Collagen Hydrolysates: A Source of Bioactive Peptides Derived from Food Sources for the Treatment of Osteoarthritis
Osteoarthritis (OA) is the most common joint disorder, with a social and financial burden that is expected to increase in the coming years. Currently, there are no effective medications to treat it. Due to limited treatment options, patients often resort to supplements, such as collagen hydrolysates...
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| Published in | Medicines (Basel, Switzerland) Vol. 10; no. 9; p. 50 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Basel
MDPI AG
01.09.2023
MDPI |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2305-6320 2305-6320 |
| DOI | 10.3390/medicines10090050 |
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| Abstract | Osteoarthritis (OA) is the most common joint disorder, with a social and financial burden that is expected to increase in the coming years. Currently, there are no effective medications to treat it. Due to limited treatment options, patients often resort to supplements, such as collagen hydrolysates (CHs). CHs are products with low molecular weight (MW) peptides, often between 3 and 6 kDa, and are a result of industrialized processed collagen. Collagen extraction is often a by-product of the meat industry, with the main source for collagen-based products being bovine, although it can also be obtained from porcine and piscine sources. CHs have demonstrated positive results in clinical trials related to joint health, such as decreased joint pain, increased mobility, and structural joint improvements. The bioactivity of CHs is primarily attributed to their bioactive peptide (BAP) content. However, there are significant knowledge gaps regarding the digestion, bioavailability, and bioactivity of CH-derived BAPs, and how different CH products compare in that regard. The present review discusses CHs and their BAP content as potential treatments for OA. |
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| AbstractList | Osteoarthritis (OA) is the most common joint disorder, with a social and financial burden that is expected to increase in the coming years. Currently, there are no effective medications to treat it. Due to limited treatment options, patients often resort to supplements, such as collagen hydrolysates (CHs). CHs are products with low molecular weight (MW) peptides, often between 3 and 6 kDa, and are a result of industrialized processed collagen. Collagen extraction is often a by-product of the meat industry, with the main source for collagen-based products being bovine, although it can also be obtained from porcine and piscine sources. CHs have demonstrated positive results in clinical trials related to joint health, such as decreased joint pain, increased mobility, and structural joint improvements. The bioactivity of CHs is primarily attributed to their bioactive peptide (BAP) content. However, there are significant knowledge gaps regarding the digestion, bioavailability, and bioactivity of CH-derived BAPs, and how different CH products compare in that regard. The present review discusses CHs and their BAP content as potential treatments for OA. Osteoarthritis (OA) is the most common joint disorder, with a social and financial burden that is expected to increase in the coming years. Currently, there are no effective medications to treat it. Due to limited treatment options, patients often resort to supplements, such as collagen hydrolysates (CHs). CHs are products with low molecular weight (MW) peptides, often between 3 and 6 kDa, and are a result of industrialized processed collagen. Collagen extraction is often a by-product of the meat industry, with the main source for collagen-based products being bovine, although it can also be obtained from porcine and piscine sources. CHs have demonstrated positive results in clinical trials related to joint health, such as decreased joint pain, increased mobility, and structural joint improvements. The bioactivity of CHs is primarily attributed to their bioactive peptide (BAP) content. However, there are significant knowledge gaps regarding the digestion, bioavailability, and bioactivity of CH-derived BAPs, and how different CH products compare in that regard. The present review discusses CHs and