Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery

The Open Targets Platform (https://platform.opentargets.org) is a unique, open-source, publicly-available knowledge base providing data and tooling for systematic drug target identification, annotation, and prioritisation. Since our last report, we have expanded the scope of the Platform through a n...

Full description

Saved in:
Bibliographic Details
Published inNucleic acids research Vol. 53; no. D1; pp. D1467 - D1475
Main Authors Buniello, Annalisa, Suveges, Daniel, Cruz-Castillo, Carlos, Llinares, Manuel Bernal, Cornu, Helena, Lopez, Irene, Tsukanov, Kirill, Roldán-Romero, Juan María, Mehta, Chintan, Fumis, Luca, McNeill, Graham, Hayhurst, James D, Martinez Osorio, Ricardo Esteban, Barkhordari, Ehsan, Ferrer, Javier, Carmona, Miguel, Uniyal, Prashant, Falaguera, Maria J, Rusina, Polina, Smit, Ines, Schwartzentruber, Jeremy, Alegbe, Tobi, Ho, Vivien W, Considine, Daniel, Ge, Xiangyu, Szyszkowski, Szymon, Tsepilov, Yakov, Ghoussaini, Maya, Dunham, Ian, Hulcoop, David G, McDonagh, Ellen M, Ochoa, David
Format Journal Article
LanguageEnglish
Published England Oxford University Press 06.01.2025
Subjects
Database Issue
Drug Discovery
Humans
Internet
Knowledge Bases
Software
Online AccessGet full text
ISSN0305-1048
1362-4962
1362-4962
DOI10.1093/nar/gkae1128

Cover

Abstract The Open Targets Platform (https://platform.opentargets.org) is a unique, open-source, publicly-available knowledge base providing data and tooling for systematic drug target identification, annotation, and prioritisation. Since our last report, we have expanded the scope of the Platform through a number of significant enhancements and data updates, with the aim to enable our users to formulate more flexible and impactful therapeutic hypotheses. In this context, we have completely revamped our target–disease associations page with more interactive facets and built-in functionalities to empower users with additional control over their experience using the Platform, and added a new Target Prioritisation view. This enables users to prioritise targets based upon clinical precedence, tractability, doability and safety attributes. We have also implemented a direction of effect assessment for eight sources of target–disease association evidence, showing the effect of genetic variation on the function of a target is associated with risk or protection for a trait to inform on potential mechanisms of modulation suitable for disease treatment. These enhancements and the introduction of new back and front-end technologies to support them have increased the impact and usability of our resource within the drug discovery community.
AbstractList The Open Targets Platform (https://platform.opentargets.org) is a unique, open-source, publicly-available knowledge base providing data and tooling for systematic drug target identification, annotation, and prioritisation. Since our last report, we have expanded the scope of the Platform through a number of significant enhancements and data updates, with the aim to enable our users to formulate more flexible and impactful therapeutic hypotheses. In this context, we have completely revamped our target-disease associations page with more interactive facets and built-in functionalities to empower users with additional control over their experience using the Platform, and added a new Target Prioritisation view. This enables users to prioritise targets based upon clinical precedence, tractability, doability and safety attributes. We have also implemented a direction of effect assessment for eight sources of target-disease association evidence, showing the effect of genetic variation on the function of a target is associated with risk or protection for a trait to inform on potential mechanisms of modulation suitable for disease treatment. These enhancements and the introduction of new back and front-end technologies to support them have increased the impact and usability of our resource within the drug discovery community.The Open Targets Platform (https://platform.opentargets.org) is a unique, open-source, publicly-available knowledge base providing data and tooling for systematic drug target identification, annotation, and prioritisation. Since our last report, we have expanded the scope of the Platform through a number of significant enhancements and data updates, with the aim to enable our users to formulate more flexible and impactful therapeutic hypotheses. In this context, we have completely revamped our target-disease associations page with more interactive facets and built-in functionalities to empower users with additional control over their experience using the Platform, and added a new Target Prioritisation view. This enables users to prioritise targets based upon clinical precedence, tractability, doability and safety attributes. We have also implemented a direction of effect assessment for eight sources of target-disease association evidence, showing the effect of genetic variation on the function of a target is associated with risk or protection for a trait to inform on potential mechanisms of modulation suitable for disease treatment. These enhancements and the introduction of new back and front-end technologies to support them have increased the impact and usability of our resource within the drug discovery community.
