In Vitro Plasma Protein Binding of Neuromuscular Blocking Agents in Different Subpopulations of Patients
In vitro protein binding of several neuromuscular blocking agents (NMBAs) was measured by ultrafiltration in plasma from patients susceptible to demonstrate changes in their protein constituents.First, the relationship between the free fraction of atracurium and plasma lipoproteins levels in young v...
Saved in:
Published in | Anesthesia and analgesia Vol. 81; no. 5; pp. 1019 - 1025 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Hagerstown, MD
International Anesthesia Research Society
01.11.1995
Lippincott |
Subjects | |
Online Access | Get full text |
ISSN | 0003-2999 |
DOI | 10.1097/00000539-199511000-00022 |
Cover
Abstract | In vitro protein binding of several neuromuscular blocking agents (NMBAs) was measured by ultrafiltration in plasma from patients susceptible to demonstrate changes in their protein constituents.First, the relationship between the free fraction of atracurium and plasma lipoproteins levels in young volunteers (22-32 yr old, n = 6) and hyperlipidemic patients (44-68 yr old, n = 13) was studied, and second, the free fraction of atracurium, mivacurium, doxacurium, and vecuronium was determined in plasma of healthy young (27-47 yr old, n = 10), elderly (72-89 yr old, n = 11) and obese (21-57 yr old, n = 9, 200%-360% ideal body weight) patients scheduled for elective surgery. In hyperlipidemic patients, atracurium free fraction was significantly less than in young volunteers (40% +/- 5% vs 50% +/- 5%, mean +/- SD), and decreased as total cholesterol, low-density lipoprotein cholesterol and triglycerides increased (P < 0.05). In young individuals, NMBA free fraction was 25% +/- 5% for vecuronium, 58% +/- 8% for doxacurium, 52% +/- 6% for atracurium, and 72% +/- 3%, 70% +/- 3%, 70% +/- 4% for mivacurium trans-trans, cis-trans, and cis-cis isomers, respectively. Higher triglyceride concentrations in obese patients and lower high-density-lipoprotein cholesterol concentrations in both obese and elderly patients were observed when compared with young subjects. However, there was no significant difference in protein binding of NMBAs among these three groups. We conclude that, in otherwise healthy patients, age and weight are not likely to alter the free fraction of NMBAs.(Anesth Analg 1995;81:1019-25) |
---|---|
AbstractList | In vitro protein binding of several neuromuscular blocking agents (NMBAs) was measured by ultrafiltration in plasma from patients susceptible to demonstrate changes in their protein constituents. First, the relationship between the free fraction of atracurium and plasma lipoproteins levels in young volunteers (22-32 yr old, n = 6) and hyperlipidemic patients (44-68 yr old, n = 13) was studied, and second, the free fraction of atracurium, mivacurium, doxacurium, and vecuronium was determined in plasma of healthy young (27-47 yr old, n = 10), elderly (72-89 yr old, n = 11) and obese (21-57 yr old, n = 9, 200%-360% ideal body weight) patients scheduled for elective surgery. In hyperlipidemic patients, atracurium free fraction was significantly less than in young volunteers (40% +/- 5% vs 50% +/- 5%, mean +/- SD), and decreased as total cholesterol, low-density lipoprotein cholesterol and triglycerides increased (P < 0.05). In young individuals, NMBA free fraction was 25% +/- 5% for vecuronium, 58% +/- 8% for doxacurium, 52% +/- 6% for atracurium, and 