Age-related Changes in Amplitude Ratio, Duration Ratio and Area Ratio in Nerve Conduction Studies

We investigated the effect of aging on nerve conduction parameters in 184 subjects (aged 10-75 years) without any history or signs of peripheral neuropathy, in order to clarify the diagnostic parameters of demyelinating neuropathies in the aged. The CMAP amplitude ratio (proximal CMAP/distal CMAP),...

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Published inNihon Rōnen Igakkai zasshi Vol. 32; no. 8-9; pp. 547 - 552
Main Authors Kurokawa, Katsumi, Tanaka, Eiji, Nakayama, Takayasu, Maruyama, Hirofumi, Nakamura, Shigenobu, Mimori, Yasuyo, Yamashita, Hiroshi, Kohriyama, Tatsuo, Yukawa, Motoko
Format Journal Article
LanguageJapanese
Published Japan The Japan Geriatrics Society 1995
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ISSN0300-9173
DOI10.3143/geriatrics.32.547

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Abstract We investigated the effect of aging on nerve conduction parameters in 184 subjects (aged 10-75 years) without any history or signs of peripheral neuropathy, in order to clarify the diagnostic parameters of demyelinating neuropathies in the aged. The CMAP amplitude ratio (proximal CMAP/distal CMAP), duration ratio and area ratio remained unchanged throughout the second to eighth decades. The lower limits of normal CMAP amplitude ratio (mean -3SD) were 0.79 (median nerve), 0.74 (ulnar nerve), 0.59 (peroneal nerve), and 0.48 (tibial nerve). The upper limits of normal CMAP duration ratio (mean 11+3SD) were 1.22 (median nerve), 1.19 (ulnar nerve), 1.35 (peroneal nerve), and 1.32 (tibial nerve). The lower limits of normal CMAP area ratio (mean-3SD) were 0.84 (median nerve), 0.78 (ulnar nerve), 0.61 (peroneal nerve), and 0.62 (tibial nerve). There were no age-related changes in amplitude ratio or duration ratio of SNAP, although the standard deviations increased with age. Since the amplitude ratio, duration ratio and area ratio are simple and age-independent, they can provide useful and reliable information for routine nerve conduction studies for aged patients with demyelinating neuropathies.
AbstractList We investigated the effect of aging on nerve conduction parameters in 184 subjects (aged 10-75 years) without any history or signs of peripheral neuropathy, in order to clarify the diagnostic parameters of demyelinating neuropathies in the aged. The CMAP amplitude ratio (proximal CMAP/distal CMAP), duration ratio and area ratio remained unchanged throughout the second to eighth decades. The lower limits of normal CMAP amplitude ratio (mean -3SD) were 0.79 (median nerve), 0.74 (ulnar nerve), 0.59 (peroneal nerve), and 0.48 (tibial nerve). The upper limits of normal CMAP duration ratio (mean 11+ 3SD) were 1.22 (median nerve), 1.19 (ulnar nerve), 1.35 (peroneal nerve), and 1.32 (tibial nerve). The lower limits of normal CMAP area ratio (mean -3SD) were 0.84 (median nerve), 0.78 (ulnar nerve), 0.61 (peroneal nerve), and 0.62 (tibial nerve). There were no age-related changes in amplitude ratio or duration ratio of SNAP, although the standard deviations increased with age. Since the amplitude ratio, duration ratio and area ratio are simple and age-independent, they can provide useful and reliable information for routine nerve conduction studies for aged patients with demyelinating neuropathies.
We investigated the effect of aging on nerve conduction parameters in 184 subjects (aged 10-75 years) without any history or signs of peripheral neuropathy, in order to clarify the diagnostic parameters of demyelinating neuropathies in the aged. The CMAP amplitude ratio (proximal CMAP/distal CMAP), duration ratio and area ratio remained unchanged throughout the second to eighth decades. The lower limits of normal CMAP amplitude ratio (mean -3SD) were 0.79 (median nerve), 0.74 (ulnar nerve), 0.59 (peroneal nerve), and 0.48 (tibial nerve). The upper limits of normal CMAP duration ratio (mean 11+ 3SD) were 1.22 (median nerve), 1.19 (ulnar nerve), 1.35 (peroneal nerve), and 1.32 (tibial nerve). The lower limits of normal CMAP area ratio (mean -3SD) were 0.84 (median nerve), 0.78 (ulnar nerve), 0.61 (peroneal nerve), and 0.62 (tibial