their BAP content as potential treatments for OA.Osteoarthritis (OA) is the most common joint disorder, with a social and financial burden that is expected to increase in the coming years. Currently, there are no effective medications to treat it. Due to limited treatment options, patients often resort to supplements, such as collagen hydrolysates (CHs). CHs are products with low molecular weight (MW) peptides, often between 3 and 6 kDa, and are a result of industrialized processed collagen. Collagen extraction is often a by-product of the meat industry, with the main source for collagen-based products being bovine, although it can also be obtained from porcine and piscine sources. CHs have demonstrated positive results in clinical trials related to joint health, such as decreased joint pain, increased mobility, and structural joint improvements. The bioactivity of CHs is primarily attributed to their bioactive peptide (BAP) content. However, there are significant knowledge gaps regarding the digestion, bioavailability, and bioactivity of CH-derived BAPs, and how different CH products compare in that regard. The present review discusses CHs and their BAP content as potential treatments for OA. |
| Audience | Academic |
| Author | Iskandar, Michèle M. Larder, Christina E. Kubow, Stan |
| AuthorAffiliation | 1 School of Human Nutrition, McGill University, Ste-Anne-de-Bellevue, QC H9X 3V9, Canada; christina.larder@genacol.ca (C.E.L.); michele.iskandar@mcgill.ca (M.M.I.) 2 Corporation Genacol Canada Inc., Blainville, QC J7C 6B4, Canada |
| AuthorAffiliation_xml | – name: 1 School of Human Nutrition, McGill University, Ste-Anne-de-Bellevue, QC H9X 3V9, Canada; christina.larder@genacol.ca (C.E.L.); michele.iskandar@mcgill.ca (M.M.I.) – name: 2 Corporation Genacol Canada Inc., Blainville, QC J7C 6B4, Canada |
| Author_xml | – sequence: 1 givenname: Christina E. orcidid: 0000-0002-2980-4462 surname: Larder fullname: Larder, Christina E. – sequence: 2 givenname: Michèle M. orcidid: 0000-0002-6076-8148 surname: Iskandar fullname: Iskandar, Michèle M. – sequence: 3 givenname: Stan orcidid: 0000-0001-5831-9880 surname: Kubow fullname: Kubow, Stan |
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| Cites_doi | 10.1016/S0140-6736(20)32230-3 10.1186/s12937-015-0053-9 10.3390/nu12071967 10.1002/jsfa.6854 10.1039/D0FO01981J 10.1021/jf300497p 10.3390/molecules24224031 10.1038/srep30594 10.1093/jn/129.10.1891 10.1039/D0FO00219D 10.1248/bpb.35.422 10.1016/j.tifs.2016.03.006 10.1097/BOR.0000000000000479 10.1016/j.bcp.2019.02.037 10.1023/A:1018814627484 10.1002/art.34453 10.1016/j.vascn.2005.08.002 10.1016/j.foodchem.2016.12.044 10.1007/978-3-319-16104-4 10.3390/ijms22062851 10.1136/rmdopen-2017-000442 10.1021/acs.jafc.7b03714 10.1002/(SICI)1097-0029(19970515)37:4<324::AID-JEMT7>3.0.CO;2-K 10.3390/nu10010097 10.3390/molecules24010148 10.1002/btpr.3142 10.1038/s41598-018-23532-x 10.1185/030079906X148373 10.1016/j.jbspin.2013.09.007 10.1371/journal.pone.0099920 10.3389/fvets.2018.00178 10.1016/j.ifset.2016.03.015 10.1016/j.ctim.2011.12.007 10.1053/sarh.2000.9622 10.1146/annurev-food-031414-111800 10.1016/j.bone.2009.10.035 10.1016/j.cger.2014.08.019 10.3109/14756366.2013.858143 10.1136/rmdopen-2015-000077 10.3390/nu13082720 10.1016/j.joca.2011.12.003 10.3390/app10062041 10.1080/14756366.2021.1886093 10.1124/dmd.114.059493 10.1038/s41467-020-18208-y 10.1038/s41584-021-00673-4 10.1371/journal.pone.0191424 10.3390/nu12113469 10.1016/j.bbrc.2014.09.121 10.1016/j.xphs.2015.11.035 10.1016/j.joca.2015.01.013 10.1016/j.joca.2009.07.001 10.1093/bmb/ldv028 10.1016/j.foodres.2013.08.027 10.1021/jf050206p 10.1007/s11926-021-01042-6 10.1080/10408398.2018.1436038 10.3390/foods7010008 10.1021/acs.jafc.6b02955 10.1016/j.joca.2020.10.007 10.1007/s11999-009-1119-9 10.1177/1941738109350438 10.3389/fcell.2021.641162 10.1038/s41598-018-36046-3 10.1002/jsfa.6752 10.1021/jf5057502 10.1002/jsfa.8677 10.1016/j.lwt.2021.112880 10.1172/jci.insight.95997 10.1007/s00394-017-1445-8 10.1016/j.semarthrit.2019.01.005 10.3389/fendo.2018.00424 10.1074/jbc.M111.337063 10.4110/in.2018.18.e8 10.1155/2016/5276130 10.1248/bpb.b15-00624 10.1185/030079908X291967 10.3390/cimb43030113 10.1016/j.cger.2010.03.001 10.1155/2015/832127 10.3390/nu11051064 10.1080/09637480802498820 10.3390/nu9121376 10.26689/jcnr.v1i3.158 10.1016/j.joca.2004.08.008 10.5604/01.3001.0010.8633 10.1017/S0007114515002810 10.1039/c3fo60509d 10.1038/s41551-020-0559-0 10.1021/jf062834s 10.1016/j.regpep.2004.03.002 10.1016/j.joca.2011.01.001 10.1007/s12018-017-9228-6 10.1139/apnm-2016-0390 10.1080/10408398.2017.1421900 10.3389/fcell.2020.601224 10.3390/ijms20235978 10.1093/jaoac/91.4.965 10.3390/molecules25194479 10.1002/jsfa.7008 10.1016/S0008-6363(98)00306-X |
