Effect of treadmill exercise on pain-related Wnt/β-catenin signaling pathway in dorsal root ganglion neurons at the early phase regeneration of the injured sciatic nerve
The purpose of this study was to determine whether treadmill walking exercise can improve mechanical allodynia through regulation of Wnt/β-catenin signaling in dorsal root ganglion (DRG) neurons at the early stage of regeneration after sciatic nerve injury (SNI). The experimental rats were divided i...
Saved in:
| Published in | Journal of exercise rehabilitation Vol. 17; no. 2; pp. 96 - 102 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
Korean Society of Exercise Rehabilitation
01.04.2021
한국운동재활학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2288-176X 2288-1778 2288-1778 |
| DOI | 10.12965/jer.2142136.068 |
Cover
| Abstract | The purpose of this study was to determine whether treadmill walking exercise can improve mechanical allodynia through regulation of Wnt/β-catenin signaling in dorsal root ganglion (DRG) neurons at the early stage of regeneration after sciatic nerve injury (SNI). The experimental rats were divided into seven groups: the normal control, sedentary groups for 3-, 7-, and 14-day post crush (dpc), and exercise group for 3, 7, and 14 dpc. The rats in exercise groups performed treadmill walking exercise at a speed of 8 m/min for 20 min once a day according to ex-periment duration. For evaluating neuropathic pain-like behavior after SNI, the mechanical allodynia was examined by von Frey apparatus. And the expression levels of pain-related protein were identified in the cytoplasm or nucleus of DRG neurons using Western blot techniques. Mechanical allodynia was significantly ameliorated in the exercise group at 7 and 14 dpc. Treadmill exercise further decreased Wnt3a ex-pression at 3, 7, and 14 dpc compared to in the sedentary group. Also, phosphorylated-low-density lipoprotein receptor 6 was decreased in exercise groups at 3 and 14 dpc. Beta-catenin was significantly de-creased in exercise groups at 3 and 14 dpc compared to sedentary groups as well as treadmill exercise decreased translocation of β-cat-enin towards the nucleus of DRG neurons at 14 dpc. Our findings indi-cate that treadmill walking exercise may be an important regulator of neuropathic pain after peripheral nerve injury through delayed Wnt/β-catenin signaling pathway in DRG neurons. |
|---|---|
| AbstractList | The purpose of this study was to determine whether treadmill walking exercise can improve mechanical allodynia through regulation of Wnt/β-catenin signaling in dorsal root ganglion (DRG) neurons at the early stage of regeneration after sciatic nerve injury (SNI). The experimental rats were divided into seven groups: the normal control, sedentary groups for 3-, 7-, and 14-day post crush (dpc), and exercise group for 3, 7, and 14 dpc. The rats in exercise groups performed treadmill walking exercise at a speed of 8 m/min for 20 min once a day according to experiment duration. For evaluating neuropathic pain-like behavior after SNI, the mechanical allodynia was examined by von Frey apparatus. And the expression levels of pain-related protein were identified in the cytoplasm or nucleus of DRG neurons using Western blot techniques. Mechanical allodynia was significantly ameliorated in the exercise group at 7 and 14 dpc. Treadmill exercise