Effect of treadmill exercise on pain-related Wnt/β-catenin signaling pathway in dorsal root ganglion neurons at the early phase regeneration of the injured sciatic nerve

The purpose of this study was to determine whether treadmill walking exercise can improve mechanical allodynia through regulation of Wnt/β-catenin signaling in dorsal root ganglion (DRG) neurons at the early stage of regeneration after sciatic nerve injury (SNI). The experimental rats were divided i...

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Bibliographic Details
Published inJournal of exercise rehabilitation Vol. 17; no. 2; pp. 96 - 102
Main Authors Cho, Yeong-Hyun, Kim, Ji-Eun, Seo, Tae-Beom
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Society of Exercise Rehabilitation 01.04.2021
한국운동재활학회
Subjects
Original
심리과학
Treadmill exercise
β-catenin
Wnt3a
Sciatic nerve
Neuropathic pain
Online AccessGet full text
ISSN2288-176X
2288-1778
2288-1778
DOI10.12965/jer.2142136.068

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Table of Contents:
  • Abstract INTRODUCTION MATERIALS AND METHODS Experimental animals Sciatic nerve injury Treadmill exercise Western blot analysis Paw withdrawal test Statistical analysis RESULTS Treadmill exercise improved mechanical allodynia after SNI Treadmill exercise decreased Wnt3a and p-LRP6 levels in the DRG neurons after SNI Treadmill exercise regulates translocation of β-catenin to nucleus of DRG neurons after SNI DISCUSSION CONFLICT OF INTEREST ACKNOWLEDGMENTS REFERENCES