Protein engineering via Bayesian optimization-guided evolutionary algorithm and robotic experiments - Hu, Ruyun; Fu, Lihao; Chen, Yongcan; Chen, Junyu; Qiao, Yu; Si, Tong (Briefings in bioinformatics, 2023)
Keywords: Algorithms; Bayes Theorem; Bayesian analysis; Biological Evolution; Biosurfactants; Combinatorial analysis; Congeners; Cycle protein; Design specifications; Directed evolution; E coli; Enzymes; Epistasis; Evolutionary algorithms; Gene sequencing; Humans; Kinases; Learning algorithms; Machine learning; Mutagenesis; Mutants; Optimization; Protein Engineering; Protein folding; Protein G; Proteins; Proteins - genetics; Rhamnolipids; Robot learning; Robotics; Screening; adaptive experimental design; Bayesian optimization; machine learning; evolutionary algorithm; directed evolution