72% +/- 3%, 70% +/- 3%, 70% +/- 4% for mivacurium trans-trans, cis-trans, and cis-cis isomers, respectively. Higher triglyceride concentrations in obese patients and lower high-density-lipoprotein cholesterol concentrations in both obese and elderly patients were observed when compared with young subjects. However, there was no significant difference in protein binding of NMBAs among these three groups. We conclude that, in otherwise healthy patients, age and weight are not likely to alter the free fraction of NMBAs.In vitro protein binding of several neuromuscular blocking agents (NMBAs) was measured by ultrafiltration in plasma from patients susceptible to demonstrate changes in their protein constituents. First, the relationship between the free fraction of atracurium and plasma lipoproteins levels in young volunteers (22-32 yr old, n = 6) and hyperlipidemic patients (44-68 yr old, n = 13) was studied, and second, the free fraction of atracurium, mivacurium, doxacurium, and vecuronium was determined in plasma of healthy young (27-47 yr old, n = 10), elderly (72-89 yr old, n = 11) and obese (21-57 yr old, n = 9, 200%-360% ideal body weight) patients scheduled for elective surgery. In hyperlipidemic patients, atracurium free fraction was significantly less than in young volunteers (40% +/- 5% vs 50% +/- 5%, mean +/- SD), and decreased as total cholesterol, low-density lipoprotein cholesterol and triglycerides increased (P < 0.05). In young individuals, NMBA free fraction was 25% +/- 5% for vecuronium, 58% +/- 8% for doxacurium, 52% +/- 6% for atracurium, and 72% +/- 3%, 70% +/- 3%, 70% +/- 4% for mivacurium trans-trans, cis-trans, and cis-cis isomers, respectively. Higher triglyceride concentrations in obese patients and lower high-density-lipoprotein cholesterol concentrations in both obese and elderly patients were observed when compared with young subjects. However, there was no significant difference in protein binding of NMBAs among these three groups. We conclude that, in otherwise healthy patients, age and weight are not likely to alter the free fraction of NMBAs. In vitro protein binding of several neuromuscular blocking agents (NMBAs) was measured by ultrafiltration in plasma from patients susceptible to demonstrate changes in their protein constituents. First, the relationship between the free fraction of atracurium and plasma lipoproteins levels in young volunteers (22-32 yr old, n = 6) and hyperlipidemic patients (44-68 yr old, n = 13) was studied, and second, the free fraction of atracurium, mivacurium, doxacurium, and vecuronium was determined in plasma of healthy young (27-47 yr old, n = 10), elderly (72-89 yr old, n = 11) and obese (21-57 yr old, n = 9, 200%-360% ideal body weight) patients scheduled for elective surgery. In hyperlipidemic patients, atracurium free fraction was significantly less than in young volunteers (40% +/- 5% vs 50% +/- 5%, mean +/- SD), and decreased as total cholesterol, low-density lipoprotein cholesterol and triglycerides increased (P < 0.05). In young individuals, NMBA free fraction was 25% +/- 5% for vecuronium, 58% +/- 8% for doxacurium, 52% +/- 6% for atracurium, and 72% +/- 3%, 70% +/- 3%, 70% +/- 4% for mivacurium trans-trans, cis-trans, and cis-cis isomers, respectively. Higher triglyceride concentrations in obese patients and lower high-density-lipoprotein cholesterol concentrations in both obese and elderly patients were observed when