nerve). There were no age-related changes in amplitude ratio or duration ratio of SNAP, although the standard deviations increased with age. Since the amplitude ratio, duration ratio and area ratio are simple and age-independent, they can provide useful and reliable information for routine nerve conduction studies for aged patients with demyelinating neuropathies.We investigated the effect of aging on nerve conduction parameters in 184 subjects (aged 10-75 years) without any history or signs of peripheral neuropathy, in order to clarify the diagnostic parameters of demyelinating neuropathies in the aged. The CMAP amplitude ratio (proximal CMAP/distal CMAP), duration ratio and area ratio remained unchanged throughout the second to eighth decades. The lower limits of normal CMAP amplitude ratio (mean -3SD) were 0.79 (median nerve), 0.74 (ulnar nerve), 0.59 (peroneal nerve), and 0.48 (tibial nerve). The upper limits of normal CMAP duration ratio (mean 11+ 3SD) were 1.22 (median nerve), 1.19 (ulnar nerve), 1.35 (peroneal nerve), and 1.32 (tibial nerve). The lower limits of normal CMAP area ratio (mean -3SD) were 0.84 (median nerve), 0.78 (ulnar nerve), 0.61 (peroneal nerve), and 0.62 (tibial nerve). There were no age-related changes in amplitude ratio or duration ratio of SNAP, although the standard deviations increased with age. Since the amplitude ratio, duration ratio and area ratio are simple and age-independent, they can provide useful and reliable information for routine nerve conduction studies for aged patients with demyelinating neuropathies.
Author Nakamura, Shigenobu
Nakayama, Takayasu
Maruyama, Hirofumi
Mimori, Yasuyo
Yukawa, Motoko
Kohriyama, Tatsuo
Tanaka, Eiji
Kurokawa, Katsumi
Yamashita, Hiroshi
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5) Cornblath DR, Asbury AK, Albers JW, Feasby TE, Hahn AF, Mcleod JG, et al: Research criteria for diagnosis of chronic inflammatory demyelonating polyneuropathy (CIDP). Neurology 1991.
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3) Taylor PK: CMAP dispersion, amplitude decay, and area decay in a normal population. Muscle Nerve 1993; 16: 1181-1187.
7) Taylor PK: Non-linear effects of age on nerve conduction in adults. J Neurol Sci 1984; 66: 223-234.
8) 黒川勝己, 田中英司, 山下拓史, 郡山達男, 三森康世, 中村重信, 他: 末梢神経伝導検査所見の加齢変化 (会). 日老医誌 1993; 30: 527.
2) Kimura J, Machida M, Ishida T, Yamada T, Robert LR, Kudo Y, et al: Relation between size of compound sensory or muscle action potentials, and length of nerve segment. Neurology 1986; 36: 647-652.
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References_xml – reference: 3) Taylor PK: CMAP dispersion, amplitude decay, and area decay in a normal population. Muscle Nerve 1993; 16: 1181-1187.
– reference: 7) Taylor PK: Non-linear effects of age on nerve conduction in adults. J Neurol Sci 1984; 66: 223-234.
– reference: 5) Cornblath DR, Asbury AK, Albers JW, Feasby TE, Hahn AF, Mcleod JG, et al: Research criteria for diagnosis of chronic inflammatory demyelonating polyneuropathy (CIDP). Neurology 1991.
– reference: 9) 三森康世, 木村淳: 波形分析. 総合リハ1990; 18: 341-345.
– reference: 8) 黒川勝己, 田中英司, 山下拓史, 郡山達男, 三森康世, 中村重信, 他: 末梢神経伝導検査所見の加齢変化 (会). 日老医誌 1993; 30: 527.
– reference: 4) 平岡達也: 脛骨神経におけるM波振幅比の評価. 脳波と筋電図 1989; 17: 59-66.
– reference: 6) 園生雅弘: 伝導ブロックの判定基準, 及び伝導ブロックを生ずる疾患のスペクトラム. 臨床神経1991; 31: 1337-1339.
– reference: 1) 永田博司: 末梢神経疾患. 新老年学 (折茂肇編), 東京大学出版会, 東京, 1992, p546-549.
– reference: 2) Kimura J, Machida M, Ishida T, Yamada T, Robert LR, Kudo Y, et al: Relation between size of compound sensory or muscle action potentials, and length of nerve segment. Neurology 1986; 36: 647-652.
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SubjectTerms Action Potentials
Adolescent
Adult
Aged
Aging - physiology
Child
Compoung muscle action potential
Conduction block
Demyelinating Diseases - diagnosis
Humans
Middle Aged
Muscles - physiology
Muscles - physiopathology
Nerve conduction study
Neural Conduction
Peripheral Nerves - physiology
Peripheral Nerves - physiopathology
Sensory nerve action potential
Temporal dispersion
Title Age-related Changes in Amplitude Ratio, Duration Ratio and Area Ratio in Nerve Conduction Studies
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