval [CI], 1.09-3.61; p = 0.03), 180-day graft failure (HR, 1.85; 95% CI, 1.19-2.88; p = 0.01), 1-year graft failure (HR, 1.45; 95% CI, 1.01-2.17; p = 0.05), and overall graft failure (HR, 1.42; 95% CI, 1.08-1.87; p = 0.01). In addition, recipient sarcopenia was associated with 180-day mortality (HR, 1.88; 95% CI, 1.17-3.01; p = 0.01), 1-year mortality (HR, 1.53; 95% CI, 1.01-2.29; p = 0.04), and overall mortality (HR, 1.43; 95% CI, 1.08-1.90; p = 0.01). Preoperative sarcopenia was associated with high rates of graft failure and mortality in LDLT recipients. Therefore, preoperative sarcopenia may be a strong predictor of the surgical prognosis in LDLT recipients. |
| Author | Kim, Kyung‐Won Kwon, Hye‐Mee Moon, Young‐Jin Ko, You‐Sun Kim, Kyoung‐Sun Song, Jun‐Gol Sim, Ji‐Hoon Jun, In‐Gu Kim, Sung‐Hoon Hwang, Gyu‐Sam |
| Author_xml | – sequence: 1 givenname: Ji‐Hoon surname: Sim fullname: Sim, Ji‐Hoon organization: University of Ulsan College of Medicine – sequence: 2 givenname: Hye‐Mee surname: Kwon fullname: Kwon, Hye‐Mee organization: University of Ulsan College of Medicine – sequence: 3 givenname: Kyung‐Won surname: Kim fullname: Kim, Kyung‐Won organization: University of Ulsan College of Medicine – sequence: 4 givenname: You‐Sun surname: Ko fullname: Ko, You‐Sun organization: University of Ulsan College of Medicine – sequence: 5 givenname: In‐Gu surname: Jun fullname: Jun, In‐Gu organization: University of Ulsan College of Medicine – sequence: 6 givenname: Sung‐Hoon surname: Kim fullname: Kim, Sung‐Hoon organization: University of Ulsan College of Medicine – sequence: 7 givenname: Kyoung‐Sun surname: Kim fullname: Kim, Kyoung‐Sun organization: University of Ulsan College of Medicine – sequence: 8 givenname: Young‐Jin surname: Moon fullname: Moon, Young‐Jin organization: University of Ulsan College of Medicine – sequence: 9 givenname: Jun‐Gol surname: Song fullname: Song, Jun‐Gol email: jungol.song@amc.seoul.kr organization: University of Ulsan College of Medicine – sequence: 10 givenname: Gyu‐Sam surname: Hwang fullname: Hwang, Gyu‐Sam organization: University of Ulsan College of Medicine |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35243771$$D View this record in MEDLINE/PubMed |
| BookMark | eNp10UtrJCEQAGAJWTaPXdhfsAi55NKz2g_LPoaQFwzkkj2Lo_aswdFetRPm38dJ5wEhOUgpfFWW5RHa98EbhH5RsqCE1H9cXtSsbWEPHdKuhoq10Oy_7Vl3gI5SuieE0q4n39FB09VtA0AP0XSWUlBWZht8wmHASUYVRuOtxI82_8PrKIeMB2ndFA2WXuNNiFk6m7fYejyWTONzwpPXJq6D9Wvs7MMu6OBD3B1MxDlKn0YnfX6-6Qf6NkiXzM-XeIz-Xl7cnV9Xy9urm_OzZaUazqBqGdVkaGkNHVF8xZhUrAZtuOw7qNtOGs40gAFKgUqiFe-5WWngAJL0A2uO0elcd4zh_2RSFhublHGlEROmJGrWMNqSvodCTz7Q-zBFX7orivddWbwv6veLmlYbo8UY7UbGrXgdaAGLGagYUopmEMrOby4jsE5QInY_JlwWzz_23uJbwmvNT2g100frzPZLJ5Z3s38Ce_CkvA |
| CitedBy_id | crossref_primary_10_1097_CLD_0000000000000215 crossref_primary_10_4174_astr_2023_105_4_219 crossref_primary_10_3350_cmh_2024_0870 crossref_primary_10_3748_wjg_v30_i8_956 crossref_primary_10_1097_JS9_0000000000000688 crossref_primary_10_1016_j_transproceed_2023_03_011 crossref_primary_10_1111_os_14053 crossref_primary_10_23736_S0031_0808_23_04863_2 |
| Cites_doi | 10.1016/j.maturitas.2020.11.009 10.1016/j.jceh.2019.12.003 10.1016/j.maturitas.2016.11.006 10.1016/j.clnu.2017.08.016 10.1002/lt.23970 10.1002/jcsm.12349 10.1016/j.jhep.2010.11.008 10.12659/AOT.909112 10.1111/jgh.12930 10.1016/j.asjsur.2019.10.010 10.1002/jcsm.12276 10.1017/S0029665112000158 10.1111/ajt.12907 10.1016/j.jhep.2021.09.004 10.1111/j.1440-1746.2007.05002.x 10.1016/j.ejso.2020.04.044 10.1002/hep.25551 10.3348/kjr.2018.0479 10.1111/ajt.12221 10.21037/hbsn.2019.11.08 10.1016/j.cgh.2011.08.028 10.3748/wjg.v22.i21.4966 10.1097/TP.0000000000001587 10.1038/nri1937 10.3348/kjr.2019.0470 10.1002/lt.25314 10.1002/lt.23863 10.1002/lt.23752 10.1016/j.jamcollsurg.2010.03.039 10.1097/TP.0000000000002246 10.1002/hep.32268 |