further decreased Wnt3a expression at 3, 7, and 14 dpc compared to in the sedentary group. Also, phosphorylated-low-density lipoprotein receptor 6 was decreased in exercise groups at 3 and 14 dpc. Beta-catenin was significantly decreased in exercise groups at 3 and 14 dpc compared to sedentary groups as well as treadmill exercise decreased translocation of β-catenin towards the nucleus of DRG neurons at 14 dpc. Our findings indicate that treadmill walking exercise may be an important regulator of neuropathic pain after peripheral nerve injury through delayed Wnt/β-catenin signaling pathway in DRG neurons.The purpose of this study was to determine whether treadmill walking exercise can improve mechanical allodynia through regulation of Wnt/β-catenin signaling in dorsal root ganglion (DRG) neurons at the early stage of regeneration after sciatic nerve injury (SNI). The experimental rats were divided into seven groups: the normal control, sedentary groups for 3-, 7-, and 14-day post crush (dpc), and exercise group for 3, 7, and 14 dpc. The rats in exercise groups performed treadmill walking exercise at a speed of 8 m/min for 20 min once a day according to experiment duration. For evaluating neuropathic pain-like behavior after SNI, the mechanical allodynia was examined by von Frey apparatus. And the expression levels of pain-related protein were identified in the cytoplasm or nucleus of DRG neurons using Western blot techniques. Mechanical allodynia was significantly ameliorated in the exercise group at 7 and 14 dpc. Treadmill exercise further decreased Wnt3a expression at 3, 7, and 14 dpc compared to in the sedentary group. Also, phosphorylated-low-density lipoprotein receptor 6 was decreased in exercise groups at 3 and 14 dpc. Beta-catenin was significantly decreased in exercise groups at 3 and 14 dpc compared to sedentary groups as well as treadmill exercise decreased translocation of β-catenin towards the nucleus of DRG neurons at 14 dpc. Our findings indicate that treadmill walking exercise may be an important regulator of neuropathic pain after peripheral nerve injury through delayed Wnt/β-catenin signaling pathway in DRG neurons. The purpose of this study was to determine whether treadmill walking exercise can improve mechanical allodynia through regulation of Wnt/β-catenin signaling in dorsal root ganglion (DRG) neurons at the early stage of regeneration after sciatic nerve injury (SNI). The experimental rats were divided into seven groups: the normal control, sedentary groups for 3-, 7-, and 14-day post crush (dpc), and exercise group for 3, 7, and 14 dpc. The rats in exercise groups performed treadmill walking exercise at a speed of 8 m/min for 20 min once a day according to experiment duration. For evaluating neuropathic pain-like behavior after SNI, the mechanical allodynia was examined by von Frey apparatus. And the expression levels of pain-related protein were identified in the cytoplasm or nucleus of DRG neurons using Western blot techniques. Mechanical allodynia was significantly ameliorated in the exercise group at 7 and 14 dpc. Treadmill exercise further decreased Wnt3a expression at 3, 7, and 14 dpc compared to in the sedentary group. Also, phosphorylated-low-density lipoprotein receptor 6 was decreased in exercise groups at 3 and 14 dpc. Beta-catenin was significantly decreased in