compared with young subjects. However, there was no significant difference in protein binding of NMBAs among these three groups. We conclude that, in otherwise healthy patients, age and weight are not likely to alter the free fraction of NMBAs. In vitro protein binding of several neuromuscular blocking agents (NMBAs) was measured by ultrafiltration in plasma from patients susceptible to demonstrate changes in their protein constituents.First, the relationship between the free fraction of atracurium and plasma lipoproteins levels in young volunteers (22-32 yr old, n = 6) and hyperlipidemic patients (44-68 yr old, n = 13) was studied, and second, the free fraction of atracurium, mivacurium, doxacurium, and vecuronium was determined in plasma of healthy young (27-47 yr old, n = 10), elderly (72-89 yr old, n = 11) and obese (21-57 yr old, n = 9, 200%-360% ideal body weight) patients scheduled for elective surgery. In hyperlipidemic patients, atracurium free fraction was significantly less than in young volunteers (40% +/- 5% vs 50% +/- 5%, mean +/- SD), and decreased as total cholesterol, low-density lipoprotein cholesterol and triglycerides increased (P < 0.05). In young individuals, NMBA free fraction was 25% +/- 5% for vecuronium, 58% +/- 8% for doxacurium, 52% +/- 6% for atracurium, and 72% +/- 3%, 70% +/- 3%, 70% +/- 4% for mivacurium trans-trans, cis-trans, and cis-cis isomers, respectively. Higher triglyceride concentrations in obese patients and lower high-density-lipoprotein cholesterol concentrations in both obese and elderly patients were observed when compared with young subjects. However, there was no significant difference in protein binding of NMBAs among these three groups. We conclude that, in otherwise healthy patients, age and weight are not likely to alter the free fraction of NMBAs.(Anesth Analg 1995;81:1019-25) |
Author | Cameron, Maryse Varin, France Donati, Francois |
AuthorAffiliation | Faculte de Pharmacie, Universite de Montreal (Cameron, Varin), and Department of Anaesthesia, Royal Victoria Hospital and McGill University, Montreal, Quebec, Canada (Donati). This research was supported by the Medical Research Council of Canada. Presented in part at the XII International Congress of Pharmacology, July 24-29, 1994, Montreal, Quebec, Canada. Accepted for publication June 26, 1995. Address correspondence and reprint requests to France Varin, BPharm, PhD, Faculte de Pharmacie, Universite de Montreal, 2900 Edouard Montpetit, Montreal, Quebec, H3C 3J7 Canada |
AuthorAffiliation_xml | – name: Faculte de Pharmacie, Universite de Montreal (Cameron, Varin), and Department of Anaesthesia, Royal Victoria Hospital and McGill University, Montreal, Quebec, Canada (Donati). This research was supported by the Medical Research Council of Canada. Presented in part at the XII International Congress of Pharmacology, July 24-29, 1994, Montreal, Quebec, Canada. Accepted for publication June 26, 1995. Address correspondence and reprint requests to France Varin, BPharm, PhD, Faculte de Pharmacie, Universite de Montreal, 2900 Edouard Montpetit, Montreal, Quebec, H3C 3J7 Canada |