| ContentType | Journal Article |
| Copyright | 2022 American Association for the Study of Liver Diseases. 2022 by the American Association for the Study of Liver Diseases. |
| Copyright_xml | – notice: 2022 American Association for the Study of Liver Diseases. – notice: 2022 by the American Association for the Study of Liver Diseases. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM K9. 7X8 |
| DOI | 10.1002/lt.26447 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1527-6473 |
| EndPage | 1355 |
| ExternalDocumentID | 35243771 10_1002_lt_26447 LT26447 |
| Genre | article Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: Korea Health Industry Development Institute funderid: HI18C2383 |
| GroupedDBID | --- --K .3N .55 .GA .GJ .Y3 05W 0R~ 10A 1B1 1L6 1OC 1~5 24P 31~ 33P 3SF 3WU 4.4 4G. 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5VS 7-5 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAEDT AAESR AAEVG AAHHS AALRI AAOCO AAONW AAQFI AAQXK AASGY AAXRX AAXUO AAZKR ABCQN ABCUV ABEML ABIJN ABJNI ABLJU ABMAC ABPVW ABWVN ABXGK ACAHQ ACCFJ ACCZN ACGFO ACGFS ACLDA ACMXC ACPOU ACRPL ACSCC ACXBN ACXQS ADEOM ADIZJ ADKYN ADMGS ADMUD ADNMO ADOZA ADXAS ADZMN AECAP AEEZP AEGXH AEIMD AENEX AEQDE AEUQT AFBPY AFGKR AFPWT AFUWQ AFZJQ AHMBA AIACR AIURR AIWBW AJAOE AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ATUGU AZBYB AZVAB BAFTC BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DIK DPXWK DR2 DRFUL DRMAN DRSTM DU5 E3Z EBS EJD F00 F01 F04 F5P FD6 FDB FEDTE FGOYB FUBAC G-S G.N GNP GODZA H.X HBH HF~ HHY HHZ HVGLF HZ~ IHE IX1 J0M J5H JPC KBYEO KQQ LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M41 MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NNB NQ- O66 O9- OIG OK1 OVD P2W P2X P2Z P4B P4D PQQKQ Q.N Q11 QB0 QRW R.K R2- RIG ROL RPZ RWI RX1 SEW SSZ SUPJJ TEORI UB1 UHS V2E V8K V9Y W8V W99 WBKPD WHWMO WIH WIJ WIK WIN WJL WOHZO WQJ WRC WVDHM WXI X7M XG1 XV2 ZZTAW ~IA ~WT AAFWJ AAMMB AAYXX ACZKN ADSXY AEFGJ AFNMH AGQPQ AGXDD AHQVU AIDQK AIDYY CITATION MEWTI WXSBR CGR CUY CVF ECM EIF NPM K9. 7X8 |
| ID | FETCH-LOGICAL-c3867-461d0f412750c8b66ac627de8a957245ae86d77e71171a0dc898ebd7877a09f63 |
| IEDL.DBID | DR2 |
| ISSN | 1527-6465 1527-6473 |
| IngestDate | Thu Sep 04 21:55:23 EDT 2025 Wed Aug 13 03:38:26 EDT 2025 Mon Jul 21 06:05:09 EDT 2025 Wed Aug 27 16:26:56 EDT 2025 Thu Apr 24 23:04:38 EDT 2025 Wed Jan 22 16:25:15 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Language | English |
| License | 2022 American Association for the Study of Liver Diseases. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c3867-461d0f412750c8b66ac627de8a957245ae86d77e71171a0dc898ebd7877a09f63 |
| Notes | Funding information This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI18C2383, HI18C0022). This study was also supported by a grant (2022IP0053) from the Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| PMID | 35243771 |
| PQID | 2689568989 |
| PQPubID | 1016400 |
| PageCount | 11 |
| ParticipantIDs | proquest_miscellaneous_2636140997 proquest_journals_2689568989 pubmed_primary_35243771 crossref_citationtrail_10_1002_lt_26447 crossref_primary_10_1002_lt_26447 wiley_primary_10_1002_lt_26447_LT26447 |
| PublicationCentury | 2000 |
| PublicationDate | August 2022 2022-08-00 20220801 |
| PublicationDateYYYYMMDD | 2022-08-01 |
| PublicationDate_xml | – month: 08 year: 2022 text: August 2022 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Philadelphia |
| PublicationTitle | Liver transplantation |
| PublicationTitleAlternate | Liver Transpl |
| PublicationYear | 2022 |
| Publisher | Wolters Kluwer Health, Inc |
| Publisher_xml | – name: Wolters Kluwer Health, Inc |