The Open Targets Platform ( https://platform.opentargets.org ) is a unique, open-source, publicly-available knowledge base providing data and tooling for systematic drug target identification, annotation, and prioritisation. Since our last report, we have expanded the scope of the Platform through a number of significant enhancements and data updates, with the aim to enable our users to formulate more flexible and impactful therapeutic hypotheses. In this context, we have completely revamped our target–disease associations page with more interactive facets and built-in functionalities to empower users with additional control over their experience using the Platform, and added a new Target Prioritisation view. This enables users to prioritise targets based upon clinical precedence, tractability, doability and safety attributes. We have also implemented a direction of effect assessment for eight sources of target–disease association evidence, showing the effect of genetic variation on the function of a target is associated with risk or protection for a trait to inform on potential mechanisms of modulation suitable for disease treatment. These enhancements and the introduction of new back and front-end technologies to support them have increased the impact and usability of our resource within the drug discovery community. Graphical Abstract
The Open Targets Platform (https://platform.opentargets.org) is a unique, open-source, publicly-available knowledge base providing data and tooling for systematic drug target identification, annotation, and prioritisation. Since our last report, we have expanded the scope of the Platform through a number of significant enhancements and data updates, with the aim to enable our users to formulate more flexible and impactful therapeutic hypotheses. In this context, we have completely revamped our target-disease associations page with more interactive facets and built-in functionalities to empower users with additional control over their experience using the Platform, and added a new Target Prioritisation view. This enables users to prioritise targets based upon clinical precedence, tractability, doability and safety attributes. We have also implemented a direction of effect assessment for eight sources of target-disease association evidence, showing the effect of genetic variation on the function of a target is associated with risk or protection for a trait to inform on potential mechanisms of modulation suitable for disease treatment. These enhancements and the introduction of new back and front-end technologies to support them have increased the impact and usability of our resource within the drug discovery community.
Author Fumis, Luca
Buniello, Annalisa
Falaguera, Maria J
Schwartzentruber, Jeremy
Cruz-Castillo, Carlos
Tsukanov, Kirill
McNeill, Graham
Considine, Daniel
Szyszkowski, Szymon
Barkhordari, Ehsan
Smit, Ines
Uniyal, Prashant
McDonagh, Ellen M
Dunham, Ian
Mehta, Chintan
Lopez, Irene
Ghoussaini, Maya
Alegbe, Tobi
Hayhurst, James D
Tsepilov, Yakov
Ochoa, David
Suveges, Daniel
Llinares, Manuel Bernal
Cornu, Helena
Ho, Vivien W
Roldán-Romero, Juan María
Ge, Xiangyu
Hulcoop, David G
Ferrer, Javier
Martinez Osorio, Ricardo Esteban
Rusina, Polina
Carmona, Miguel
Author_xml – sequence: 1
  givenname: Annalisa
  orcidid: 0000-0002-4623-8642
  surname: Buniello
  fullname: Buniello, Annalisa
– sequence: 2
  givenname: Daniel
  surname: Suveges
  fullname: Suveges, Daniel
– sequence: 3
  givenname: Carlos
  surname: Cruz-Castillo
  fullname: Cruz-Castillo, Carlos
– sequence: 4
  givenname: Manuel Bernal
  orcidid: 0000-0002-7368-180X
  surname: Llinares
  fullname: Llinares, Manuel Bernal
– sequence: 5
  givenname: Helena
  surname: Cornu
  fullname: Cornu, Helena
– sequence: 6
  givenname: Irene
  surname: Lopez
  fullname: Lopez, Irene
– sequence: 7
  givenname: Kirill
  surname: Tsukanov
  fullname: Tsukanov, Kirill
– sequence: 8
  givenname: Juan María
  surname: Roldán-Romero
  fullname: Roldán-Romero, Juan María
– sequence: 9
  givenname: Chintan
  surname: Mehta
  fullname: Mehta, Chintan
– sequence: 10
  givenname: Luca
  surname: Fumis
  fullname: Fumis, Luca