Author_xml | – sequence: 1 givenname: Maryse surname: Cameron fullname: Cameron, Maryse organization: Faculte de Pharmacie, Universite de Montreal (Cameron, Varin), and Department of Anaesthesia, Royal Victoria Hospital and McGill University, Montreal, Quebec, Canada (Donati). This research was supported by the Medical Research Council of Canada. Presented in part at the XII International Congress of Pharmacology, July 24-29, 1994, Montreal, Quebec, Canada. Accepted for publication June 26, 1995. Address correspondence and reprint requests to France Varin, BPharm, PhD, Faculte de Pharmacie, Universite de Montreal, 2900 Edouard Montpetit, Montreal, Quebec, H3C 3J7 Canada – sequence: 2 givenname: Francois surname: Donati fullname: Donati, Francois – sequence: 3 givenname: France surname: Varin fullname: Varin, France |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2893429$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/7486041$$D View this record in MEDLINE/PubMed |
BookMark | eNqNkktrHSEUx12kpHn0IxRclO4mHR8zjptCkr4Cob3Qx1Yc7zHXxtFbdQj59nVyb7IoFCKI58_5nePj7zE6CDEAQpi0Z6SV4l27jI7JhkjZEVJFUyelB-iorqyhUsqX6Djn31WSdugP0aHgQ99ycoQ2VwH_ciVFvPI6TxqvUizgAr5wYe3CDY4Wf4U5xWnOZvY64Qsfze2SOb-BUDKu7AdnLaSq8Pd53MZt5YqLIS_Fqxou3Cl6YbXP8Gq_nqCfnz7-uPzSXH_7fHV5ft0YNnDadNBpM9ZDDkQI2UEL7WgYUMYt050W4zgQUoMq2NpaZoztKR3FwK2wes3ZCXq767tN8c8MuajJZQPe6wBxzkqIXvS86yr4eg_O4wRrtU1u0ule7Z-m5t_s8zob7W3Swbj8hNFBMk5lxd7vMJNizgmsMq48XL8k7bwirVpcUo8uqSeX1INLtcHwT4PHLZ5Ryneld9EXSPnWz3eQ1Aa0Lxv1v3_B_gLrk6dp |
CODEN | AACRAT |
CitedBy_id | crossref_primary_10_1111_j_1460_9592_2010_03514_x crossref_primary_10_1034_j_1399_6576_2000_441002_x |
Cites_doi | 10.1097/00000542-198905000-00007 10.1111/j.1365-2125.1983.tb02258.x 10.2165/00003088-198400091-00013 10.1159/000213314 10.1038/clpt.1990.112 10.1111/j.1365-2125.1990.tb03620.x 10.1038/clpt.1993.30 10.1097/00000542-198105000-00006 10.1093/bja/52.suppl_1.3S 10.1007/BF02395213 10.1016/0895-4356(92)90080-7 10.1016/0531-5565(93)90067-N 10.1093/clinchem/18.6.499 10.1097/00000542-199409001-01101 10.1097/00000542-197310000-00015 10.1097/00000542-199409001-01061 10.1097/00000542-199111000-00001 10.2165/00003088-198409020-00005 10.1093/infdis/136.6.778 10.1002/j.1552-4604.1987.tb05582.x 10.1111/j.1365-2125.1979.tb01000.x 10.1097/00007691-198609000-00003 10.1093/bja/54.5.513 10.1016/0378-4347(92)80477-8 10.1097/00007611-199312000-00007 10.1016/S0378-4347(00)83838-4 10.1111/j.1365-2125.1984.tb02567.x 10.1038/clpt.1981.136 10.1038/clpt.1981.73 10.1097/00000542-197911000-00007 10.1002/bdd.2510100604 10.3109/00365518609083648 10.1016/0378-4347(94)00443-9 10.1002/cpt1979251103 10.1093/geronj/43.1.M18 10.1093/clinchem/30.3.404 10.1016/0895-4356(92)90081-W 10.1111/j.0954-6820.1988.tb05567.x 10.3181/00379727-200-43418 10.1097/00000542-196411000-00010 10.1213/00000539-198301000-00005 10.1093/ajcn/59.1.32 |
ContentType | Journal Article |
Copyright | 1995 International Anesthesia Research Society 1996 INIST-CNRS |
Copyright_xml | – notice: 1995 International Anesthesia Research Society – notice: 1996 INIST-CNRS |
DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 |
DOI | 10.1097/00000539-199511000-00022 |
DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
EndPage | 1025 |
ExternalDocumentID | 7486041 2893429 10_1097_00000539_199511000_00022 00000539-199511000-00022 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- .