| References | 2015; 15 2018; 102 2015; 30 2019; 14 2006; 6 2011; 54 2020; 12 2021; 144 2020; 10 2018; 23 2012; 55 2012; 10 2014; 20 2013; 19 2012; 71 2011; 2011 2018; 9 2017; 96 2019; 20 2013; 13 2010; 211 2020; 9 2019; 25 2013; 111 2020; 46 2022; 75 2022; 76 2020; 43 2020; 21 2017; 101 2007; 22 2012; 4 2014; 11 2018; 37 2016; 22 (lt26447-bib-0036-20250824) 2011; 54 (lt26447-bib-0005-20250824) 2014; 20 (lt26447-bib-0027-20250824) 2018; 37 (lt26447-bib-0007-20250824) 2014; 20 (lt26447-bib-0002-20250824) 2021; 144 (lt26447-bib-0029-20250824) 2019; 25 (lt26447-bib-0026-20250824) 2020; 12 (lt26447-bib-0034-20250824) 2015; 30 (lt26447-bib-0023-20250824) 2012; 71 (lt26447-bib-0022-20250824) 2012; 10 (lt26447-bib-0037-20250824) 2015; 15 (lt26447-bib-0019-20250824) 2017; 101 (lt26447-bib-0025-20250824) 2017; 96 (lt26447-bib-0030-20250824) 2018; 9 (lt26447-bib-0009-20250824) 2018; 9 (lt26447-bib-0013-20250824) 2007; 22 (lt26447-bib-0004-20250824) 2020; 43 (lt26447-bib-0024-20250824) 2018; 23 (lt26447-bib-0018-20250824) 2020; 10 (lt26447-bib-0010-20250824) 2020; 21 (lt26447-bib-0033-20250824) 2016; 22 (lt26447-bib-0011-20250824) 2019; 14 (lt26447-bib-0020-20250824) 2006; 6 (lt26447-bib-0017-20250824) 2013; 13 (lt26447-bib-0016-20250824) 2020; 9 (lt26447-bib-0032-20250824) 2018; 102 (lt26447-bib-0028-20250824) 2022; 75 (lt26447-bib-0001-20250824) 2014; 11 (lt26447-bib-0012-20250824) 2019; 20 (lt26447-bib-0015-20250824) 2013; 111 (lt26447-bib-0008-20250824) 2010; 211 (lt26447-bib-0021-20250824) 2012; 4 (lt26447-bib-0035-20250824) 2011; 2011 (lt26447-bib-0003-20250824) 2020; 46 (lt26447-bib-0031-20250824) 2022; 76 (lt26447-bib-0006-20250824) 2013; 19 (lt26447-bib-0014-20250824) 2012; 55 |
| References_xml | – volume: 9 start-page: 183 year: 2020 end-page: 94 article-title: Is there any correlation between liver graft regeneration and recipient's pretransplant skeletal muscle mass? A study in extended left lobe graft living‐donor liver transplantation publication-title: Hepatobiliary Surg Nutr – volume: 2011 year: 2011 article-title: Liver regeneration and aging: a current perspective publication-title: Curr Gerontol Geriatr Res – volume: 102 start-page: 2025 year: 2018 end-page: 32 article-title: Recipient age and mortality after liver transplantation: a population‐based cohort study publication-title: Transplantation – volume: 96 start-page: 10 year: 2017 end-page: 5 article-title: Inflammation and sarcopenia: a systematic review and meta‐analysis publication-title: Maturitas – volume: 75 start-page: 1471 year: 2022 article-title: Frailty, mortality, and health care utilization after liver transplantation: from the Multicenter Functional Assessment in Liver Transplantation (FrAILT) study publication-title: Hepatology – volume: 144 start-page: 102 year: 2021 end-page: 7 article-title: Frailty and sarcopenia in combination are more predictive of mortality than either condition alone publication-title: Maturitas – volume: 111 start-page: i71 issue: Suppl 1 year: 2013 end-page: 82 article-title: Update on massive transfusion publication-title: Br J Anaesth – volume: 11 start-page: 177 year: 2014 end-page: 80 article-title: Clinical definition of sarcopenia publication-title: Clin Cases Miner Bone Metab – volume: 20 start-page: 1413 year: 2014 end-page: 9 article-title: Impact of quality as well as quantity of skeletal muscle on outcomes after liver transplantation publication-title: Liver Transpl – volume: 54 start-page: 1297 year: 2011 end-page: 306 article-title: The MELD score in patients awaiting liver transplant: strengths and weaknesses publication-title: J Hepatol – volume: 25 start-page: 45 year: 2019 end-page: 55 article-title: Relationship between total body protein and cross‐sectional skeletal muscle area in liver cirrhosis is influenced by overhydration