TIM-3 rs1036199 polymorphism increases susceptibility to autoimmune diseases: evidence based on 4200 subjects
Conflicting results have been reported regarding differing studies on the association between T-cell immunoglobulin and mucin domain 3 polymorphisms and autoimmune disease. The purpose of the present study was to evaluate the association of TIM-3 rs1036199 (4259 G/T) polymorphism with autoimmune dis...
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| Published in | Bioscience reports Vol. 38; no. 6 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Portland Press Ltd
21.12.2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0144-8463 1573-4935 1573-4935 |
| DOI | 10.1042/BSR20181235 |
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| Abstract | Conflicting results have been reported regarding differing studies on the association between T-cell immunoglobulin and mucin domain 3 polymorphisms and autoimmune disease. The purpose of the present study was to evaluate the association of TIM-3 rs1036199 (4259 G/T) polymorphism with autoimmune disease susceptibility. A meta-analysis was performed to obtain a more precise evaluation of the association. Ten eligible studies were retrieved by searching PubMed, Embase and Web of Science databases, and statistical analyses were performed using STATA software. The pooled results indicated that TIM-3 rs1036199 polymorphism was significantly associated with an increased risk of overall autoimmune disease in allele comparison (G versus T: OR = 1.59, 95%CI: 1.17–2.17) and heterozygous comparison (GT versus TT: OR = 1.68, 95%CI: 1.37–2.06). Subgroup analyses based on disease type demonstrated that TIM-3 rs1036199 polymorphism was associated with an increased risk of rheumatic arthritis (G versus T: OR = 1.88, 95%CI: 1.45–2.44; GT versus TT: OR = 2.02, 95%CI: 1.53–2.65), especially in Asian populations. |
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| AbstractList | Conflicting results have been reported regarding differing studies on the association between T-cell immunoglobulin and mucin domain 3 polymorphisms and autoimmune disease. The purpose of the present study was to evaluate the association of TIM-3 rs1036199 (4259 G/T) polymorphism with autoimmune disease susceptibility. A meta-analysis was performed to obtain a more precise evaluation of the association. Ten eligible studies were retrieved by searching PubMed, Embase and Web of Science databases, and statistical analyses were performed using STATA software. The pooled results indicated that TIM-3 rs1036199 polymorphism was significantly associated with an increased risk of overall autoimmune disease in allele comparison (G versus T: OR = 1.59, 95%CI: 1.17-2.17) and heterozygous comparison (GT versus TT: OR = 1.68, 95%CI: 1.37-2.06). Subgroup analyses based on disease type demonstrated that TIM-3 rs1036199 polymorphism was associated with an increased risk of rheumatic arthritis (G versus T: OR = 1.88, 95%CI: 1.45-2.44; GT versus TT: OR = 2.02, 95%CI: 1.53-2.65), especially in Asian populations. Conflicting results have been reported regarding differing studies on the association between T-cell immunoglobulin and mucin domain 3 polymorphisms and autoimmune disease. The purpose of the present study was to evaluate the association of TIM-3 rs1036199 (4259 G/T) polymorphism with autoimmune disease susceptibility. A meta-analysis was performed to obtain a more precise evaluation of the association. Ten eligible studies were retrieved by searching PubMed, Embase and Web of Science databases, and statistical analyses were performed using STATA software. The pooled results indicated that TIM-3 rs1036199 polymorphism was significantly associated with an increased risk of overall autoimmune disease in allele comparison (G versus T: OR = 1.59, 95%CI: 1.17-2.17) and heterozygous comparison (GT versus TT: OR = 1.68, 95%CI: 1.37-2.06). Subgroup analyses based on disease type demonstrated that TIM-3 rs1036199 polymorphism was associated with an increased risk of rheumatic arthritis (G versus T: OR = 1.88, 95%CI: 1.45-2.44; GT versus TT: OR = 2.02, 95%CI: 1.53-2.65), especially