-D .55 .GJ .XZ .Z2 01R 026 0R~ 1CY 1J1 23M 2WC 3O- 40H 4Q1 4Q2 4Q3 53G 5GY 5RE 5VS 71W 77Y 7O~ AAAAV AAAXR AAGIX AAHPQ AAIQE AAJCS AAMOA AAMTA AAQKA AAQQT AARTV AASCR AASOK AAUEB AAWTL AAXQO ABASU ABBUW ABDIG ABJNI ABKPX ABOCM ABPPZ ABPXF ABVCZ ABXVJ ABXYN ABZAD ABZZY ACCJW ACDDN ACDOF ACEWG ACGFO ACGFS ACILI ACLDA ACLED ACWDW ACWRI ACXJB ACXNZ ACZKN ADBBV ADFPA ADGGA ADHPY ADNKB AE3 AE6 AEBDS AEETU AENEX AFBFQ AFDTB AFEXH AFFNX AFMBP AFMFG AFNMH AFSOK AFUWQ AGINI AHOMT AHQNM AHQVU AHRYX AHVBC AHXIK AIJEX AINUH AJCLO AJIOK AJNWD AJNYG AJRGT AJZMW AKCTQ AKULP ALKUP ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AOQMC BAWUL BOYCO BQLVK BS7 C1A C45 CS3 DIWNM DUNZO E.X E3Z EBS EEVPB EJD ERAAH EX3 F2K F2L F2M F2N F5P FCALG FL- FRP FW0 GNXGY GQDEL GX1 H0~ HLJTE HZ~ IKREB IKYAY IN~ IPNFZ J5H JF9 JG8 JK3 JK8 K8S KD2 KMI L-C L7B M18 MZP N4W N9A N~7 N~B N~M O9- OAG OAH OB4 OCUKA ODA ODMTH OHYEH OK1 OL1 OLG OLH OLL OLU OLV OLY OLZ OPUJH ORVUJ OUVQU OVD OVDNE OVIDH OVLEI OVOZU OWBYB OWU OWV OWW OWX OWY OWZ OXXIT P-K P2P PONUX R58 RIG RLZ S4R S4S TEORI TR2 TSPGW V2I VVN W3M W8F WOQ WOW X3V X3W X7M XXN XYM YFH YOC YQJ ZFV ZGI ZXP ZZMQN AAFWJ AAYXX ADKSD ADSXY CITATION IQODW ACIJW AWKKM CGR CUY CVF DIK ECM EIF NPM OJAPA OLW PKN 7X8 |
ID | FETCH-LOGICAL-c3842-5e5acb086817795e0e0bc3e234f3a5a7bb811a5a3a53dff3ccf622b784f7fad43 |
ISSN | 0003-2999 |
IngestDate | Mon Sep 08 12:01:45 EDT 2025 Wed Feb 19 02:35:52 EST 2025 Mon Jul 21 09:15:44 EDT 2025 Thu Apr 24 23:04:18 EDT 2025 Wed Oct 01 02:11:58 EDT 2025 Fri May 16 03:43:50 EDT 2025 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 5 |
Keywords | Human Obesity Nutrition disorder Metabolic diseases Lipids In vitro Blood plasma Proteins Biological fixation Non depolarisant myorelaxant Interindividual comparison Hyperlipemia Pharmacokinetics Age Nutritional status |
Language | English |
License | CC BY 4.0 |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c3842-5e5acb086817795e0e0bc3e234f3a5a7bb811a5a3a53dff3ccf622b784f7fad43 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
PMID | 7486041 |
PQID | 77676455 |
PQPubID | 23479 |
PageCount | 7 |
ParticipantIDs | proquest_miscellaneous_77676455 pubmed_primary_7486041 pascalfrancis_primary_2893429 crossref_citationtrail_10_1097_00000539_199511000_00022 crossref_primary_10_1097_00000539_199511000_00022 wolterskluwer_health_00000539-199511000-00022 |
ProviderPackageCode | CITATION AAYXX |
PublicationCentury | 1900 |
PublicationDate | 1995-November |
PublicationDateYYYYMMDD | 1995-11-01 |
PublicationDate_xml | – month: 11 year: 1995 text: 1995-November |
PublicationDecade | 1990 |
PublicationPlace | Hagerstown, MD |
PublicationPlace_xml | – name: Hagerstown, MD – name: United States |
PublicationTitle | Anesthesia and analgesia |
PublicationTitleAlternate | Anesth Analg |
PublicationYear | 1995 |
Publisher | International Anesthesia Research Society Lippincott |
Publisher_xml | – name: International Anesthesia Research Society – name: Lippincott |
References | Patterson (R20-22-20061207) 1988; 728 Wood (R4-22-20061207) 1983; 62 Shum (R38-22-20061207) 1989; 10 Wood (R2-22-20061207) 1991; 75 Chaudrey (R33-22-20061207) 1994; 81 Meijer (R8-22-20061207) 1979; 51 Varin (R13-22-20061207) 1990; 48 Lamon-Fava (R19-22-20061207) 1994; 59 Asmal (R40-22-20061207) 1979; 7 Marathe (R10-22-20061207) 1989; 70 Benedek (R22-22-20061207) 1983; 16 Howard (R27-22-20061207) 1992; 200 Wood (R41-22-20061207) 1979; 25 Wood (R9-22-20061207) 1981; 29 Benedek (R23-22-20061207) 1984; 18 Campion (R51-22-20061207) 1988; 43 Salive (R48-22-20061207) 1992; 45 Cederholm (R50-22-20061207) 1992; 38 Kremer (R53-22-20061207) 1988; 40 Tsujimoto (R44-22-20061207) 1989; 27 Dal Santo (R5-22-20061207) 1964; 25 Walker (R1-22-20061207) 1983; 62 Foster (R24-22-20061207) 1987; 11 Abernathy (R37-22-20061207) 1984; 9 (R17-22-20061207) 