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| References | ref_91 Oesser (ref_95) 1999; 129 Singh (ref_9) 2002; 8 Zdzieblik (ref_55) 2015; 114 Mackie (ref_84) 2020; 11 Eymard (ref_8) 2015; 23 ref_99 Poole (ref_28) 2012; 8 Shi (ref_66) 2004; 120 Takenaka (ref_102) 2014; 42 Sellam (ref_11) 2013; 80 ref_16 Iwai (ref_48) 2005; 53 Kubassova (ref_4) 2019; 165 Punt (ref_85) 2017; 34 Zegels (ref_53) 2012; 20 Rowland (ref_111) 2017; 57 Mahmoudian (ref_34) 2021; 17 Park (ref_21) 2020; 11 Moskowitz (ref_62) 2000; 30 Stewart (ref_18) 2018; 5 ref_24 Nakatani (ref_63) 2009; 17 ref_22 Pomothy (ref_104) 2021; 36 Adam (ref_61) 1996; 135 Shigemura (ref_46) 2018; 98 Knight (ref_67) 1999; 41 Veronese (ref_7) 2019; 49 (ref_51) 2009; 60 Arulselvan (ref_37) 2016; 2016 Amarasekara (ref_31) 2015; 2015 Kawaguchi (ref_93) 2012; 35 Peat (ref_2) 2021; 29 Montero (ref_88) 2013; 54 Pal (ref_41) 2016; 37 ref_72 Leopoldino (ref_35) 2019; 2 Dickinson (ref_39) 2015; 14 Brayden (ref_79) 2020; 4 Elango (ref_19) 2018; 8 ref_78 ref_77 Taga (ref_97) 2017; 65 ref_76 ref_75 Bourne (ref_38) 2010; 468 Bedi (ref_15) 2009; 1 Schott (ref_110) 2018; 3 Song (ref_100) 2020; 11 Kumar (ref_54) 2015; 95 ref_82 Vicente (ref_13) 2017; 15 ref_80 Baudart (ref_10) 2017; 3 Nishimura (ref_26) 2012; 287 Clark (ref_58) 2008; 24 Louati (ref_70) 2015; 1 Liu (ref_112) 2016; 6 Hatanaka (ref_68) 2014; 29 ref_86 Wang (ref_27) 2004; 12 Wang (ref_47) 2015; 95 Piva (ref_69) 2015; 31 Ohara (ref_49) 2007; 55 Liu (ref_43) 2015; 6 Simons (ref_81) 2018; 8 Feliciano (ref_57) 2017; 9 Wang (ref_96) 2015; 63 Nedeva (ref_20) 2021; 9 Larder (ref_89) 2022; 155 ref_52 Guillerminet (ref_71) 2010; 46 Loeser (ref_14) 2012; 64 (ref_33) 2012; 20 Sontakke (ref_98) 2016; 64 Rivero (ref_60) 2011; 24 Bello (ref_94) 2006; 22 Lau (ref_108) 2004; 32 ref_65 Takenaka (ref_103) 2016; 105 Feng (ref_90) 2017; 224 Mobasheri (ref_114) 2021; 23 Liu (ref_25) 2020; 8 Daneault (ref_17) 2017; 57 Ferraro (ref_42) 2016; 51 Zhang (ref_109) 2018; 9 Kim (ref_74) 2014; 5 Kimira (ref_73) 2014; 453 Hunter (ref_5) 2020; 396 Guo (ref_87) 2015; 95 Shigemura (ref_92) 2012; 60 Cheng (ref_107) 2006; 53 Oegema (ref_29) 1997; 37 ref_30 Meunier (ref_36) 2018; 17 Fu (ref_44) 2019; 59 Minkiewicz (ref_64) 2008; 91 Min (ref_23) 2017; 1 Bretschneider (ref_106) 1999; 16 ref_105 Vina (ref_3) 2018; 30 Kluzek (ref_12) 2015; 115 Amarasekara (ref_32) 2018; 18 Dupont (ref_83) 2018; 59 Yamamoto (ref_50) 2016; 39 Larregieu (ref_101) 2013; 15 Ashaolu (ref_113) 2021; 37 ref_45 ref_40 Zhang (ref_1) 2010; 26 ref_6 Zdzieblik (ref_56) 2017; 42 McAlindon (ref_59) 2011; 19 |
| References_xml | – volume: 8 start-page: 4 year: 2012 ident: ref_28 article-title: Osteoarthritis as a whole joint disease publication-title: HSS J. Musculoskelet. J. Hosp. Spec. Surg. – volume: 396 start-page: 1711 year: 2020 ident: ref_5 article-title: Osteoarthritis in 2020 and beyond: A Lancet Commission publication-title: Lancet doi: 10.1016/S0140-6736(20)32230-3 – volume: 14 start-page: 66 year: 2015 ident: ref_39 article-title: Consumer attitudes about the role of multivitamins and other dietary supplements: Report of a survey publication-title: Nutr. J. doi: 10.1186/s12937-015-0053-9 – ident: ref_72 doi: 10.3390/nu12071967 – volume: 95 start-page: 1514 year: 2015 ident: ref_87 article-title: In Vitro assessment of the multifunctional bioactive potential of Alaska pollock skin collagen following simulated gastrointestinal digestion publication-title: J. Sci. Food Agric. doi: 10.1002/jsfa.6854 – volume: 11 start-page: 9397 year: 2020 ident: ref_84 article-title: Simulating human digestion: Developing our knowledge to create healthier and more sustainable foods publication-title: Food Funct. doi: 10.1039/D0FO01981J – volume: 60 start-page: 5128 year: 2012 ident: ref_92 article-title: Identification of food-derived elastin peptide, prolyl-glycine (Pro-Gly), in human