Amyloid-β Increases Tau by Mediating Sirtuin 3 in Alzheimer’s Disease
Increasing evidence indicates that sirtuin 3 (Sirt3) has neuroprotective effects in regulating oxidative stress and energy metabolism, both of which are involved in the pathogenesis of Alzheimer’s disease (AD). However, it is unclear whether Sirt3 is associated with cognitive performance and patholo...
Saved in:
Published in | Molecular neurobiology Vol. 55; no. 11; pp. 8592 - 8601 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Springer US
01.11.2018
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
ISSN | 0893-7648 1559-1182 1559-1182 |
DOI | 10.1007/s12035-018-0977-0 |
Cover
Abstract | Increasing evidence indicates that sirtuin 3 (Sirt3) has neuroprotective effects in regulating oxidative stress and energy metabolism, both of which are involved in the pathogenesis of Alzheimer’s disease (AD). However, it is unclear whether Sirt3 is associated with cognitive performance and pathological changes in AD. We conducted a case-control study of the postmortem brains of AD (
n
= 16), mild cognitive impairment (
n
= 13), and age- and education-matched cognitively normal (CN,
n
= 11) subjects. We measured the mRNA and protein levels of Sirt3 and assessed their association with cognitive performance and AD pathology. In an ex vivo model of cortical neurons from transgenic mice that carry human tau protein, we modified Sirt3 expression by genetic knockdown and knock-in to investigate the cause-effect relationship between Sirt3 and tau. Sirt3 levels were reduced in the entorhinal cortex, the middle temporal gyrus, and the superior frontal gyrus of AD subjects compared to those of CN. This reduction was associated with poorer test scores of neuropsychological evaluation and the severity of tau pathology. Further study with genetic manipulation of Sirt3 revealed that amyloid-β increased levels of total tau acetylated tau through its modulation of Sirt3. These data suggest that reduction of Sirt3 is critically involved in pathogenesis of AD. |
---|---|
AbstractList | Increasing evidence indicates that sirtuin 3 (Sirt3) has neuroprotective effects in regulating oxidative stress and energy metabolism, both of which are involved in the pathogenesis of Alzheimer’s disease (AD). However, it is unclear whether Sirt3 is associated with cognitive performance and pathological changes in AD. We conducted a case-control study of the postmortem brains of AD (n = 16), mild cognitive impairment (n = 13), and age- and education-matched cognitively normal (CN, n = 11) subjects. We measured the mRNA and protein levels of Sirt3 and assessed their association with cognitive performance and AD pathology. In an ex vivo model of cortical neurons from transgenic mice that carry human tau protein, we modified Sirt3 expression by genetic knockdown and knock-in to investigate the cause-effect relationship between Sirt3 and tau. Sirt3 levels were reduced in the entorhinal cortex, the middle temporal gyrus, and the superior frontal gyrus of AD subjects compared to those of CN. This reduction was associated with poorer test scores of neuropsychological evaluation and the severity of tau pathology. Further study with genetic manipulation of Sirt3 revealed that amyloid-β increased levels of total tau acetylated tau through its modulation of Sirt3. These data suggest that reduction of Sirt3 is critically involved in pathogenesis of AD. Increasing evidence indicates that sirtuin 3 (Sirt3) has neuroprotective effects in regulating oxidative stress and energy metabolism, both of which are involved in the pathogenesis of Alzheimer’s disease (AD). However, it is unclear whether Sirt3 is associated with cognitive performance and pathological changes in AD. We conducted a case-control study of the postmortem brains of AD ( n = 16), mild cognitive impairment ( n = 13), and age- and education-matched cognitively normal (CN, n = 11) subjects. We measured the mRNA and protein levels of Sirt3 and assessed their association with cognitive performance and AD pathology. In an ex vivo model of cortical neurons from transgenic mice that carry human tau protein, we modified Sirt3 expression by genetic knockdown and knock-in to investigate the cause-effect relationship between Sirt3 and tau. Sirt3 levels were reduced in the entorhinal cortex, the middle temporal gyrus, and the superior frontal gyrus of AD subjects compared to those of CN. This reduction was associated with poorer test scores of neuropsychological evaluation and the severity of tau pathology. Further study with genetic manipulation of Sirt3 revealed that amyloid-β increased levels of total tau acetylated tau through its modulation of Sirt3. These data suggest that reduction of Sirt3 is critically involved in pathogenesis of AD. Increasing evidence indicates that sirtuin 3 (Sirt3) has neuroprotective effects in regulating oxidative stress and energy metabolism, both of which are involved in the pathogenesis of Alzheimer's disease (AD). However, it is unclear whether Sirt3 is associated with cognitive performance and pathological changes in AD. We conducted a case-control study of the postmortem brains of AD (n = 16), mild cognitive impairment (n = 13), and age- and education-matched cognitively normal (CN, n = 11) subjects. We measured the mRNA and protein levels of Sirt3 and assessed their association with cognitive performance and AD pathology. In an ex vivo model of cortical neurons from transgenic mice that carry human tau protein, we modified Sirt3 expression by genetic knockdown and knock-in to investigate the cause-effect relationship between Sirt3 and tau. Sirt3 levels were reduced in the entorhinal cortex, the middle temporal gyrus, and the superior frontal gyrus of AD