Chiral Phosphoric Acid Catalyzed Enantioselective Allylation of Aldehydes with Allyltrichlorosilane

Easily accessible chiral phosphoric acid lb has been applied as efficient organocatalyst for the asymmetric al- lylation of aldehydes with allyltrichlorosilane. In the presence of 20 mol% of lb, the allylation of a broad range of aldehydes proceeded smoothly to give the corresponding homoallylic alc...

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Published inChinese journal of chemistry Vol. 29; no. 8; pp. 1669 - 1671
Main Author 程柯 范甜甜 孙健
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.08.2011
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects
Aldehydes
allylation
allyltrichlorosilane
phosphoric acid
不对称
手性
有机催化剂
烯丙基化
磷酸
酸催化
醛
高烯丙基醇
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ISSN1001-604X
1614-7065
DOI10.1002/cjoc.201180244

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Summary:Easily accessible chiral phosphoric acid lb has been applied as efficient organocatalyst for the asymmetric al- lylation of aldehydes with allyltrichlorosilane. In the presence of 20 mol% of lb, the allylation of a broad range of aldehydes proceeded smoothly to give the corresponding homoallylic alcohol with up to 87% ee and 97% yield.
Bibliography:phosphoric acid, allylation, aldehydes, allyltrichlorosilane
31-1547/O6
Cheng, Ke Fan, Tiantian Sun, Jian（a Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan 610041, China b Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, Sichuan 610041, China）
Easily accessible chiral phosphoric acid lb has been applied as efficient organocatalyst for the asymmetric al- lylation of aldehydes with allyltrichlorosilane. In the presence of 20 mol% of lb, the allylation of a broad range of aldehydes proceeded smoothly to give the corresponding homoallylic alcohol with up to 87% ee and 97% yield.
istex:A6C2736E0AFA94C757A87C2CAFE77AF89602A94B
ArticleID:CJOC201180244
the National Natural Science Foundation of China - No. 20732006 and 20972152
ark:/67375/WNG-ZV3RQDK1-C
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201180244