publication-title: Liver Transpl – volume: 13 start-page: 1549 year: 2013 end-page: 56 article-title: Impact of sarcopenia on survival in patients undergoing living donor liver transplantation publication-title: Am J Transplant – volume: 6 start-page: 772 year: 2006 end-page: 83 article-title: Adipocytokines: mediators linking adipose tissue, inflammation and immunity publication-title: Nat Rev Immunol – volume: 76 start-page: 983 year: 2022 article-title: Sarcopenia should be evaluated in patients with acute‐on‐chronic liver failure and candidates to liver transplantation publication-title: J Hepatol – volume: 20 start-page: 205 year: 2019 end-page: 17 article-title: Recent issues on body composition imaging for sarcopenia evaluation publication-title: Korean J Radiol – volume: 43 start-page: 647 year: 2020 end-page: 53 article-title: Impact of sarcopenia in trauma and surgical patient population: a literature review publication-title: Asian J Surg – volume: 14 year: 2019 article-title: Reliable and robust method for abdominal muscle mass quantification using CT/MRI: an explorative study in healthy subjects publication-title: PLoS One – volume: 55 start-page: 965 year: 2012 end-page: 7 article-title: Introduction to the revised American Association for the Study of Liver Diseases position paper on acute liver failure 2011 publication-title: Hepatology – volume: 9 start-page: 1053 year: 2018 end-page: 62 article-title: Poor performance of psoas muscle index for identification of patients with higher waitlist mortality risk in cirrhosis publication-title: J Cachexia Sarcopenia Muscle – volume: 37 start-page: 1121 year: 2018 end-page: 32 article-title: Does nutrition play a role in the prevention and management of sarcopenia? publication-title: Clin Nutr – volume: 71 start-page: 298 year: 2012 end-page: 306 article-title: The impact of obesity on the immune response to infection publication-title: Proc Nutr Soc – volume: 211 start-page: 271 year: 2010 end-page: 8 article-title: Sarcopenia and mortality after liver transplantation publication-title: J Am Coll Surg – volume: 21 start-page: 88 year: 2020 end-page: 100 article-title: Development and validation of a deep learning system for segmentation of abdominal muscle and fat on computed tomography publication-title: Korean J Radiol – volume: 10 start-page: 166 year: 2012 end-page: 73.e161 article-title: Muscle wasting is associated with mortality in patients with cirrhosis publication-title: Clin Gastroenterol Hepatol – volume: 12 year: 2020 article-title: Nutritional supplements to support resistance exercise in countering the sarcopenia of aging publication-title: Nutrients – volume: 101 start-page: 565 year: 2017 end-page: 74 article-title: Impact of skeletal muscle mass index, intramuscular adipose tissue content, and visceral to subcutaneous adipose tissue area ratio on early mortality of living donor liver transplantation publication-title: Transplantation – volume: 22 start-page: 4966 year: 2016 end-page: 76 article-title: How important is donor age in liver transplantation? publication-title: World J Gastroenterol – volume: 20 start-page: 640 year: 2014 end-page: 8 article-title: Severe muscle depletion predicts postoperative length of stay but is not associated with survival after liver transplantation publication-title: Liver Transpl – volume: 4 start-page: 535 year: 2012 end-page: 46 article-title: Sarcopenia, obesity, and natural killer cell immune senescence in aging: altered cytokine levels as a common mechanism publication-title: Aging (Albany NY) – volume: 19 start-page: 1396 year: 2013 end-page: 402 article-title: Association between sarcopenia and the risk of serious infection among adults undergoing liver transplantation publication-title: Liver