subjects compared to those of CN. This reduction was associated with poorer test scores of neuropsychological evaluation and the severity of tau pathology. Further study with genetic manipulation of Sirt3 revealed that amyloid-β increased levels of total tau acetylated tau through its modulation of Sirt3. These data suggest that reduction of Sirt3 is critically involved in pathogenesis of AD.Increasing evidence indicates that sirtuin 3 (Sirt3) has neuroprotective effects in regulating oxidative stress and energy metabolism, both of which are involved in the pathogenesis of Alzheimer's disease (AD). However, it is unclear whether Sirt3 is associated with cognitive performance and pathological changes in AD. We conducted a case-control study of the postmortem brains of AD (n = 16), mild cognitive impairment (n = 13), and age- and education-matched cognitively normal (CN, n = 11) subjects. We measured the mRNA and protein levels of Sirt3 and assessed their association with cognitive performance and AD pathology. In an ex vivo model of cortical neurons from transgenic mice that carry human tau protein, we modified Sirt3 expression by genetic knockdown and knock-in to investigate the cause-effect relationship between Sirt3 and tau. Sirt3 levels were reduced in the entorhinal cortex, the middle temporal gyrus, and the superior frontal gyrus of AD subjects compared to those of CN. This reduction was associated with poorer test scores of neuropsychological evaluation and the severity of tau pathology. Further study with genetic manipulation of Sirt3 revealed that amyloid-β increased levels of total tau acetylated tau through its modulation of Sirt3. These data suggest that reduction of Sirt3 is critically involved in pathogenesis of AD. |
Author | Liang, Winnie S. Han, Pengcheng Yin, Junxiang Nielsen, Megan Serrano, Geidy E. Shi, Jiong Song, Melissa Beach, Thomas G. Caselli, Richard J. |
AuthorAffiliation | 5 Department of Neurology, Mayo Clinic Arizona, Scottsdale, AZ, USA 3 Civin Laboratory for Neuropathology, Banner Sun Health Research, Institute, Sun City, AZ, USA 6 Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China 1 Barrow Neurological Institute, St. Joseph Hospital and Medical Center, Phoenix, AZ, USA 2 School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA 4 Translational Genomics Research Institute (TGen), Phoenix, AZ, USA 7 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China |
AuthorAffiliation_xml | – name: 6 Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China – name: 2 School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA – name: 4 Translational Genomics Research Institute (TGen), Phoenix, AZ, USA – name: 1 Barrow Neurological Institute, St. Joseph Hospital and Medical Center, Phoenix, AZ, USA – name: 5 Department of Neurology, Mayo Clinic Arizona, Scottsdale, AZ, USA – name: 3 Civin Laboratory for Neuropathology, Banner Sun Health Research, Institute, Sun City, AZ, USA – name: 7 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China |
Author_xml | – sequence: 1 givenname: Junxiang surname: Yin fullname: Yin, Junxiang organization: Barrow Neurological Institute, St. Joseph Hospital and Medical Center – sequence: 2 givenname: Pengcheng surname: Han fullname: Han, Pengcheng organization: Barrow Neurological Institute, St. Joseph Hospital and Medical Center – sequence: 3 givenname: Melissa surname: Song fullname: Song, Melissa organization: Barrow Neurological Institute, St. Joseph Hospital and Medical Center, School of Arts and Sciences, University of Pennsylvania – sequence: 4 givenname: Megan surname: Nielsen fullname: Nielsen, Megan organization: Barrow Neurological Institute, St. Joseph Hospital and Medical Center – sequence: 5 givenname: Thomas G. surname: Beach fullname: Beach, Thomas G. organization: Civin Laboratory for Neuropathology, Banner Sun Health Research Institute – sequence: 6 givenname: Geidy E. surname: Serrano fullname: Serrano, Geidy E. organization: Civin Laboratory for Neuropathology, Banner Sun Health Research Institute – sequence: 7 givenname: Winnie S. surname: Liang fullname: Liang, Winnie S. organization: Translational Genomics Research Institute (TGen) – sequence: 8 givenname: Richard J. surname: Caselli fullname: Caselli, Richard J. organization: Department of Neurology, Mayo Clinic Arizona – sequence: 9 givenname: Jiong orcidid: 0000-0001-7694-1366 surname: Shi fullname: Shi, Jiong email: Jiong.Shi@DignityHealth.org organization: Barrow Neurological Institute, St. Joseph Hospital and Medical Center, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29574628$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kU1u1TAUhS1URF8LC2CCIjFhYrjXSWxngvRUCq1UxIAythzHeXWV2MVOKj1GbKPbYCEsgpXg6LX8VIKJPbjfOT4-94Ds-eAtIU8RXiKAeJWQQVlTQEmhEYLCA7LCum4oomR7ZAWyKangldwnByldAjCGIB6RfdbUouJMrsjJetwOwXX0-7fi1JtodbKpONdz0W6L97ZzenJ-U3x0cZqdL8oiH-vhy4V1o40_vt6k4o1Li-gxedjrIdknt_ch-fT2-PzohJ59eHd6tD6jppQ10KbViMygsLqtdQdl1XNZdQaZEBpKqfPMiFb0jDMGBrHvrSlNIzNisJPlIXm9872a29F2xvop6kFdRTfquFVBO_X3xLsLtQnXinMh6qrKBi9uDWL4PNs0qdElY4dBexvmpFiuk_MagWf0-T30MszR5-8tVHarOSyGz_5M9CvKXckZEDvAxJBStL0ybsq9hiWgGxSCWtapdutU-X21rFNBVuI95Z35_zRsp0mZ9Rsbf4f-t-gneFeyLA |
