EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR IN SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Localization of epidermal growth factor receptor (EGFR) was investigated immunohistologically in 68 untreated patients with squamous cell carcinoma of the head and neck regions. These patients consisted of 16 with cancer of the lips and mouth, seven with mesopharyngeal cancer, six with epipharyngeal...
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| Published in | Nippon Jibi Inkoka Gakkai Kaiho Vol. 96; no. 12; pp. 2039 - 2043,2191 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
Japan
The Oto-Rhino-Laryngological Society of Japan, Inc
1993
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0030-6622 1883-0854 1883-0854 |
| DOI | 10.3950/jibiinkoka.96.2039 |
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| Abstract | Localization of epidermal growth factor receptor (EGFR) was investigated immunohistologically in 68 untreated patients with squamous cell carcinoma of the head and neck regions. These patients consisted of 16 with cancer of the lips and mouth, seven with mesopharyngeal cancer, six with epipharyngeal cancer, 15 with hypopharyngeal cancer, 10 with laryngeal cancer, 12 with maxillary cancer and two with other tumors (cancer of the auricle and cancer of the eyelid in one patient each). The patients consisted of 57 men and 11 women, with a mean age of 60 years. In cases with a normal oral mucosa, marked expression of EGFR was observed in the epithelial cell membrane, while expression decreased toward the luminal surface. Cancer cells also showed positive staining of EGFR in all patients, but the intensity of staining was inconsistent among them. Among the 32 patients in whom the staining intensity of EGFR was equal to or weaker than that in basal cells of the normal oral mucosa, 12 patients had lymph node metastasis. Twenty-eight of the 36 patients in whom the staining was stronger than that in the normal cells had lymph node metastasis, suggesting that overexpression of EGFR in carcinoma cells is a risk factor for lymph node metastasis of head and neck cancers (P<0.005). On the other hand, there were no obvious relationships between either the size or the degree of keratinization of the primary lesion and EGFR expression. |
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| AbstractList | Localization of epidermal growth factor receptor (EGFR) was investigated immunohistologically in 68 untreated patients with squamous cell carcinoma of the head and neck regions. These patients consisted of 16 with cancer of the lips and mouth, seven with mesopharyngeal cancer, six with epipharyngeal cancer, 15 with hypopharyngeal cancer, 10 with laryngeal cancer, 12 with maxillary cancer and two with other tumors (cancer of the auricle and cancer of the eyelid in one patient each). The patients consisted of 57 men and 11 women, with a mean age of 60 years. In cases with a normal oral mucosa, marked expression of EGFR was observed in the epithelial cell membrane, while expression decreased toward the luminal surface. Cancer cells also showed positive staining of EGFR in all patients, but the intensity of staining was inconsistent among them. Among the 32 patients in whom the staining intensity of EGFR was equal to or weaker than that in basal cells of the normal oral mucosa, 12 patients had lymph node metastasis. Twenty-eight of the 36 patients in whom the staining was stronger than that in the normal cells had lymph node metastasis, suggesting that overexpression of EGFR in carcinoma cells is a risk factor for lymph node metastasis of head and neck cancers (P < 0.005). On the other hand, there were no obvious relationships between either the size or the degree of keratinization of the primary lesion and EGFR expression. Localization of epidermal growth factor receptor (EGFR) was investigated immunohistologically in 68 untreated patients with squamous cell carcinoma of the head and neck regions. These patients consisted of 16 with cancer of the lips and mouth, seven with mesopharyngeal cancer, six with epipharyngeal cancer, 15 with hypopharyngeal cancer, 10 with laryngeal cancer, 12 with maxillary cancer and two with other tumors (cancer of the auricle and cancer of the eyelid in one patient each). The patients consisted of 57 men and 11 women, with a mean age of 60 years. In cases with a normal oral mucosa, marked expression of EGFR was observed in the epithelial cell membrane, while expression decreased toward the luminal surface. Cancer cells also showed positive staining of EGFR in all patients, but the intensity of staining was inconsistent among them. Among the 32 patients in whom the staining intensity of EGFR was equal to or weaker than that in basal cells of the normal oral mucosa, 12 patients had lymph node metastasis. Twenty-eight of the 36 patients in whom the staining was stronger than that in the normal cells had lymph node metastasis, suggesting that overexpression of EGFR in carcinoma cells is a risk factor for lymph node metastasis of head and neck cancers (P < 0.005). On the other hand, there were no obvious relationships between either the size or the degree of keratinization of the primary lesion and EGFR expression.Localization of epidermal growth factor receptor (EGFR) was investigated immunohistologically in 68 untreated patients with squamous cell carcinoma of the head and neck regions. These patients consisted of 16 with cancer of the lips and mouth, seven with mesopharyngeal cancer, six with epipharyngeal cancer, 15 with hypopharyngeal cancer, 10 with laryngeal cancer, 12 with