Transpl – volume: 9 start-page: 246 year: 2018 end-page: 54 article-title: Proposal for new selection criteria considering pre‐transplant muscularity and visceral adiposity in living donor liver transplantation publication-title: J Cachexia Sarcopenia Muscle – volume: 10 start-page: 467 year: 2020 end-page: 76 article-title: Sarcopenia in cirrhosis: fallout on liver transplantation publication-title: J Clin Exp Hepatol – volume: 22 start-page: 775 year: 2007 end-page: 7 article-title: Guidelines for the assessment and management of non‐alcoholic fatty liver disease in the Asia‐Pacific region: executive summary publication-title: J Gastroenterol Hepatol – volume: 23 start-page: 481 year: 2018 end-page: 90 article-title: Graft regeneration and functional recovery in patients with early allograft dysfunction after living‐donor liver transplantation publication-title: Ann Transplant – volume: 46 start-page: 1963 year: 2020 end-page: 70 article-title: Poor nutritional status and sarcopenia influences survival outcomes in gastric carcinoma patients undergoing radical surgery publication-title: Eur J Surg Oncol – volume: 30 start-page: 1217 year: 2015 end-page: 24 article-title: Dysfunction of liver regeneration in aged liver after partial hepatectomy publication-title: J Gastroenterol Hepatol – volume: 15 start-page: 17 year: 2015 end-page: 38 article-title: A complete treatment of adult living donor liver transplantation: a review of surgical technique and current challenges to expand indication of patients publication-title: Am J Transplant – volume: 144 start-page: 102 year: 2021 ident: lt26447-bib-0002-20250824 article-title: Frailty and sarcopenia in combination are more predictive of mortality than either condition alone publication-title: Maturitas doi: 10.1016/j.maturitas.2020.11.009 – volume: 2011 year: 2011 ident: lt26447-bib-0035-20250824 article-title: Liver regeneration and aging: a current perspective publication-title: Curr Gerontol Geriatr Res – volume: 14 year: 2019 ident: lt26447-bib-0011-20250824 article-title: Reliable and robust method for abdominal muscle mass quantification using CT/MRI: an explorative study in healthy subjects publication-title: PLoS One – volume: 10 start-page: 467 year: 2020 ident: lt26447-bib-0018-20250824 article-title: Sarcopenia in cirrhosis: fallout on liver transplantation publication-title: J Clin Exp Hepatol doi: 10.1016/j.jceh.2019.12.003 – volume: 96 start-page: 10 year: 2017 ident: lt26447-bib-0025-20250824 article-title: Inflammation and sarcopenia: a systematic review and meta‐analysis publication-title: Maturitas doi: 10.1016/j.maturitas.2016.11.006 – volume: 37 start-page: 1121 year: 2018 ident: lt26447-bib-0027-20250824 article-title: Does nutrition play a role in the prevention and management of sarcopenia? publication-title: Clin Nutr doi: 10.1016/j.clnu.2017.08.016 – volume: 20 start-page: 1413 year: 2014 ident: lt26447-bib-0007-20250824 article-title: Impact of quality as well as quantity of skeletal muscle on outcomes after liver transplantation publication-title: Liver Transpl doi: 10.1002/lt.23970 – volume: 9 start-page: 1053 year: 2018 ident: lt26447-bib-0030-20250824 article-title: Poor performance of psoas muscle index for identification of patients with higher waitlist mortality risk in cirrhosis publication-title: J Cachexia Sarcopenia Muscle doi: 10.1002/jcsm.12349 – volume: 54 start-page: 1297 year: 2011 ident: lt26447-bib-0036-20250824 article-title: The MELD score in patients awaiting liver transplant: strengths and weaknesses publication-title: J Hepatol doi: 10.1016/j.jhep.2010.11.008 – volume: 23 start-page: 481 year: 2018 ident: lt26447-bib-0024-20250824 article-title: Graft regeneration and functional recovery in patients with early