CitedBy_id | crossref_primary_10_3390_ijms241411640 crossref_primary_10_18632_aging_102070 crossref_primary_10_3389_fncel_2021_746631 crossref_primary_10_1007_s11055_023_01449_x crossref_primary_10_3389_fphys_2022_908689 crossref_primary_10_1016_j_drudis_2023_103583 crossref_primary_10_3389_fphys_2022_962769 crossref_primary_10_1007_s11011_022_01111_4 crossref_primary_10_1038_s42003_020_01584_y crossref_primary_10_3389_fnagi_2024_1486762 crossref_primary_10_3390_biomedicines9111574 crossref_primary_10_18632_aging_102516 crossref_primary_10_1016_j_arr_2025_102699 crossref_primary_10_3389_fnins_2020_00791 crossref_primary_10_3390_antiox10020229 crossref_primary_10_1007_s12035_019_01819_y crossref_primary_10_3233_JAD_190014 crossref_primary_10_3389_fncel_2018_00196 crossref_primary_10_17116_jnevro20221220917 crossref_primary_10_3390_nu16234088 crossref_primary_10_1159_000494723 crossref_primary_10_1186_s13020_023_00722_y crossref_primary_10_1007_s12264_023_01056_3 crossref_primary_10_1093_hmg_ddab285 crossref_primary_10_1007_s10517_020_04986_4 crossref_primary_10_1212_WNL_0000000000009582 crossref_primary_10_1523_JNEUROSCI_1259_22_2023 crossref_primary_10_1186_s13293_023_00487_x crossref_primary_10_1007_s12035_021_02671_9 crossref_primary_10_1007_s11055_022_01217_3 crossref_primary_10_1159_000520325 crossref_primary_10_1016_j_bioorg_2025_108347 crossref_primary_10_1016_j_arr_2019_100983 crossref_primary_10_1016_j_jgg_2021_11_005 crossref_primary_10_1016_j_neuint_2024_105873 crossref_primary_10_1016_j_lfs_2023_121532 crossref_primary_10_1016_j_arr_2020_101107 crossref_primary_10_14336_AD_2023_0203 crossref_primary_10_1021_acschemneuro_0c00696 crossref_primary_10_3390_ijms23020643 crossref_primary_10_1016_j_tips_2019_09_003 crossref_primary_10_1080_00207454_2022_2057849 crossref_primary_10_1080_19336918_2019_1629224 crossref_primary_10_1042_BSR20190069 crossref_primary_10_1016_j_preteyeres_2020_100899 crossref_primary_10_1093_hmg_ddz227 crossref_primary_10_18632_aging_101592 crossref_primary_10_1016_j_lfs_2025_123488 crossref_primary_10_1002_alz_13847 crossref_primary_10_1016_j_heliyon_2024_e40756 crossref_primary_10_1016_j_ijbiomac_2024_139258 crossref_primary_10_1007_s12035_021_02381_2 crossref_primary_10_3390_biom13050735 crossref_primary_10_1089_ars_2023_0350 crossref_primary_10_5607_en21021 crossref_primary_10_3389_fphar_2020_00584 crossref_primary_10_1016_j_phrs_2024_107436 |
Cites_doi | 10.1016/j.neurobiolaging.2014.03.022 10.1212/WNL.0000000000000392 10.1038/jcbfm.2015.123 10.1101/cshperspect.a006189 10.1080/10673220216210 10.1038/nrneurol.2013.21 10.1016/j.neuron.2016.03.005 10.1212/WNL.0000000000000417 10.1016/S1474-4422(12)70291-0 10.1016/j.tem.2015.06.001 10.1007/s00401-010-0789-4 10.1002/pro.50 10.1111/j.1365-2796.2004.01380.x 10.1093/cercor/4.2.138 10.1016/j.exger.2006.10.003 10.1038/ncomms1255 10.1186/s12868-017-0364-1 10.1523/JNEUROSCI.3712-09.2010 10.3389/fnagi.2013.00048 10.1016/S1474-4422(09)70299-6 10.1097/YCO.0b013e32835112c1 10.1007/s00401-013-1162-1 10.1016/S1474-4422(14)70252-2 10.1212/WNL.58.12.1791 10.1096/fj.11-199851 10.1007/s12017-014-8288-8 10.1007/BF00308809 10.1212/WNL.38.11.1688 10.1152/physiolgenomics.00242.2007 10.1089/ars.2009.2952 10.1007/s11064-015-1630-1 10.1046/j.1471-4159.2003.01879.x 10.1016/j.neurobiolaging.2009.04.002 10.1016/j.bandl.2010.03.001 10.1097/NEN.0b013e31825018f7 10.1038/nm.3951 10.1016/j.jalz.2011.03.005 10.1016/bs.acr.2016.01.004 10.1007/s00401-013-1167-9 10.1038/nrneurol.2013.21-c1 10.3389/fneur.2013.00102 10.1111/neup.12189 10.1016/j.neurobiolaging.2015.11.018 10.1038/sj.emboj.7601758 |
ContentType | Journal Article |
Copyright | Springer Science+Business Media, LLC, part of Springer Nature 2018 Molecular Neurobiology is a copyright of Springer, (2018). All Rights Reserved. |
Copyright_xml | – notice: Springer Science+Business Media, LLC, part of Springer Nature 2018 – notice: Molecular Neurobiology is a copyright of Springer, (2018). All Rights Reserved. |
DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QR 7TK 7X7 7XB 88A 88E 88G 88I 8AO 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2M M2P M7P P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ Q9U 7X8 5PM |
DOI | 10.1007/s12035-018-0977-0 |
DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Chemoreception Abstracts Neurosciences Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Psychology Database Science Database Biological Science Database Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Psychology ProQuest Central Student Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | MEDLINE ProQuest One Psychology MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology |
EISSN | 1559-1182 |
EndPage | 8601 |
ExternalDocumentID | PMC6677544 29574628 10_1007_s12035_018_0977_0 |
Genre | Journal Article |
GrantInformation_xml | – fundername: National Institute on Aging grantid: AG19610 funderid: http://dx.doi.org/10.13039/100000049 – fundername: NIA NIH HHS grantid: P30 AG019610 – fundername: National Institute on Aging grantid: AG19610 |
GroupedDBID | --- -4W -56 -5G -BR -EM -Y2 -~C -~X .86 .GJ .VR 06C 06D 0R~ 0VY 123 1N0 2.D 203 28- 29M 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2VQ 2~H 30V 3SX 3V. 4.4 406 408 40D 40E 53G 5VS 67N 6NX 78A 7X7 88A 88E 88I 8AO 8CJ 8FE 8FH 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AACDK AAHNG AAIAL AAJBT AAJKR AANXM AANZL AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO AAYZH ABAKF ABDZT ABECU ABFTV ABHLI ABHQN ABIVO ABJNI ABJOX ABKCH ABMNI ABMQK ABNWP ABPLI ABQBU ABQSL ABSXP ABTEG ABTHY ABTKH ABTMW ABUWG ABWNU ABXPI ACAOD ACBXY ACCUX ACDTI ACGFS ACGOD ACHSB ACHXU ACIWK ACKNC ACMDZ ACMLO ACOKC ACOMO ACPIV ACPRK ACZOJ ADBBV ADHHG ADHIR ADINQ ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADYPR ADZKW AEBTG AEFQL AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AETLH AEVLU AEXYK AFBBN AFEXP AFGCZ AFKRA AFLOW AFQWF AFWTZ AFZKB AGAYW AGDGC AGGDS AGJBK AGMZJ AGQEE AGQMX AGRTI AGWIL AGWZB AGYKE AHAVH AHBYD AHKAY AHMBA AHSBF AIAKS AIGIU AIIXL AILAN AITGF AIZAD AJBLW AJRNO AJZVZ AKMHD ALIPV ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG ARMRJ ASPBG AVWKF AXYYD AZFZN AZQEC B-. BA0 BBNVY BBWZM BDATZ BENPR BGNMA BHPHI BPHCQ BSONS BVXVI CAG CCPQU COF CS3 CSCUP D1J DDRTE DNIVK DPUIP DU5 DWQXO EBD EBLON EBS EIOEI EJD EMOBN ESBYG