– sequence: 11
  givenname: Graham
  surname: McNeill
  fullname: McNeill, Graham
– sequence: 12
  givenname: James D
  surname: Hayhurst
  fullname: Hayhurst, James D
– sequence: 13
  givenname: Ricardo Esteban
  surname: Martinez Osorio
  fullname: Martinez Osorio, Ricardo Esteban
– sequence: 14
  givenname: Ehsan
  surname: Barkhordari
  fullname: Barkhordari, Ehsan
– sequence: 15
  givenname: Javier
  surname: Ferrer
  fullname: Ferrer, Javier
– sequence: 16
  givenname: Miguel
  surname: Carmona
  fullname: Carmona, Miguel
– sequence: 17
  givenname: Prashant
  surname: Uniyal
  fullname: Uniyal, Prashant
– sequence: 18
  givenname: Maria J
  surname: Falaguera
  fullname: Falaguera, Maria J
– sequence: 19
  givenname: Polina
  surname: Rusina
  fullname: Rusina, Polina
– sequence: 20
  givenname: Ines
  surname: Smit
  fullname: Smit, Ines
– sequence: 21
  givenname: Jeremy
  surname: Schwartzentruber
  fullname: Schwartzentruber, Jeremy
– sequence: 22
  givenname: Tobi
  surname: Alegbe
  fullname: Alegbe, Tobi
– sequence: 23
  givenname: Vivien W
  surname: Ho
  fullname: Ho, Vivien W
– sequence: 24
  givenname: Daniel
  surname: Considine
  fullname: Considine, Daniel
– sequence: 25
  givenname: Xiangyu
  surname: Ge
  fullname: Ge, Xiangyu
– sequence: 26
  givenname: Szymon
  surname: Szyszkowski
  fullname: Szyszkowski, Szymon
– sequence: 27
  givenname: Yakov
  surname: Tsepilov
  fullname: Tsepilov, Yakov
– sequence: 28
  givenname: Maya
  surname: Ghoussaini
  fullname: Ghoussaini, Maya
– sequence: 29
  givenname: Ian
  orcidid: 0000-0003-2525-5598
  surname: Dunham
  fullname: Dunham, Ian
– sequence: 30
  givenname: David G
  surname: Hulcoop
  fullname: Hulcoop, David G
– sequence: 31
  givenname: Ellen M
  orcidid: 0000-0001-5806-6174
  surname: McDonagh
  fullname: McDonagh, Ellen M
– sequence: 32
  givenname: David
  orcidid: 0000-0003-1857-278X
  surname: Ochoa
  fullname: Ochoa, David
BackLink https://www.ncbi.nlm.nih.gov/pubmed/39657122$$D View this record in MEDLINE/PubMed
BookMark eNptUUtv1DAQtlAR3RZunFGOHAj1-JWEC6oqXlKlcmjPluOMs4asHWyn0v57srSLAHEajeZ7aL7vjJyEGJCQl0DfAu34RTDpYvxuEIC1T8gGuGK16BQ7IRvKqayBivaUnOX8jVIQIMUzcso7JRtgbEPubmYM1a1JI5ZcfZ1McTHt3lXOWD_5YooPY1W2mMyMS_G22u7nuO4Zc9UvfhoOdx-qIS1jNfhs4z2m_XPy1Jkp44vHeU7uPn64vfpcX998-nJ1eV1b3spSg0NFJYXBWSV7KbEVjLG-BQAraNspbilwpMp1vQLRdo4yKylzTdcMnXP8nLx_0J2XfoeDxVCSmfSc_M6kvY7G678vwW_1GO81QENBcrEqvH5USPHHgrno3foETpMJGJesOQjViqbp5Ap99afZb5djmCuAPQBsijkndNr-SjAevP2kgepDY3ptTB8bW0lv_iEddf8L_wnFNJrH
CitedBy_id crossref_primary_10_3389_fmolb_2025_1553667
crossref_primary_10_1038_d41573_024_00204_2
Cites_doi 10.1093/nar/gkaa840
10.1093/nar/gkad986
10.1146/annurev-pharmtox-040323-040828
10.1038/s41588-024-01854-z
10.1093/nar/gkae413
10.1371/journal.pgen.1008605
10.1038/s41573-024-00942-3
10.1093/nar/gkaa882
10.1093/nar/gkw1055
10.1038/s42003-022-04245-4
10.1016/j.apsb.2022.02.002
10.1093/nar/gkad751
10.1093/nar/gky1133
10.1038/s41593-021-00862-0
10.1093/nar/gkab994
10.1002/cpt.2350
10.1038/s41588-023-01538-0
10.1093/nar/gkac1010
10.1038/s41586-022-05473-8
10.1038/d41573-022-00120-3
10.2139/ssrn.2746044
10.1038/s41467-019-10016-3
10.1093/nar/gkad1021
10.1038/s41586-021-03855-y
10.1021/acs.chemrestox.0c00296
10.1038/s41586-022-04556-w
10.1038/s41568-020-0290-x
10.1038/s41586-023-06388-8
10.1038/nmeth.4365
10.1093/nar/gkaa994
10.1093/nar/gkad1049
10.1126/science.aaz1776
10.1093/nar/gkz972
10.1038/s41467-023-43726-w
10.1093/nar/gkab1061
10.1016/j.ccell.2023.12.016
10.1038/s41588-021-00945-5
10.1126/science.aay5947
10.1038/s41586-024-07316-0
10.1038/sdata.2016.18
10.1038/d41573-019-00074-z
10.1146/annurev-biodatasci-102523-103838
10.1038/s41588-019-0528-2
10.1093/nar/gkac972
10.1093/nar/gkac1052
10.1093/brain/awad214
10.1093/bioadv/vbae018
10.1126/science.adg7492
10.1038/s41586-020-2308-7
10.1038/s41591-023-02653-5
10.1093/genetics/iyae031
10.1371/journal.pone.0232644
10.1093/nar/gkac1046
10.1038/d41573-023-00158-x
10.1093/nar/gki387
10.1093/bioinformatics/btad441
10.1093/nar/gkac1004
10.1093/bioinformatics/btq099
10.1093/nar/gky1075
ContentType Journal Article
Copyright The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research.