allograft dysfunction after living‐donor liver transplantation publication-title: Ann Transplant doi: 10.12659/AOT.909112 – volume: 30 start-page: 1217 year: 2015 ident: lt26447-bib-0034-20250824 article-title: Dysfunction of liver regeneration in aged liver after partial hepatectomy publication-title: J Gastroenterol Hepatol doi: 10.1111/jgh.12930 – volume: 43 start-page: 647 year: 2020 ident: lt26447-bib-0004-20250824 article-title: Impact of sarcopenia in trauma and surgical patient population: a literature review publication-title: Asian J Surg doi: 10.1016/j.asjsur.2019.10.010 – volume: 9 start-page: 246 year: 2018 ident: lt26447-bib-0009-20250824 article-title: Proposal for new selection criteria considering pre‐transplant muscularity and visceral adiposity in living donor liver transplantation publication-title: J Cachexia Sarcopenia Muscle doi: 10.1002/jcsm.12276 – volume: 71 start-page: 298 year: 2012 ident: lt26447-bib-0023-20250824 article-title: The impact of obesity on the immune response to infection publication-title: Proc Nutr Soc doi: 10.1017/S0029665112000158 – volume: 15 start-page: 17 year: 2015 ident: lt26447-bib-0037-20250824 article-title: A complete treatment of adult living donor liver transplantation: a review of surgical technique and current challenges to expand indication of patients publication-title: Am J Transplant doi: 10.1111/ajt.12907 – volume: 76 start-page: 983 year: 2022 ident: lt26447-bib-0031-20250824 article-title: Sarcopenia should be evaluated in patients with acute‐on‐chronic liver failure and candidates to liver transplantation publication-title: J Hepatol doi: 10.1016/j.jhep.2021.09.004 – volume: 4 start-page: 535 year: 2012 ident: lt26447-bib-0021-20250824 article-title: Sarcopenia, obesity, and natural killer cell immune senescence in aging: altered cytokine levels as a common mechanism publication-title: Aging (Albany NY) – volume: 22 start-page: 775 year: 2007 ident: lt26447-bib-0013-20250824 article-title: Guidelines for the assessment and management of non‐alcoholic fatty liver disease in the Asia‐Pacific region: executive summary publication-title: J Gastroenterol Hepatol doi: 10.1111/j.1440-1746.2007.05002.x – volume: 46 start-page: 1963 year: 2020 ident: lt26447-bib-0003-20250824 article-title: Poor nutritional status and sarcopenia influences survival outcomes in gastric carcinoma patients undergoing radical surgery publication-title: Eur J Surg Oncol doi: 10.1016/j.ejso.2020.04.044 – volume: 55 start-page: 965 year: 2012 ident: lt26447-bib-0014-20250824 article-title: Introduction to the revised American Association for the Study of Liver Diseases position paper on acute liver failure 2011 publication-title: Hepatology doi: 10.1002/hep.25551 – volume: 20 start-page: 205 year: 2019 ident: lt26447-bib-0012-20250824 article-title: Recent issues on body composition imaging for sarcopenia evaluation publication-title: Korean J Radiol doi: 10.3348/kjr.2018.0479 – volume: 11 start-page: 177 year: 2014 ident: lt26447-bib-0001-20250824 article-title: Clinical definition of sarcopenia publication-title: Clin Cases Miner Bone Metab – volume: 13 start-page: 1549 year: 2013 ident: lt26447-bib-0017-20250824 article-title: Impact of sarcopenia on survival in patients undergoing living donor liver transplantation publication-title: Am J Transplant doi: 10.1111/ajt.12221 – volume: 9 start-page: 183 year: 2020 ident: lt26447-bib-0016-20250824 article-title: Is there any correlation between liver graft regeneration and recipient's pretransplant skeletal muscle mass? A study in extended left lobe graft living‐donor liver transplantation publication-title: Hepatobiliary Surg Nutr doi: 10.21037/hbsn.2019.11.08 – volume: 10 start-page: 166 year: 2012 ident: lt26447-bib-0022-20250824 