Age-related Changes in Amplitude Ratio, Duration Ratio and Area Ratio in Nerve Conduction Studies
We investigated the effect of aging on nerve conduction parameters in 184 subjects (aged 10-75 years) without any history or signs of peripheral neuropathy, in order to clarify the diagnostic parameters of demyelinating neuropathies in the aged. The CMAP amplitude ratio (proximal CMAP/distal CMAP),...
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Published in | Nihon Rōnen Igakkai zasshi Vol. 32; no. 8-9; pp. 547 - 552 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | Japanese |
Published |
Japan
The Japan Geriatrics Society
1995
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Subjects | |
Online Access | Get full text |
ISSN | 0300-9173 |
DOI | 10.3143/geriatrics.32.547 |
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Abstract | We investigated the effect of aging on nerve conduction parameters in 184 subjects (aged 10-75 years) without any history or signs of peripheral neuropathy, in order to clarify the diagnostic parameters of demyelinating neuropathies in the aged. The CMAP amplitude ratio (proximal CMAP/distal CMAP), duration ratio and area ratio remained unchanged throughout the second to eighth decades. The lower limits of normal CMAP amplitude ratio (mean -3SD) were 0.79 (median nerve), 0.74 (ulnar nerve), 0.59 (peroneal nerve), and 0.48 (tibial nerve). The upper limits of normal CMAP duration ratio (mean 11+3SD) were 1.22 (median nerve), 1.19 (ulnar nerve), 1.35 (peroneal nerve), and 1.32 (tibial nerve). The lower limits of normal CMAP area ratio (mean-3SD) were 0.84 (median nerve), 0.78 (ulnar nerve), 0.61 (peroneal nerve), and 0.62 (tibial nerve). There were no age-related changes in amplitude ratio or duration ratio of SNAP, although the standard deviations increased with age. Since the amplitude ratio, duration ratio and area ratio are simple and age-independent, they can provide useful and reliable information for routine nerve conduction studies for aged patients with demyelinating neuropathies. |
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AbstractList | We investigated the effect of aging on nerve conduction parameters in 184 subjects (aged 10-75 years) without any history or signs of peripheral neuropathy, in order to clarify the diagnostic parameters of demyelinating neuropathies in the aged. The CMAP amplitude ratio (proximal CMAP/distal CMAP), duration ratio and area ratio remained unchanged throughout the second to eighth decades. The lower limits of normal CMAP amplitude ratio (mean -3SD) were 0.79 (median nerve), 0.74 (ulnar nerve), 0.59 (peroneal nerve), and 0.48 (tibial nerve). The upper limits of normal CMAP duration ratio (mean 11+ 3SD) were 1.22 (median nerve), 1.19 (ulnar nerve), 1.35 (peroneal nerve), and 1.32 (tibial nerve). The lower limits of normal CMAP area ratio (mean -3SD) were 0.84 (median nerve), 0.78 (ulnar nerve), 0.61 (peroneal nerve), and 0.62 (tibial nerve). There were no age-related changes in amplitude ratio or duration ratio of SNAP, although the standard deviations increased with age. Since the amplitude ratio, duration ratio and area ratio are simple and age-independent, they can provide useful and reliable information for routine nerve conduction studies for aged patients with demyelinating neuropathies. We investigated the effect of aging on nerve conduction parameters in 184 subjects (aged 10-75 years) without any history or signs of peripheral neuropathy, in order to clarify the diagnostic parameters of demyelinating neuropathies in the aged. The CMAP amplitude ratio (proximal CMAP/distal CMAP), duration ratio and area ratio remained unchanged throughout the second to eighth decades. The lower limits of normal CMAP amplitude ratio (mean -3SD) were 0.79 (median nerve), 0.74 (ulnar nerve), 0.59 (peroneal nerve), and 0.48 (tibial nerve). The upper limits of normal CMAP duration ratio (mean 11+ 3SD) were 1.22 (median nerve), 1.19 (ulnar nerve), 1.35 (peroneal nerve), and 1.32 (tibial nerve). The lower limits of normal CMAP area ratio (mean -3SD) were 0.84 (median nerve), 0.78 (ulnar nerve), 0.61 (peroneal nerve), and 0.62 (tibial nerve). There were no age-related changes in amplitude ratio or duration ratio of SNAP, although the standard deviations increased with age. Since