F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNUQQ GNWQR GQ6 GQ7 H13 HCIFZ HF~ HG6 HMCUK HMJXF HRMNR HVGLF HZ~ IJ- IKXTQ ITM IWAJR IXC I~X I~Z J-C J0Z JBSCW JZLTJ KDC KOV LK8 LLZTM M0L M1P M2M M2P M4Y M7P MA- N2Q N9A NDZJH NF0 NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OVD P19 P2P PF0 PQQKQ PROAC PSQYO PSYQQ PT4 PT5 Q2X QOK QOR QOS R4E R89 R9I RHV RNI ROL RPX RSV RZK S16 S1Z S26 S27 S28 S3A S3B SAP SBL SBY SCLPG SDH SDM SHX SISQX SJYHP SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZN T13 T16 TEORI TSG TUC U2A U9L UG4 UKHRP UOJIU UTJUX UZXMN VC2 VFIZW W48 WK6 WK8 XJT YLTOR Z7U Z7W Z82 Z83 Z87 Z8O Z8V Z91 ZGI ZMTXR ZOVNA ~EX ~KM AAPKM AAYXX ABBRH ABDBE ABFSG ABRTQ ACSTC ADHKG AEZWR AFDZB AFHIU AFOHR AGQPQ AHDLI AHPBZ AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT PJZUB PPXIY PQGLB PUEGO CGR CUY CVF ECM EIF NPM 7QR 7TK 7XB 8FD 8FK FR3 K9. P64 PKEHL PQEST PQUKI PRINS Q9U 7X8 5PM |
ID | FETCH-LOGICAL-c3850-9ba112c17eab5ad034f684dc1277a038a2c1c7b7f26220c11ffec3c98dc1c1d83 |
IEDL.DBID | 7X7 |
ISSN | 0893-7648 1559-1182 |
IngestDate | Tue Sep 30 16:45:20 EDT 2025 Fri Sep 05 11:57:50 EDT 2025 Mon Sep 29 05:13:13 EDT 2025 Mon Jul 21 05:58:24 EDT 2025 Wed Oct 01 01:53:34 EDT 2025 Thu Apr 24 23:09:46 EDT 2025 Fri Feb 21 02:38:16 EST 2025 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 11 |
Keywords | Tau Amyloid Acetylation Alzheimer’s disease Mild cognitive impairment Sirtuin |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c3850-9ba112c17eab5ad034f684dc1277a038a2c1c7b7f26220c11ffec3c98dc1c1d83 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
ORCID | 0000-0001-7694-1366 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/6677544 |
PMID | 29574628 |
PQID | 2017545604 |
PQPubID | 55365 |
PageCount | 10 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_6677544 proquest_miscellaneous_2018665106 proquest_journals_2017545604 pubmed_primary_29574628 crossref_citationtrail_10_1007_s12035_018_0977_0 crossref_primary_10_1007_s12035_018_0977_0 springer_journals_10_1007_s12035_018_0977_0 |
ProviderPackageCode | CITATION AAYXX |
PublicationCentury | 2000 |
PublicationDate | 20181100 |
PublicationDateYYYYMMDD | 2018-11-01 |
PublicationDate_xml | – month: 11 year: 2018 text: 20181100 |
PublicationDecade | 2010 |
PublicationPlace | New York |
PublicationPlace_xml | – name: New York – name: United States – name: Totowa |
PublicationTitle | Molecular neurobiology |
PublicationTitleAbbrev | Mol Neurobiol |
PublicationTitleAlternate | Mol Neurobiol |
PublicationYear | 2018 |
Publisher | Springer US Springer Nature B.V |
Publisher_xml | – name: Springer US – name: Springer Nature B.V |
References | Yin, Maalouf, Han, Zhao, Gao, Dharshaun, Ryan, Whitelegge, Wu, Eisenberg, Reiman, Schweizer, Shi (CR20) 2016; 39 Thal, Rub, Orantes, Braak (CR6) 2002; 58 Kincaid, Bossy-Wetzel (CR23) 2013; 5 Han, Liang, Baxter, Yin, Tang, Beach, Caselli, Reiman, Shi (CR44) 2014; 82 Yin, Han, Tang, Liu, Shi (CR42) 2015; 35 Jack, Knopman, Jagust, Shaw, Aisen, Weiner, Petersen, Trojanowski (CR26) 2010; 9 Braak, Braak (CR7) 1991; 82 Vishnu (CR25) 2013; 9 Mann, Hardy (CR29) 2013; 126 Singh, Hanson, Morris (CR39) 2017; 18 Yang, Zou, Zhang, Zhao, Tian, Gu, Liu, Shi, Lu, Yu (CR9) 2015; 40 Ren, Sahara (CR34) 2013; 4 Tracy, Sohn, Minami, Wang, Min, Li, Zhou, Le, Lo, Ponnusamy (CR11) 2016; 90 Rinetti, Schweizer (CR19) 2010; 30 Liang, Dunckley, Beach, Grover, Mastroeni, Ramsey, Caselli, Kukull, McKeel, Morris, Hulette, Schmechel, Reiman, Rogers, Stephan (CR16) 2008; 33 Lutz, Milenkovic, Regelsberger, Kovacs (CR12) 2014; 16 Vina, Borras (CR37) 2010; 13 Jack, Knopman, Jagust, Petersen, Weiner, Aisen, Shaw, Vemuri, Wiste, Weigand, Lesnick, Pankratz, Donohue, Trojanowski (CR5) 2013; 12 Obler, Rykhlevskaia, Schnyer, Clark-Cotton, Spiro, Hyun, Kim, Goral, Albert (CR22) 2010; 113 Lasagna-Reeves, Castillo-Carranza, Sengupta, Sarmiento, Troncoso, Jackson, Kayed (CR33) 2012; 26 Bouras, Hof, Giannakopoulos, Michel, Morrison (CR2) 1994; 4 Braak, Del Tredici (CR30) 2011; 121 Kim, Nguyen, Dobbin, Fischer, Sananbenesi, Rodgers, Delalle, Baur, Sui, Armour, Puigserver, Sinclair, Tsai (CR40) 2007; 26 Ottowitz, Dougherty, Savage (CR21) 2002; 10 Braidy, Jayasena, Poljak, Sachdev (CR41) 2012; 25 Winblad, Palmer, Kivipelto, Jelic, Fratiglioni, Wahlund, Nordberg, Backman, Albert, Almkvist, Arai, Basun, Blennow, de Leon, DeCarli, Erkinjuntti, Giacobini, Graff, Hardy, Jack, Jorm, Ritchie, van Duijn, Visser, Petersen (CR14) 2004; 256 Jin, Galonek, Israelian, Choy, Morrison, Xia, Wang, Xu, Yang, Smith, Hoffmann, Carney, Perni, Jirousek, Bemis, Milne, Sinclair, Westphal (CR17) 2009; 18 Price, McKeel, Buckles, Roe, Xiong, Grundman, Hansen, Petersen, Parisi, Dickson (CR1) 2009; 30 Serrano-Pozo, Frosch, Masliah, Hyman (CR8) 2011; 1 Cohen, Guo, Hurtado, Kwong, Mills, Trojanowski, Lee (CR35) 2011; 2 Chetelat (CR32) 2013; 9 Beach, Adler, Sue, Serrano, Shill, Walker, Lue, Roher, Dugger, Maarouf, Birdsill, Intorcia, Saxon-Labelle, Pullen, Scroggins, Filon, Scott, Hoffman, Garcia, Caviness, Hentz, Driver-Dunckley, Jacobson, Davis, Belden, Long, Malek-Ahmadi, Powell, Gale, Nicholson, Caselli, Woodruff, Rapscak, Ahern, Shi, Burke, Reiman, Sabbagh (CR43) 2015; 35 Han, Tang, Yin, Maalouf, Beach, Reiman, Shi (CR13) 2014; 35 Davies, Wolska, Hilbich, Multhaup, Martins, Simms, Beyreuther, Masters (CR4) 1988; 38 Min, Chen, Tracy, Li, Zhou, Wang, Shirakawa, Minami, Defensor, Mok, Sohn, Schilling, Cong, Ellerby, Gibson, Johnson, Krogan, Shamloo, Gestwicki, Masliah, Verdin, Gan (CR10) 2015; 21 McKhann, Knopman, Chertkow, Hyman, Jack, Kawas, Klunk, Koroshetz, Manly, Mayeux (CR15) 2011; 7 Attems, Jellinger (CR28) 2013; 126 Germain (CR38) 2016; 130 Villemagne, Fodero-Tavoletti, Masters, Rowe (CR31) 2015; 14 Landau, Frosch (CR27) 2014; 