article-title: Muscle wasting is associated with mortality in patients with cirrhosis publication-title: Clin Gastroenterol Hepatol doi: 10.1016/j.cgh.2011.08.028 – volume: 22 start-page: 4966 year: 2016 ident: lt26447-bib-0033-20250824 article-title: How important is donor age in liver transplantation? publication-title: World J Gastroenterol doi: 10.3748/wjg.v22.i21.4966 – volume: 101 start-page: 565 year: 2017 ident: lt26447-bib-0019-20250824 article-title: Impact of skeletal muscle mass index, intramuscular adipose tissue content, and visceral to subcutaneous adipose tissue area ratio on early mortality of living donor liver transplantation publication-title: Transplantation doi: 10.1097/TP.0000000000001587 – volume: 6 start-page: 772 year: 2006 ident: lt26447-bib-0020-20250824 article-title: Adipocytokines: mediators linking adipose tissue, inflammation and immunity publication-title: Nat Rev Immunol doi: 10.1038/nri1937 – volume: 21 start-page: 88 year: 2020 ident: lt26447-bib-0010-20250824 article-title: Development and validation of a deep learning system for segmentation of abdominal muscle and fat on computed tomography publication-title: Korean J Radiol doi: 10.3348/kjr.2019.0470 – volume: 25 start-page: 45 year: 2019 ident: lt26447-bib-0029-20250824 article-title: Relationship between total body protein and cross‐sectional skeletal muscle area in liver cirrhosis is influenced by overhydration publication-title: Liver Transpl doi: 10.1002/lt.25314 – volume: 111 start-page: i71 issue: Suppl 1 year: 2013 ident: lt26447-bib-0015-20250824 article-title: Update on massive transfusion publication-title: Br J Anaesth – volume: 20 start-page: 640 year: 2014 ident: lt26447-bib-0005-20250824 article-title: Severe muscle depletion predicts postoperative length of stay but is not associated with survival after liver transplantation publication-title: Liver Transpl doi: 10.1002/lt.23863 – volume: 19 start-page: 1396 year: 2013 ident: lt26447-bib-0006-20250824 article-title: Association between sarcopenia and the risk of serious infection among adults undergoing liver transplantation publication-title: Liver Transpl doi: 10.1002/lt.23752 – volume: 211 start-page: 271 year: 2010 ident: lt26447-bib-0008-20250824 article-title: Sarcopenia and mortality after liver transplantation publication-title: J Am Coll Surg doi: 10.1016/j.jamcollsurg.2010.03.039 – volume: 102 start-page: 2025 year: 2018 ident: lt26447-bib-0032-20250824 article-title: Recipient age and mortality after liver transplantation: a population‐based cohort study publication-title: Transplantation doi: 10.1097/TP.0000000000002246 – volume: 12 year: 2020 ident: lt26447-bib-0026-20250824 article-title: Nutritional supplements to support resistance exercise in countering the sarcopenia of aging publication-title: Nutrients – volume: 75 start-page: 1471 year: 2022 ident: lt26447-bib-0028-20250824 article-title: Frailty, mortality, and health care utilization after liver transplantation: from the Multicenter Functional Assessment in Liver Transplantation (FrAILT) study publication-title: Hepatology doi: 10.1002/hep.32268 |
| SSID | ssj0011590 |
| Score | 2.437344 |
| Snippet | Recent studies have reported that sarcopenia influences morbidity and mortality in surgical patients. However, few studies have investigated the associations... |
| SourceID | proquest pubmed crossref wiley |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1345 |
| SubjectTerms | Graft rejection Graft Survival Grafts Humans Liver transplantation Liver Transplantation - adverse effects Liver transplants Living Donors Morbidity Mortality Retrospective Studies Sarcopenia Sarcopenia - complications Sarcopenia - epidemiology Treatment Outcome |