in Asian populations.Conflicting results have been reported regarding differing studies on the association between T-cell immunoglobulin and mucin domain 3 polymorphisms and autoimmune disease. The purpose of the present study was to evaluate the association of TIM-3 rs1036199 (4259 G/T) polymorphism with autoimmune disease susceptibility. A meta-analysis was performed to obtain a more precise evaluation of the association. Ten eligible studies were retrieved by searching PubMed, Embase and Web of Science databases, and statistical analyses were performed using STATA software. The pooled results indicated that TIM-3 rs1036199 polymorphism was significantly associated with an increased risk of overall autoimmune disease in allele comparison (G versus T: OR = 1.59, 95%CI: 1.17-2.17) and heterozygous comparison (GT versus TT: OR = 1.68, 95%CI: 1.37-2.06). Subgroup analyses based on disease type demonstrated that TIM-3 rs1036199 polymorphism was associated with an increased risk of rheumatic arthritis (G versus T: OR = 1.88, 95%CI: 1.45-2.44; GT versus TT: OR = 2.02, 95%CI: 1.53-2.65), especially in Asian populations. |
| Author | Wang, Xing Zhang, Heqian Liu, Rongzeng Wang, Shengnan Chen, Xiafei |
| Author_xml | – sequence: 1 givenname: Rongzeng orcidid: 0000-0002-0518-6145 surname: Liu fullname: Liu, Rongzeng organization: Department of Immunology, Medical College, Henan University of Science and Technology, Luoyang 471023, China – sequence: 2 givenname: Xing surname: Wang fullname: Wang, Xing organization: Department of Immunology, Medical College, Henan University of Science and Technology, Luoyang 471023, China – sequence: 3 givenname: Xiafei surname: Chen fullname: Chen, Xiafei organization: Network Information Center, Henan University of Science and Technology, Luoyang 471023, China – sequence: 4 givenname: Shengnan surname: Wang fullname: Wang, Shengnan organization: Department of Immunology, Medical College, Henan University of Science and Technology, Luoyang 471023, China – sequence: 5 givenname: Heqian surname: Zhang fullname: Zhang, Heqian organization: Department of Immunology, Medical College, Henan University of Science and Technology, Luoyang 471023, China |
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| CitedBy_id | crossref_primary_10_1016_j_trim_2024_102084 crossref_primary_10_1016_j_jaut_2019_102333 crossref_primary_10_3389_fimmu_2020_606721 crossref_primary_10_3390_biomedicines11041130 crossref_primary_10_3389_fimmu_2022_793234 crossref_primary_10_3390_ijms21218318 crossref_primary_10_1016_j_semcancer_2020_07_001 |
| Cites_doi | 10.1016/S0092-8674(00)81110-1 10.1371/journal.pone.0088884 10.1016/j.imlet.2004.06.008 10.1093/mutage/ger009 10.1007/s00580-013-1716-6 10.1007/s12026-014-8524-1 10.1038/nrg2489 10.1016/j.humimm.2009.03.013 10.1507/endocrj.EJ16-0551 10.1158/0008-5472.CAN-13-2908 10.1186/gm305 10.1016/j.coi.2006.09.009 10.1016/j.humimm.2011.04.007 10.1556/EuJMI.3.2013.3.10 10.3892/ol.2015.2845 10.1038/ni988 10.1007/s10038-008-0286-y 10.1111/j.1744-313X.2011.01046.x 10.1016/j.msard.2017.09.031 10.1016/j.molmed.2005.06.008 10.1016/j.bbrc.2004.01.154 10.1038/emm.2004.37 10.1007/s00251-004-0743-5 10.4049/jimmunol.1302290 10.1111/iji.12201 10.1111/j.1744-313X.2012.01103.x 10.4238/2012.January.9.7 10.1111/iji.12264 10.1089/dna.2014.2456 10.1016/j.humimm.2014.02.001 10.1038/nrendo.2013.161 10.1002/eji.200939274 10.1016/j.clinbiochem.2012.08.004 10.1172/JCI78086 10.1007/s00439-010-0844-1 10.1186/1753-6561-1-s1-s33 |
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| Keywords | Autoimmune diseases TIM-3 Meta-analysis Polymorphism |
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| SubjectTerms | Alleles Autoimmune Diseases - epidemiology Autoimmune Diseases - genetics Autoimmune Diseases - pathology Female Genetic Association Studies Genetic Predisposition to Disease Hepatitis A Virus Cellular Receptor 2 - genetics Heterozygote Humans Male Polymorphism, Single Nucleotide |
| Title | TIM-3 rs1036199 polymorphism increases susceptibility to autoimmune diseases: evidence based on 4200 subjects |
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