blood after ingestion of elastin hydrolysate publication-title: J. Agric. Food Chem. doi: 10.1021/jf300497p – volume: 24 start-page: 147 year: 2011 ident: ref_60 article-title: A nutritional intervention study with hydrolyzed collagen in pre-pubertal spanish children: Influence on bone modeling biomarkers publication-title: J. Pediatr. Endocrinol. Metab. – ident: ref_16 doi: 10.3390/molecules24224031 – volume: 6 start-page: 30594 year: 2016 ident: ref_112 article-title: Role of the Gut Microbiome in Modulating Arthritis Progression in Mice publication-title: Sci. Rep. doi: 10.1038/srep30594 – volume: 129 start-page: 1891 year: 1999 ident: ref_95 article-title: Oral administration of 14C labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL) publication-title: J. Nutr. doi: 10.1093/jn/129.10.1891 – volume: 11 start-page: 5553 year: 2020 ident: ref_100 article-title: Novel Hyp-Gly-containing antiplatelet peptides from collagen hydrolysate after simulated gastrointestinal digestion and intestinal absorption publication-title: Food Funct. doi: 10.1039/D0FO00219D – volume: 35 start-page: 422 year: 2012 ident: ref_93 article-title: Distribution of prolylhydroxyproline and its metabolites after oral administration in rats publication-title: Biol. Pharm. Bull. doi: 10.1248/bpb.35.422 – volume: 51 start-page: 65 year: 2016 ident: ref_42 article-title: The “sisters” α-helices of collagen, elastin and keratin recovered from animal by-products: Functionality, bioactivity and trends of application publication-title: Trends Food Sci. Technol. doi: 10.1016/j.tifs.2016.03.006 – volume: 30 start-page: 160 year: 2018 ident: ref_3 article-title: Epidemiology of osteoarthritis: Literature update publication-title: Curr. Opin. Rheumatol. doi: 10.1097/BOR.0000000000000479 – volume: 165 start-page: 41 year: 2019 ident: ref_4 article-title: Osteoarthritis phenotypes and novel therapeutic targets publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2019.02.037 – volume: 16 start-page: 55 year: 1999 ident: ref_106 article-title: Intestinal transport of beta-lactam antibiotics: Analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux publication-title: Pharm. Res. doi: 10.1023/A:1018814627484 – volume: 64 start-page: 1697 year: 2012 ident: ref_14 article-title: Osteoarthritis: A disease of the joint as an organ publication-title: Arthritis Rheum. doi: 10.1002/art.34453 – volume: 53 start-page: 215 year: 2006 ident: ref_107 article-title: Development of a high-throughput in vitro assay using a novel Caco-2/rat hepatocyte system for the prediction of oral plasma area under the concentration versus time curve (AUC) in rats publication-title: J. Pharmacol. Toxicol. Methods doi: 10.1016/j.vascn.2005.08.002 – volume: 224 start-page: 242 year: 2017 ident: ref_90 article-title: Transepithelial transport efficiency of bovine collagen hydrolysates in a human Caco-2 cell line model publication-title: Food Chem. doi: 10.1016/j.foodchem.2016.12.044 – ident: ref_99 doi: 10.1007/978-3-319-16104-4 – ident: ref_24 doi: 10.3390/ijms22062851 – volume: 3 start-page: e000442 year: 2017 ident: ref_10 article-title: Association between osteoarthritis and dyslipidaemia: A systematic literature review and meta-analysis publication-title: RMD Open doi: 10.1136/rmdopen-2017-000442 – volume: 2 start-page: Cd013273 year: 2019 ident: ref_35 article-title: Paracetamol versus placebo for knee and hip osteoarthritis publication-title: Cochrane Database Syst. Rev. – ident: ref_82 doi: 10.1007/978-3-319-16104-4 – volume: 65 start-page: 9514 year: 2017 ident: ref_97 article-title: Identification of Collagen-Derived Hydroxyproline (Hyp)-Containing Cyclic Dipeptides with High Oral Bioavailability: Efficient Formation of Cyclo(X-Hyp) from X-Hyp-Gly-Type Tripeptides by Heating publication-title: J. Agric. Food Chem. doi: 10.1021/acs.jafc.7b03714 – volume: 37 start-page: 324 year: 1997 ident: ref_29 article-title: The interaction of the zone of calcified cartilage and subchondral bone in osteoarthritis publication-title: Microsc. Res. Tech. doi: 10.1002/(SICI)1097-0029(19970515)37:4<324::AID-JEMT7>3.0.CO;2-K – ident: ref_52 doi: 10.3390/nu10010097 – ident: ref_105 doi: 10.3390/molecules24010148 – ident: ref_76 doi: 10.1007/978-3-319-16104-4 – volume: 37 start-page: e3142 year: 2021 ident: ref_113 