1988; 18 Ghoneim (R6-22-20061207) 1973; 39 Foldes (R11-22-20061207) 1983; 55 Barre (R36-22-20061207) 1984; 9 Veering (R47-22-20061207) 1990; 29 Van der Sluijs (R15-22-20061207) 1985; 234 Kessler (R42-22-20061207) 1981; 30 Ducharme (R30-22-20061207) 1992; 573 Mattila (R18-22-20061207) 1986; 46 Peterson (R35-22-20061207) 1977; 136 Pacifici (R46-22-20061207) 1986; 8 Duvaldestin (R3-22-20061207) 1982; 54 Leibel (R7-22-20061207) 1981; 54 McEllistrum (R52-22-20061207) 1993; 86 Alvarez (R21-22-20061207) 1984; 30 Varin (R28-22-20061207) 1990; 529 Verbeeck (R45-22-20061207) 1984; 27 Gariepy (R14-22-20061207) 1993; 53 Lacroix (R31-22-20061207) 1995; 663 Katzel (R26-22-20061207) 1993; 28 Klonoff-Cohen (R49-22-20061207) 1992; 45 Savage (R32-22-20061207) 1980; 52 Friedwald (R29-22-20061207) 1972; 18 Schieren (R34-22-20061207) 1994; 81 Despres (R25-22-20061207) 1989; 12 Cheymol (R39-22-20061207) 1987; 27 |
References_xml | – volume: 70 start-page: 752 year: 1989 ident: R10-22-20061207 publication-title: Anesthesiology doi: 10.1097/00000542-198905000-00007 – volume: 16 start-page: 751 year: 1983 ident: R22-22-20061207 publication-title: Br J Clin Pharmacol doi: 10.1111/j.1365-2125.1983.tb02258.x – volume: 9 start-page: 84 year: 1984 ident: R36-22-20061207 publication-title: Clin Pharmacokinet doi: 10.2165/00003088-198400091-00013 – volume: 38 start-page: 105 year: 1992 ident: R50-22-20061207 publication-title: Gerontology doi: 10.1159/000213314 – volume: 48 start-page: 18 year: 1990 ident: R13-22-20061207 publication-title: Clin Pharmacol Ther doi: 10.1038/clpt.1990.112 – volume: 29 start-page: 201 year: 1990 ident: R47-22-20061207 publication-title: Br J Clin Pharmacol doi: 10.1111/j.1365-2125.1990.tb03620.x – volume: 53 start-page: 340 year: 1993 ident: R14-22-20061207 publication-title: Clin Pharmacol Ther doi: 10.1038/clpt.1993.30 – volume: 54 start-page: 378 year: 1981 ident: R7-22-20061207 publication-title: Anesthesiology doi: 10.1097/00000542-198105000-00006 – volume: 52 start-page: 3S year: 1980 ident: R32-22-20061207 publication-title: Br J Anaesth doi: 10.1093/bja/52.suppl_1.3S – volume: 27 start-page: 91 year: 1984 ident: R45-22-20061207 publication-title: Eur J Clin Pharmacol doi: 10.1007/BF02395213 – volume: 40 start-page: 1 year: 1988 ident: R53-22-20061207 publication-title: Pharmacol Rev – volume: 45 start-page: 213 year: 1992 ident: R49-22-20061207 publication-title: J Clin Epidemiol doi: 10.1016/0895-4356(92)90080-7 – volume: 28 start-page: 411 year: 1993 ident: R26-22-20061207 publication-title: Exp Gerontol doi: 10.1016/0531-5565(93)90067-N – volume: 18 start-page: 499 year: 1972 ident: R29-22-20061207 publication-title: Clin Chem doi: 10.1093/clinchem/18.6.499 – volume: 81 start-page: A1102 year: 1994 ident: R34-22-20061207 publication-title: Anesthesiology doi: 10.1097/00000542-199409001-01101 – volume: 62 start-page: 870 year: 1983 ident: R1-22-20061207 publication-title: Anesth Analg – volume: 39 start-page: 410 year: 1973 ident: R6-22-20061207 publication-title: Anesthesiology doi: 10.1097/00000542-197310000-00015 – volume: 81 start-page: A1062 year: 1994 ident: R33-22-20061207 publication-title: Anesthesiology doi: 10.1097/00000542-199409001-01061 – volume: 75 start-page: 721 year: 1991 ident: R2-22-20061207 publication-title: Anesthesiology doi: 10.1097/00000542-199111000-00001 – volume: 9 start-page: 177 year: 1984 ident: R37-22-20061207 publication-title: Clin Pharmacokinet