Peroxisome proliferator-activated receptor-α-mediated transcription of miR-301a and miR-454 and their host gene SKA2 regulates endothelin-1 and PAI-1 expression in sickle cell disease - Gonsalves, Caryn S.; Li, Chen; Malik, Punam; Tahara, Stanley M.; Kalra, Vijay K. (Bioscience reports, 2015)
Keywords: Anemia, Sickle Cell - complications; Anemia, Sickle Cell - drug therapy; Anemia, Sickle Cell - genetics; Anemia, Sickle Cell - pathology; Animals; Cell Line; Chromosomal Proteins, Non-Histone - biosynthesis; Chromosomal Proteins, Non-Histone - genetics; Endothelin-1 - biosynthesis; Endothelin-1 - genetics; Fenofibrate - administration & dosage; Gene Expression Regulation - drug effects; Humans; Hypertension, Pulmonary - complications; Hypertension, Pulmonary - drug therapy; Hypertension, Pulmonary - genetics; Hypertension, Pulmonary - pathology; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Mice; MicroRNAs - biosynthesis; MicroRNAs - genetics; Original Paper; Original Papers; Placenta Growth Factor; Plasminogen Activator Inhibitor 1 - biosynthesis; Plasminogen Activator Inhibitor 1 - genetics; PPAR alpha - antagonists & inhibitors; PPAR alpha - genetics; PPAR alpha - metabolism; Pregnancy Proteins - genetics; Pregnancy Proteins - metabolism; Promoter Regions, Genetic; endothelin-1 (ET-1); spindle and kinetochore-associated protein-2 (SKA2); plasminogen activator inhibitor-1 (PAI-1); sickle cell disease (SCD); micro ribonucleic acid (miRNA); peroxisome proliferator-activated receptor-α (PPAR-α)