| Title | Associations of sarcopenia with graft failure and mortality in patients undergoing living donor liver transplantation |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Flt.26447 https://www.ncbi.nlm.nih.gov/pubmed/35243771 https://www.proquest.com/docview/2689568989 https://www.proquest.com/docview/2636140997 |
| Volume | 28 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVBFR databaseName: Free Medical Journals - Free Access to All customDbUrl: eissn: 1527-6473 dateEnd: 20240930 omitProxy: true ssIdentifier: ssj0011590 issn: 1527-6465 databaseCode: DIK dateStart: 19950101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVWIB databaseName: Wiley Online Library - Core collection (SURFmarket) issn: 1527-6465 databaseCode: DR2 dateStart: 19950101 customDbUrl: isFulltext: true eissn: 1527-6473 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0011590 providerName: Wiley-Blackwell |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Ja90wEBYhh5JLuiRpX_taFCjNyS9eZC3HUhJCSHIICQRyMGNJDo-6drH9Lv311chLdgg5GWMttjWj-RjNfEPIdwUm1c6yBtJyCBiEYSCToggkMNCMCa58utjpGT-6ZMdX6dUQVYm5MD0_xORwQ83w-zUqOOTt_i1paNkt0JhjInmUpP6E9nxijnI4x7tXsGhrwBlPR97ZMN4fO963RI_g5X206s3N4VtyPb5oH2Xye7Hq8oX-94DD8XVf8o5sDiiU_uzF5j1Zs9UH8uZ0OGffIqs7q9bSuqCt0wcstLUEip5betNA0dEClhjVTqEy9I_H8Q7T02VFB7bWlmKKWnNTO_tIyyX6Lqipq7rBG9vQzjOrl9CnP1Xb5PLw4OLXUTAUaAh0IpEvnUcmLJjniNcy5xw0j4WxElQqYpaCldwIYUUUiQhCo6WSNjdujxAQqoInO2S9qiv7idDc9ZBGO_yTW6YSJ0IxAMeKOG4Cw-WM7I2LlemBvRyLaJRZz7scZ2WX-b84I7tTy789Y8cTbebjemeDzrbuicTcSSWVG2J67LQNj1CgsvUK2yQcKcKUG-JjLyfTJA7KskSIaEZ--NV-dvbs5MJfP7-04ReyEWPWhY87nJP1rlnZrw4Ldfk3L_X_AcQSBbM |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VIgEX3oWFAkZCcMo2D8d2xAkB1QK7PaCt1ANSNLGdakVIUDZ74dfjcR5QHhLiFEUZ20nG4_k09nwD8CxDk2rnWQNlBQYcwzBQSVkGCjlqzqXIfLrY6kQsTvn7s_RsD16OuTA9P8QUcCPL8Os1GTgFpI9-sIZW3Zy8ubwEl2l7jqzyzceJO8ohHR9gobKtgeAiHZlnw_hobHnRF_0GMC_iVe9wjm_Ap_FV-3Mmn-e7rpjrb7-wOP7nt9yE6wMQZa_6mXML9mx9G66shq32O7D7SXFb1pRs60yCam1tkFHwlp23WHasxA0dbGdYG_bFQ3kH69mmZgNh65ZRllp73jgXyaoNhS-YaeqmpRvbss6Tq1fYZ0DVd-H0-O369SIYajQEOlFEmS4iE5bc08RrVQiBWsTSWIVZKmOeolXCSGllFMkIQ6NVpmxh3DIhMcxKkRzAft3U9j6wwrVQRjsIVFieJW4WxYiCiuK4AYxQM3gxaivXA4E51dGo8p56Oc6rLvd_cQZPJ8mvPWnHH2QOR4Xng9lu3RNF6ZOZylwX02NncLSLgrVtdiSTCGIJy1wX9_qJMg3i0CxPpIxm8Nyr-6-j58u1vz74V8EncHWxXi3z5buTDw_hWkxJGP4Y4iHsd-3OPnLQqCseexP4DhEVCc8 |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1JT90wELYoSKgXoBt9FFpXqtpTHlkcL8cK-gQtoKoCCamHaGI76KkhQXl5F349Hmdp6SJVnKLIW5LxeL6MPd8Q8k6BSbWzrIG0HAIGYRjIpCgCCQw0Y4IrHy52esaPLtjny_SyP1WJsTAdP8TocEPN8Os1KviNKfZ_koaW7RSNuXhE1hh3P1cIiL6N1FEO6Hj_CmZtDTjj6UA8G8b7Q8v7pugPfHkfrnp7M9sk34cn7Y6Z_Jgu23yqb38jcXzYq2yRjR6G0o_dvHlCVmz1lKyf9hvtz8jyF7EtaF3QhVMIzLQ1B4quW3rVQNHSAuZ4rJ1CZei1B_IO1NN5RXu61gXFGLXmqnYGkpZzdF5QU1d1gze2oa2nVi-hi3-qnpOL2afzg6Ogz9AQ6EQiYTqPTFgwTxKvZc45aB4LYyWoVMQsBSu5EcKKKBIRhEZLJW1u3CIhIFQFT16Q1aqu7EtCc9dCGu0AUG6ZStwcigE4psRxAxguJ-TDIKxM9_TlmEWjzDri5Tgr28x_xQl5O9a86Sg7_lJnd5B31ivtwpVIDJ5UUrkuxmKnbriHApWtl1gn4cgRplwX2908GQdxWJYlQkQT8t5L-5-jZyfn_rrzvxXfkPWvh7Ps5PjsyyvyOMYIDH8GcZests3S7jlc1OavvQLcAfNwCH4 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Associations+of+sarcopenia+with+graft+failure+and+mortality+in+patients+undergoing+living+donor+liver+transplantation&rft.jtitle=Liver+transplantation&rft.au=Sim%2C+Ji%E2%80%90Hoon&rft.au=Kwon%2C+Hye%E2%80%90Mee&rft.au=Kim%2C+Kyung%E2%80%90Won&rft.au=Ko%2C+You%E2%80%90Sun&rft.date=2022-08-01&rft.issn=1527-6465&rft.eissn=1527-6473&rft.volume=28&rft.issue=8&rft.spage=1345&rft.epage=1355&rft_id=info:doi/10.1002%2Flt.26447&rft.externalDBID=10.1002%252Flt.26447&rft.externalDocID=LT26447 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1527-6465&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1527-6465&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1527-6465&client=summon |