doi: 10.2165/00003088-198409020-00005 – volume: 136 start-page: 778 year: 1977 ident: R35-22-20061207 publication-title: J Infect Dis doi: 10.1093/infdis/136.6.778 – volume: 27 start-page: 874 year: 1987 ident: R39-22-20061207 publication-title: J Clin Pharmacol doi: 10.1002/j.1552-4604.1987.tb05582.x – volume: 7 start-page: 531 year: 1979 ident: R40-22-20061207 publication-title: Br J Clin Pharmacol doi: 10.1111/j.1365-2125.1979.tb01000.x – volume: 55 start-page: 31S year: 1983 ident: R11-22-20061207 publication-title: Br J Anaesth – volume: 8 start-page: 259 year: 1986 ident: R46-22-20061207 publication-title: Ther Drug Monit doi: 10.1097/00007691-198609000-00003 – volume: 27 start-page: 13 year: 1989 ident: R44-22-20061207 publication-title: Int J Clin Pharmacol Ther Toxicol – volume: 54 start-page: 513 year: 1982 ident: R3-22-20061207 publication-title: Br J Anaesth doi: 10.1093/bja/54.5.513 – volume: 573 start-page: 79 year: 1992 ident: R30-22-20061207 publication-title: J Chromatogr doi: 10.1016/0378-4347(92)80477-8 – volume: 86 start-page: 1360 year: 1993 ident: R52-22-20061207 publication-title: South Med J doi: 10.1097/00007611-199312000-00007 – volume: 234 start-page: 703 year: 1985 ident: R15-22-20061207 publication-title: J Pharmacol Exp Ther – volume: 529 start-page: 319 year: 1990 ident: R28-22-20061207 publication-title: J Chromatogr doi: 10.1016/S0378-4347(00)83838-4 – volume: 18 start-page: 941 year: 1984 ident: R23-22-20061207 publication-title: Br J Clin Pharmacol doi: 10.1111/j.1365-2125.1984.tb02567.x – volume: 30 start-page: 121 year: 1981 ident: R42-22-20061207 publication-title: Clin Pharmacol Ther doi: 10.1038/clpt.1981.136 – volume: 12 start-page: 374 year: 1989 ident: R25-22-20061207 publication-title: Clin Invest Med – volume: 29 start-page: 522 year: 1981 ident: R9-22-20061207 publication-title: Clin Pharmacol Ther doi: 10.1038/clpt.1981.73 – volume: 51 start-page: 402 year: 1979 ident: R8-22-20061207 publication-title: Anesthesiology doi: 10.1097/00000542-197911000-00007 – volume: 10 start-page: 549 year: 1989 ident: R38-22-20061207 publication-title: Biopharm Drug Dispos doi: 10.1002/bdd.2510100604 – volume: 46 start-page: 131 year: 1986 ident: R18-22-20061207 publication-title: Scand J Clin Lab Invest doi: 10.3109/00365518609083648 – volume: 663 start-page: 297 year: 1995 ident: R31-22-20061207 publication-title: J Chromatogr B Biomed Appl doi: 10.1016/0378-4347(94)00443-9 – volume: 25 start-page: 103 year: 1979 ident: R41-22-20061207 publication-title: Clin Pharmacol Ther doi: 10.1002/cpt1979251103 – volume: 43 start-page: M18 year: 1988 ident: R51-22-20061207 publication-title: J Gerontol doi: 10.1093/geronj/43.1.M18 – volume: 30 start-page: 404 year: 1984 ident: R21-22-20061207 publication-title: Clin Chem doi: 10.1093/clinchem/30.3.404 – volume: 45 start-page: 213 year: 1992 ident: R48-22-20061207 publication-title: J Clin Epideol doi: 10.1016/0895-4356(92)90081-W – volume: 728 start-page: 150 year: 1988 ident: R20-22-20061207 publication-title: Acta Med Scand doi: 10.1111/j.0954-6820.1988.tb05567.x – volume: 18 start-page: 36 year: 1988 ident: R17-22-20061207 publication-title: Arch Intern Med – volume: 200 start-page: 202 year: 1992 ident: R27-22-20061207 publication-title: Proc Soc Exp Biol Med doi: 10.3181/00379727-200-43418 – volume: 25 start-page: 788 year: 1964 ident: R5-22-20061207 publication-title: Anesthesiology doi: 10.1097/00000542-196411000-00010 – volume: 62 start-page: 29 year: 1983 ident: R4-22-20061207 publication-title: Anesth Analg doi: 10.1213/00000539-198301000-00005 – volume: 11 start-page: 151 year: 1987 ident: R24-22-20061207 publication-title: Int J Obes – volume: 59 start-page: 32 year: 1994 ident: R19-22-20061207 publication-title: Am J Clin Nutr doi: 10.1093/ajcn/59.1.32 |