article-title: Prebiotic peptides, their formation, fermentation in the gut, and health implications publication-title: Biotechnol. Prog. doi: 10.1002/btpr.3142 – volume: 8 start-page: 5318 year: 2018 ident: ref_19 article-title: Cross-talk between primary osteocytes and bone marrow macrophages for osteoclastogenesis upon collagen treatment publication-title: Sci. Rep. doi: 10.1038/s41598-018-23532-x – volume: 22 start-page: 2221 year: 2006 ident: ref_94 article-title: Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders:a review of the literature publication-title: Curr. Med. Res. Opin. doi: 10.1185/030079906X148373 – volume: 80 start-page: 568 year: 2013 ident: ref_11 article-title: Is osteoarthritis a metabolic disease? publication-title: Joint Bone Spine doi: 10.1016/j.jbspin.2013.09.007 – ident: ref_22 doi: 10.1371/journal.pone.0099920 – volume: 5 start-page: 178 year: 2018 ident: ref_18 article-title: The Importance of Subchondral Bone in the Pathophysiology of Osteoarthritis publication-title: Front. Vet. Sci. doi: 10.3389/fvets.2018.00178 – volume: 37 start-page: 201 year: 2016 ident: ref_41 article-title: Sustainable valorisation of seafood by-products: Recovery of collagen and development of collagen-based novel functional food ingredients publication-title: Innov. Food Sci. Emerg. Technol. doi: 10.1016/j.ifset.2016.03.015 – volume: 20 start-page: 124 year: 2012 ident: ref_53 article-title: Effect of collagen hydrolysate in articular pain: A 6-month randomized, double-blind, placebo controlled study publication-title: Complement. Ther. Med. doi: 10.1016/j.ctim.2011.12.007 – volume: 30 start-page: 87 year: 2000 ident: ref_62 article-title: Role of collagen hydrolysate in bone and joint disease publication-title: Semin. Arthritis Rheum. doi: 10.1053/sarh.2000.9622 – volume: 6 start-page: 527 year: 2015 ident: ref_43 article-title: Collagen and Gelatin publication-title: Annu. Rev. Food Sci. Technol. doi: 10.1146/annurev-food-031414-111800 – volume: 46 start-page: 827 year: 2010 ident: ref_71 article-title: Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice: An in vitro and in vivo study publication-title: Bone doi: 10.1016/j.bone.2009.10.035 – ident: ref_6 – volume: 31 start-page: 67 year: 2015 ident: ref_69 article-title: Links between osteoarthritis and diabetes: Implications for management from a physical activity perspective publication-title: Clin. Geriatr. Med. doi: 10.1016/j.cger.2014.08.019 – volume: 29 start-page: 823 year: 2014 ident: ref_68 article-title: Inhibitory effect of collagen-derived tripeptides on dipeptidylpeptidase-IV activity publication-title: J. Enzyme Inhib. Med. Chem. doi: 10.3109/14756366.2013.858143 – volume: 32 start-page: 937 year: 2004 ident: ref_108 article-title: Evaluation of a novel in vitro Caco-2 hepatocyte hybrid system for predicting in vivo oral bioavailability publication-title: Drug Metab. Dispos. – volume: 1 start-page: e000077 year: 2015 ident: ref_70 article-title: Association between diabetes mellitus and osteoarthritis: Systematic literature review and meta-analysis publication-title: RMD Open doi: 10.1136/rmdopen-2015-000077 – ident: ref_77 doi: 10.3390/nu13082720 – volume: 20 start-page: 223 year: 2012 ident: ref_33 article-title: Chondrocyte hypertrophy and osteoarthritis: Role in initiation and progression of cartilage degeneration? publication-title: Osteoarthr. Cartil. doi: 10.1016/j.joca.2011.12.003 – ident: ref_86 doi: 10.3390/app10062041 – volume: 36 start-page: 659 year: 2021 ident: ref_104 article-title: Exposure of human intestinal epithelial cells and primary human hepatocytes to trypsin-like serine protease inhibitors with potential antiviral effect publication-title: J. Enzym. Inhib. Med. Chem. doi: 10.1080/14756366.2021.1886093 – volume: 42 start-page: 1947 year: 2014 ident: ref_102 article-title: Human small intestinal epithelial cells differentiated from adult intestinal stem cells as a novel system for predicting oral drug absorption in humans publication-title: Drug Metab. Dispos. doi: 10.1124/dmd.114.059493 – volume: 11 start-page: 4343 year: 2020 ident: ref_21 article-title: Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation publication-title: Nat. Commun. doi: 10.1038/s41467-020-18208-y – volume: 17 start-page: 621 year: 2021 ident: ref_34 