The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research. 2025
Copyright_xml – notice: The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research.
– notice: The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research. 2025
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
DOI 10.1093/nar/gkae1128
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic

MEDLINE
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
Chemistry
EISSN 1362-4962
EndPage D1475
ExternalDocumentID PMC11701534
39657122
10_1093_nar_gkae1128
Genre Journal Article
GrantInformation_xml – fundername: Wellcome Trust
– fundername: Wellcome Trust
  grantid: 206194
– fundername: Open Targets
– fundername: ;
– fundername: ;
  grantid: 206194
GroupedDBID ---
-DZ
-~X
.I3
0R~
123
18M
1TH
29N
2WC
4.4
482
5VS
5WA
70E
85S
A8Z
AAFWJ
AAHBH
AAMVS
AAOGV
AAPXW
AAVAP
AAYXX
ABEJV
ABGNP
ABPTD
ABQLI
ABXVV
ACGFO
ACGFS
ACIWK
ACNCT
ACPRK
ACUTJ
ADBBV
ADHZD
AEGXH
AENEX
AENZO
AFFNX
AFPKN
AFRAH
AFYAG
AHMBA
AIAGR
ALMA_UNASSIGNED_HOLDINGS
ALUQC
AMNDL
AOIJS
BAWUL
BAYMD
BCNDV
CAG
CIDKT
CITATION
CS3
CZ4
DIK
DU5
D~K
E3Z
EBD
EBS
EMOBN
F5P
GROUPED_DOAJ
GX1
H13
HH5
HYE
HZ~
IH2
KAQDR
KQ8
KSI
OAWHX
OBC
OBS
OEB
OES
OJQWA
OVT
P2P
PEELM
PQQKQ
R44
RD5
RNS
ROL
ROZ
RPM
RXO
SV3
TN5
TOX
TR2
WG7
WOQ
X7H
XSB
YSK
ZKX
~91
~D7
~KM
CGR
CUY
CVF
ECM
EIF
NPM
7X8
ESTFP
53G
5PM
ID FETCH-LOGICAL-c385t-1fe60501dfc65b55e84222b8111c408963c013e06f9b61489f02c502f797d9ff3
ISSN 0305-1048
1362-4962
IngestDate Thu Aug 21 18:34:52 EDT 2025
Mon Sep 08 16:18:17 EDT 2025
Mon Jul 21 05:51:31 EDT 2025
Tue Jul 01 02:59:34 EDT 2025
Thu Apr 24 23:07:06 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue D1
Language English
License https://creativecommons.org/licenses/by/4.0
The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c385t-1fe60501dfc65b55e84222b8111c408963c013e06f9b61489f02c502f797d9ff3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0003-1857-278X
0000-0002-4623-8642
0000-0001-5806-6174
0000-0002-7368-180X
0000-0003-2525-5598
OpenAccessLink http://dx.doi.org/10.1093/nar/gkae1128
PMID 39657122
PQID 3146847795
PQPubID 23479
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_11701534
proquest_miscellaneous_3146847795
pubmed_primary_39657122
crossref_citationtrail_10_1093_nar_gkae1128
crossref_primary_10_1093_nar_gkae1128
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2025-01-06
PublicationDateYYYYMMDD 2025-01-06
PublicationDate_xml – month: 01
  year: 2025
  text: 2025-01-06
  day: 06
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Nucleic acids research
PublicationTitleAlternate Nucleic Acids Res
PublicationYear 2025
Publisher Oxford University Press
Publisher_xml – name: Oxford University Press
References Rusina (2025010610490211300_B56) 2023; 22
Martin (2025010610490211300_B26) 2019; 51
Trajanoska (2025010610490211300_B15) 2023; 620
Mountjoy (2025010610490211300_B20) 2021; 53
Martínez-Jiménez (2025010610490211300_B31) 2020; 20
Wilkinson (2025010610490211300_B52) 2016; 3
Razuvayevskaya (2025010610490211300_B4) 2024; 56
Zhou (2025010610490211300_B61) 2023; 29
Karczewski (2025010610490211300_B44) 2020; 581
Brennan (2025010610490211300_B50) 2024; 23
Riveros-Mckay (2025010610490211300_B22) 2020; 16
Malone (2025010610490211300_B13) 2010; 26
Hunter (2025010610490211300_B47) 2021; 34
Landrum (2025010610490211300_B29) 2020; 48
Soh (2025010610490211300_B25) 2023; 14
Schymkowitz (2025010610490211300_B38) 2005; 33
Whirl-Carrillo (2025010610490211300_B49) 2021; 110
Fang (2025010610490211300_B7) 2022; 50
Dowden (2025010610490211300_B2) 2019; 18
Piñero (2025010610490211300_B6) 2020; 48
Pacini (2025010610490211300_B32) 2024; 42
Dwane (2025010610490211300_B55) 2020; 49
Tian (2025010610490211300_B33) 2021; 24
Ferguson (2025010610490211300_B39) 2021; 49
Thormann (2025010610490211300_B27) 2019; 10
Baldarelli (2025010610490211300_B51) 2024; 227
Stephenson (2025010610490211300_B35) 2024; 52
Kurki (2025010610490211300_B18) 2023; 613