the amplitude ratio, duration ratio and area ratio are simple and age-independent, they can provide useful and reliable information for routine nerve conduction studies for aged patients with demyelinating neuropathies.We investigated the effect of aging on nerve conduction parameters in 184 subjects (aged 10-75 years) without any history or signs of peripheral neuropathy, in order to clarify the diagnostic parameters of demyelinating neuropathies in the aged. The CMAP amplitude ratio (proximal CMAP/distal CMAP), duration ratio and area ratio remained unchanged throughout the second to eighth decades. The lower limits of normal CMAP amplitude ratio (mean -3SD) were 0.79 (median nerve), 0.74 (ulnar nerve), 0.59 (peroneal nerve), and 0.48 (tibial nerve). The upper limits of normal CMAP duration ratio (mean 11+ 3SD) were 1.22 (median nerve), 1.19 (ulnar nerve), 1.35 (peroneal nerve), and 1.32 (tibial nerve). The lower limits of normal CMAP area ratio (mean -3SD) were 0.84 (median nerve), 0.78 (ulnar nerve), 0.61 (peroneal nerve), and 0.62 (tibial nerve). There were no age-related changes in amplitude ratio or duration ratio of SNAP, although the standard deviations increased with age. Since the amplitude ratio, duration ratio and area ratio are simple and age-independent, they can provide useful and reliable information for routine nerve conduction studies for aged patients with demyelinating neuropathies. |
Author | Nakamura, Shigenobu Nakayama, Takayasu Maruyama, Hirofumi Mimori, Yasuyo Yukawa, Motoko Kohriyama, Tatsuo Tanaka, Eiji Kurokawa, Katsumi Yamashita, Hiroshi |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/8531399$$D View this record in MEDLINE/PubMed |
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References | 4) 平岡達也: 脛骨神経におけるM波振幅比の評価. 脳波と筋電図 1989; 17: 59-66. 9) 三森康世, 木村淳: 波形分析. 総合リハ1990; 18: 341-345. 5) Cornblath DR, Asbury AK, Albers JW, Feasby TE, Hahn AF, Mcleod JG, et al: Research criteria for diagnosis of chronic inflammatory demyelonating polyneuropathy (CIDP). Neurology 1991. 1) 永田博司: 末梢神経疾患. 新老年学 (折茂肇編), 東京大学出版会, 東京, 1992, p546-549. 3) Taylor PK: CMAP dispersion, amplitude decay, and area decay in a normal population. Muscle Nerve 1993; 16: 1181-1187. 7) Taylor PK: Non-linear effects of age on nerve conduction in adults. J Neurol Sci 1984; 66: 223-234. 8) 黒川勝己, 田中英司, 山下拓史, 郡山達男, 三森康世, 中村重信, 他: 末梢神経伝導検査所見の加齢変化 (会). 日老医誌 1993; 30: 527. 2) Kimura J, Machida M, Ishida T, Yamada T, Robert LR, Kudo Y, et al: Relation between size of compound sensory or muscle action potentials, and length of nerve segment. Neurology 1986; 36: 647-652. 6) 園生雅弘: 伝導ブロックの判定基準, 及び伝導ブロックを生ずる疾患のスペクトラム. 臨床神経1991; 31: 1337-1339. |
References_xml | – reference: 3) Taylor PK: CMAP dispersion, amplitude decay, and area decay in a normal population. Muscle Nerve 1993; 16: 1181-1187. – reference: 7) Taylor PK: Non-linear effects of age on nerve conduction in adults. J Neurol Sci 1984; 66: 223-234. – reference: 5) Cornblath DR, Asbury AK, Albers JW, Feasby TE, Hahn AF, Mcleod JG, et al: Research criteria for diagnosis of chronic inflammatory demyelonating polyneuropathy (CIDP). Neurology 1991. – reference: 9) 三森康世, 木村淳: 波形分析. 総合リハ1990; 18: 341-345. – reference: 8) 黒川勝己, 田中英司, 山下拓史, 郡山達男, 三森康世, 中村重信, 他: 末梢神経伝導検査所見の加齢変化 (会). 日老医誌 1993; 30: 527. – reference: 4) 平岡達也: 脛骨神経におけるM波振幅比の評価. 脳波と筋電図 1989; 17: 59-66. – reference: 6) 園生雅弘: 伝導ブロックの判定基準, 及び伝導ブロックを生ずる疾患のスペクトラム. 臨床神経1991; 31: 1337-1339. – reference: 1) 永田博司: 末梢神経疾患. 新老年学 (折茂肇編), 東京大学出版会, 東京, 1992, p546-549. – reference: 2) Kimura J, Machida M, Ishida T, Yamada T, Robert LR, Kudo Y, et al: Relation between size of compound sensory or muscle action potentials, and length of nerve segment. Neurology 1986; 36: 647-652. |
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SubjectTerms | Action Potentials Adolescent Adult Aged Aging - physiology Child Compoung muscle action potential Conduction block Demyelinating Diseases - diagnosis Humans Middle Aged Muscles - physiology Muscles - physiopathology Nerve conduction study Neural Conduction Peripheral Nerves - physiology Peripheral Nerves - physiopathology Sensory nerve action potential Temporal dispersion |
Title | Age-related Changes in Amplitude Ratio, Duration Ratio and Area Ratio in Nerve Conduction Studies |
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