Inhibition of the Ras oncoprotein reduces proliferation of hepatocytes in vitro and in vivo in rats - da Silva Morais, Alain; Saliez, Alain; Leclercq, Isabelle; Horsmans, Yves; Stärkel, Peter (Clinical science (1979), 2008)
Keywords: Animals; Biological and medical sciences; Body Mass Index; Cell Cycle Proteins - metabolism; Cell Membrane - metabolism; Cell Proliferation - drug effects; Cyclin-Dependent Kinase Inhibitor Proteins - biosynthesis; Cytosol - metabolism; Farnesol - analogs & derivatives; Farnesol - pharmacology; Gastroenterology. Liver. Pancreas. Abdomen; Gene Expression Regulation; General aspects; Hepatectomy; Hepatocytes - drug effects; Hepatocytes - metabolism; Hepatocytes - pathology; Humans; Liver - pathology; Liver Neoplasms, Experimental - pathology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; MAP Kinase Signaling System - drug effects; Medical sciences; Oncogene Protein p21(ras) - antagonists & inhibitors; Oncogene Protein p21(ras) - metabolism; Organ Size - drug effects; Proliferating Cell Nuclear Antigen - metabolism; Rats; Rats, Wistar; RNA, Messenger; Salicylates - pharmacology; Tumor Cells, Cultured; Tumors; Cell proliferation; Rat; Ras; Liver; Hepatic disease; Hepatocellular carcinoma; Hepatectomy; Liver cancer; Hepatocyte; Partial; Surgery; Cell cycle; Inhibition; Protooncogene; partial hepatectomy; Enzyme; S-farnesylthiosalicylic acid (FTS); Transferases; Rodentia; Mitogen-activated protein kinase; mitogen-activated protein kinase (MAPK); Malignant tumor; Serum thymic factor; In vitro; Medicine; In vivo; Vertebrata; Mammalia; Treatment; Acids; Animal; C-Onc gene; Oncoprotein; Digestive diseases; Inhibitor; Onc gene; Cancer