Shen (2025010610490211300_B28) 2024; 4
Groza (2025010610490211300_B34) 2023; 51
George (2025010610490211300_B45) 2024; 52
Skuta (2025010610490211300_B48) 2017; 14
Zhou (2025010610490211300_B57) 2024; 52
Mendez (2025010610490211300_B41) 2019; 47
De Cesco (2025010610490211300_B9) 2020; 15
Makarious (2025010610490211300_B24) 2023; 146
Vaswani (2025010610490211300_B40) 2017
Singh (2025010610490211300_B23) 2022; 604
Sollis (2025010610490211300_B42) 2023; 51
Raies (2025010610490211300_B58) 2022; 5
Feizi (2025010610490211300_B54) 2023; 39
Sun (2025010610490211300_B1) 2022; 12
Sjöstedt (2025010610490211300_B46) 2020; 367
Minikel (2025010610490211300_B3) 2024; 629
GTEx Consortium (2025010610490211300_B19) 2020; 369
Wang (2025010610490211300_B21) 2021; 597
Ochoa (2025010610490211300_B10) 2023; 51
Margoni (2025010610490211300_B53) 2016
Cheng (2025010610490211300_B36) 2023; 381
di Micco (2025010610490211300_B8) 2023; 51
McDonagh (2025010610490211300_B5) 2024; 7
Bjornsdottir (2025010610490211300_B60) 2023; 55
Ghoussaini (2025010610490211300_B17) 2021; 49
UniProt Consortium (2025010610490211300_B43) 2022; 51
Carvalho-Silva (2025010610490211300_B14) 2019; 47
Harrison (2025010610490211300_B12) 2024; 52
Sondka (2025010610490211300_B30) 2024; 52
Varadi (2025010610490211300_B37) 2022; 50
Ochoa (2025010610490211300_B16) 2022; 21
Hasselgren (2025010610490211300_B59) 2024; 64
Koscielny (2025010610490211300_B11) 2017; 45
References_xml – volume: 49
  start-page: D1311
  year: 2021
  ident: 2025010610490211300_B17
  article-title: Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkaa840
– volume: 52
  start-page: D1210
  year: 2024
  ident: 2025010610490211300_B30
  article-title: COSMIC: a curated database of somatic variants and clinical data for cancer
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkad986
– volume: 64
  start-page: 527
  year: 2024
  ident: 2025010610490211300_B59
  article-title: Artificial Intelligence for Drug Discovery: Are We There Yet
  publication-title: Annu. Rev. Pharmacol. Toxicol.
  doi: 10.1146/annurev-pharmtox-040323-040828
– volume: 56
  start-page: 1862
  year: 2024
  ident: 2025010610490211300_B4
  article-title: Genetic factors associated with reasons for clinical trial stoppage
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-024-01854-z
– volume: 52
  start-page: W140
  year: 2024
  ident: 2025010610490211300_B35
  article-title: ProtVar: mapping and contextualizing human missense variation
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkae413
– volume: 16
  start-page: e1008605
  year: 2020
  ident: 2025010610490211300_B22
  article-title: The influence of rare variants in circulating metabolic biomarkers
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1008605
– volume: 23
  start-page: 525
  year: 2024
  ident: 2025010610490211300_B50
  article-title: The state of the art in secondary pharmacology and its impact on the safety of new medicines
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/s41573-024-00942-3
– volume: 49
  start-page: D1365
  year: 2020
  ident: 2025010610490211300_B55
  article-title: Project Score database: a resource for investigating cancer cell dependencies and prioritizing therapeutic targets
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkaa882
– volume: 45
  start-page: D985
  year: 2017
  ident: 2025010610490211300_B11
  article-title: Open Targets: a platform for therapeutic target identification and validation
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkw1055
– volume: 5
  start-page: 1
  year: 2022
  ident: 2025010610490211300_B58
  article-title: DrugnomeAI is an ensemble machine-learning framework for predicting druggability of candidate drug targets
  publication-title: Communications Biology
  doi: 10.1038/s42003-022-04245-4
– volume: 12
  start-page: 3049
  year: 2022
  ident: 2025010610490211300_B1
  article-title: Why 90% of clinical drug development fails and how to improve it?