SSID | ssj0001086 |
Score | 1.58078 |
Snippet | In vitro protein binding of several neuromuscular blocking agents (NMBAs) was measured by ultrafiltration in plasma from patients susceptible to demonstrate... |
SourceID | proquest pubmed pascalfrancis crossref wolterskluwer |
SourceType | Aggregation Database Index Database Enrichment Source Publisher |
StartPage | 1019 |
SubjectTerms | Adult Age Factors Aged Anesthetics. Neuromuscular blocking agents Atracurium - blood Biological and medical sciences Blood Proteins - metabolism Body Weight Cholesterol - blood Female Humans Hyperlipidemias - blood Isoquinolines - blood Male Medical sciences Middle Aged Mivacurium Neuromuscular Nondepolarizing Agents - blood Neuropharmacology Pharmacology. Drug treatments Protein Binding Triglycerides - blood Vecuronium Bromide - blood |
Title | In Vitro Plasma Protein Binding of Neuromuscular Blocking Agents in Different Subpopulations of Patients |
URI | https://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00000539-199511000-00022 https://www.ncbi.nlm.nih.gov/pubmed/7486041 https://www.proquest.com/docview/77676455 |
Volume | 81 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
journalDatabaseRights | – providerCode: PRVFQY databaseName: GFMER Free Medical Journals issn: 0003-2999 databaseCode: GX1 dateStart: 19570101 customDbUrl: isFulltext: true dateEnd: 20241001 titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php omitProxy: true ssIdentifier: ssj0001086 providerName: Geneva Foundation for Medical Education and Research |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Pb9MwFLZgXJAQAsFEgYEPiEsVtCR2nBwntLGhMS4t6i2KnRiirUlpUpD463nPdn5JRQwOjdIobqp8X16ek_e9j5A3uc-FVCL3IPpzj-ko8WSmmBeEMheBVpopfKD_6So6X7KPK74a3EaNuqSV79SvvbqS_0EVtgGuqJL9B2T7H4UNsA74whIQhuWtML6o5j_KdlujF3Szzuam6UJZzWVptSpYpIHNN9Y7V24q4dZ1bWSJX42yDUthnUNKO292ctPbeZkKD9d0tRlnsCcQGyFpbKyYCz5oFNKUQ8FPti62riS_z5LxEX05qSP-AnP0atiSOyEedwK8cSxFFzhrb9TF0tgfcYaPAiNc-cneiG07AZu5Cg8TrHvh2MXOyN2tYnnaJPvqc3q2vLxMF6erxdvNdw_9w_A9uzNTuUvuBSKK0Mviw2oo9kE_qc47Ef-zq-nq2nfuO_QkUXmwyRq4ZrQ1O9k3G4F9ftZY4NBcG33DKEtZPCIP3fSCnliuPCZ3iuoJ-XZRUcMTanlCHU-o4wmtNZ3whHY8oZYnFPbteUKnPMHBHU-ekuXZ6eL9ueccNjwVxizweMEzJeHcxL4QCS-Oi2OpwiIImQ4zngkpY9-HFfgS5lqHSukoCKSImRY6y1l4SA6quiqeEQppKsRyJuMix_YKfsICnfOA6xBmuDxJZkR0pzNVrv08uqDcpKMyCANE2gORGiBmxO9HbmwLlluMOZog1g8MID-HFGxGXncIphBP8SVZVhX1rkmxu1XEOJ-RQwtsP1SgXxvzZ8SbAJ1awXL6Jx49_-uhXpD7wwX2khy0211xBKluK18ZFv8GwIOmDA |
linkProvider | Geneva Foundation for Medical Education and Research |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=In+vitro+plasma+protein+binding+of+neuromuscular+blocking+agents+in+different+subpopulations+of+patients&rft.jtitle=Anesthesia+and+analgesia&rft.au=Cameron%2C+M&rft.au=Donati%2C+F&rft.au=Varin%2C+F&rft.date=1995-11-01&rft.issn=0003-2999&rft.volume=81&rft.issue=5&rft.spage=1019&rft_id=info:doi/10.1097%2F00000539-199511000-00022&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0003-2999&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0003-2999&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0003-2999&client=summon |