Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain - He, Yingfang; Grether, Uwe; Taddio, Marco F.; Meier, Carla; Keller, Claudia; Edelmann, Martin R.; Honer, Michael; Huber, Sylwia; Wittwer, Matthias B.; Heer, Dominik; Richter, Hans; Collin, Ludovic; et al. (European journal of medicinal chemistry, 2022)
Keywords: Brain imaging; Chemistry, Medicinal; Life Sciences & Biomedicine; MAGL; Morpholin-3-one derivatives; PET tracer; Pharmacology & Pharmacy; Science & Technology; Structural optimization; MAGL; Brain imaging; PET tracer; Structural optimization; Morpholin-3-one derivatives; CENTRAL-NERVOUS-SYSTEM; DISCOVERY