  publication-title: Acta Pharm Sin B
  doi: 10.1016/j.apsb.2022.02.002
– volume: 52
  start-page: D1465
  year: 2024
  ident: 2025010610490211300_B57
  article-title: TTD: Therapeutic Target Database describing target druggability information
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkad751
– volume: 47
  start-page: D1056
  year: 2019
  ident: 2025010610490211300_B14
  article-title: Open Targets Platform: new developments and updates two years on
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gky1133
– volume: 24
  start-page: 1020
  year: 2021
  ident: 2025010610490211300_B33
  article-title: Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-021-00862-0
– volume: 50
  start-page: D1358
  year: 2022
  ident: 2025010610490211300_B7
  article-title: Priority index: database of genetic targets in immune-mediated disease
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkab994
– volume: 110
  start-page: 563
  year: 2021
  ident: 2025010610490211300_B49
  article-title: An Evidence-Based Framework for Evaluating Pharmacogenomics Knowledge for Personalized Medicine
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1002/cpt.2350
– volume: 55
  start-page: 1843
  year: 2023
  ident: 2025010610490211300_B60
  article-title: Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-023-01538-0
– volume: 51
  start-page: D977
  year: 2023
  ident: 2025010610490211300_B42
  article-title: The NHGRI-EBI GWAS Catalog: knowledgebase and deposition resource
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkac1010
– volume: 613
  start-page: 508
  year: 2023
  ident: 2025010610490211300_B18
  article-title: FinnGen provides genetic insights from a well-phenotyped isolated population
  publication-title: Nature
  doi: 10.1038/s41586-022-05473-8
– volume: 21
  start-page: 551
  year: 2022
  ident: 2025010610490211300_B16
  article-title: Human genetics evidence supports two-thirds of the 2021 FDA-approved drugs
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/d41573-022-00120-3
– year: 2016
  ident: 2025010610490211300_B53
  article-title: Creative Commons Licenses: Empowering Open Access
  doi: 10.2139/ssrn.2746044
– volume: 10
  start-page: 2373
  year: 2019
  ident: 2025010610490211300_B27
  article-title: Flexible and scalable diagnostic filtering of genomic variants using G2P with Ensembl VEP
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-10016-3
– volume: 52
  start-page: D107
  year: 2024
  ident: 2025010610490211300_B45
  article-title: Expression Atlas update: insights from sequencing data at both bulk and single cell level
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkad1021
– volume: 597
  start-page: 527
  year: 2021
  ident: 2025010610490211300_B21
  article-title: Rare variant contribution to human disease in 281,104 UK Biobank exomes
  publication-title: Nature
  doi: 10.1038/s41586-021-03855-y
– volume: 34
  start-page: 385
  year: 2021
  ident: 2025010610490211300_B47
  article-title: Drug Safety Data Curation and Modeling in ChEMBL: Boxed Warnings and Withdrawn Drugs
  publication-title: Chem. Res. Toxicol.
  doi: 10.1021/acs.chemrestox.0c00296
– volume: 604
  start-page: 509
  year: 2022
  ident: 2025010610490211300_B23
  article-title: Rare coding variants in ten genes confer substantial risk for schizophrenia
  publication-title: Nature
  doi: 10.1038/s41586-022-04556-w
– volume: 20
  start-page: 555
  year: 2020
  ident: 2025010610490211300_B31
  article-title: A compendium of mutational cancer driver genes
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-020-0290-x
– volume: 620
  start-page: 737
  year: 2023
  ident: 2025010610490211300_B15
  article-title: From target discovery to clinical drug development with human genetics
  publication-title: Nature
  doi: 10.1038/s41586-023-06388-8
– volume: 14
  start-page: 759
  year: 2017
  ident: 2025010610490211300_B48
  article-title: Probes &Drugs portal: an interactive, open data resource for chemical biology
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.4365
– volume: 49
  start-page: D1507
  year: 2021
  ident: 2025010610490211300_B39
  article-title: Europe PMC in 2020
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkaa994
– volume: 52
  start-page: D891
  year: 2024
  ident: 2025010610490211300_B12
  article-title: Ensembl 2024
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkad1049
– volume: 369
  start-page: 1318
  year: 2020
  ident: 2025010610490211300_B19
  article-title: The GTEx Consortium atlas of genetic regulatory effects across human tissues
  publication-title: Science
  doi: 10.1126/science.aaz1776
– volume: 48
  start-page: D835
  year: 2020
  ident: 2025010610490211300_B29
  article-title: ClinVar: improvements to accessing data
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkz972
– volume: 14
  start-page: 8037
  year: 2023
  ident: 2025010610490211300_B25
  article-title: Prostate cancer genetic risk and associated aggressive disease in men of African ancestry
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-023-43726-w
– volume: 50
  start-page: D439
  year: 2022
  ident: 2025010610490211300_B37
  article-title: AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkab1061
– volume: 42
  start-page: 301
  year: 2024
  ident: 2025010610490211300_B32
  article-title: A comprehensive clinically informed map of dependencies in cancer cells and framework for target prioritization
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2023.12.016