82 Nelson, Alafuzoff, Bigio, Bouras, Braak, Cairns, Castellani, Crain, Davies, Del Tredici (CR3) 2012; 71 Sanz, Hiona, Kujoth, Seo, Hofer, Kouwenhoven, Kalani, Prolla, Barja, Leeuwenburgh (CR36) 2007; 42 Andorfer, Kress, Espinoza, de Silva, Tucker, Barde, Duff, Davies (CR18) 2003; 86 McDonnell, Peterson, Bomze, Hirschey (CR24) 2015; 26 C Bouras (977_CR2) 1994; 4 B Kincaid (977_CR23) 2013; 5 MI Lutz (977_CR12) 2014; 16 A Sanz (977_CR36) 2007; 42 A Serrano-Pozo (977_CR8) 2011; 1 SW Min (977_CR10) 2015; 21 VL Villemagne (977_CR31) 2015; 14 J Attems (977_CR28) 2013; 126 SM Landau (977_CR27) 2014; 82 J Yin (977_CR42) 2015; 35 D Kim (977_CR40) 2007; 26 D Germain (977_CR38) 2016; 130 DR Thal (977_CR6) 2002; 58 LK Obler (977_CR22) 2010; 113 H Braak (977_CR30) 2011; 121 P Han (977_CR13) 2014; 35 CA Lasagna-Reeves (977_CR33) 2012; 26 H Braak (977_CR7) 1991; 82 P Singh (977_CR39) 2017; 18 TG Beach (977_CR43) 2015; 35 Y Ren (977_CR34) 2013; 4 TJ Cohen (977_CR35) 2011; 2 L Davies (977_CR4) 1988; 38 CR Jack Jr (977_CR26) 2010; 9 J Vina (977_CR37) 2010; 13 TE Tracy (977_CR11) 2016; 90 DM Mann (977_CR29) 2013; 126 L Jin (977_CR17) 2009; 18 WE Ottowitz (977_CR21) 2002; 10 E McDonnell (977_CR24) 2015; 26 P Han (977_CR44) 2014; 82 W Yang (977_CR9) 2015; 40 GM McKhann (977_CR15) 2011; 7 JX Yin (977_CR20) 2016; 39 N Braidy (977_CR41) 2012; 25 B Winblad (977_CR14) 2004; 256 WS Liang (977_CR16) 2008; 33 CR Jack Jr (977_CR5) 2013; 12 VY Vishnu (977_CR25) 2013; 9 PT Nelson (977_CR3) 2012; 71 C Andorfer (977_CR18) 2003; 86 JL Price (977_CR1) 2009; 30 GV Rinetti (977_CR19) 2010; 30 G Chetelat (977_CR32) 2013; 9 |
References_xml | – volume: 35 start-page: 2064 year: 2014 end-page: 2071 ident: CR13 article-title: Pituitary adenylate cyclase-activating polypeptide protects against beta-amyloid toxicity publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2014.03.022 – volume: 82 start-page: 1576 year: 2014 end-page: 1577 ident: CR27 article-title: Tracking the earliest pathologic changes in Alzheimer disease publication-title: Neurology doi: 10.1212/WNL.0000000000000392 – volume: 35 start-page: 1783 year: 2015 end-page: 1789 ident: CR42 article-title: Sirtuin 3 mediates neuroprotection of ketones against ischemic stroke publication-title: J Cereb Blood Flow Metab doi: 10.1038/jcbfm.2015.123 – volume: 1 start-page: a006189 year: 2011 ident: CR8 article-title: Neuropathological alterations in Alzheimer disease publication-title: Cold Spring Harb Perspect Med doi: 10.1101/cshperspect.a006189 – volume: 10 start-page: 86 year: 2002 end-page: 99 ident: CR21 article-title: The neural network basis for abnormalities of attention and executive function in major depressive disorder: implications for application of the medical disease model to psychiatric disorders publication-title: Harv Rev Psychiatry doi: 10.1080/10673220216210 – volume: 9 start-page: 123 year: 2013 end-page: 124 ident: CR32 article-title: Alzheimer disease: Abeta-independent processes-rethinking preclinical AD publication-title: Nat Rev Neurol doi: 10.1038/nrneurol.2013.21 – volume: 90 start-page: 245 year: 2016 end-page: 260 ident: CR11 article-title: Acetylated tau obstructs KIBRA-mediated signaling in synaptic plasticity and promotes tauopathy-related memory loss publication-title: Neuron doi: 10.1016/j.neuron.2016.03.005 – volume: 82 start-page: 1724 year: 2014 end-page: 1728 ident: CR44 article-title: Pituitary adenylate cyclase-activating polypeptide is reduced in Alzheimer disease publication-title: Neurology doi: 10.1212/WNL.0000000000000417 – volume: 12 start-page: 207 year: 2013 end-page: 216 ident: CR5 article-title: Tracking pathophysiological processes in Alzheimer’s disease: an updated hypothetical model of dynamic biomarkers publication-title: Lancet Neurol doi: 10.1016/S1474-4422(12)70291-0 – volume: 26 start-page: 486 year: 2015 end-page: 492 ident: CR24 article-title: SIRT3 regulates progression and development of diseases of aging publication-title: Trends Endocrinol Metab doi: 10.1016/j.tem.2015.06.001 – volume: 121 start-page: 171 year: 2011 end-page: 181 ident: CR30 article-title: The pathological process underlying Alzheimer’s disease in individuals under thirty publication-title: Acta Neuropathol doi: 10.1007/s00401-010-0789-4 – volume: 18 start-page: 514 year: 2009 end-page: 525 ident: CR17 article-title: Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3 publication-title: Protein Sci doi: 10.1002/pro.50 – volume: 256 start-page: 240 year: 2004 end-page: 246 ident: CR14 article-title: Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment publication-title: J Intern Med doi: 10.1111/j.1365-2796.2004.01380.x – volume: 4 start-page: 138 year: 1994 end-page: 150 ident: CR2 article-title: Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of elderly patients: a quantitative evaluation of a one-year autopsy population from a geriatric hospital publication-title: Cereb Cortex doi: 10.1093/cercor/4.2.138 – volume: 42 start-page: 173 year: 2007 end-page: 182 ident: CR36 article-title: Evaluation of sex differences on mitochondrial bioenergetics and apoptosis in mice publication-title: Exp Gerontol doi: 10.1016/j.exger.2006.10.003 – volume: 2 start-page: 252 year: 2011 ident: CR35 article-title: The acetylation of tau inhibits its function and promotes pathological tau aggregation publication-title: Nat Commun doi: 10.1038/ncomms1255 – volume: 18 start-page: 46 year: 2017 ident: CR39 article-title: SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson’s disease publication-title: BMC Neurosci doi: 10.1186/s12868-017-0364-1 – volume: 30 start-page: 3157 year: 2010 end-page: 3166 ident: CR19 article-title: Ubiquitination acutely regulates presynaptic neurotransmitter release in mammalian neurons