Structure and Anti-HIV Activity of Betulinic Acid Analogues
Summary Firstly discovered in 1980s, human immunodeficiency virus (HIV) continues to affect more and more people. However, there is no effective drug available for the therapy of HIV infection. Betulinic acid existing in various medicinal herbs and fruits exhibits multiple biological effects, especi...
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| Published in | Current medical science Vol. 38; no. 3; pp. 387 - 397 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Wuhan
Huazhong University of Science and Technology
01.06.2018
University of South China, Hengyang 421001, China Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang 421001, China |
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| Online Access | Get full text |
| ISSN | 2096-5230 2523-899X 1672-0733 2523-899X |
| DOI | 10.1007/s11596-018-1891-4 |
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| Abstract | Summary
Firstly discovered in 1980s, human immunodeficiency virus (HIV) continues to affect more and more people. However, there is no effective drug available for the therapy of HIV infection. Betulinic acid existing in various medicinal herbs and fruits exhibits multiple biological effects, especially its outstanding anti-HIV activity, which has drawn the attentions of many pharmacists. Among the derivatives of betulinic acid, some compounds exhibited inhibitory activities at the nanomolar concentration, and have entered phase II clinical trials. This paper summarizes the current investigations on the anti-HIV activity of betulinic acid analogues, and provides valuable data for subsequent researches. |
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| AbstractList | Summary
Firstly discovered in 1980s, human immunodeficiency virus (HIV) continues to affect more and more people. However, there is no effective drug available for the therapy of HIV infection. Betulinic acid existing in various medicinal herbs and fruits exhibits multiple biological effects, especially its outstanding anti-HIV activity, which has drawn the attentions of many pharmacists. Among the derivatives of betulinic acid, some compounds exhibited inhibitory activities at the nanomolar concentration, and have entered phase II clinical trials. This paper summarizes the current investigations on the anti-HIV activity of betulinic acid analogues, and provides valuable data for subsequent researches. Firstly discovered in 1980s, human immunodeficiency virus (HIV) continues to affect more and more people. However, there is no effective drug available for the therapy of HIV infection. Betulinic acid existing in various medicinal herbs and fruits exhibits multiple biological effects, especially its outstanding anti-HIV activity, which has drawn the attentions of many pharmacists. Among the derivatives of betulinic acid, some compounds exhibited inhibitory activities at the nanomolar concentration, and have entered phase II clinical trials. This paper summarizes the current investigations on the anti-HIV activity of betulinic acid analogues, and provides valuable data for subsequent researches.Firstly discovered in 1980s, human immunodeficiency virus (HIV) continues to affect more and more people. However, there is no effective drug available for the therapy of HIV infection. Betulinic acid existing in various medicinal herbs and fruits exhibits multiple biological effects, especially its outstanding anti-HIV activity, which has drawn the attentions of many pharmacists. Among the derivatives of betulinic acid, some compounds exhibited inhibitory activities at the nanomolar concentration, and have entered phase II clinical trials. This paper summarizes the current investigations on the anti-HIV activity of betulinic acid analogues, and provides valuable data for subsequent researches. Firstly discovered in 1980s,human immunodeficiency virus (HIV) continues to affect more and more people.However,there is no effective drug available for the therapy of HIV infection.Betulinic acid existing in various medicinal herbs and fruits exhibits multiple biological effects,especially its outstanding anti-HIV activity,which has drawn the attentions of many pharmacists.Among the derivatives of betulinic acid,some compounds exhibited inhibitory activities at the nanomolar concentration,and have entered phase Ⅱ clinical trials.This paper summarizes the current investigations on the anti-HIV activity of betulinic acid analogues,and provides valuable data for subsequent researches. Firstly discovered in 1980s, human immunodeficiency virus (HIV) continues to affect more and more people. However, there is no effective drug available for the therapy of HIV infection. Betulinic acid existing in various medicinal herbs and fruits exhibits multiple biological effects, especially its outstanding anti-HIV activity, which has drawn the attentions of many pharmacists. Among the derivatives of betulinic acid, some compounds exhibited inhibitory activities at the nanomolar concentration, and have entered phase II clinical trials. This paper summarizes the current investigations on the anti-HIV activity of betulinic acid analogues, and provides valuable data for subsequent researches. |
| Author | Yao, Xu Chen, Hong-fei Zhang, Yin-xiang Luo, Xing-rui Huang, Qiu-xia Zheng, Xing |
| AuthorAffiliation | University of South China, Hengyang 421001, China;Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang 421001, China |
| AuthorAffiliation_xml | – name: University of South China, Hengyang 421001, China;Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang 421001, China |
| Author_xml | – sequence: 1 givenname: Qiu-xia surname: Huang fullname: Huang, Qiu-xia organization: University of South China, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study – sequence: 2 givenname: Hong-fei surname: Chen fullname: Chen, Hong-fei organization: University of South China, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study – sequence: 3 givenname: Xing-rui surname: Luo fullname: Luo, Xing-rui organization: University of South China, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study – sequence: 4 givenname: Yin-xiang surname: Zhang fullname: Zhang, Yin-xiang organization: University of South China, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study – sequence: 5 givenname: Xu surname: Yao fullname: Yao, Xu email: 355938360@qq.com organization: University of South China, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study – sequence: 6 givenname: Xing surname: Zheng fullname: Zheng, Xing email: zhengxing5018@yahoo.com organization: University of South China, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study |
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Firstly discovered in 1980s, human immunodeficiency virus (HIV) continues to affect more and more people. However, there is no effective drug available... Firstly discovered in 1980s, human immunodeficiency virus (HIV) continues to affect more and more people. However, there is no effective drug available for the... Firstly discovered in 1980s,human immunodeficiency virus (HIV) continues to affect more and more people.However,there is no effective drug available for the... |
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| Title | Structure and Anti-HIV Activity of Betulinic Acid Analogues |
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