exercise groups at 3 and 14 dpc compared to sedentary groups as well as treadmill exercise decreased translocation of β-catenin towards the nucleus of DRG neurons at 14 dpc. Our findings indicate that treadmill walking exercise may be an important regulator of neuropathic pain after peripheral nerve injury through delayed Wnt/β-catenin signaling pathway in DRG neurons. The purpose of this study was to determine whether treadmill walking exercise can improve mechanical allodynia through regulation of Wnt/β-catenin signaling in dorsal root ganglion (DRG) neurons at the early stage of regeneration after sciatic nerve injury (SNI). The experimental rats were divided into seven groups: the normal control, sedentary groups for 3-, 7-, and 14-day post crush (dpc), and exercise group for 3, 7, and 14 dpc. The rats in exercise groups performed treadmill walking exercise at a speed of 8 m/min for 20 min once a day according to ex-periment duration. For evaluating neuropathic pain-like behavior after SNI, the mechanical allodynia was examined by von Frey apparatus. And the expression levels of pain-related protein were identified in the cytoplasm or nucleus of DRG neurons using Western blot techniques. Mechanical allodynia was significantly ameliorated in the exercise group at 7 and 14 dpc. Treadmill exercise further decreased Wnt3a ex-pression at 3, 7, and 14 dpc compared to in the sedentary group. Also, phosphorylated-low-density lipoprotein receptor 6 was decreased in exercise groups at 3 and 14 dpc. Beta-catenin was significantly de-creased in exercise groups at 3 and 14 dpc compared to sedentary groups as well as treadmill exercise decreased translocation of β-cat-enin towards the nucleus of DRG neurons at 14 dpc. Our findings indi-cate that treadmill walking exercise may be an important regulator of neuropathic pain after peripheral nerve injury through delayed Wnt/β-catenin signaling pathway in DRG neurons. The purpose of this study was to determine whether treadmill walking exercise can improve mechanical allodynia through regulation of Wnt/β-catenin signaling in dorsal root ganglion (DRG) neurons at the early stage of regeneration after sciatic nerve injury (SNI). The experimental rats were divided into seven groups: the normal control, sedentary groups for 3-, 7-, and 14-day post crush (dpc), and exercise group for 3, 7, and 14 dpc. The rats in exercise groups performed treadmill walking exercise at a speed of 8 m/min for 20 min once a day according to ex-periment duration. For evaluating neuropathic pain-like behavior after SNI, the mechanical allodynia was examined by von Frey apparatus. And the expression levels of pain-related protein were identified in the cytoplasm or nucleus of DRG neurons using Western blot techniques. Mechanical allodynia was significantly ameliorated in the exercise group at 7 and 14 dpc. Treadmill exercise further decreased Wnt3a ex-pression at 3, 7, and 14 dpc compared to in the sedentary group. Also, phosphorylated-low-density lipoprotein receptor 6 was decreased in exercise groups at 3 and 14 dpc. Beta-catenin was significantly de-creased in exercise groups at 3 and 14 dpc compared to sedentary groups as well as treadmill exercise decreased translocation of β-cat-enin towards the nucleus of DRG neurons at 14 dpc. Our findings indi-cate that treadmill walking exercise may be an important regulator of neuropathic pain after peripheral nerve injury through delayed Wnt/β-catenin signaling pathway in DRG neurons. KCI Citation Count: 1 |