publication-title: J Neurosci doi: 10.1523/JNEUROSCI.3712-09.2010 – volume: 5 start-page: 48 year: 2013 ident: CR23 article-title: Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration publication-title: Front Aging Neurosci doi: 10.3389/fnagi.2013.00048 – volume: 9 start-page: 119 year: 2010 end-page: 128 ident: CR26 article-title: Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade publication-title: Lancet Neurol doi: 10.1016/S1474-4422(09)70299-6 – volume: 25 start-page: 226 year: 2012 end-page: 230 ident: CR41 article-title: Sirtuins in cognitive ageing and Alzheimer’s disease publication-title: Curr Opin Psychiatry doi: 10.1097/YCO.0b013e32835112c1 – volume: 126 start-page: 609 year: 2013 end-page: 613 ident: CR29 article-title: Amyloid or tau: the chicken or the egg? publication-title: Acta Neuropathol doi: 10.1007/s00401-013-1162-1 – volume: 14 start-page: 114 year: 2015 end-page: 124 ident: CR31 article-title: Tau imaging: early progress and future directions publication-title: Lancet Neurol doi: 10.1016/S1474-4422(14)70252-2 – volume: 58 start-page: 1791 year: 2002 end-page: 1800 ident: CR6 article-title: Phases of A beta-deposition in the human brain and its relevance for the development of AD publication-title: Neurology doi: 10.1212/WNL.58.12.1791 – volume: 26 start-page: 1946 year: 2012 end-page: 1959 ident: CR33 article-title: Identification of oligomers at early stages of tau aggregation in Alzheimer’s disease publication-title: FASEB J doi: 10.1096/fj.11-199851 – volume: 16 start-page: 405 year: 2014 end-page: 414 ident: CR12 article-title: Distinct patterns of sirtuin expression during progression of Alzheimer’s disease publication-title: NeuroMolecular Med doi: 10.1007/s12017-014-8288-8 – volume: 82 start-page: 239 year: 1991 end-page: 259 ident: CR7 article-title: Neuropathological stageing of Alzheimer-related changes publication-title: Acta Neuropathol doi: 10.1007/BF00308809 – volume: 38 start-page: 1688 year: 1988 end-page: 1693 ident: CR4 article-title: A4 amyloid protein deposition and the diagnosis of Alzheimer’s disease: prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques publication-title: Neurology doi: 10.1212/WNL.38.11.1688 – volume: 33 start-page: 240 year: 2008 end-page: 256 ident: CR16 article-title: Altered neuronal gene expression in brain regions differentially affected by Alzheimer’s disease: a reference data set publication-title: Physiol Genomics doi: 10.1152/physiolgenomics.00242.2007 – volume: 13 start-page: 269 year: 2010 end-page: 278 ident: CR37 article-title: Women live longer than men: understanding molecular mechanisms offers opportunities to intervene by using estrogenic compounds publication-title: Antioxid Redox Signal doi: 10.1089/ars.2009.2952 – volume: 40 start-page: 1576 year: 2015 end-page: 1582 ident: CR9 article-title: Mitochondrial Sirt3 expression is decreased in APP/PS1 double transgenic mouse model of Alzheimer’s disease publication-title: Neurochem Res doi: 10.1007/s11064-015-1630-1 – volume: 86 start-page: 582 year: 2003 end-page: 590 ident: CR18 article-title: Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms publication-title: J Neurochem doi: 10.1046/j.1471-4159.2003.01879.x – volume: 30 start-page: 1026 year: 2009 end-page: 1036 ident: CR1 article-title: Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2009.04.002 – volume: 113 start-page: 113 year: 2010 end-page: 123 ident: CR22 article-title: Bilateral brain regions associated with naming in older adults publication-title: Brain Lang doi: 10.1016/j.bandl.2010.03.001 – volume: 71 start-page: 362 year: 2012 end-page: 381 ident: CR3 article-title: Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature publication-title: J Neuropathol Exp Neurol doi: 10.1097/NEN.0b013e31825018f7 – volume: 21 start-page: 1154 year: 2015 end-page: 1162 ident: CR10 article-title: Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits publication-title: Nat Med doi: 10.1038/nm.3951 – volume: 7 start-page: 263 year: 2011 end-page: 269 ident: CR15 article-title: The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease publication-title: Alzheimers Dement doi: 10.1016/j.jalz.2011.03.005 – volume: 130 start-page: 211 year: 2016 end-page: 256 ident: CR38 article-title: Sirtuins and the estrogen receptor as regulators of the mammalian mitochondrial UPR in cancer and aging publication-title: Adv Cancer Res doi: 10.1016/bs.acr.2016.01.004 – volume: 126 start-page: 619 year: 2013 end-page: 621 ident: CR28 article-title: Amyloid and tau: neither chicken nor egg but two partners in crime! publication-title: Acta Neuropathol doi: 10.1007/s00401-013-1167-9 – volume: 9 start-page: 356 year: 2013 ident: CR25 article-title: Can tauopathy shake the amyloid cascade hypothesis? publication-title: Nat Rev Neurol doi: 10.1038/nrneurol.2013.21-c1 – volume: 4 start-page: 102 year: 2013 ident: CR34 article-title: Characteristics of tau oligomers publication-title: Front Neurol doi: 10.3389/fneur.2013.00102 – volume: 35 start-page: 354 year: 2015 end-page: 389 ident: CR43 article-title: Arizona study of aging and neurodegenerative disorders and brain and body donation program publication-title: Neuropathology doi: 10.1111/neup.12189 – volume: 39 start-page: 25 year: 2016 end-page: 37 ident: CR20 article-title: Ketones block amyloid entry and improve cognition in an Alzheimer’s model publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2015.11.018 – volume: 26 start-page: 3169 year: 2007 end-page: 3179 ident: CR40 article-title: SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis publication-title: EMBO J doi: 10.1038/sj.emboj.7601758 – volume: 25 start-page: 226 year: 2012 ident: 977_CR41 publication-title: Curr Opin Psychiatry doi: 10.1097/YCO.0b013e32835112c1 – volume: 9 start-page: 119 year: 2010 ident: 977_CR26 publication-title: Lancet Neurol doi: 10.1016/S1474-4422(09)70299-6 – volume: 16 start-page: 405 year: 2014 ident: 977_CR12 publication-title: NeuroMolecular Med doi: 10.1007/s12017-014-8288-8 – volume: 130 start-page: 211 year: 2016 ident: 977_CR38 publication-title: Adv Cancer Res doi: 10.1016/bs.acr.2016.01.004 – volume: 58 start-page: 1791 year: 2002 ident: 977_CR6 publication-title: Neurology doi: 10.1212/WNL.58.12.1791 – volume: 90 start-page: 245 year: 2016 ident: 977_CR11 publication-title: Neuron doi: 10.1016/j.neuron.2016.03.005 – volume: 121 start-page: 171 year: 2011 ident: 977_CR30 publication-title: Acta Neuropathol doi: 10.1007/s00401-010-0789-4 – volume: 21 start-page: 1154 year: 2015 ident: 977_CR10 publication-title: Nat Med doi: 10.1038/nm.3951 – volume: 126 start-page: 609 year: 2013 ident: 977_CR29 publication-title: Acta Neuropathol doi: 10.1007/s00401-013-1162-1 – volume: 30 start-page: 3157 year: 2010 ident: 977_CR19 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.3712-09.2010 – volume: 82 start-page: 1576 year: 2014 ident: 977_CR27 publication-title: Neurology doi: 10.1212/WNL.0000000000000392 – volume: 126 start-page: 619 year: 2013 ident: 977_CR28 publication-title: Acta Neuropathol doi: 10.1007/s00401-013-1167-9 – volume: 18 start-page: 46 year: 2017 ident: 977_CR39 publication-title: BMC Neurosci doi: 10.1186/s12868-017-0364-1 – volume: 9 start-page: 123 year: 2013 ident: 977_CR32 publication-title: Nat Rev Neurol doi: 10.1038/nrneurol.2013.21 – volume: 30 start-page: 1026 year: 2009 ident: 977_CR1 publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2009.04.002 – volume: 1 start-page: a006189 year: 2011 ident: 977_CR8 publication-title: Cold Spring Harb Perspect Med doi: 10.1101/cshperspect.a006189 – volume: 82 start-page: 1724 year: 2014 ident: 977_CR44 publication-title: Neurology doi: 10.1212/WNL.0000000000000417 – volume: 13 start-page: 269 year: 2010 ident: 977_CR37 publication-title: Antioxid Redox Signal doi: 10.1089/ars.2009.2952 – volume: 113 start-page: 113 year: 2010 ident: 977_CR22 publication-title: Brain Lang doi: 10.1016/j.bandl.2010.03.001 – volume: 26 start-page: 486 year: 2015 ident: 977_CR24 publication-title: Trends Endocrinol Metab doi: 10.1016/j.tem.2015.06.001 – volume: 26 start-page: 1946 year: 2012 ident: 977_CR33 publication-title: FASEB J doi: 10.1096/fj.11-199851 – volume: 71 start-page: 362 year: 2012 ident: 977_CR3 publication-title: J Neuropathol Exp Neurol doi: 10.1097/NEN.0b013e31825018f7 – volume: 26 start-page: 3169 year: 2007 ident: 977_CR40 publication-title: EMBO J doi: 10.1038/sj.emboj.7601758 – volume: 9 start-page: 356 year: 2013 ident: 977_CR25 publication-title: Nat Rev Neurol doi: 10.1038/nrneurol.2013.21-c1 – volume: 40 start-page: 1576 year: 2015 ident: 977_CR9 publication-title: Neurochem Res doi: 10.1007/s11064-015-1630-1 – volume: 33 start-page: 240 year: 2008 ident: 977_CR16 publication-title: Physiol Genomics doi: 10.1152/physiolgenomics.00242.2007 – volume: 4 start-page: 138 year: 1994 ident: 977_CR2 publication-title: Cereb Cortex doi: 10.1093/cercor/4.2.138 – volume: 38 start-page: 1688 year: 1988 ident: 977_CR4 publication-title: Neurology doi: 10.1212/WNL.38.11.1688 – volume: 5 start-page: 48 year: 2013 ident: 977_CR23 publication-title: Front Aging Neurosci doi: 10.3389/fnagi.2013.00048 – volume: 39 start-page: 25 year: 2016 ident: 977_CR20 publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2015.11.018 – volume: 82 start-page: 239 year: 1991 ident: 977_CR7 publication-title: Acta Neuropathol doi: 10.1007/BF00308809 – volume: 35 start-page: 354 year: 2015 ident: 977_CR43 publication-title: Neuropathology doi: 10.1111/neup.12189 – volume: 4 start-page: 102 year: 2013 ident: 977_CR34 publication-title: Front Neurol doi: 10.3389/fneur.2013.00102 – volume: 2 start-page: 252 year: 2011 ident: 977_CR35 publication-title: Nat Commun doi: 10.1038/ncomms1255 – volume: 14 start-page: 114 year: 2015 ident: 977_CR31 publication-title: Lancet Neurol doi: 10.1016/S1474-4422(14)70252-2 – volume: 86 start-page: 582 year: 2003 ident: 977_CR18 publication-title: J Neurochem doi: 10.1046/j.1471-4159.2003.01879.x – volume: 35 start-page: 1783 year: 2015 ident: 977_CR42 publication-title: J Cereb Blood Flow Metab doi: 10.1038/jcbfm.2015.123 – volume: 256 start-page: 240 year: 2004 ident: 977_CR14 publication-title: J Intern Med doi: 10.1111/j.1365-2796.2004.01380.x – volume: 7 start-page: 263 year: 2011 ident: 977_CR15 publication-title: Alzheimers Dement doi: 10.1016/j.jalz.2011.03.005 – volume: 10 start-page: 86 year: 2002 ident: 977_CR21 publication-title: Harv Rev Psychiatry doi: 10.1080/10673220216210 – volume: 12 start-page: 207 year: 2013 ident: 977_CR5 publication-title: Lancet Neurol doi: 10.1016/S1474-4422(12)70291-0 – volume: 18 start-page: 514 year: 2009 ident: 977_CR17 publication-title: Protein Sci doi: 10.1002/pro.50 – volume: 35 start-page: 2064 year: 2014 ident: 977_CR13 publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2014.03.022 – volume: 42 start-page: 173 year: 2007 ident: 977_CR36 publication-title: Exp Gerontol doi: 10.1016/j.exger.2006.10.003 |
SSID | ssj0022107 |
Score | 2.4559772 |
Snippet | Increasing evidence indicates that sirtuin 3 (Sirt3) has neuroprotective effects in regulating oxidative stress and energy metabolism, both of which are... |
SourceID | pubmedcentral proquest pubmed crossref springer |
SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
StartPage | 8592 |