– volume: 53
  start-page: 1527
  year: 2021
  ident: 2025010610490211300_B20
  article-title: An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-021-00945-5
– volume: 367
  start-page: eaay5947
  year: 2020
  ident: 2025010610490211300_B46
  article-title: An atlas of the protein-coding genes in the human, pig, and mouse brain
  publication-title: Science
  doi: 10.1126/science.aay5947
– volume: 629
  start-page: 624
  year: 2024
  ident: 2025010610490211300_B3
  article-title: Refining the impact of genetic evidence on clinical success
  publication-title: Nature
  doi: 10.1038/s41586-024-07316-0
– volume: 3
  start-page: 160018
  year: 2016
  ident: 2025010610490211300_B52
  article-title: The FAIR Guiding Principles for scientific data management and stewardship
  publication-title: Sci Data
  doi: 10.1038/sdata.2016.18
– volume: 18
  start-page: 495
  year: 2019
  ident: 2025010610490211300_B2
  article-title: Trends in clinical success rates and therapeutic focus
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/d41573-019-00074-z
– volume: 7
  start-page: 59
  year: 2024
  ident: 2025010610490211300_B5
  article-title: Human Genetics and Genomics for Drug Target Identification and Prioritization: Open Targets’ Perspective
  publication-title: Annu Rev Biomed Data Sci
  doi: 10.1146/annurev-biodatasci-102523-103838
– volume: 51
  start-page: 1560
  year: 2019
  ident: 2025010610490211300_B26
  article-title: PanelApp crowdsources expert knowledge to establish consensus diagnostic gene panels
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-019-0528-2
– volume: 51
  start-page: D1038
  year: 2023
  ident: 2025010610490211300_B34
  article-title: The International Mouse Phenotyping Consortium: comprehensive knockout phenotyping underpinning the study of human disease
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkac972
– volume: 51
  start-page: D523
  year: 2022
  ident: 2025010610490211300_B43
  article-title: UniProt: the Universal Protein Knowledgebase in 2023
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkac1052
– volume: 146
  start-page: 4622
  year: 2023
  ident: 2025010610490211300_B24
  article-title: Large-scale rare variant burden testing in Parkinson's disease
  publication-title: Brain
  doi: 10.1093/brain/awad214
– volume: 4
  start-page: vbae018
  year: 2024
  ident: 2025010610490211300_B28
  article-title: CMAT: ClinVar Mapping and Annotation Toolkit
  publication-title: Bioinform Adv
  doi: 10.1093/bioadv/vbae018
– volume: 381
  start-page: eadg7492
  year: 2023
  ident: 2025010610490211300_B36
  article-title: Accurate proteome-wide missense variant effect prediction with AlphaMissense
  publication-title: Science
  doi: 10.1126/science.adg7492
– volume: 581
  start-page: 434
  year: 2020
  ident: 2025010610490211300_B44
  article-title: The mutational constraint spectrum quantified from variation in 141,456 humans
  publication-title: Nature
  doi: 10.1038/s41586-020-2308-7
– volume: 29
  start-page: 3184
  year: 2023
  ident: 2025010610490211300_B61
  article-title: Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals
  publication-title: Nat. Med.
  doi: 10.1038/s41591-023-02653-5
– volume: 227
  start-page: iyae031
  year: 2024
  ident: 2025010610490211300_B51
  article-title: Mouse Genome Informatics: an integrated knowledgebase system for the laboratory mouse
  publication-title: Genetics
  doi: 10.1093/genetics/iyae031
– volume: 15
  start-page: e0232644
  year: 2020
  ident: 2025010610490211300_B9
  article-title: TargetDB: A target information aggregation tool and tractability predictor
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0232644
– volume: 51
  start-page: D1353
  year: 2023
  ident: 2025010610490211300_B10
  article-title: The next-generation Open Targets Platform: reimagined, redesigned, rebuilt
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkac1046
– volume: 22
  start-page: 864
  year: 2023
  ident: 2025010610490211300_B56
  article-title: Genetic support for FDA-approved drugs over the past decade
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/d41573-023-00158-x
– volume: 33
  start-page: W382
  year: 2005
  ident: 2025010610490211300_B38
  article-title: The FoldX web server: an online force field
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gki387
– volume: 39
  start-page: btad441
  year: 2023
  ident: 2025010610490211300_B54
  article-title: otargen: GraphQL-based R package for tidy data accessing and processing from Open Targets Genetics
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btad441
– start-page: 6000
  volume-title: Proceedings of the 31st International Conference on Neural Information Processing Systems, NIPS’17
  year: 2017
  ident: 2025010610490211300_B40
  article-title: Attention is all you need
– volume: 51
  start-page: D1212
  year: 2023
  ident: 2025010610490211300_B8
  article-title: canSAR: update to the cancer translational research and drug discovery knowledgebase
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkac1004
– volume: 26
  start-page: 1112
  year: 2010
  ident: 2025010610490211300_B13
  article-title: Modeling sample variables with an Experimental Factor Ontology
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btq099
– volume: 48
  start-page: D845
  year: 2020
  ident: 2025010610490211300_B6
  article-title: The DisGeNET knowledge platform for disease genomics: 2019 update
  publication-title: Nucleic Acids Res.