| Author | Cho, Yeong-Hyun Seo, Tae-Beom Kim, Ji-Eun |
| Author_xml | – sequence: 1 givenname: Yeong-Hyun surname: Cho fullname: Cho, Yeong-Hyun – sequence: 2 givenname: Ji-Eun surname: Kim fullname: Kim, Ji-Eun – sequence: 3 givenname: Tae-Beom surname: Seo fullname: Seo, Tae-Beom |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34012935$$D View this record in MEDLINE/PubMed https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002712714$$DAccess content in National Research Foundation of Korea (NRF) |
| BookMark | eNqNUstu1DAUjVARLaV7VshLWGRqO4nj2SBVVYFKlZBQEeysO56bjKceO9hOy_wSSz6Eb8LzoAUWiI2vH-clHT8tDpx3WBTPGZ0wPhXN6RLDhLOas0pMqJCPiiPOpSxZ28qD-734fFicxLiklDJGG87ok-KwqmmWqJqj4ttF16FOxHckBYT5ylhL8CsGbSIS78gAxpUBLSSck08unf74Xup8cMaRaHoH1rg-o9LiDtYkX859iGBJ8D6RHlxvTVZxOAbvIoFE0gIJQrBrMiwgewTs0WGAtMFtYuR345ZjyH5Rm3yvMz3c4rPicQc24sl-Hhcf31xcn78rr96_vTw_uyp1JatUSoqs1tWsFVzUoqtQgO5a0LOmbqiopZhLxiVKLaChNdaca8p5x2XdghQgquPi1U7XhU7daKM8mO3svboJ6uzD9aWatpIxvsGyHXZ0A6zvwFo1BLOCsFaMqm1NKtek9jWpXFPmvN5xhnG2wrlGlwI88DZuf744s8jet0oyWjHJs8DLvUDwX0aMSa1M1GgtOPRjVLzh02kt85KhL373ujf59QEygO4AOvgYA3b_k1_8RdEmbevLaY39F3EfJtefW7X4EGdaCV5XPwEPm-PD |
| CitedBy_id | crossref_primary_10_3390_biomedicines11123174 crossref_primary_10_3389_fnmol_2024_1345864 crossref_primary_10_1093_jbcr_irad043 crossref_primary_10_1186_s12890_024_03048_z crossref_primary_10_1007_s13577_024_01036_3 crossref_primary_10_3390_ijerph182413333 crossref_primary_10_3390_cells14060462 crossref_primary_10_1007_s12035_024_04214_4 crossref_primary_10_12965_jer_2244382_191 crossref_primary_10_1590_acb370804 |
| Cites_doi | 10.1016/bs.pmbts.2017.11.026 10.1523/jneurosci.1425-09.2010 10.1016/j.pain.2005.10.036 10.1152/physrev.00045.2019 10.1186/1750-1326-6-49 10.1111/pme.12057 10.1249/01.mss.0000227311.00976.68 10.1007/s12565-016-0360-z 10.1016/j.neuron.2014.05.037 10.1073/pnas.1510137112 10.1016/j.expneurol.2014.02.013 10.1172/jci65364 10.1002/jor.24349 10.1016/j.biopha.2018.07.116 10.1016/j.neures.2013.12.002 10.1016/j.jpain.2006.06.005 10.1097/j.pain.0000000000000268 10.1093/pm/pnx294 10.4161/org.4.2.5851 10.3390/diagnostics11010074 10.3892/etm.2018.6512 10.1038/s41598-019-51140-w 10.1177/1753193413484627 10.1556/2060.106.2019.07 10.1213/ane.0000000000001662 10.1016/j.pharep.2017.09.009 |
| ContentType | Journal Article |
| Copyright | Copyright © 2021 Korean Society of Exercise Rehabilitation. Copyright © 2021 Korean Society of Exercise Rehabilitation 2021 |
| Copyright_xml | – notice: Copyright © 2021 Korean Society of Exercise Rehabilitation. – notice: Copyright © 2021 Korean Society of Exercise Rehabilitation 2021 |
| DBID | M1Z AAYXX CITATION NPM 7X8 5PM ADTOC UNPAY ACYCR |
| DOI | 10.12965/jer.2142136.068 |
| DatabaseName | 학술교육원 E-Article CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall Korean Citation Index |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Physical Therapy |
| EISSN | 2288-1778 |
| EndPage | 102 |
| ExternalDocumentID | oai_kci_go_kr_ARTI_9781126 10.12965/jer.2142136.068 PMC8103182 34012935 10_12965_jer_2142136_068 393624 |
| Genre | Journal Article |
| GroupedDBID | 53G ADBBV ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL DIK GROUPED_DOAJ HYE KQ8 M1Z M48 OK1 RPM AAYXX CITATION PGMZT ADRAZ NPM 7X8 5PM ADTOC UNPAY ACYCR |
