The Genetic Architecture of Parkinson's Disease in the AfrAbia Population: Current State and Future Perspectives

Over 80% of genetic studies in the Parkinson’s disease (PD) field have been conducted on individuals of European descent. There is a social and scientific imperative to understand the genetic basis of PD across global populations for therapeutic development and deployment. PD etiology is impacted by...

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Published inJournal of integrative neuroscience Vol. 23; no. 8; pp. 152 - 9
Main Authors Mohamed, Wael, Eltantawi, Mohamed Abdelhalim, Agarwal, Vidhu, Bandres-Ciga, Sara, Makarious, Mary B, Mecheri, Yasser, Zewde, Yared Zenebe, Kamel, Walaa A., Al-Mubarak, Bashayer, Alzoubi, Karem H., Kissani, Najib, Alghamdi, Badrah S, Sassi, Samia Ben, AA-PD-GC, on behalf of
Format Journal Article
LanguageEnglish
Published Singapore IMR Press 01.01.2024
Subjects
15th century
afrabia
Arab people
challenges
Environmental factors
Etiology
gaps
Gene frequency
Genes
Genetic diversity
Genetic Predisposition to Disease
Genetic variance
Genetics
Haplotypes
Health risk assessment
Humans
Movement disorders
Mutation
Neurodegenerative diseases
Parkinson Disease - genetics
Parkinson's disease
Patients
prospects
Middle East
Morocco
Europe
Egypt
Africa
Red Sea
North Africa
Tunisia
Parkinson's disease
genetics
challenges
gaps
prospects
AfrAbia
Online AccessGet full text
ISSN0219-6352
1757-448X
DOI10.31083/j.jin2308152

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Abstract Over 80% of genetic studies in the Parkinson’s disease (PD) field have been conducted on individuals of European descent. There is a social and scientific imperative to understand the genetic basis of PD across global populations for therapeutic development and deployment. PD etiology is impacted by genetic and environmental factors that are variable by ancestry and region, emphasising the need for worldwide programs to gather large numbers of patients to identify novel candidate genes and risk loci involved in disease. Only a handful of documented genetic assessments have investigated families with PD in AfrAbia, which comprises the member nations of the Arab League and the African Union, with very limited cohort and case-control studies reported. This review article summarises prior research on PD genetics in AfrAbia, highlighting gaps and challenges. We discuss the etiological risk spectrum in the context of historical interactions, highlighting allele frequencies, penetrance, and the clinical manifestations of known genetic variants in the AfrAbian PD patient community.
AbstractList Over 80% of genetic studies in the Parkinson's disease (PD) field have been conducted on individuals of European descent. There is a social and scientific imperative to understand the genetic basis of PD across global populations for therapeutic development and deployment. PD etiology is impacted by genetic and environmental factors that are variable by ancestry and region, emphasising the need for worldwide programs to gather large numbers of patients to identify novel candidate genes and risk loci involved in disease. Only a handful of documented genetic assessments have investigated families with PD in AfrAbia, which comprises the member nations of the Arab League and the African Union, with very limited cohort and case-control studies reported. This review article summarises prior research on PD genetics in AfrAbia, highlighting gaps and challenges. We discuss the etiological risk spectrum in the context of historical interactions, highlighting allele frequencies, penetrance, and the clinical manifestations of known genetic variants in the AfrAbian PD patient community.
Over 80% of genetic studies in the Parkinson's disease (PD) field have been conducted on individuals of European descent. There is a social and scientific imperative to understand the genetic basis of PD across global populations for therapeutic development and deployment. PD etiology is impacted by genetic and environmental factors that are variable by ancestry and region, emphasising the need for worldwide programs to gather large numbers of patients to identify novel candidate genes and risk loci involved in disease. Only a handful of documented genetic assessments have investigated families with PD in AfrAbia, which comprises the member nations of the Arab League and the African Union, with very limited cohort and case-control studies reported. This review article summarises prior research on PD genetics in AfrAbia, highlighting gaps and challenges. We discuss the etiological risk spectrum in the context of historical interactions, highlighting allele frequencies, penetrance, and the clinical manifestations of known genetic variants in the AfrAbian PD patient community.Over 80% of genetic studies in the Parkinson's disease (PD) field have been conducted on individuals of European descent. There is a social and scientific imperative to understand the genetic basis of PD across global populations for therapeutic development and deployment. PD etiology is impacted by genetic and environmental factors that are variable by ancestry and region, emphasising the need for worldwide programs to gather large numbers of patients to identify novel candidate genes and risk loci involved in disease. Only a handful of documented genetic assessments have investigated families with PD in AfrAbia, which comprises the member nations of the Arab League and the African Union, with very limited cohort and case-control studies reported. This review article summarises prior research on PD genetics in AfrAbia, highlighting gaps and challenges. We discuss the etiological risk spectrum in the context of historical interactions, highlighting allele frequencies, penetrance, and the clinical manifestations of known genetic variants in the AfrAbian PD patient community.
Author Mohamed, Wael
Kissani, Najib
Bandres-Ciga, Sara
Al-Mubarak, Bashayer
Alghamdi, Badrah S
Agarwal, Vidhu
Eltantawi, Mohamed Abdelhalim
Makarious, Mary B
Alzoubi, Karem H.
Sassi, Samia Ben
Mecheri, Yasser
Zewde, Yared Zenebe
Kamel, Walaa A.
AA-PD-GC, on behalf of
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Keywords Parkinson's disease
genetics
challenges
gaps
prospects
AfrAbia
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Snippet Over 80% of genetic studies in the Parkinson’s disease (PD) field have been conducted on individuals of European descent. There is a social and scientific...
Over 80% of genetic studies in the Parkinson's disease (PD) field have been conducted on individuals of European descent. There is a social and scientific...
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SubjectTerms 15th century
afrabia
Arab people
challenges
Environmental factors
Etiology
gaps
Gene frequency
Genes
Genetic diversity
Genetic Predisposition to Disease
Genetic variance
Genetics
Haplotypes
Health risk assessment
Humans
Movement disorders
Mutation
Neurodegenerative diseases
Parkinson Disease - genetics
Parkinson's disease
Patients
prospects
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Title The Genetic Architecture of Parkinson's Disease in the AfrAbia Population: Current State and Future Perspectives
URI https://www.ncbi.nlm.nih.gov/pubmed/39207075
https://www.proquest.com/docview/3222371402
https://www.proquest.com/docview/3099797662
https://doaj.org/article/9e070d81e7db45478f5774ce77a8f78c
Volume 23
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