How Does the Analytical Quality of the High-Sensitivity Cardiac Troponin T Assay Affect the ESC Rule Out Algorithm for NSTEMI?
The ESC algorithm requires that a difference of <3 ng/L can be detected (4) and, by implication, that there is an absolute RCV (8) value of <3 ng/L. Because cardiac troponin is reported in whole numbers, the actual lowest detectable 8 value should be 2 ng/L. [...]the hs-cTnT assay showed satis...
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| Published in | Clinical chemistry (Baltimore, Md.) Vol. 65; no. 3; pp. 494 - 496 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Oxford University Press
01.03.2019
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0009-9147 1530-8561 1530-8561 |
| DOI | 10.1373/clinchem.2018.298703 |
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| Abstract | The ESC algorithm requires that a difference of <3 ng/L can be detected (4) and, by implication, that there is an absolute RCV (8) value of <3 ng/L. Because cardiac troponin is reported in whole numbers, the actual lowest detectable 8 value should be 2 ng/L. [...]the hs-cTnT assay showed satisfactory analytical precision when using 2 Cobas e801 modules, but laboratories should still verify their CVA locally before implementing the ESC rule-out algorithm. Hormone Laboratory Haukeland University Hospital PO Box 1400 5021 Bergen, Norway E-mail kristin.moberg.aakre@helse-bergen.no Previously published online at DOI: 10.1373/clinchem.2018.298703 1 Nonstandard abbreviations: ESC, European Society of Cardiology; NSTEMI, non-ST elevation myocardial infarction; hs-cTnT, high-sensitivity cardiac troponin T; CVA, analytical variation; RCV, reference change values; CV,, intra-individual biological variation. |
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| AbstractList | The ESC algorithm requires that a difference of <3 ng/L can be detected (4) and, by implication, that there is an absolute RCV (8) value of <3 ng/L. Because cardiac troponin is reported in whole numbers, the actual lowest detectable 8 value should be 2 ng/L. [...]the hs-cTnT assay showed satisfactory analytical precision when using 2 Cobas e801 modules, but laboratories should still verify their CVA locally before implementing the ESC rule-out algorithm. Hormone Laboratory Haukeland University Hospital PO Box 1400 5021 Bergen, Norway E-mail kristin.moberg.aakre@helse-bergen.no Previously published online at DOI: 10.1373/clinchem.2018.298703 1 Nonstandard abbreviations: ESC, European Society of Cardiology; NSTEMI, non-ST elevation myocardial infarction; hs-cTnT, high-sensitivity cardiac troponin T; CVA, analytical variation; RCV, reference change values; CV,, intra-individual biological variation. |
| Author | Collinson, Paul Åsberg, Arne Aakre, Kristin M Haagensen, Kristin |
| Author_xml | – sequence: 1 givenname: Kristin surname: Haagensen fullname: Haagensen, Kristin organization: Department of Medical Biochemistry and Pharmacology Haukeland University Hospital Bergen, Norway – sequence: 2 givenname: Paul surname: Collinson fullname: Collinson, Paul organization: Departments of Clinical Blood Sciences and Cardiology St Georges University Hospitals NHS Foundation Trust and St George's University of London London, United Kingdom – sequence: 3 givenname: Arne surname: Åsberg fullname: Åsberg, Arne organization: Department of Clinical Chemistry Trondheim University Hospital Trondheim, Norway – sequence: 4 givenname: Kristin M surname: Aakre fullname: Aakre, Kristin M organization: Department of Medical Biochemistry and Pharmacology Haukeland University Hospital Bergen, Norway, Hormone Laboratory Haukeland University Hospital Bergen, Norway, Department of Clinical Science University of Bergen, Bergen, Norway |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30647124$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1373/clinchem.2013.216978 10.1016/j.cjca.2017.11.010 10.1093/eurheartj/ehv320 10.1016/j.clinbiochem.2013.03.022 10.3109/10408368909106595 |
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| References | Kavsak (2020022605460019000_B5) 2018; 34 Fraser (2020022605460019000_B3) 1989; 27 Hammarsten (2020022605460019000_B2) 2013; 46 Roffi (2020022605460019000_B1) 2016; 37 Aakre (2020022605460019000_B4) 2014; 60 |
| References_xml | – volume: 60 start-page: 838 year: 2014 ident: 2020022605460019000_B4 article-title: Weekly and 90-Minute biological variations in cardiac troponin T and cardiac troponin I in hemodialysis patients and healthy controls publication-title: Clin Chem doi: 10.1373/clinchem.2013.216978 – volume: 34 start-page: 209.e5 year: 2018 ident: 2020022605460019000_B5 article-title: Variability between reagent lots for high-sensitivity cardiac troponin I may affect performance of early rule out strategies publication-title: Can J Cardiol doi: 10.1016/j.cjca.2017.11.010 – volume: 37 start-page: 267 year: 2016 ident: 2020022605460019000_B1 article-title: 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC) publication-title: Eur Heart J doi: 10.1093/eurheartj/ehv320 – volume: 46 start-page: 1055 year: 2013 ident: 2020022605460019000_B2 article-title: Long-time quality assessment of the Elecsys Troponin T hs assay publication-title: Clin Biochem doi: 10.1016/j.clinbiochem.2013.03.022 – volume: 27 start-page: 409 year: 1989 ident: 2020022605460019000_B3 article-title: Generation and application of data on biological variation in clinical chemistry publication-title: Crit Rev Clin Lab Sci doi: 10.3109/10408368909106595 |
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| SubjectTerms | Abbreviations Algorithms Angina pectoris Bias Biological variation Biomarkers - blood Blood Chemical Analysis - statistics & numerical data Calcium-binding protein Cardiology Clinching Heart Heart attacks Humans Laboratories Mathematical analysis Myocardial infarction Non-ST Elevated Myocardial Infarction - diagnosis Sensitivity analysis Statistical analysis Troponin Troponin T Troponin T - blood Values |
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| Title | How Does the Analytical Quality of the High-Sensitivity Cardiac Troponin T Assay Affect the ESC Rule Out Algorithm for NSTEMI? |
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