| ID | FETCH-LOGICAL-c383t-80e14c3b762646f3e6acf7acb54506486d8128e8c6a504e422c022f2847a86a63 |
| IEDL.DBID | M48 |
| ISSN | 2288-176X 2288-1778 |
| IngestDate | Fri Sep 26 03:51:16 EDT 2025 Sun Oct 26 04:09:49 EDT 2025 Thu Aug 21 18:08:13 EDT 2025 Fri Jul 11 11:00:08 EDT 2025 Thu Jan 02 22:56:17 EST 2025 Thu Apr 24 23:10:24 EDT 2025 Tue Jul 01 04:27:28 EDT 2025 Tue Sep 26 04:10:33 EDT 2023 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | Treadmill exercise β-catenin Wnt3a Sciatic nerve Neuropathic pain |
| Language | English |
| License | Copyright © 2021 Korean Society of Exercise Rehabilitation. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. cc-by-nc |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c383t-80e14c3b762646f3e6acf7acb54506486d8128e8c6a504e422c022f2847a86a63 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 https://doi.org/10.12965/jer.2142136.068 |
| ORCID | 0000-0001-9213-2251 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.12965/jer.2142136.068 |
| PMID | 34012935 |
| PQID | 2529948299 |
| PQPubID | 23479 |
| PageCount | 7 |
| ParticipantIDs | nrf_kci_oai_kci_go_kr_ARTI_9781126 unpaywall_primary_10_12965_jer_2142136_068 pubmedcentral_primary_oai_pubmedcentral_nih_gov_8103182 proquest_miscellaneous_2529948299 pubmed_primary_34012935 crossref_primary_10_12965_jer_2142136_068 crossref_citationtrail_10_12965_jer_2142136_068 earticle_primary_393624 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2021-04-01 |
| PublicationDateYYYYMMDD | 2021-04-01 |
| PublicationDate_xml | – month: 04 year: 2021 text: 2021-04-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Korea (South) |
| PublicationPlace_xml | – name: Korea (South) |
| PublicationTitle | Journal of exercise rehabilitation |
| PublicationTitleAlternate | J Exerc Rehabil |
| PublicationYear | 2021 |
| Publisher | Korean Society of Exercise Rehabilitation 한국운동재활학회 |
| Publisher_xml | – name: Korean Society of Exercise Rehabilitation – name: 한국운동재활학회 |
| References | ref13 Marchetti (ref17) 2013 ref12 ref15 ref14 ref30 ref11 ref10 ref2 ref1 Zhang (ref28) 2010 ref16 ref19 ref18 Bussa (ref3) 2021 ref24 ref23 ref26 ref25 ref22 ref21 ref27 ref29 ref8 ref7 Sarikcioglu (ref20) 2009 ref9 ref4 ref6 ref5 |
| References_xml | – ident: ref8 doi: 10.1016/bs.pmbts.2017.11.026 – ident: ref25 doi: 10.1523/jneurosci.1425-09.2010 – ident: ref2 doi: 10.1016/j.pain.2005.10.036 – ident: ref7 doi: 10.1152/physrev.00045.2019 – ident: ref15 doi: 10.1186/1750-1326-6-49 – ident: ref22 doi: 10.1111/pme.12057 – ident: ref21 doi: 10.1249/01.mss.0000227311.00976.68 – ident: ref12 doi: 10.1007/s12565-016-0360-z – start-page: 1 volume-title: Walking track analysis: an assessment method for functional recovery after sciatic nerve injury in the rat year: 2009 ident: ref20 – ident: ref23 doi: 10.1016/j.neuron.2014.05.037 – ident: ref10 doi: 10.1073/pnas.1510137112 – ident: ref4 doi: 10.1016/j.expneurol.2014.02.013 – start-page: 1067 volume-title: Expression of NF-κB and TNF-α in spinal dorsal horn in a rat model of neuropathic pain year: 2010 ident: ref28 – ident: ref29 doi: 10.1172/jci65364 – ident: ref18 doi: 10.1002/jor.24349 – ident: ref26 doi: 10.1016/j.biopha.2018.07.116 – ident: ref11 doi: 10.1016/j.neures.2013.12.002 – ident: ref5 doi: 10.1016/j.jpain.2006.06.005 – ident: ref16 doi: 10.1097/j.pain.0000000000000268 – start-page: 144 volume-title: Wnt your brain be inflamed? year: 2013 ident: ref17 – ident: ref6 doi: 10.1093/pm/pnx294 – ident: ref13 doi: 10.4161/org.4.2.5851 – ident: ref1 doi: 10.3390/diagnostics11010074 – ident: ref30 doi: 10.3892/etm.2018.6512 – ident: ref19 doi: 10.1038/s41598-019-51140-w – ident: ref27 doi: 10.1177/1753193413484627 – ident: ref9 doi: 10.1556/2060.106.2019.07 – start-page: 1990 volume-title: Understanding peripheral neuropathic pain in primary care: diagnosis and management year: 2021 ident: ref3 – ident: ref24 doi: 10.1213/ane.0000000000001662 – ident: ref14 doi: 10.1016/j.pharep.2017.09.009 |
| SSID | ssj0001105210 |
| Score | 2.2225919 |
| Snippet | The purpose of this study was to determine whether treadmill walking exercise can improve mechanical allodynia through regulation of Wnt/β-catenin signaling in... |
| SourceID | nrf unpaywall pubmedcentral proquest pubmed crossref earticle |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 96 |
| SubjectTerms | Original 심리과학 |
| SummonAdditionalLinks | – databaseName: Unpaywall dbid: UNPAY link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwEB6V7QEulGcJLxnEBUR2EyfxZo8VoipIrXroinKyHMfZbnflRNmEqvwkjvwQfhMzeWxZQDwueWzsTCx_yXxej78BeJGkSIKUVm6ixtoNdWrwiNOEo5d6QayVntBC4cMjcTAN359Gp1vwul8L04RVuuembGbx62KZq3SEpy5-TLk7EcMiza7BtoiQeQ9ge3p0vPeR8sdx7HB_LE6vjsdxNyvJJyKiWwxJXcwPxNAjXdUNL9T1EvoXW2a_45q_hkxer22hLi_UcvmDP9rfgcO-JW0YymJYV8lQf_5J5PFfm3oLbnbElO21z3gbtoy9AzvHXTeyk1Z94C58afWOWZ4xClJPKW0R6xM3sdyyQs2t2yyRMSn7YKvRt68uhV3ZuWUULaJoATyjTMgX6pLhj2lertACUviKzRQtK8a7NDqbdsVUxZCiMkM6zKw4Q5_LSjNrtLIJUs1j4PW5Pa9LtLdqoKaxevnJ3IPp_tuTNwdul_DB1ThQrtBbGj_UQYIfaBGKLDBC6WysdII0D6lTLBBYPDaxFiryQhNyrpGCZORhVSyUCO7DwObWPACG1T1PCd9QwoAo85M0nfgZslcTecrzEgdGPQCk7tTQKSnHUtKoiCAjsStkBxmJkHHg5bpG0SqB_KHsbo-pddlgglwhdOA5Qkwu9FySsDftZ7lclBKHL-8kCZD5XDjwrEegxLedpnCUNXm9kjxC-hDGuEETLSKvDIT0p2IQOTDewOq6ABncvGLnZ42ieEzJPmLuwKs1qv_axof_U_gR3OAUDNSEPD2GQVXW5gmyuSp52r3E3wGXXErV priority: 102 providerName: Unpaywall |
| TableOfContents | Abstract
INTRODUCTION
MATERIALS AND METHODS
Experimental animals
Sciatic nerve injury
Treadmill exercise
Western blot analysis
Paw withdrawal test
Statistical analysis
RESULTS
Treadmill exercise improved mechanical allodynia after SNI
Treadmill exercise decreased Wnt3a and p-LRP6 levels in the DRG neurons after SNI
Treadmill exercise regulates translocation of β-catenin to nucleus of DRG neurons after SNI
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES |
| Title | Effect of treadmill exercise on pain-related Wnt/β-catenin signaling pathway in dorsal root ganglion neurons at the early phase regeneration of the injured sciatic nerve |
| URI | https://www.earticle.net/Article/A393624 https://www.ncbi.nlm.nih.gov/pubmed/34012935 https://www.proquest.com/docview/2529948299 https://pubmed.ncbi.nlm.nih.gov/PMC8103182 https://www.e-jer.org/upload/jer-17-2-96.pdf https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002712714 |
| UnpaywallVersion | publishedVersion |