maxillary cancer and two with other tumors (cancer of the auricle and cancer of the eyelid in one patient each). The patients consisted of 57 men and 11 women, with a mean age of 60 years. In cases with a normal oral mucosa, marked expression of EGFR was observed in the epithelial cell membrane, while expression decreased toward the luminal surface. Cancer cells also showed positive staining of EGFR in all patients, but the intensity of staining was inconsistent among them. Among the 32 patients in whom the staining intensity of EGFR was equal to or weaker than that in basal cells of the normal oral mucosa, 12 patients had lymph node metastasis. Twenty-eight of the 36 patients in whom the staining was stronger than that in the normal cells had lymph node metastasis, suggesting that overexpression of EGFR in carcinoma cells is a risk factor for lymph node metastasis of head and neck cancers (P < 0.005). On the other hand, there were no obvious relationships between either the size or the degree of keratinization of the primary lesion and EGFR expression. |
| Author | OHI, KIYOYUKI SATAKE, JUN-ICHI TAKASAKA, TOMONORI SUZUKI, MAMORU KOIKE, SYUJI MATSU-URA, KAZUTO |
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| References | 8) 塩崎均, 矢野浩司, 森武貞: 食道癌の進展と予後. Oncologia 22 (3): 5-9, 1989. 1) Carpenter G, Cohen S: Epidermal growth factor. Ann Rev Biochem 48: 193-216, 1979. 3) Broders AC: Practical points on the microscopic grading of carcinoma. New york J Med 32: 667, 1932 (下里幸雄: 広戸幾一郎他編: 臨床耳鼻咽喉科・頭頸部外科全書8-A頭頸部腫瘍総論. 金原出版, 東京, 1985, 53-56頁 7) Ozawa S, Ueda M, Ando N: Prognostic significance of epidermal growth factor receptor in esophageal squamous cell carcinomas. Cancer 63: 2169-2173, 1989. 9) 上田政和, 小沢壮治, 森光生, 清水信義, 阿部令彦: 扁平上皮癌とレセプター. 最新医学42: 950-955, 1987. 10) Bergler W, Bier H, Ganzer U: The expression of epidermal growth factor receptors in the oral mucosa with oral cancer. Arch Otorhinolaryngol 246: 121-125, 1989. 6) Yasui W, Sumiyosi H, Hata J: Expression of epidermal growth factor receptor in human gastric and colonic carcinoma. Cancer Res 48: 137-141, 1988. 5) Sainsbury JRC, Farndon JR, Needham GK: Epidermal-growth-factor receptor status as predictor of early recurrence of and death from breast cancer. Lancet June 20: 1398-1402, 1987. 13) Sundareshan P, Misiorowski RL, Davis JR: Effect of epidermal growth factor on growth response, morphology, and invasive potential of human endometrial carcinoma cell line RL95-2. Cancer Comm 3: 149-158, 1991. 11) 宮口衛: 予後因子としての上皮成長因子受容体. 頭頸部腫瘍19: 63-66, 1993. 12) Koyasu S, Kadowaki T, Nisida E: Alteration in growth, cell morphology, and cytoskeletal structures of KB cells induced by epidermal growth factor and transforming growth factor-β. Exp cell Res 176: 107-116, 1988. 4) Neal DE, Marsh C, Bennett MK: Epidermalgrowth-factor receptors in human bladder cancer: comparison of invasive and superficial tumors. Lancet February 16: 366-368, 1985. 2) Shimizu N, Hunts J, Merlino G: Amplification and rearrangement of EGF receptor gene in translocation chromosome 7 (M4) of human epidermoid carcinoma A 431 cells. Cytogenet Cell Genet 40: 744, 1985. |
| References_xml | – reference: 3) Broders AC: Practical points on the microscopic grading of carcinoma. New york J Med 32: 667, 1932 (下里幸雄: 広戸幾一郎他編: 臨床耳鼻咽喉科・頭頸部外科全書8-A頭頸部腫瘍総論. 金原出版, 東京, 1985, 53-56頁) – reference: 9) 上田政和, 小沢壮治, 森光生, 清水信義, 阿部令彦: 扁平上皮癌とレセプター. 最新医学42: 950-955, 1987. – reference: 6) Yasui W, Sumiyosi H, Hata J: Expression of epidermal growth factor receptor in human gastric and colonic carcinoma. Cancer Res 48: 137-141, 1988. – reference: 4) Neal DE, Marsh C, Bennett MK: Epidermalgrowth-factor receptors in human bladder cancer: comparison of invasive and superficial tumors. Lancet February 16: 366-368, 1985. – reference: 12) Koyasu S, Kadowaki T, Nisida E: Alteration in growth, cell morphology, and cytoskeletal structures of KB cells induced by epidermal growth factor and transforming growth factor-β. Exp cell Res 176: 107-116, 1988. – reference: 5) Sainsbury JRC, Farndon JR, Needham GK: Epidermal-growth-factor receptor status as predictor of early recurrence of and death from breast cancer. Lancet June 20: 1398-1402, 1987. – reference: 1) Carpenter G, Cohen S: Epidermal growth factor. Ann Rev Biochem 48: 193-216, 1979. – reference: 8) 塩崎均, 矢野浩司, 森武貞: 食道癌の進展と予後. Oncologia 22 (3): 5-9, 1989. – reference: 2) Shimizu N, Hunts J, Merlino G: Amplification and rearrangement of EGF receptor gene in translocation chromosome 7 (M4) of human epidermoid carcinoma A 431 cells. Cytogenet Cell Genet 40: 744, 1985. – reference: 10) Bergler W, Bier H, Ganzer U: The expression of epidermal growth factor receptors in the oral mucosa with oral cancer. Arch Otorhinolaryngol 246: 121-125, 1989. – reference: 7) Ozawa S, Ueda M, Ando N: Prognostic significance of epidermal growth factor receptor in esophageal squamous cell carcinomas. Cancer 63: 2169-2173, 1989. – reference: 13) Sundareshan P, Misiorowski RL, Davis JR: Effect of epidermal growth factor on growth response, morphology, and invasive potential of human endometrial carcinoma cell line RL95-2. Cancer Comm 3: 149-158, 1991. – reference: 11) 宮口衛: 予後因子としての上皮成長因子受容体. 頭頸部腫瘍19: 63-66, 1993. |
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| SubjectTerms | Adult Aged Aged, 80 and over Carcinoma, Squamous Cell - chemistry ErbB Receptors - analysis Female Head and Neck Neoplasms - chemistry Humans Immunohistochemistry Male Middle Aged |
| Title | EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR IN SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK |
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