The PCSK9 gene R46L variant is associated with lower plasma lipid levels and cardiovascular risk in healthy U.K. men - Scartezini, Marileia; Hubbart, Christina; Whittall, Ros A.; Cooper, Jackie A.; Neil, Andrew H. W.; Humphries, Steve E. (Clinical science (1979), 2007)
Keywords: Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cholesterol - blood; Cholesterol, LDL - blood; Coronary Disease - blood; Coronary Disease - genetics; Female; Gene Frequency; General aspects; Genetic Predisposition to Disease; Genotype; Humans; Hyperlipoproteinemia Type II - genetics; Lipids - blood; Male; Medical sciences; Middle Aged; Polymorphism, Genetic; Proprotein Convertase 9; Proprotein Convertases; Risk Factors; Serine Endopeptidases - genetics; Genetic variability; apolipoprotein B (ApoB); Lipids; Male; Cardiovascular disease; Hyperlipoproteinemia; total cholesterol; Blood plasma; Vascular disease; Apolipoprotein B; Lipoprotein LDL; Association; Lipemia; Gene; Atherosclerosis; Adult; Genetics; Dyslipemia; Human; Serine endopeptidases; Healthy subject; Enzyme; Metabolic diseases; Cholesterol LDL; Genotype; Subtilisin; Coronary heart disease; Protein; Genetic disease; Variant; low-density lipoprotein cholesterol (LDL-C); Peptidases; Hypercholesterolemia; Kexin; familial hypercholesterolaemia; protein convertase subtilisin/kexin type 9 gene (PCSK9); Risk factor; Cardiovascular risk; Hydrolases; Medicine