| Volume | 17 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Journal of exercise rehabilitation, 2021, 17(2), 72, pp.96-102 |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 2288-1778 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001105210 issn: 2288-176X databaseCode: KQ8 dateStart: 20130101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2288-1778 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001105210 issn: 2288-176X databaseCode: DOA dateStart: 20130101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 2288-1778 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001105210 issn: 2288-176X databaseCode: DIK dateStart: 20130101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 2288-1778 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001105210 issn: 2288-176X databaseCode: RPM dateStart: 20130101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVFZP databaseName: Scholars Portal Journals: Open Access customDbUrl: eissn: 2288-1778 dateEnd: 20250831 omitProxy: true ssIdentifier: ssj0001105210 issn: 2288-176X databaseCode: M48 dateStart: 20130401 isFulltext: true titleUrlDefault: http://journals.scholarsportal.info providerName: Scholars Portal |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELfG9gAvfH-Ej8oghARS2sRJ3OQBoQkxDaRNe1hFebIcx-myVU6WpIz-Szzyh_A3ceekhUEFvLRVY_vS3jn3s333O0KepxmAIKmkm8qxckOVafjE8MDRy7wgVlIlmCh8cMj3J-GHaTTdIqvskv4PbDYu7bCe1KSeD7-cL9_AhH9tuRESHo1OdT1E6jA_4EOPxy-qcxfLSuHxa19j4wrZAdeVYG2Hgx7_200YH3NXcR-GMbAYf8yn_VHmpnF_c129asEpmTrfBFD_jLO8ujCVXF7I-fwXJ7Z3k1zv0Sfd7ca8Rba0uU1uHPW6oscdxcAd8rUjNaZlTjESPcPaRHRVnYmWhlayMK7Ng9EZ_Wja0fdvLsZWmcJQDAmRmOVOsdzxhVxS-DIr6wYkAE5v6Uxi7jCMYsk0TUNlSwGHUo1ky7Q6AcdKaz2zhNhoN_Y24HphThc1yGusPSnoXn_Wd8lk793x2323r-rgKlgNt-AStR-qIIWnMA95HmguVT6WKgUsB_go5mA9LNax4jLyQh0ypgBn5OhGZcwlD-6RbVMa_YBQ6O55kvsaqwJEuZ9mWeLnAFF15EnPSx0yWilMqJ7yHCtvzAUufVDFAlQsehULULFDXq57VB3dx1_a3l_ZwLptkAAgCB3yDExCnKlCIHs3vs9KcVYLWKO8F8gy5jPukKcrixEwpfGcRhpdLhrBIsAIYQwvIKKzoJ8CQtw5DCKHjC_Z1roBCrx8xRQnljY8xooeMXPIq7UV_vM3PvyPm3xErjEM9LHhTI_Jdlsv9BNAam06sDscAzvnBmRncni0--kHfBtCLQ |
| linkProvider | Scholars Portal |
| linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwEB6V7QEulGcJLxnEBUR2EyfxZo8VoipIrXroinKyHMfZbnflRNmEqvwkjvwQfhMzeWxZQDwueWzsTCx_yXxej78BeJGkSIKUVm6ixtoNdWrwiNOEo5d6QayVntBC4cMjcTAN359Gp1vwul8L04RVuuembGbx62KZq3SEpy5-TLk7EcMiza7BtoiQeQ9ge3p0vPeR8sdx7HB_LE6vjsdxNyvJJyKiWwxJXcwPxNAjXdUNL9T1EvoXW2a_45q_hkxer22hLi_UcvmDP9rfgcO-JW0YymJYV8lQf_5J5PFfm3oLbnbElO21z3gbtoy9AzvHXTeyk1Z94C58afWOWZ4xClJPKW0R6xM3sdyyQs2t2yyRMSn7YKvRt68uhV3ZuWUULaJoATyjTMgX6pLhj2lertACUviKzRQtK8a7NDqbdsVUxZCiMkM6zKw4Q5_LSjNrtLIJUs1j4PW5Pa9LtLdqoKaxevnJ3IPp_tuTNwdul_DB1ThQrtBbGj_UQYIfaBGKLDBC6WysdII0D6lTLBBYPDaxFiryQhNyrpGCZORhVSyUCO7DwObWPACG1T1PCd9QwoAo85M0nfgZslcTecrzEgdGPQCk7tTQKSnHUtKoiCAjsStkBxmJkHHg5bpG0SqB_KHsbo-pddlgglwhdOA5Qkwu9FySsDftZ7lclBKHL-8kCZD5XDjwrEegxLedpnCUNXm9kjxC-hDGuEETLSKvDIT0p2IQOTDewOq6ABncvGLnZ42ieEzJPmLuwKs1qv_axof_U_gR3OAUDNSEPD2GQVXW5gmyuSp52r3E3wGXXErV |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effect+of+treadmill+exercise+on+pain-related+Wnt%2F%CE%B2-catenin+signaling+pathway+in+dorsal+root+ganglion+neurons+at+the+early+phase+regeneration+of+the+injured+sciatic+nerve&rft.jtitle=Journal+of+exercise+rehabilitation&rft.au=Cho%2C+Yeong-Hyun&rft.au=Kim%2C+Ji-Eun&rft.au=Seo%2C+Tae-Beom&rft.date=2021-04-01&rft.issn=2288-176X&rft.volume=17&rft.issue=2&rft.spage=96&rft_id=info:doi/10.12965%2Fjer.2142136.068&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2288-176X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2288-176X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2288-176X&client=summon |