article-title: Early-stage symptomatic osteoarthritis of the knee—Time for action publication-title: Nat. Rev. Rheumatol. doi: 10.1038/s41584-021-00673-4 – ident: ref_40 doi: 10.1371/journal.pone.0191424 – ident: ref_30 doi: 10.3390/nu12113469 – volume: 453 start-page: 498 year: 2014 ident: ref_73 article-title: Collagen-derived dipeptide prolyl-hydroxyproline promotes differentiation of MC3T3-E1 osteoblastic cells publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2014.09.121 – volume: 105 start-page: 915 year: 2016 ident: ref_103 article-title: Application of a human intestinal epithelial cell monolayer to the prediction of oral drug absorption in humans as a superior alternative to the Caco-2 cell monolayer publication-title: J. Pharm. Sci. doi: 10.1016/j.xphs.2015.11.035 – volume: 23 start-page: 851 year: 2015 ident: ref_8 article-title: Diabetes is a risk factor for knee osteoarthritis progression publication-title: Osteoarthr. Cartil. doi: 10.1016/j.joca.2015.01.013 – volume: 17 start-page: 1620 year: 2009 ident: ref_63 article-title: Chondroprotective effect of the bioactive peptide prolyl-hydroxyproline in mouse articular cartilage in vitro and in vivo publication-title: Osteoarthr. Cartil. doi: 10.1016/j.joca.2009.07.001 – volume: 115 start-page: 111 year: 2015 ident: ref_12 article-title: Is osteoarthritis a metabolic disorder? publication-title: Br. Med. Bull. doi: 10.1093/bmb/ldv028 – volume: 54 start-page: 790 year: 2013 ident: ref_88 article-title: Identification of ace-inhibitory peptides from squid skin collagen after in vitro gastrointestinal digestion publication-title: Food Res. Int. doi: 10.1016/j.foodres.2013.08.027 – volume: 53 start-page: 6531 year: 2005 ident: ref_48 article-title: Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates publication-title: J. Agric. Food Chem. doi: 10.1021/jf050206p – volume: 23 start-page: 78 year: 2021 ident: ref_114 article-title: A White Paper on Collagen Hydrolyzates and Ultrahydrolyzates: Potential Supplements to Support Joint Health in Osteoarthritis? publication-title: Curr. Rheumatol. Rep. doi: 10.1007/s11926-021-01042-6 – volume: 9 start-page: 4 year: 2017 ident: ref_57 article-title: Effect of collagen hydrolysate as adjuvant treatment to exercise for knee osteoarthritis publication-title: Philipp. Acad. Rehabil. Med. – volume: 59 start-page: 2011 year: 2019 ident: ref_44 article-title: Exploration of collagen recovered from animal by-products as a precursor of bioactive peptides: Successes and challenges publication-title: Crit. Rev. Food Sci. Nutr. doi: 10.1080/10408398.2018.1436038 – ident: ref_80 doi: 10.3390/foods7010008 – volume: 64 start-page: 7127 year: 2016 ident: ref_98 article-title: Orally Available Collagen Tripeptide: Enzymatic Stability, Intestinal Permeability, and Absorption of Gly-Pro-Hyp and Pro-Hyp publication-title: J. Agric. Food Chem. doi: 10.1021/acs.jafc.6b02955 – volume: 29 start-page: 180 year: 2021 ident: ref_2 article-title: Osteoarthritis year in review 2020: Epidemiology & therapy publication-title: Osteoarthr. Cartil. doi: 10.1016/j.joca.2020.10.007 – volume: 468 start-page: 57 year: 2010 ident: ref_38 article-title: Patient satisfaction after total knee arthroplasty: Who is satisfied and who is not? publication-title: Clin. Orthop. Relat. Res. doi: 10.1007/s11999-009-1119-9 – volume: 1 start-page: 461 year: 2009 ident: ref_15 article-title: The basic science of articular cartilage: Structure, composition, and function publication-title: Sports Health doi: 10.1177/1941738109350438 – volume: 9 start-page: 641162 year: 2021 ident: ref_20 article-title: Role of OSCAR Signaling in Osteoclastogenesis and Bone Disease publication-title: Front. Cell Dev. Biol. doi: 10.3389/fcell.2021.641162 – volume: 8 start-page: 17733 year: 2018 ident: ref_81 article-title: Comparative Analysis of Peptide Composition and Bioactivity of Different Collagen Hydrolysate Batches on Human Osteoarthritic Synoviocytes publication-title: Sci. Rep. doi: 10.1038/s41598-018-36046-3 – volume: 95 start-page: 702 year: 2015 ident: ref_54 article-title: A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis publication-title: J. Sci. Food Agric. doi: 10.1002/jsfa.6752 – volume: 63 start-page: 3752 year: 2015 ident: ref_96 article-title: Bioavailability and Bioavailable