SubjectTerms | Aged, 80 and over Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer's disease Amyloid beta-Peptides - toxicity Animals Autopsy Biomedical and Life Sciences Biomedicine Brain - metabolism Brain - pathology Cell Biology Cells, Cultured Cognition Cognitive ability Cortex (entorhinal) Energy metabolism Female Frontal gyrus Humans Male Mice, Transgenic mRNA Neurobiology Neurofibrillary Tangles - metabolism Neurology Neuroprotection Neuropsychological Tests Neurosciences Oxidative metabolism Oxidative stress Pathogenesis Pathology Rodents Sirtuin 3 - metabolism Tau protein tau Proteins - metabolism Temporal gyrus Temporal lobe Temporal Lobe - metabolism Temporal Lobe - pathology Transgenic mice |
SummonAdditionalLinks | – databaseName: SpringerLINK - Czech Republic Consortium dbid: AGYKE link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3NbtQwEB6h7YULPy0_gVIZCXEAuYoT_-UYQdsVqFzYSuUU2Y5XjdpN0e7m0J76Gn0NHoSH4EmwnZ_VthSpl1w8iWN7xp7PM_4M8I4Ik2baGVIpKMNUcY0zRSgmlEhhjZI8bF0cfuPjI_rlmB1357gXfbZ7H5IMM_XqsFvi6RVj4sP1QmCH0zeYxycj2MgPfnzdG3CWQzEtwWeWYsGp7IOZ__rI-nJ0y8e8nSp5I14alqH9xzDpG9Bmn5zuNku9ay5vcDves4VP4FHnlqK81aOn8MDWm7CV1w6Szy7QexQSRcMO_BaM85lD-VWJf_9CbnrxWe12gSaqQfoCHYarP1yt6Hs1XzZVjVLkHvnZ5YmtZnb-5-p6gT63UaFncLS_N_k0xt2FDNikksU408q5Z4YIqzRTZZzSKZe0NCQRQsWpVK7MCC2mCU-S2BDiU1JSk0knYkgp0-cwqs9r-xKQlsKBY2IZF1MHMTMllWXSaiYUyyTjEcT9uBSmYyv3l2acFSueZd9bheutwvdWEUfwYXjlZ0vV8T_h7X6wi85qF4VzhoT3KGMawduh2NmbD6Ko2p43QcZTBDokHcGLVjeG2pKMCX_WNwKxpjWDgOfyXi-pq5PA6c15oCKM4GOvGqvfurMRr-4l_Roe-p9vD1Juw2g5b-wb51Et9U5nQX8Bj6UWWA priority: 102 providerName: Springer Nature |
Title | Amyloid-β Increases Tau by Mediating Sirtuin 3 in Alzheimer’s Disease |
URI | https://link.springer.com/article/10.1007/s12035-018-0977-0 https://www.ncbi.nlm.nih.gov/pubmed/29574628 https://www.proquest.com/docview/2017545604 https://www.proquest.com/docview/2018665106 https://pubmed.ncbi.nlm.nih.gov/PMC6677544 |
Volume | 55 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
journalDatabaseRights | – providerCode: PRVLSH databaseName: SpringerLink Journals customDbUrl: mediaType: online eissn: 1559-1182 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0022107 issn: 0893-7648 databaseCode: AFBBN dateStart: 19970201 isFulltext: true providerName: Library Specific Holdings – providerCode: PRVAVX databaseName: SpringerLINK - Czech Republic Consortium customDbUrl: eissn: 1559-1182 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0022107 issn: 0893-7648 databaseCode: AGYKE dateStart: 19970101 isFulltext: true titleUrlDefault: http://link.springer.com providerName: Springer Nature – providerCode: PRVAVX databaseName: SpringerLink Journals (ICM) customDbUrl: eissn: 1559-1182 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0022107 issn: 0893-7648 databaseCode: U2A dateStart: 19970101 isFulltext: true titleUrlDefault: http://www.springerlink.com/journals/ providerName: Springer Nature |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3NbtQwEB5Be-GCgPITKJWREAeQJTuJf3KqAmxZgVoh6ErLKXIcrxqpmy37c2hPvAavwYPwEDwJYyfZ1VLRSyLFjmzPjO0Zz_gbgJdc2SQrcSJVKhU0NbKkmeEp5SnXylmjZTi6OD6Rw1H6cSzG3YHbogur7NfEsFBXM-vPyNFIx40Od3uWHl58pz5rlPeudik0bsMuR1XFS7UabwwuNGdapM8soUqmuvdqhqtzsQdrZNw7_5WibHtfuqZsXo-Z_MdxGvajo3twt1MkSd5y_j7ccs0D2MsbNKKnl-QVCaGd4cx8D4b5FO3yuqK_fxFcEHwculuQU7Mi5SU5Dsk6sA3ytZ4vV3VDEoKP_PzqzNVTN__z4-eCvG_9OA9hdDQ4fTekXQoFahMtGM1KgwqV5cqZUpiKJelE6rSyPFbKsEQbLLOqVJNYxjGznPsgksRmGqtYXunkEew0s8Y9AVJqheYsd0KqCRqFmdHGCe1KoYzItJARsJ6Ahe3wxX2ai_Nig4zsaV4gzQtP84JF8Hr9y0ULrnFT5f2eK0U3zxbFRioieLEuxhni3R6mcbNVqONB_dD2jeBxy8R1a3EmlL-dG4HaYu-6gkff3i5p6rOAwi1lAA-M4E0vCJtu_XcQT28exDO443vb3nXch53lfOWeo9KzLA-CZB_Abv7h26cBvt8OTj5_wa-jOP8L8L4BFw |
linkProvider | ProQuest |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3NbhMxEB6VcoALKpSfpQWMBBxAK9m7_tsDQhGlSmnTC6mU2-L1OmqkZFPyIxROvAYvwYEH4SF4EsbebKJQ0Vsve7F3vR6PPTOemW8AXjBl06zAjVQqLmJuZBFnhvGYcaaVs0bLcHXROZXtM_6xJ3pb8LPJhfFhlc2ZGA7qcmz9HTka6SjoUNpT_u7iS-yrRnnvalNCo2aLY7f4iibb9O3RAa7vyyQ5_NB9346XVQVim2pB46wwqGNYppwphClpyvtS89KyRClDU22wzapC9ROZJNQy5uMqUptp7GJZqVP87g24yVPKPVa_6q0NPDSfamTRLI2V5LrxooZUvcSDQ1Lmgw2UiummHLyk3F6O0fzHURvk3-EO3FkqrqRVc9pd2HLVPdhtVWi0jxbkFQmhpOGOfhfardFiOB6U8e9fBA8gH_fupqRr5qRYkE4oDoJjkE-DyWw-qEhK8NEafjt3g5Gb_Pn-Y0oOar_RfTi7FuI-gO1qXLlHQAqt0HxmTkjVRyM0M9o4oV0hlBGZFjIC2hAwt0s8c19WY5ivkZg9zXOkee5pntMIXq9euajBPK7qvN-sSr7c19N8zYURPF814470bhZTufE89PEggmhrR_CwXsTVaEkmlM8GjkBtLO-qg0f73mypBucB9VvKAFYYwZuGEda_9d9JPL56Es_gVrvbOclPjk6P9-C2__M6z3IftmeTuXuCCteseBq4nMDn695WfwG5xDoA |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3NbtQwEB6VIiEuCCg_gQJGAg6gqHHs2M4BoRXLaktphUQr7S04jleNtJst-yO0nHgNXoMjD8FD8CSMnWRXS0VvveRiJ47HM54Zz_gbgGdUGpbmKEiF5EnItcjDVFMeUk6VtEYr4Y8uDo9E_4S_HySDLfjV3oVxaZXtnug36mJi3Bk5Oumo6FDbR3xv2KRFfOz23px9CV0FKRdpbctp1CxyYJdf0X2bvd7v4lo_j-Peu-O3_bCpMBAappIoTHON9oah0uo80UXE-FAoXhgaS6kjpjS2GZnLYSziODKUuhwLZlKFXQwtFMPvXoGrknHm0snkYO3soStVo4ymLJSCqzai6q_txQ4oMqIu8UDKMNrUiecM3fP5mv8Ebb0u7N2EG40RSzo1192CLVvdhp1OhQ78eEleEJ9W6s_rd6DfGS9Hk7IIf_8kuBm5HHg7I8d6QfIlOfSFQnAM8qmczhdlRRjBR2f07dSWYzv98_3HjHTrGNIdOLkU4t6F7WpS2ftAciXRlaY2EXKIDmmqlbaJsnkidZKqRAQQtQTMTINt7kpsjLI1KrOjeYY0zxzNsyiAl6tXzmpgj4s677arkjUyPsvWHBnA01UzSqcLuejKTha-jwMURL87gHv1Iq5Gi9NEupvBAciN5V11cMjfmy1VeeoRwIXwwIUBvGoZYf1b_53Eg4sn8QSuoUBlH_aPDh7Cdffj9ZXLXdieTxf2Edpe8_yxZ3ICny9bqv4CfO4-Ow |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Amyloid-%CE%B2+Increases+Tau+by+Mediating+Sirtuin+3+in+Alzheimer%E2%80%99s+Disease&rft.jtitle=Molecular+neurobiology&rft.au=Yin%2C+Junxiang&rft.au=Han%2C+Pengcheng&rft.au=Song%2C+Melissa&rft.au=Nielsen%2C+Megan&rft.date=2018-11-01&rft.issn=0893-7648&rft.eissn=1559-1182&rft.volume=55&rft.issue=11&rft.spage=8592&rft.epage=8601&rft_id=info:doi/10.1007%2Fs12035-018-0977-0&rft_id=info%3Apmid%2F29574628&rft.externalDocID=PMC6677544 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0893-7648&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0893-7648&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0893-7648&client=summon |