– volume: 47
  start-page: D930
  year: 2019
  ident: 2025010610490211300_B41
  article-title: ChEMBL: towards direct deposition of bioassay data
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gky1075
SSID ssj0014154
Score 2.557958
Snippet The Open Targets Platform (https://platform.opentargets.org) is a unique, open-source, publicly-available knowledge base providing data and tooling for...
The Open Targets Platform ( https://platform.opentargets.org ) is a unique, open-source, publicly-available knowledge base providing data and tooling for...
SourceID pubmedcentral
proquest
pubmed
crossref
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage D1467
SubjectTerms Database Issue
Drug Discovery
Humans
Internet
Knowledge Bases
Software
Title Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery
URI https://www.ncbi.nlm.nih.gov/pubmed/39657122
https://www.proquest.com/docview/3146847795
https://pubmed.ncbi.nlm.nih.gov/PMC11701534
Volume 53
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fb9MwELbKeIAXBBuwMpiMxHipsiXOb95Kt2lCbC-00t4ix3W6ipFOTTJp-2f4V7mzHTfdhjR4idrUF7W-6_nsu-87Qj7FQe6LgAcOJoWcQMS5k_tF4kTC4yyWTAiFej89i04mwbfz8LzX-92pWmrqfF_cPogr-R-twj3QK6Jk_0Gz9qFwA16DfuEKGobro3SM1SCDsarlrrD9UI0RKO7xCy4M-7YGQ7UQq8HFzRVCripZDXLTEFvVwy6bGeZqBBZ0riV6z5DvGDldxXyKGYbO4ZcCQSBAXWdvFBXzvLJu_kdzLWfaCWkcu013LJtbZ8TBtxjJEV9eLmxs_11BhLXgKS8bCeEv2xu6X6WdEHNKwUJ1ShF1nJmvGE81q-a-1M5WIbbSdW-sqYON1R16Hd96iE69s1DDe9105d4qoBmySqxQP5795BJiymS13rU5_jvLoC1O1Gl5PwP5rJV-Qp6yGIIzcJixe2TTVBD9aH4y8-MMsgKkD0D6oJVej3nubWTu1uN2ApzxS_LC7EzoUJvZK9KT5SbZGpa8Xvy6oZ-pqhVWSZhN8mzU9gncIhO0QmqskLZW-IV2bZB2bJCubJC2NkjnJUUbpNYGX5PJ8dF4dOKYZh2O8JOwdrxCws7Y9aaFiMI8DGWCh4t5AmupCNwE_LzAE3c3KtIcyWfTwmUidFkRp_E0LQr_DdkoF6XcJlQy7okpC_zITQMPlkGRFBA3C5Zybxox3ieDdjozYZjssaHKZfaQ6vpkz46-0gwufxn3sdVMBjOIeTNeykVTZT7CE4M4TsM-eas1ZZ_kp1EYe4z1SbKmQzsA6dvXPynnF4rGHXs-QbwRvHvkF9whz1f_rPdko1428gNExHW-q6xyV50n_QG2nr3-
linkProvider Oxford University Press
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Open+Targets+Platform%3A+facilitating+therapeutic+hypotheses+building+in+drug+discovery&rft.jtitle=Nucleic+acids+research&rft.au=Buniello%2C+Annalisa&rft.au=Suveges%2C+Daniel&rft.au=Cruz-Castillo%2C+Carlos&rft.au=Llinares%2C+Manuel%C2%A0Bernal&rft.date=2025-01-06&rft.issn=0305-1048&rft.eissn=1362-4962&rft.volume=53&rft.issue=D1&rft.spage=D1467&rft.epage=D1475&rft_id=info:doi/10.1093%2Fnar%2Fgkae1128&rft.externalDBID=n%2Fa&rft.externalDocID=10_1093_nar_gkae1128
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0305-1048&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0305-1048&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0305-1048&client=summon