Forms of Collagen after Oral Administration to Rats publication-title: J. Agric. Food Chem. doi: 10.1021/jf5057502 – volume: 98 start-page: 1944 year: 2018 ident: ref_46 article-title: Changes in composition and content of food-derived peptide in human blood after daily ingestion of collagen hydrolysate for 4 weeks publication-title: J. Sci. Food Agric. doi: 10.1002/jsfa.8677 – volume: 155 start-page: 112880 year: 2022 ident: ref_89 article-title: Complementary and efficient methods for di- and tri-peptide analysis and amino acid quantification from simulated gastrointestinal digestion of collagen hydrolysate publication-title: LWT doi: 10.1016/j.lwt.2021.112880 – volume: 3 start-page: e95997 year: 2018 ident: ref_110 article-title: Targeting the gut microbiome to treat the osteoarthritis of obesity publication-title: JCI Insight doi: 10.1172/jci.insight.95997 – volume: 57 start-page: 1 year: 2017 ident: ref_111 article-title: Gut microbiota functions: Metabolism of nutrients and other food components publication-title: Eur. J. Nutr. doi: 10.1007/s00394-017-1445-8 – volume: 34 start-page: 501 year: 2017 ident: ref_85 article-title: Non-animal approaches for toxicokinetics in risk evaluations of food chemicals publication-title: ALTEX – volume: 49 start-page: 9 year: 2019 ident: ref_7 article-title: Type 2 diabetes mellitus and osteoarthritis publication-title: Semin. Arthritis Rheum. doi: 10.1016/j.semarthrit.2019.01.005 – volume: 9 start-page: 424 year: 2018 ident: ref_109 article-title: The dipeptide Pro-Gly promotes IGF-1 expression and secretion in HepG2 and female mice via PepT1-JAK2/STAT5 Pathway publication-title: Front. Endocrinol. doi: 10.3389/fendo.2018.00424 – volume: 287 start-page: 33179 year: 2012 ident: ref_26 article-title: Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (MMP13) expression in association with transcription factor Runx2 during endochondral ossification publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.337063 – volume: 18 start-page: e8 year: 2018 ident: ref_32 article-title: Regulation of Osteoclast Differentiation by Cytokine Networks publication-title: Immune Netw. doi: 10.4110/in.2018.18.e8 – volume: 2016 start-page: 5276130 year: 2016 ident: ref_37 article-title: Role of antioxidants and natural products in inflammation publication-title: Oxid. Med. Cell. Longev. doi: 10.1155/2016/5276130 – volume: 39 start-page: 428 year: 2016 ident: ref_50 article-title: Absorption and urinary excretion of peptides after collagen tripeptide ingestion in humans publication-title: Biol. Pharm. Bull. doi: 10.1248/bpb.b15-00624 – volume: 24 start-page: 1485 year: 2008 ident: ref_58 article-title: 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain publication-title: Curr. Med. Res. Opin. doi: 10.1185/030079908X291967 – ident: ref_91 doi: 10.3390/cimb43030113 – volume: 26 start-page: 355 year: 2010 ident: ref_1 article-title: Epidemiology of osteoarthritis publication-title: Clin. Geriatr. Med. doi: 10.1016/j.cger.2010.03.001 – volume: 2015 start-page: 832127 year: 2015 ident: ref_31 article-title: Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases publication-title: J. Immunol. Res. doi: 10.1155/2015/832127 – volume: 57 start-page: 1922 year: 2017 ident: ref_17 article-title: Biological effect of hydrolyzed collagen on bone metabolism publication-title: Crit. Rev. Food Sci. Nutr. – ident: ref_45 doi: 10.3390/nu11051064 – volume: 60 start-page: 99 year: 2009 ident: ref_51 article-title: A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort publication-title: Int. J. Food Sci. Nutr. doi: 10.1080/09637480802498820 – ident: ref_78 doi: 10.3390/nu9121376 – volume: 1 start-page: 40 year: 2017 ident: ref_23 article-title: Collagen Hydrolysate Gly-Pro-Hyp on Osteoblastic Proliferation and Differentiation of MC3T3-E1 Cells publication-title: J. Clin. Nurs. Res. doi: 10.26689/jcnr.v1i3.158 – volume: 12 start-page: 963 year: 2004 ident: ref_27 article-title: Regulation of MMP-13 expression by RUNX2 and FGF2 in osteoarthritic cartilage publication-title: Osteoarthr. Cartil. doi: 10.1016/j.joca.2004.08.008 – volume: 17 start-page: 187 year: 2018 ident: ref_36 article-title: Recent Advances in Hepatotoxicity of Non Steroidal Anti-inflammatory Drugs publication-title: Ann. Hepatol. doi: 10.5604/01.3001.0010.8633 – volume: 15 start-page: 483 year: 2013 ident: ref_101 article-title: Drug discovery and regulatory considerations for improving in silico and in vitro predictions that use Caco-2 as a surrogate for human intestinal permeability measurements publication-title: Am. Assoc. Pharm. Sci. J. – volume: 114 start-page: 1237 year: 2015 ident: ref_55 article-title: Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: A randomised controlled trial publication-title: Br. J. Nutr. doi: 10.1017/S0007114515002810 – volume: 8 start-page: S383 year: 2002 ident: ref_9 article-title: Prevalence of cardiovascular disease risk factors among US adults with self-reported osteoarthritis: Data from the Third National Health and Nutrition Examination Survey publication-title: Am. J. Manag. Care – volume: 5 start-page: 573 year: 2014 ident: ref_74 article-title: Collagen hydrolysates increased osteogenic gene expressions via a MAPK signaling pathway in MG-63 human osteoblasts publication-title: Food Funct. doi: 10.1039/c3fo60509d – volume: 4 start-page: 487 year: 2020 ident: ref_79 article-title: Evolving peptides for oral intake publication-title: Nat. Biomed. Eng. doi: 10.1038/s41551-020-0559-0 – volume: 55 start-page: 1532 year: 2007 ident: ref_49 article-title: Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources publication-title: J. Agric. Food Chem. doi: 10.1021/jf062834s – volume: 120 start-page: 1 year: 2004 ident: ref_66 article-title: BioPD: A web-based information center for bioactive peptides publication-title: Regul. Pept. doi: 10.1016/j.regpep.2004.03.002 – volume: 19 start-page: 399 year: 2011 ident: ref_59 article-title: Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: A pilot randomized controlled trial publication-title: Osteoarthr. Cartil. doi: 10.1016/j.joca.2011.01.001 – volume: 15 start-page: 69 year: 2017 ident: ref_13 article-title: Osteoarthritis: More than Cartilage Degeneration publication-title: Clin. Rev. Bone. Miner. Metab. doi: 10.1007/s12018-017-9228-6 – volume: 42 start-page: 588 year: 2017 ident: ref_56 article-title: Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides publication-title: Appl. Physiol. Nutr. Metab. doi: 10.1139/apnm-2016-0390 – volume: 59 start-page: 1546 year: 2018 ident: ref_83 article-title: Can dynamic in vitro digestion systems mimic the physiological reality? publication-title: Crit. Rev. Food Sci. Nutr. doi: 10.1080/10408398.2017.1421900 – volume: 8 start-page: 601224 year: 2020 ident: ref_25 article-title: Recent Advances of Osterix Transcription Factor in Osteoblast Differentiation and Bone Formation publication-title: Front. Cell Dev. Biol. doi: 10.3389/fcell.2020.601224 – ident: ref_65 doi: 10.3390/ijms20235978 – volume: 91 start-page: 965 year: 2008 ident: ref_64 article-title: BIOPEP Database and Other Programs for Processing Bioactive Peptide Sequences publication-title: J. AOAC Int. doi: 10.1093/jaoac/91.4.965 – ident: ref_75 doi: 10.3390/molecules25194479 – volume: 95 start-page: 2712 year: 2015 ident: ref_47 article-title: Determination of bioavailability and identification of collagen peptide in blood after oral ingestion of gelatin publication-title: J. Sci. Food Agric. doi: 10.1002/jsfa.7008 – volume: 41 start-page: 450 year: 1999 ident: ref_67 article-title: Collagen-platelet interaction: Gly-Pro-Hyp is uniquely specific for platelet Gp VI and mediates platelet activation by collagen publication-title: Cardiovasc. Res. doi: 10.1016/S0008-6363(98)00306-X – volume: 135 start-page: 74 year: 1996 ident: ref_61 article-title: Postmenopausal osteoporosis. Treatment with calcitonin and a diet rich in collagen proteins publication-title: Cas. Lek. Cesk. |
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| SubjectTerms | amino acids Analysis Arthritis Bioavailability Care and treatment Cartilage Collagen collagen hydrolysate Cytokines Diagnosis Health aspects human health Metabolism Osteoarthritis Patients peptide Peptides Phosphatase Physical therapy Proteins Review Risk factors Signal transduction Transcription factors Tumor necrosis factor-TNF |
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| Title | Collagen Hydrolysates: A Source of Bioactive Peptides Derived from Food Sources for the Treatment of Osteoarthritis |
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